Article
Microbiology
Vinciane Monod, Valerie Hofstetter, Vivian Zufferey, Olivier Viret, Katia Gindro, Daniel Croll
Summary: The evolution of sequencing technology and multiplexing has expanded our ability to characterize fungal diversity. However, obtaining an unbiased assessment of the fungal community remains challenging. This study found that shorter amplicons had higher sequencing depths and overall diversity, with no significant bias in phylogenetic composition. Despite the increased resolution of longer amplicons, the shorter amplicons provided clearer resolution of the fungal community. The choice of ribosomal amplicons should be carefully evaluated and adjusted according to specific goals.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Hong Li, Jing Sun, Xiaoyan Wang, Jing Shi
Summary: The oral microbiome in atrophic glossitis patients has lower diversity, with Lactobacillus and Saccharomycetales potentially serving as indicators for the initiation and development of atrophic glossitis. The relationship between oral microbial ecology and atrophic glossitis is also discussed in the study.
JOURNAL OF ORAL MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Bwalya Katati, Pierre Schoenmakers, Henry Njapau, Paul W. Kachapulula, Bas J. Zwaan, Anne D. van Diepeningen, Sijmen E. Schoustra
Summary: Fungi contamination in maize crops is influenced by weather conditions. The abundance and composition of preharvest maize mycobiome vary based on rainfall pattern and dry spell. Aspergillus and Fusarium genera play a significant role in mycotoxin production, with Aspergillus associated with dry conditions and Fusarium unaffected by weather patterns. Understanding the spectrum of preharvest fungi and their relationship with weather conditions can help in managing crop health and mycotoxin contamination.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Physiology
Cary Pirone Davies, Katie Lynn Summers, Ann M. M. Arfken, Nadia Darwish, Atul Chaudhari, Juli Foster Frey, Lori Schreier, Monika Proszkowiec-Weglarz
Summary: The study investigated the fungal communities in the chicken gastrointestinal tract and the effect of delayed feeding on the mycobiome composition. It found that fungi play a critical role in chicken gut health and that delayed feeding does not have long-lasting effects on the fungal populations.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Yufeng Chen, Wanxin Li, Ellen T. Chang, Justine W. Debelius, Lokeshwaran Manoharan, Yuming Zheng, Yancheng Li, Guangwu Huang, Hans-Olov Adami, Rob Knight, Yonglin Cai, Zhe Zhang, Weimin Ye
Summary: Dysbiosis of the oral mycobiome, characterized by a loss of fungal community diversity and overgrowth of several fungal organisms, is associated with a significantly increased risk of nasopharyngeal carcinoma (NPC).
Article
Microbiology
Weiwei Heng, Wenmei Wang, Tingting Dai, Ping Jiang, Yong Lu, Ruowei Li, Miaomiao Zhang, Ruiqi Xie, Yifan Zhou, Maomao Zhao, Ning Duan, Zhengqin Ye, Fuhua Yan, Xiang Wang
Summary: Oral microbial dysbiosis is linked with the development of oral squamous cell carcinoma (OSCC). This study analyzed the microbial communities in the oral cavity at different stages of oral carcinogenesis and found several specific bacteria and fungi species associated with OSCC. The differences in OSCC-associated diversity, species distinction, and functional alterations were most prominent in mucosal samples.
MICROBIOLOGY SPECTRUM
(2022)
Article
Endocrinology & Metabolism
Esther Bandala-Sanchez, Alexandra J. Roth-Schulze, Helena Oakey, Megan A. S. Penno, Naiara G. Bediaga, Gaetano Naselli, Katrina M. Ngui, Alannah D. Smith, Dexing Huang, Enrique Zozaya-Valdes, Rebecca L. Thomson, James D. Brown, Peter J. Vuillermin, Simon C. Barry, Maria E. Craig, William D. Rawlinson, Elizabeth A. Davis, Mark Harris, Georgia Soldatos, Peter G. Colman, John M. Wentworth, Aveni Haynes, Grant Morahan, Richard O. Sinnott, Anthony T. Papenfuss, Jennifer J. Couper, Leonard C. Harrison
Summary: The study reveals that pregnant women with type 1 diabetes experience changes in their gut fungal microbiome during pregnancy, accompanied by intestinal inflammation and impaired intestinal barrier function.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Immunology
Ye Tu, Zhiyan Zhou, Chang Shu, Yuan Zhou, Xuedong Zhou
