Review
Neurosciences
Lingui Gu, Mingjiang Sun, Ruihao Li, Yihao Tao, Xu Luo, Xingyu Zhang, Ye Yuan, Zongyi Xie
Summary: This review outlines the role of microglial pyroptosis in the pathological process of intracerebral hemorrhage (ICH) and highlights the potential of targeted strategies to inhibit microglial pyroptosis as a therapeutic approach.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Review
Neurosciences
Yuan Cao, Wenbiao Xiao, Shuzhen Liu, Yi Zeng
Summary: Intracerebral hemorrhage (ICH) is a severe cerebrovascular disease with unclear underlying mechanisms. Ferroptosis, a newly identified form of cell death, has been implicated in ICH-induced neuronal death. This review summarizes the current evidence on the mechanism of ferroptosis after ICH and discusses its interaction with other forms of cell death, such as apoptosis and autophagy. The therapeutic application of targeting ferroptosis in ICH is also explored.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Pharmacology & Pharmacy
Lingling Wang, Ling Zhou, Yuhao Zhou, Lu Liu, Weiling Jiang, Huojun Zhang, Huiguo Liu
Summary: Apoptosis has been extensively studied as a regulated cell death mechanism, but recently necroptosis, a novel form of RCD, has gained attention. Necroptosis, mediated by RIPK3 and MLKL phosphorylation, triggers inflammation through DAMP release and is implicated in various human diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chahat Garg, Heena Khan, Amarjot Kaur, Thakur Gurjeet Singh, Vivek Kumar Sharma, Sachin Kumar Singh
Summary: This article reviews the role of Sonic hedgehog pathway in metabolic control and its interaction with other pathways. The study suggests that pharmacological modulation of the Shh pathway may be beneficial for metabolic disorders. Understanding the importance of these molecular networks provides a rational basis for influencing its activity.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Cell Biology
Hui-Yuan Zhang, Xi Lu, Yue-Han Hao, Ling Tang, Zhi-Yi He
Summary: OLR1 plays an important role in intracerebral hemorrhage and its knockdown has a protective effect against brain damage, suggesting it may be a potential therapeutic target.
NEURAL REGENERATION RESEARCH
(2022)
Article
Neurosciences
Jeong-Min Kim, Jangsup Moon, Jung-Suk Yu, Dong-Kyu Park, Keun-Hwa Jung
Summary: This study investigated the expression pattern of circular RNA (circRNA) in a rat intracerebral hemorrhage (ICH) model and tested a therapeutic strategy. The circRNA expression was studied at different time points after ICH induction, and the significantly altered circRNAs were examined by quantitative real-time polymerase chain reaction. The study also validated the predicted target microRNA and nearby messenger RNA levels of the altered circRNAs. A therapeutic strategy based on the potential target microRNA of the significantly depressed circRNA was examined using in vitro and in vivo hemorrhagic models.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lu Tang, Sitong Liu, Shiwei Li, Ye Chen, Bingqing Xie, Jun Zhou
Summary: In recent years, the emerging cell deaths of ferroptosis, necroptosis, and pyroptosis have attracted attention for their roles in various diseases. Ferroptosis is an iron-dependent form of cell death characterized by accumulation of reactive oxygen species (ROS). Necroptosis is a regulated necrotic cell death mediated by RIPK1 and RIPK3. Pyroptosis, or cell inflammatory necrosis, is a programmed cell death mediated by GSDMD. This article provides a review of the specific mechanisms of these cell deaths, their relationship with neurological diseases, and the evidence for their role in these diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Ziyu Yu, Nan Jiang, Wenru Su, Yehong Zhuo
