Article
Cardiac & Cardiovascular Systems
Raina Sinha, Peter Chen, Rebecca Sam, Ali Dodge-Khatami, Jorge D. Salazar
Summary: This study compared early outcomes of neonatal palliation in SV patients using less than 5-mm versus 5-mm RV-PA conduits, finding statistical differences in some indicators but no significant differences in others. The results support further exploration into tailoring RV-PA conduit size based on individual patient characteristics.
ANNALS OF THORACIC SURGERY
(2021)
Article
Cardiac & Cardiovascular Systems
Scott H. Wirth, Haleh C. Heydarian, Elisa Marcuccio, Brooke E. Tepe, Laurel H. Stein, Garick D. Hill
Summary: This study evaluated the trends and factors influencing the first-stage palliation for hypoplastic left heart syndrome. It found that the use of right ventricle-to-pulmonary artery shunt increased over time, while the use of modified Blalock-Taussig shunt decreased. Higher-volume centers, male patients, and less complex patients were more likely to receive modified Blalock-Taussig shunt. However, compared to the right ventricle-to-pulmonary artery shunt, the modified Blalock-Taussig shunt was associated with higher mortality/transplant rates before the second-stage palliation.
ANNALS OF THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Aditya Sengupta, Kimberlee Gauvreau, Aditya Kaza, Catherine Allan, Ravi Thiagarajan, Pedro J. del Nido, Meena Nathan
Summary: A retrospective study found that residual lesions during surgery are associated with the need for postoperative ECMO. Furthermore, the timing of postoperative ECMO has an impact on hospital outcomes.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Environmental Sciences
Chao Yue, Jin Li, Jiaqi Zhang, Qiang Wang, Xu Wang
Summary: The study revealed that postoperative exposure to PM2.5 affects the patency of biologic prosthetic conduits, especially xenografts. The increase in the velocity of the ePTFE conduit is not associated with PM2.5 exposure, making it a suitable material for patients living in areas with high pollutant concentrations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cardiac & Cardiovascular Systems
Ryan J. Pewowaruk, Gregory P. Barton, Cody Johnson, J. Carter Ralphe, Christopher J. Francois, Luke Lamers, Alejandro Roldan-Alzate
Summary: The study reveals previously unknown consequences of PAS on ventricular function in an animal model of unilateral PA stenosis, and demonstrates that PA stent interventions can improve ventricular flow efficiency. The study also highlights the sensitivity of 4D flow CMR biomarkers in detecting early ventricular dysfunction for identifying patients who may benefit from PAS interventions.
JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE
(2021)
Article
Cardiac & Cardiovascular Systems
Aditya Sengupta, Emily M. Bucholz, Kimberlee Gauvreau, Jane W. Newburger, Margaret Schroeder, Aditya K. Kaza, Pedro J. del Nido, Meena Nathan
Summary: This study found that neighborhood socioeconomic status (SES) plays a significant role in the outcomes of patients with single ventricle heart disease undergoing first-stage palliation. Patients from lower SES neighborhoods had a higher risk of early mortality, longer hospital stays, higher costs, and late mortality. It is important to implement interventions to reduce in-hospital mortality and improve long-term survival in these patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Mohamed Farhan Nasser, Ahmad Jabri, Sneha Limaye, Shorabh Sharma, Hani Hamade, Mohammed Mhanna, Ashish Aneja, Sanjay Gandhi
Summary: This article discusses the risk stratification of patients with pulmonary embolism (PE) and emphasizes the importance of echocardiography in risk assessment and diagnosis of PE.