Summary: Early childhood caries (ECC) is a prevalent oral disease in children, and this study investigates the correlation between oral mycobiome and ECC progression. Salivary samples from ECC patients and caries-free controls were analyzed using 16S rRNA and ITS1 rRNA gene sequencing. The study reveals significant alterations in the salivary fungal community of ECC patients and identifies correlations between specific bacteria/fungi and carious phenotypes. These findings enhance our understanding of the etiological role of bacteria/fungi in ECC development and provide insights for disease management.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Medicine, General & Internal
Ke Dong, Kunpeng Wu, Tianli Zheng, Ji Yue, Weipeng Wang, Ruocheng Luo, Lan You, Xun He, Jingjing Li, Zehui Hong, Haojiang Zuo, Xiaofang Pei
Summary: The study found significant differences in oral microbiota composition at the phylum and genus levels between Tibetan and Han populations, indicating the impact of altitude and ethnicity on oral microbiota. Tibetan individuals had higher abundances of certain bacteria and fungi compared to Han individuals, with different dominant genus compositions and distinct changes in microbial functions.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Medicine, General & Internal
Saumya Shah, Alberto Locca, Yair Dorsett, Claudia Cantoni, Laura Ghezzi, Qingqi Lin, Suresh Bokoliya, Hunter Panier, Cassandra Suther, Matthew Gormley, Yue Liu, Emily Evans, Robert Mikesell, Kathleen Obert, Amber Salter, Anne H. Cross, Phillip I. Tarr, Amy Lovett-Racke, Laura Piccio, Yanjiao Zhou
Summary: This study revealed alterations in the gut mycobiome of patients with multiple sclerosis compared to healthy controls, with Saccharomyces and Aspergillus being over-represented in the patient group. Different mycobiome profiles were associated with specific bacterial microbiome and immune cell subsets in the blood of patients. Further research is needed to explore the potential causal relationship between the mycobiome and multiple sclerosis, as well as its interactions with bacteria and autoimmunity.
Article
Microbiology
Clifford J. Beall, Elizabeth A. Lilly, Carolina Granada, Kelly Treas, Kenneth R. Dubois, Shahr B. Hashmi, Jose A. Vazquez, Michael E. Hagensee, Ann L. Griffen, Eugene J. Leys, Paul L. Fidel
Summary: The oral microbiome is an important predictor of health and disease. HIV and highly active antiretroviral therapy (ART) have significant effects on the oral microbiome. However, their influence is similar to that of other clinical variables and overall modest.
Article
Microbiology
Sofie Marie Edslev, Paal Skytt Andersen, Tove Agner, Ditte Marie Lindhardt Saunte, Anna Cacilia Ingham, Thor Bech Johannesen, Maja-Lisa Clausen
Summary: Significant differences in the eukaryotic microbial communities were found between AD patients and non-AD individuals, with the most striking finding being the significantly overrepresentation of Demodex folliculorum on AD skin. Further investigation is needed to determine whether Demodex folliculorum can contribute to skin inflammation in AD.
Article
Physiology
Phillipp Hartmann, Sonja Lang, Suling Zeng, Yi Duan, Xinlian Zhang, Yanhan Wang, Marina Bondareva, Andrey Kruglov, Derrick E. Fouts, Peter Starkel, Bernd Schnabl
Summary: The study revealed dynamic changes in the intestinal fungal microbiome in patients with alcohol use disorder (AUD), and demonstrated that improved liver health after alcohol abstinence in AUD patients was associated with lower abundances of specific fungal genera and species, as well as changes in serum anti-fungal IgG levels. These findings suggest that intestinal fungi could be a potential therapeutic target to improve the outcome of patients with ALD.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Oncology
Weipeng Liu, Zongrui Li, Xiaopeng Li, Haiyang Cao, He Jiang, Qingbin Niu, Baoguang Hu
Summary: Cancer tissues contain a diverse microbiome, including bacteria and fungi. The tumor mycobiome has been found to be significantly correlated with the prognosis of cancer patients, and it promotes tumor progression and metastasis through various mechanisms, such as affecting the human immune system, maintaining a pro-inflammatory environment, and producing toxins. In addition, the tumor mycobiome also holds great potential for cancer prevention, diagnosis, and treatment.
