Dose Expansion Cohorts in Phase I Trials

Sequential monitoring of Phase I dose expansion cohorts

(2016) Alexia Iasonos et al.   STATISTICS IN MEDICINE

Design Considerations for Dose-Expansion Cohorts in Phase I Trials

(2013) Alexia Iasonos et al.   JOURNAL OF CLINICAL ONCOLOGY

Evolution of Clinical Trial Design in Early Drug Development: Systematic Review of Expansion Cohort Use in Single-Agent Phase I Cancer Trials

(2013) Arif Manji et al.   JOURNAL OF CLINICAL ONCOLOGY

Phase I Dose-Escalation Study of Intravenous Aflibercept in Combination with Docetaxel in Patients with Advanced Solid Tumors

(2012) N. Isambert et al.   CLINICAL CANCER RESEARCH

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Bayesian phase I/II adaptively randomized oncology trials with combined drugs

(2011) Ying Yuan et al.   Annals of Applied Statistics

Calibration of prior variance in the Bayesian continual reassessment method

(2011) Shing M. Lee et al.   STATISTICS IN MEDICINE

Dynamic calibration of pharmacokinetic parameters in dose-finding studies

(2010) J. O'quigley et al.   BIOSTATISTICS

Continual Reassessment Method vs. Traditional Empirically Based Design: Modifications Motivated by Phase I Trials in Pediatric Oncology by the Pediatric Brain Tumor Consortium

(2009) Arzu Onar et al.   Journal of Biopharmaceutical Statistics

Bayesian Model Averaging Continual Reassessment Method in Phase I Clinical Trials

(2009) Guosheng Yin et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

A comparison of model choices for the continual reassessment method in phase I cancer trials

(2009) X. Paoletti et al.   STATISTICS IN MEDICINE

A Statistical Framework for Quantile Equivalence Clinical Trials with Application to Pharmacokinetic Studies that Bridge from HIV-Infected Adults to Children

(2008) Lixia Pei et al.   BIOMETRICS

A comprehensive comparison of the continual reassessment method to the standard 3 + 3 dose escalation scheme in Phase I dose-finding studies

(2008) Alexia Iasonos et al.   Clinical Trials