JOURNAL OF THE AMERICAN SOCIETY OF ECHOCARDIOGRAPHY
(2023)
Article
Cardiac & Cardiovascular Systems
Aditya Sengupta, Kimberlee Gauvreau, Aditya Kaza, David Hoganson, Pedro J. del Nido, Meena Nathan
Summary: This study investigated the optimal timing of reintervention for patients with single-ventricle heart disease after the initial palliative surgery. The results showed that earlier reintervention was associated with improved in-hospital survival and resource utilization.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Jerome Soquet, Gabriella Ricciardi, Celine Dupre, Francis Juthier
Summary: This article describes the use of a rigid tricuspid annuloplasty ring as an external support to prevent compression of a right ventricle-to-pulmonary artery conduit.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Richard J. Czosek, David S. Spar, Jeffrey B. Anderson, Philip R. Khoury, Gregory Webster
Summary: Arrhythmias are common and associated with poor outcomes during S1P in single ventricle patients. The use of antiarrhythmic medications may improve survival, but further studies are needed.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jennifer L. Smerling, Andrew B. Goldstone, Emile A. Bacha, Leonardo Liberman
Summary: The study aims to evaluate the long-term outcomes after tricuspid valve intervention during stage 2 palliation in patients with right ventricular dominant circulation in a multicenter study.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrew Constantine, Konstantinos Dimopoulos
Summary: Pulmonary artery denervation is a novel intervention aimed at reducing sympathetic activity in the pulmonary circulation for the treatment of pulmonary arterial hypertension. Despite some positive effects shown in pre-clinical studies and initial clinical trials, the technique's scope in current practice remains limited due to the lack of well-designed, large-scale, international randomized controlled clinical trials.
TRENDS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Justin Robinson, Joseph M. M. Forbess, Michael Slack, Julianne Moss, Alicia Chaves
Summary: Patients born with obstructed total anomalous pulmonary venous return, especially when combined with single ventricle physiology and non-cardiac congenital anomalies, face high risks of morbidity and mortality. Surgery within the first weeks of life to repair the pulmonary venous connection has historically shown disappointing outcomes. A multidisciplinary approach involving pediatric interventional cardiology and cardiac surgery is necessary to reduce the risks in this high-risk patient population. Our team successfully utilized transcatheter stent placement and patent ductus arteriosus to delay and stage cardiac surgeries, reducing morbidity and mortality in an infant with multiple cardiac anomalies.
PEDIATRIC CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Christopher J. Petit, Andrew C. Glatz, Andrew B. Goldstone, Mark A. Law, Jennifer C. Romano, Shiraz A. Maskatia, Paul J. Chai, Jeffrey D. Zampi, Jeffery J. Meadows, George T. Nicholson, Shabana Shahanavaz, Athar M. Qureshi, Courtney E. Mccracken, Christopher E. Mascio, Sarosh P. Batlivala, Ivor B. Asztalos, Steven J. Healan, Justin D. Smith, Joelle A. Pettus, Asaad Beshish, James E. B. Raulston, Krissie M. Hock, Amy L. Pajk, Bryan H. Goldstein
Summary: This study aimed to quantify the impact of hypoplastic pulmonary arteries (hPA) on outcomes in neonates with symptomatic tetralogy of Fallot (sTOF), and measure the impact of management strategy on pulmonary artery (PA) growth. The study included 542 neonates and found that the presence of hPA did not increase the hazard of mortality or reintervention after definitive repair, and the hPA cohort showed superior PA growth.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
J. P. G. van der Ven, V. P. Kamphuis, E. van den Bosch, D. Gnanam, C. Terol, A. J. J. C. Bogers, J. M. P. J. Breur, R. M. F. Berger, N. A. Blom, A. D. J. ten Harkel, L. Koopman, W. A. Helbing
Summary: This study aimed to explore the biological processes related to impaired ventricular function and recovery following Fontan palliations using a biomarker panel, as well as to describe changes in ventricular function across the Fontan palliation. Observational study was conducted in patients undergoing partial or total cavo-pulmonary connection surgeries. The results showed that the single ventricular longitudinal strain temporarily decreased in partial cavo-pulmonary connection patients, but not in total cavo-pulmonary connection patients. Several biomarkers were associated with post-operative stress and adaptation, but none were related to the outcome.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Cardiac & Cardiovascular Systems