Article
Immunology
Ann M. Arfken, Juli Foster Frey, Nora Isabel Carrillo, Nneka Ijeoma Dike, Ogechukwu Onyeachonamm, Daniela Nieves Rivera, Cary Pirone Davies, Katie Lynn Summers
Summary: The gut microbiome plays a crucial role in host health, and the fungal microbiome is an important component. This study compared the accuracy of taxonomic identifications and abundances from mycobiome analyses using different target gene regions and reference databases. It was found that no marker-database combination consistently outperformed the others, highlighting the need for preliminary studies to assess primer and database choices for specific mycobiome samples.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
G. P. Schincaglia, B. Y. Hong, A. Rosania, J. Barasz, A. Thompson, T. Sobue, F. Panagakos, J. A. Burleson, A. Dongari-Bagtzoglou, P. I. Diaz
JOURNAL OF DENTAL RESEARCH
(2017)
Article
Immunology
Tyler Lewy, Bo-young Hong, Barbara Weiser, Harold Burger, Andrew Tremain, George Weinstock, Kathryn Anastos, Michael D. George
AIDS RESEARCH AND HUMAN RETROVIRUSES
(2019)
Article
Immunology
Bo-young Hong, Joseph N. Paulson, O. Colin Stine, George M. Weinstock, Jorge L. Cervantes
Article
Multidisciplinary Sciences
Wenyu Zhou, M. Reza Sailani, Kevin Contrepois, Yanjiao Zhou, Sara Ahadi, Shana R. Leopold, Martin J. Zhang, Varsha Rao, Monika Avina, Tejaswini Mishra, Jethro Johnson, Brittany Lee-McMullen, Songjie Chen, Ahmed A. Metwally, Thi Dong Binh Tran, Hoan Nguyen, Xin Zhou, Brandon Albright, Bo-Young Hong, Lauren Petersen, Eddy Bautista, Blake Hanson, Lei Chen, Daniel Spakowicz, Amir Bahmani, Denis Salins, Benjamin Leopold, Melanie Ashland, Orit Dagan-Rosenfeld, Shannon Rego, Patricia Limcaoco, Elizabeth Colbert, Candice Allister, Dalia Perelman, Colleen Craig, Eric Wei, Hassan Chaib, Daniel Hornburg, Jessilyn Dunn, Liang Liang, Sophia Miryam Schussler-Fiorenza Rose, Kim Kukurba, Brian Piening, Hannes Rost, David Tse, Tracey McLaughlin, Erica Sodergren, George M. Weinstock, Michael Snyder
Article
Microbiology
Bo-Young Hong, Takanori Sobue, Linda Choquette, Amanda K. Dupuy, Angela Thompson, Joseph A. Burleson, Andrew L. Salner, Peter K. Schauer, Pujan Joshi, Evan Fox, Dong-Guk Shin, George M. Weinstock, Linda D. Strausbaugh, Anna Dongari-Bagtzoglou, Douglas E. Peterson, Patricia I. Diaz
Article
Immunology
Maria Elvira Balcells, Noemi Yokobori, Bo-young Hong, John Corbett, Jorge Cervantes
MICROBIAL PATHOGENESIS
(2019)
Article
Multidisciplinary Sciences
Jethro S. Johnson, Daniel J. Spakowicz, Bo-Young Hong, Lauren M. Petersen, Patrick Demkowicz, Lei Chen, Shana R. Leopold, Blake M. Hanson, Hanako O. Agresta, Mark Gerstein, Erica Sodergren, George M. Weinstock
NATURE COMMUNICATIONS
(2019)
Article
Dentistry, Oral Surgery & Medicine
B. Y. Hong, A. Hoare, A. Cardenas, A. K. Dupuy, L. Choquette, A. L. Salner, P. K. Schauer, U. Hegde, D. E. Peterson, A. Dongari-Bagtzoglou, L. D. Strausbaugh, P. I. Diaz
JOURNAL OF DENTAL RESEARCH
(2020)
Article
Ophthalmology
Arnulfo Garza, Giancarlo Diaz, Marah Hamdan, Akaanksh Shetty, Bo-Young Hong, Jorge Cervantes
Summary: The literature on ocular microbiome has significantly expanded in the past decade, with the development of 16S rRNA sequencing enabling better characterization of bacterial communities in health and ocular disease. Efforts should be continued to explore the interaction between microbiome and key factors such as age, comorbidities, and contact lens usage for improved control of sight-threatening complications.
CURRENT EYE RESEARCH
(2021)
Review
Clinical Neurology
Jordan Brown, Blair Quattrochi, Colleen Everett, Bo-Young Hong, Jorge Cervantes
Summary: Intestinal microbiota alterations are directly related to various disease states, including MS. Research suggests that dysbiosis of the gut microbiota may play a role in the disease state and severity of MS. Targeting the microbiota could be a potential future therapy for MS.
MULTIPLE SCLEROSIS JOURNAL
(2021)
Article
Infectious Diseases
Jorge Cervantes, Noemi Yokobori, Bo-Young Hong
Article
Oncology
Bo-young Hong, Takayasu Ideta, Bruno S. Lemos, Yuichi Igarashi, Yuliana Tan, Michael DiSiena, Allen Mo, John W. Birk, Faripour Forouhar, Thomas J. Devers, George M. Weinstock, Daniel W. Rosenberg
NPJ PRECISION ONCOLOGY
(2019)
Article
Microbiology
Patricia Diaz, Bo-Young Hong, Amanda K. Dupuy, Linda Choquette, Angela Thompson, Andrew L. Salner, Peter K. Schauer, Upendra Hegde, Joseph A. Burleson, Linda D. Strausbaugh, Douglas E. Peterson, Anna Dongari-Bagtzoglou
Article
Biology
Loreto Abusleme, Bo-Young Hong, Anilei Hoare, Joanne E. Konkel, Patricia I. Diaz, Niki M. Moutsopoulos