Journal
SEMINARS IN OPHTHALMOLOGY
Volume 32, Issue 1, Pages 36-42Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08820538.2016.1228418
Keywords
Chronic central serous chorioretinopathy; eplerenone; mineralocorticoid-receptor antagonist; spironolactone
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Central serous chorioretinopathy (CSCR) is a challenging disease characterized by subretinal serous fluid accumulation. The complex pathogenesis is still not fully understood, but is thought to be multifactorial and involves exogenous and endogenous factors affecting the choroid and retinal pigment epithelium. The involvement of corticosteroids is undisputed, while the contribution of mineralocorticoid pathways is under investigation. This review addresses the proposed pathogenesis models and the evidence for systemic treatment of CSCR with mineralocorticoid antagonists.
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