Summary: Necroptosis, a form of cell death triggered by the rupture of dead cells, plays a significant role in the pathogenesis of neuroinflammatory diseases. Inhibitors of necroptosis have shown promise in improving pathological changes and clinical symptoms associated with neurological disorders. Targeting necroptotic factors may offer a potential therapeutic strategy for neuroinflammatory diseases.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Neurosciences
Yuan Zhang, Wanpeng Yu, Yingying Liu, Wenguang Chang, Man Wang, Lei Zhang
Summary: This article investigates the pathological mechanisms of intracerebral hemorrhage (ICH), focusing on oxidative stress and the regulatory role of nuclear factor erythroid-2-related factor 2 (Nrf2). It examines the mechanisms regulating Nrf2 at the transcriptional and post-transcriptional levels, and reviews the efficacy of Nrf2 activators in experimental ICH models. Activation of Nrf2 may have antioxidant, anti-inflammatory, and neuron-protection effects, making it a potential focus for future treatments and prevention of ICH.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Review
Clinical Neurology
Zhe Li, Suliman Khan, Yang Liu, Ruixue Wei, V. Wee Yong, Mengzhou Xue
Summary: Stroke is the second leading cause of death worldwide, and intracerebral hemorrhage (ICH) is a type of stroke associated with poor neurological outcomes and high mortality. Experimental therapies have shown potential in improving functional outcomes for ICH patients.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Mari Kamiya, Naoki Kimura, Natsuka Umezawa, Hisanori Hasegawa, Shinsuke Yasuda
Summary: Idiopathic inflammatory myopathies (IIMs) are chronic and diverse inflammatory diseases characterized by weakness in proximal muscles. Current treatments using immunosuppressive agents sometimes fail to regulate muscle inflammation and lead to adverse effects. The pathophysiology of IIMs, specifically muscle fiber necroptosis, is still not fully understood. Recent studies have shown that inhibiting necroptosis can ameliorate muscle inflammation and recover muscle weakness in IIMs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Riane Richard, Shaker Mousa
Summary: Alzheimer's disease is the sixth leading cause of death in the United States, with an estimated 20 million patients by 2050. This study examines the role of necroptosis in the development of Alzheimer's disease and finds that it plays a crucial role due to factors such as hyperglycemia, reactive oxygen species, inflammation, and insulin resistance.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Nanoscience & Nanotechnology
Liu Zi, Wencheng Zhou, Jiake Xu, Junshu Li, Ning Li, Jianguo Xu, Chao You, Chengwei Wang, Meng Tian
Summary: This study developed rosuvastatin-loaded nanomicelles to target neuroinflammation in a mouse model of ICH, which significantly reduced neuron degeneration, inhibited inflammatory cell infiltration, reduced brain edema, and improved neurological deficits. The nanomicelles also promoted the polarization of microglia/macrophages to M2 phenotype and down-regulated proinflammatory cytokines while up-regulating anti-inflammatory cytokines, suggesting potential clinical application for promoting nerve functional recovery in ICH.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Neurosciences
Qingqing Bai, Shuoyang Wang, Dongmei Rao, Zhiming Zhou, Jianfei Wang, Qi Wang, Yu Qin, Zhaohu Chu, Shoucai Zhao, Dijing Yu, Yang Xu
Summary: In this study, the researchers investigated the impact of RIPK3 activation on neuronal necroptosis and the involvement of DAXX in the nuclear necroptosis pathway after ICH. The results showed that RIPK3 promoted neuronal necroptosis in ICH mice, partially through the DAXX signaling pathway. RIPK3 and AIF interacted with nuclear DAXX to aggravate ICH injury.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Review
Immunology
Yuanyuan Li, Chenxi Tao, Na An, Haoqi Liu, Zhenhong Liu, Hongrui Zhang, Yikun Sun, Yanwei Xing, Yonghong Gao