Tim Berger, Matthias Siepe, Bjoern Simon, Friedhelm Beyersdorf, Zehang Chen, Stoyan Kondov, Christopher L. Schlett, Fabian Bamberg, Aleksandre Tarkhnishvili, Salome Chikvatia, Martin Czerny, Bartosz Rylski, Maximilian Kreibich
Summary: This study aimed to evaluate normal PA diameter, define PA aneurysms, and assess the correlation with aortic diameter, with body surface area being the only influencing factor of PA diameter. The results indicated a normal mean PA diameter of 32.0mm, suggesting that a PA aneurysm should not be considered below 45mm.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Julia Benk, Matthias Siepe, Tim Berger, Friedhelm Beyersdorf, Stoyan Kondov, Bartosz Rylski, Martin Czerny, Maximilian Kreibich
Summary: Thoracic endovascular aortic repair has become a valuable treatment modality for stabilizing patients with aortic rupture, but there is still a significant risk of postoperative complications and mortality.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Mikolaj Berezowski, Johannes Scheumann, Friedhelm Beyersdorf, Marek Jasinski, Tomasz Plonek, Matthias Siepe, Martin Czerny, Bartosz Rylski
Summary: This study assessed the changes in aortic geometry within 30 days after the onset of descending aortic dissection. The results showed that the aortic diameter rapidly increased in the first week, particularly in the first 3 days, and this was associated with the location of the dissection's entry.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Tim Berger, Maximilian Kreibich, Felix Mueller, Lara Breurer-Kellner, Bartosz Rylski, Stoyan Kondov, Holger Schroefel, Clarence Pingpoh, Friedhelm Beyersdorf, Matthias Siepe, Martin Czerny
Summary: This study analysed the risk factors, underlying mechanisms, and outcomes of postoperative stroke in patients undergoing total aortic arch replacement using the frozen elephant trunk technique. The study found that the incidence of postoperative stroke was 16.8%, with mortality rate of 10%. The most common mechanism of stroke was embolism. Age over 75, bovine arch, and acute preoperative neurological deficit were identified as predictors for postoperative stroke.
INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Clarence Pingpoh, Maximillian Kreibich, Tim Berger, Martin Thoma, Friedhelm Beyersdorf, Thomas Comberg, Albi Fagu, Matthias Siepe, Martin Czerny
Summary: This study retrospectively evaluated the in-hospital and overall outcome of patients who underwent mitral valve replacement (MVR) after a failed MitraClip procedure. The study found that the need for MVR after failed MitraClip repair is low and the results are acceptable. However, the options for reconstruction are often limited and MVR is frequently required.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Article
Cardiac & Cardiovascular Systems
Jan Gehlen, Anja Stundl, Radoslaw Debiec, Federica Fontana, Markus Krane, Dinara Sharipova, Christopher P. Nelson, Baravan Al-Kassou, Ann Sophie Giel, Jan Malte Sinning, Christopher M. H. Bruenger, Carolin F. Zelck, Laura L. Koebbe, Peter S. Braund, Thomas R. Webb, Simon Hetherington, Stephan Ensminger, Buntaro Fujita, Salah A. Mohamed, Malakh Shrestha, Heike Krueger, Matthias Siepe, Fabian Alexander Kari, Peter Nordbeck, Larissa Buravezky, Malte Kelm, Verena Veulemans, Matti Adam, Stephan Baldus, Karl Ludwig Laugwitz, Yannick Haas, Matthias Karck, Uwe Mehlhorn, Lars Oliver Conzelmann, Ingo Breitenbach, Corinna Lebherz, Paul Urbanski, Won Keun Kim, Joscha Kandels, David Ellinghaus, Ulrike Nowak-Goettl, Per Hoffmann, Felix Wirth, Stefanie Doppler, Harald Lahm, Martina Dressen, Moritz von Scheidt, Katharina Knoll, Thorsten Kessler, Christian Hengstenberg, Heribert Schunkert, Georg Nickenig, Markus M. Noethen, Aidan P. Bolger, Salim Abdelilah-Seyfried, Nilesh J. Samani, Jeanette Erdmann, Teresa Trenkwalder, Johannes Schumacher
Summary: This study provides deeper insights into the genetic risk architecture of bicuspid aortic valve (BAV) disease, including both single-marker and polygenic levels. The study identified a new risk locus and confirmed previously reported risk loci. Additionally, the study revealed that the transcriptome profile in endothelial cells plays a major role in the pathology of BAV.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Sami Kueri, Tim Berger, Paul-Catalin Puiu, Yasir Alhamami, Nawras Diab, Martin Czerny, Willibald Hochholzer, Matthias Siepe
Summary: This study compared the early results of the Perceval valve with well-established valves in terms of clinical and hemodynamic performances. The Perceval valve exhibited lower postoperative gradients and a higher rate of pacemaker implantation, which can be reduced by avoiding oversizing.
