Article
Obstetrics & Gynecology
Yimei Liao, Huaxuan Wen, Shuyuan Ouyang, Ying Yuan, Jingru Bi, Yong Guan, Qian Fu, Xia Yang, Wenjia Guo, Yi Huang, Qing Zeng, Yue Qin, Haishan Xiang, Shengli Li
Summary: First-trimester ultrasound scans have been used in China for nearly 20 years, with a recent study suggesting that a standardized anatomic protocol is crucial for improving sensitivity. This large retrospective study of over 59,000 pregnancies found that routine first-trimester scans had high detection rates for various structural abnormalities, emphasizing the importance of standardized protocols in ultrasound screening.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2021)
Article
Medical Laboratory Technology
Laurence Caron, Alexandre Fillion, Yves Giguere, Francois Audibert, Jean-Claude Forest, Cedric Gasse, Mario Girard, Genevieve Laforest, Paul Guerby, Emmanuel Bujold
Summary: The combination of maternal markers PAPP-A, free beta-hCG, PlGF and AFP has demonstrated a predictive value in Down syndrome screening. Adding nuchal translucency further increases the detection rate to above 95% with a false-positive rate below 5%.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Review
Obstetrics & Gynecology
Piya Chaemsaithong, Daljit Singh Sahota, Liona C. Poon
Summary: Preeclampsia is a significant threat to both mothers and babies, and early-onset disease requiring preterm delivery increases the risk of complications. Low-dose aspirin initiated before 16 weeks reduces the rate of preterm preeclampsia. Identifying pregnant women at risk during the first trimester is crucial, and current screening methods have suboptimal performance compared to the Fetal Medicine Foundation's first trimester prediction model (the triple test). This model has high detection rates and low false-positive rates, outperforming traditional risk factor screening methods.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Acoustics
Kristen A. Miller, Katelynn G. Sagaser, Christine B. Hertenstein, Karin J. Blakemore, Katherine R. Forster, Cathleen S. Lawson, Angie C. Jelin
Summary: This study found that repeat evaluation of the nasal bone in pregnant women with an absent/uncertain nasal bone during first-trimester screening improves the specificity of Down syndrome screening.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Obstetrics & Gynecology
I. F. Reijnders, Agmgj Mulders, M. P. H. Koster, A. T. M. Kropman, A. H. J. Koning, S. P. Willemsen, E. A. P. Steegers, R. P. M. Steegers-Theunissen
Summary: The study investigates the impact of first-trimester maternal haemodynamic adaptation on placental, embryonic, and fetal development, as well as birth outcomes in pregnancies with and without placenta-related complications. The results show that reduced haemodynamic adaptation in early pregnancy affects placental size, vascularization, and birthweight centile, particularly in pregnancies with placenta-related complications.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Immunology
Jiayang Jin, Xue Xu, Lei Hou, Yuke Hou, Jing Li, Meiying Liang, Chun Li
Summary: Thrombocytopenia during the first trimester increases the risk of preterm birth in women with APS. Effective treatment for OAPS may improve pregnancy outcomes without increasing the risk of antepartum and postpartum hemorrhage.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jake R. Thomas, Anna Appios, Xiaohui Zhao, Roksana Dutkiewicz, Maria Donde, Colin Y. C. Lee, Praveena Naidu, Christopher Lee, Joana Cerveira, Bing Liu, Florent Ginhoux, Graham Burton, Russell S. Hamilton, Ashley Moffett, Andrew Sharkey, Naomi McGovern
Summary: Hofbauer cells are an important immune cell population found in the placenta, involved in placental angiogenesis and remodeling. Additionally, there is another population of maternal macrophages in the placenta that aid in surface repair.
JOURNAL OF EXPERIMENTAL MEDICINE
(2021)
Article
Acoustics
L. Noel, G. P. Guy, S. Jones, K. Forenc, E. Buck, A. T. Papageorghiou, B. Thilaganathan
Summary: This study compared the performance of PAPP-A and PlGF in first-trimester combined screening, showing no significant difference in screening for PE and SGA. Biomarkers should be chosen based on performance and measurement requirements.
ULTRASOUND IN OBSTETRICS & GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Amir Aviram, Sara L. Jones, Tianhua Huang, Abheha Satkunaratnam, Nir Melamed, Elad Mei-Dan
Summary: This study aimed to evaluate whether a mid-trimester placental scan can provide reassurance regarding fetal growth restriction (FGR) in women with abnormal eFTS biomarkers. The results showed that a normal second trimester placental scan can reduce the risk of FGR in these women.
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Toshihide Sakuragi, Eiji Shibata, Emi Kondo, Shota Higami, Shigeki Fujimoto, Shoko Amimoto, Hiroshi Mori, Satoshi Aramaki, Mayumi Tsuji, Kiyoshi Yoshino
Summary: This study aimed to investigate the correlation between vascularization index (VI), flow index (FI), vascularization flow index (VFI) and the pathological structure of the placenta, as well as the differences in these parameters between the normal and preeclampsia (PE) groups. The results showed no positive correlation between VI, FI, VFI, intervillous blood vessels (IBV), intervillous spaces (IS), and IBV + IS. While there were no differences in VI, FI, and VFI between the normal and PE groups, there were significant differences in IBV, IS, and IBV + IS in the PE group compared to the normal group.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH
(2023)
Review
Medicine, General & Internal
Yifan Wu, Yang Liu, Yiling Ding
Summary: PP13 may be an effective serum biomarker for predicting preeclampsia, but further large prospective cohort studies and randomized controlled trials are needed to determine its clinical application. The heterogeneity of the original trials may limit the use of PP13 in clinical practice.
FRONTIERS IN MEDICINE
(2021)
Article
Obstetrics & Gynecology
Ameer Abdallah, Mohammed Khairy, Mohamed Tawfik, Safaa Mohamed, Mazen Abdel-Rasheed, Sondos Salem, Eissa Khalifa
Summary: Assessment of first-trimester 3D placental volume and power Doppler of placental vascular indices, especially when combined with uterine artery Doppler assessment, can enhance the accuracy of early detection of women at risk for developing pre-eclampsia.
INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
(2021)
Article
Developmental Biology
I. F. Reijnders, A. G. M. G. J. Mulders, M. P. H. Koster, A. T. M. Kropman, E. S. de Vos, A. H. J. Koning, S. P. Willemsen, M. Rousian, E. A. P. Steegers, R. P. M. Steegers-Theunissen
Summary: The study demonstrates that first-trimester utero-placental (vascular) development is associated with embryonic and fetal growth, with specific modifications based on fetal sex. This highlights the importance of monitoring first-trimester placental development and its impacts on embryonic and fetal growth.
Article
Developmental Biology
V. M. M. M. Schiffer, C. W. J. Borghans, N. Arts, J. A. P. Bons, C. A. H. Severens-Rijvers, S. M. J. van Kuijk, M. E. A. Spaanderman, S. Al-Nasiry
Summary: Abnormal levels of first trimester placental biomarkers are associated with the development of placental syndrome (PS), and the presence of maternal vascular malperfusion (MVM) may be predicted by the use of first trimester biomarkers as a marker for placental insufficiency.
Article
Medicine, General & Internal
Olga Buerger, Tania Elger, Antonia Varthaliti, Argyro Syngelaki, Alan Wright, Kypros H. Nicolaides
Summary: In this study, we found that maternal characteristics and medical history can be used to predict the risk of Gestational Diabetes Mellitus (GDM), with a higher risk in twin pregnancies. Factors such as maternal age, weight, family history, racial background, and conception method all influence the risk of GDM.
JOURNAL OF CLINICAL MEDICINE
(2021)