Summary: Intracerebral hemorrhage (ICH) is a stroke subtype characterized by non-traumatic rupture of blood vessels in the brain, resulting in blood pooling in the brain parenchyma. ICH remains a significant contributor to stroke-related mortality and has various complex pathological damage including mechanical damage, inflammatory response, and complement activation. This review summarizes the pathological mechanisms of brain injury after ICH, particularly focusing on the role of complement and its related mechanisms, as well as provides an overview of complement-targeted therapies for ICH.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neuroimaging
Joshua S. Catapano, Andrew F. Ducruet, Megan S. Cadigan, Dara S. Farhadi, Neil Majmundar, Candice L. Nguyen, Jacob F. Baranoski, Tyler S. Cole, D. Andrew Wilkinson, Vance L. Fredrickson, Visish M. Srinivasan, Felipe C. Albuquerque
Summary: This study retrospectively reviewed the experience of patients treated for intradural VADAs from 1999 to 2019 at a hospital, finding that endovascular FDD treatment of VADAs may be associated with lower rates of retreatment and complications compared to stent/coil treatment.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Neuroimaging
D. Andrew Wilkinson, Neil Majmundar, Joshua S. Catapano, Vance L. Fredrickson, Daniel D. Cavalcanti, Jacob F. Baranoski, Caleb Rutledge, Andrew F. Ducruet, Felipe C. Albuquerque
Summary: During the first full year of radial-first implementation, 86.2% of 500 consecutive angiograms were successfully performed using TRA. TRA efficiency exceeded that of TFA after 150 angiograms. Concerns about procedure length or radiation exposure should not be barriers to TRA adoption.
JOURNAL OF NEUROINTERVENTIONAL SURGERY
(2022)
Article
Clinical Neurology
D. Andrew Wilkinson, Neil Majmundar, Joshua S. Catapano, Tyler S. Cole, Jacob F. Baranoski, Benjamin K. Hendricks, Daniel D. Cavalcanti, Vance L. Frederickson, Andrew F. Ducruet, Felipe C. Albuquerque
Summary: The adoption of TRA in neuroendovascular procedures has an impact on the performance and outcomes of TFA. Despite being an important access route, TFA is used disproportionately in high-risk patients and has a higher complication rate.
Letter
Clinical Neurology
Neil Majmundar, Felipe C. Albuquerque
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Neil Majmundar, Andrew F. Ducruet, D. Andrew Wilkinson, Joshua S. Catapano, Jimmy Patel, Jacob F. Baranoski, Tyler S. Cole, Felipe C. Albuquerque
Summary: During the COVID-19 pandemic, patient satisfaction with telemedicine visits in endovascular neurosurgery practice was high, indicating a potential important role for telemedicine in future outpatient consultations.
WORLD NEUROSURGERY
(2022)
Editorial Material
Clinical Neurology
Anmol Nagaraj, Neil Majmundar, Fareed Jumah, Bharath Raju, Anil Nanda
WORLD NEUROSURGERY
(2022)
Editorial Material
Clinical Neurology
Chandler N. N. Berke, Raphia K. K. Rahman, Neil Majmundar, James K. K. Liu
Review
Clinical Neurology
Raphia K. Rahman, Neil Majmundar, Hira Ghani, Ali San, Monika Koirala, Avi A. Gajjar, Amy Pappert, Catherine A. Mazzola
Summary: Neurocutaneous melanocytosis (NCM) is a rare neurocutaneous disorder characterized by excess melanocytic proliferation in the skin, leptomeninges, and cranial parenchyma. This systematic review investigates approaches toward diagnosis and examines modern neurosurgical management of NCM.
NEUROSURGICAL FOCUS
(2022)
Article
Clinical Neurology
J. F. Baranoski, J. S. Catapano, C. Rutledge, T. S. Cole, N. Majmundar, E. A. Winkler, V. M. Srinivasan, A. P. Jadhav, A. F. Ducruet, F. C. Albuquerque
Summary: Nickel is commonly used in cerebral endovascular treatment devices, but the risk for patients with nickel hypersensitivity is unknown. This retrospective analysis found that treatment with nickel-containing devices in patients with nickel or metal allergies did not result in complications or symptoms of allergic reactions. Radiographic follow-up showed successful treatment outcomes without evidence of stenosis or hypersensitivity sequelae. The use of nickel-containing devices for cerebrovascular lesions was safe and effective.