THORACIC AND CARDIOVASCULAR SURGEON
(2023)
Letter
Cardiac & Cardiovascular Systems
Daijiro Tomii, Thomas Pilgrim, Taishi Okuno, Jonas Lanz, Fabien Praz, Stefan Stortecky, Matthias Siepe, Stephan Windecker, David Reineke
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2023)
Article
Cardiac & Cardiovascular Systems
Fabio Pregaldini, Hannah Widenka, Mohamed Barghout, Christoph Grani, Martin Czerny, Fabian A. Kari, Salome Chikvatia, Alexander Kadner, Matthias Siepe
Summary: The study aimed to describe the outcomes of surgical correction for AAOCA in terms of symptom relief. The results showed that most patients experienced significant improvement in symptoms after AAOCA correction.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Murat Yildiz, Maria Nucera, Silvan Jungi, Paul Philipp Heinisch, Selim Mosbahi, Daniel Becker, Matthias Siepe, Florian Schoenhoff
Summary: This study aimed to determine the outcome of Stanford type B aortic dissection in patients with Marfan syndrome (MFS) and to evaluate aortic diameters at the time of dissection as well as the impact of previous aortic root replacement. The study found that Stanford type B dissection occurs below accepted thresholds for intervention in patients with MFS. Two-thirds of patients require intervention after dissection, and there is no difference in freedom from type B dissection between different surgical procedures.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Emmanuel Zimmer, Maria Nucera, Clarence Pingpoh, Murat Yildiz, Paul Puiu, Florian Schoenhoff, Martin Czerny, Matthias Siepe
Summary: Implantation of radiopaque markers during aortic root surgery does not increase operative risk and facilitates secondary diagnostic and therapeutic interventions.
JOURNAL OF CARDIOTHORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Andrzej Juraszek, Tim Berger, Maximilian Kreibich, Konstantinos Tsagakis, Thanos Sioris, Zeynep Berkarda, Bartosz Rylski, Matthias Siepe, Martin Czerny
Summary: The frozen elephant trunk technique is a good treatment option for patients with aneurysms of an aberrant left subclavian artery with Kommerell's diverticulum arising from right aortic arches. Secondary stent graft extension is a frequently needed component of the treatment concept. The most common variant of the aortic arch branching represents 'the bovine aortic arch' with the prevalence of 11-27% in the adult population.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Medicine, General & Internal
Albi Fagu, Tim Berger, Clarence Pingpoh, Stoyan Kondov, Maximilian Kreibich, Jan Minners, Martin Czerny, Matthias Siepe
Summary: Coronary artery bypass grafting surgery achieves a high revascularization rate and favorable in-hospital outcomes in patients with multi-vessel diseases and coronary total occlusions. Older age and the presence of peripheral artery disease are independent predictors of in-hospital mortality.
MEDICINA-LITHUANIA
(2023)
Article
Cardiac & Cardiovascular Systems
Bart Meuris, Jean-Christian Roussel, Michael A. Borger, Matthias Siepe, Pierluigi Stefano, Guenther Laufer, Thierry Langanay, Alexis Theron, Martin Grabenwoeger, Konrad Binder, Philippe Demers, Renzo Pessotto, Wouter van Leeuwen, Thierry Bourguignon, Sergio Canovas, Giovanni Mariscalco, Enrico Coscioni, Francois Dagenais, Olaf Wendler, Gianluca Polvani, Matthias Eden, Beate Botta, Peter Bramlage, Ruggero De Paulis
Summary: This study reports the 1-year safety and clinical outcomes of patients under 60 years old who underwent bioprosthetic surgical aortic valve intervention. The results showed good safety, excellent haemodynamic performance, and improved quality of life after the surgery.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Umar Imran Hamid, Thomas Modine, Jos Maessen, Arnoud van't Hof, Lars Sondergaard, Sabine Bleiziffer, Patrizio Lancellotti, Matthias Siepe, Peyman Sardari Nia
Summary: This survey investigates the real-world practice of heart teams in Europe and highlights significant variability in infrastructure and execution among different institutions. The results suggest a need to formulate guidelines for the composition and execution of heart teams, which could improve transparency in decision-making and outcomes reporting and comparison across institutions.
INTERDISCIPLINARY CARDIOVASCULAR AND THORACIC SURGERY
(2023)