AMERICAN JOURNAL OF NEURORADIOLOGY
(2023)
Review
Clinical Neurology
Raphia K. Rahman, Neil Majmundar, Ali San, Praveen Sanmugananthan, Chandler Berke, Shih-Shan Lang, Ali Tayebi Meybodi, Avi A. Gajjar, James K. Liu
Summary: AC with brain mapping can be effective in precise resection of eloquent AVMs with a high rate of complete resection (89%), but it carries a risk of transient neurologic deficits (30.4%).
WORLD NEUROSURGERY
(2023)
Article
Clinical Neurology
Evgenii Belykh, Irakliy Abramov, Liudmila Bardonova, Ruchi Patel, Sarah McBryan, Lara Enriquez Bouza, Neil Majmundar, Xiaochun Zhao, Vadim A. Byvaltsev, Stephen A. Johnson, Amit Singla, Gaurav Gupta, Hai Sun, James K. Liu, Anil Nanda, Mark C. Preul, Michael T. Lawton
Summary: The study developed 7 simulation bypass scenarios using 3D printed skull models and silicone molds, accurately replicating narrow surgical corridors and hand positions. Experienced neurosurgeons confirmed the face and content validity of the models and suggested that practicing with these models may improve bypass technique.
JOURNAL OF NEUROSURGERY
(2023)
Article
Clinical Neurology
Tyler S. Cole, Sirin Gandhi, Joshua S. Catapano, Vance L. Fredrickson, Neil Majmundar, Felipe C. Albuquerque, Andrew F. Ducruet, Mark C. Preul, Michael T. Lawton
Summary: This study demonstrated the feasibility and efficacy of using a microvascular coupler for anastomosis in both animal models and patients in neurosurgery. The microvascular coupler was able to effectively improve blood flow and achieve bypass surgery, increasing the blood flow volume.
WORLD NEUROSURGERY
(2022)
Article
Clinical Neurology
Joshua S. Catapano, Stefan W. Koester, Visish M. Srinivasan, Mohamed A. Labib, Neil Majmundar, Candice L. Nguyen, Caleb Rutledge, Tyler S. Cole, Jacob F. Baranoski, Andrew F. Ducruet, Felipe C. Albuquerque, Robert F. Spetzler, Michael T. Lawton
Summary: A comparison study between microsurgical and endovascular treatment of unruptured OA aneurysms showed that microsurgical clipping is associated with a higher rate of visual deficits but a lower rate of residual and recurrent aneurysms. No significant difference was found in terms of severe complications between the two treatment methods.
JOURNAL OF NEUROSURGERY
(2022)
Meeting Abstract
Clinical Neurology
Ivo Bach, Pratit Patel, Neil Majmundar, Claire Ruane, Madheea Siddiqi, Priyank Khandelwal
Article
Clinical Neurology
Abhijith V. Matur, Laura B. Ngwenya, Charles J. Prestigiacomo
Summary: Motor vehicle collisions are a major cause of head injuries, but efforts to improve automobile design and promote helmet use have significantly reduced the number of serious head injuries. Neurosurgeons have played a crucial role in preventing head injuries and saving lives in MVCs through their recommendations and research efforts.
JOURNAL OF NEUROSURGERY
(2021)
Article
Clinical Neurology
Guilu He, Jianhao Lin, Jing Ye, Fobao Huang, Changzhi Yan, Zesi Liu, Xiuming Zhou, Qiao Li, Liang Zhang
Summary: This article introduces long tunneled external ventricular drain (LTEVD), which effectively avoids multiple surgeries by connecting an external shunt valve. It allows visual control of drainage flow, prolongs catheter indwelling time, and eliminates the need for multiple surgeries.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Vinay Suresh, H. S. Suresh, Bharath Raju, Himanshu Jindal, Ahmad Ozair
Summary: This study investigated the outcomes of postoperative discitis treated with debridement and a novel technique focused on reducing outpatient antibiotic requirement in a low- and middle-income country (LMIC) setting. The results showed that patients with medically refractory postoperative discitis potentially have good outcomes after debridement plus 2-week local antibiotic instillation in LMICs.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Beatrice C. Bono, Davide Milani, Fabio Ferreli, Simone Olei, Luca Raspagliesi, Maria Pia Tropeano, Giovanni B. Lasio, Federico Pessina
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Avi A. Gajjar, Shrey Patel, Raj Swaroop Lavadi, Rida Mitha, Rohit Prem Kumar, Tavis Taylor, Galal A. Elsayed, D. Kojo Hamilton, Nitin Agarwal
Summary: Art in neurosurgery has played a crucial role in the discipline for centuries. Medical illustrations help visualize anatomy and surgical procedures, contributing to education, surgical planning, and navigation.
WORLD NEUROSURGERY
(2024)
Article
Clinical Neurology
Joaquin Perez Zabala, Yamila Basilotta Marquez, Romina Arganaraz, Beatriz Mantese
Summary: We present a low-cost and easily accessible adaptation system for stereotactic procedures in infants. By using a headband cast technique, a stereotactic biopsy was successfully performed in a 5-month-old patient, achieving precise targeting, histopathological diagnosis, and no associated complications.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Muhammad Kusdiansah, Arnau Benet, Yosuke Suzuki, Kenichi Haraguchi, Nakao Ota, Kosumo Noda, Rokuya Tanikawa
Summary: Fusiform vertebral artery aneurysms are difficult to treat, and endovascular and open microsurgical treatments are used for different situations. This report presents a case with complex anatomy and branch involvement and describes the treatment strategy used.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Victor M. Lu
Summary: This review emphasizes four essential domains that should be considered when interpreting pediatric neurosurgical SRMAs and provides examples to ensure accurate and effective interpretation of findings in this niche.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Lapo Bonosi, Angelo Torrente, Filippo Brighina, Cateno Concetto Tito Petralia, Pietro Merlino, Chiara Avallone, Vincenzo Gulino, Roberta Costanzo, Lara Brunasso, Domenico Gerardo Iacopino, Rosario Maugeri
Summary: Corticocortical evoked potentials (CCEPs) have emerged as a valuable intraoperative monitoring technique in eloquent brain tumor surgery, aiding in preserving critical functional areas. Current research shows the potential of CCEPs in guiding surgical decision making, reducing the risk of postoperative neurological deficits, and mapping functional connectivity, but further research and standardization are needed.
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Yuchen Duan, Dagang Feng, Min Zhu, Heng Qiu, Tong Li, Zhen Chen, Leiming Jiang, Yong Huang
Summary: This study aimed to compare the effect of different Modic changes (MC) grades on the cage subsidence rate after spinal interbody fusion surgery. A meta-analysis was conducted on relevant randomized controlled trials and cohort studies. The results showed that MC may be associated with a higher cage subsidence rate. With the increase in MC grades, the incidence of subsidence decreased gradually, but it was always higher than that in the non-Modic changes (NMC). Oblique lumbar interbody fusion may be a better treatment choice for lumbar degenerative disease with MC.
WORLD NEUROSURGERY
(2024)
Editorial Material
Clinical Neurology
Brian F. Saway, Conor M. Cunningham, Mustafa Ismail, Alejandro M. Spiotta
WORLD NEUROSURGERY
(2024)
Review
Clinical Neurology
Joanna M. Roy, Michael M. Covell, Carmelo Venero Jr, Christian A. Bowers
Summary: Early exposure to neurosurgery during medical school is critical for improving recruitment into the specialty. However, about 30% of medical schools in the U.S. lack a neurosurgery program, limiting students' exposure to the field. Virtual education, facilitated by webinars during the pandemic, has advantages such as global outreach and accessibility for international medical students. This review identifies and describes 16 educational resources, serving as a guide for medical students interested in neurosurgery.
WORLD NEUROSURGERY
(2024)
