Article
Chemistry, Physical
Ke Wang, Shiyong Sun, Yevgeny Aleksandrovich Golubev, Sen Lin, Jin Liu, Faqin Dong, Elena Leonidovna Kotova, Olga Borisovna Kotova
Summary: The combination of clay mineral nanozymes and natural enzymes has led to the construction of a high-performance enzymatic cascade system, which shows improved stability and catalytic efficiency. This work provides a simple and efficient reference for the design of enzyme systems and expands the application field of clay minerals.
APPLIED CLAY SCIENCE
(2023)
Article
Engineering, Biomedical
Jianrong Wu, Xiaojun Cai, Gareth R. Williams, Zheying Meng, Weijuan Zou, Li Yao, Bing Hu, Yu Chen, Yuanyi Zheng
Summary: This study addresses the issue of thermoresistance in tumor cells during hyperthermia-based treatments by developing a calcium-based nanocatalyst. The nanocatalyst exhibits prolonged blood circulation and rapid drug release in the tumor microenvironment. Additionally, it effectively catalyzes the depletion of glucose and down-regulates HSP expression, thereby enhancing the therapeutic efficacy of photothermal hyperthermia.
BIOACTIVE MATERIALS
(2022)
Article
Nanoscience & Nanotechnology
Zhijun Zhang, Tiehong Yang, Jingwei Wang, Zhe Yu, Youbei Qiao, Chaoli Wang, Zhenggang Yue, Hong Wu
Summary: This study developed a hollow mesoporous molybdenum single-atom nanozyme (HMMo-SAzyme) as a nanoreactor for in vivo antibacterial applications. The nanoreactor, loaded with glucose oxidase (GOx) and encapsulated with hyaluronic acid (HA), showed excellent antibacterial activity and negligible biological toxicity. The acid environment at the infection site enhanced the catalytic activity of HMMo-SAzyme to convert H2O2 to ·OH for bacterial elimination.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Yuzhu Wang, Lu Jia, Tingting Hu, Zhuoran Yang, Chunyu Yang, Huiming Lin, Feng Zhang, Kai Yu, Fengyu Qu, Wei Guo
Summary: Although phototherapy has been extensively studied in recent years, its efficacy in treating tumors is often unsatisfactory due to the complex and variable tumor microenvironment. In this study, we report the discovery of novel hollow carriers named CoSn(OH)6@CoOOH with oxidase properties, which can enhance the effectiveness of phototherapy. These carriers react with oxygen to generate singlet oxygen and consume glutathione, and their hollow structure allows for the delivery of drug molecules. Loading indocyanine green and AIPH onto the carriers resulted in enhanced phototherapy effects through oxidase-catalyzed reactions, generation of alkyl radicals, and glutathione consumption. Cell and mouse experiments demonstrated that these carriers, combined with near-infrared laser irradiation, significantly inhibited tumor growth. Enrichment analysis revealed the involvement of the PI3K-Akt and MAPK signaling pathways in this therapeutic system. Hollow carriers with oxidase activity like these have great potential for the design of multifunctional drug delivery vehicles for tumor therapy.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biophysics
Valerii Myndrul, Emerson Coy, Nataliya Babayevska, Veronika Zahorodna, Vitalii Balitskyi, Ivan Baginskiy, Oleksiy Gogotsi, Mikhael Bechelany, Maria Teresa Giardi, Igor Iatsunskyi
Summary: In this study, a skin-attachable and stretchable electrochemical enzymatic sensor based on ZnO tetrapods and MXene was developed for continuous glucose detection in sweat. The sensor showed enhanced sensitivity, low limit of detection, and a broad linear detection range, making it suitable for glucose detection in human sweat. The sensor also demonstrated good mechanical stability.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Polymer Science
Bishnu Prasad Bastakoti, Nischal Bhattarai, Moses D. Ashie, Felix Tettey, Shin-ichi Yusa, Kenichi Nakashima
Summary: A laboratory-synthesized triblock copolymer was used as a template to synthesize hollow BaCO3 nanoparticles. The formation of spherical micelles with a PEG corona, PAA shell, and PS core in an aqueous solution was confirmed. The controlled precipitation of BaCO3 around the polymeric micelles allowed for the synthesis of hollow BC-NPs with specific properties.
Article
Chemistry, Analytical
Minghui Feng, Alice L. Dauphin, Laurent Bouffier, Feifei Zhang, Zonghua Wang, Neso Sojic
Summary: The study found that luminol and its derivative exhibit strong cathodic electrochemiluminescence on iron and stainless steel electrodes with hydrogen peroxide, while no luminescence was observed on other classic electrode materials. The cathodic ECL signal of L-012 is comparable to the classically used anodic ECL emission, and dual bright ECL emissions with L-012 can be obtained simultaneously in oxidation and in reduction on iron materials.
ANALYTICAL CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
Masih Darbandi, Maryam Sadat Alahmadi, Mohammad Amjadi, Tooba Hallaj
Summary: Mesoporous cobalt oxides have important applications due to their exceptional properties. In this study, mesoporous Co3O4 NPs with different porosity were successfully synthesized through a sonochemical process. The synthesized NPs were characterized using XRD, BET, and TEM. The catalytic effect of the Co3O4 NPs in the luminol-H2O2 chemiluminescence system was studied, and the system was used to detect and measure H2O2 and glucose under optimal conditions. The proposed method showed a good linear relationship and excellent LOD for both H2O2 and glucose.
Article
Engineering, Environmental
Pingli Jiang, Ruiqing Hou, Tao Chen, Lingchuang Bai, Jingan Li, Shijie Zhu, Liguo Wang, Regine Willumeit-Roemer, Shaokang Guan
Summary: Novel calcium carbonate (CaCO3) coatings were prepared via the hydrothermal method and optimized with the addition of glutamate acid (Glu) or dopamine (DOPA) to improve the degradation and biological performance of MgZnCa alloy.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Zongqi Feng, Tingyu Yang, Shichao Dong, Ting Wu, Wen Jin, Zhouying Wu, Bingping Wang, Tiantian Liang, Lei Cao, Lan Yu
Summary: This study successfully developed an industrialized method for synthesizing high drug-loaded vaterite hollow calcium carbonate, showing promising applications in tumor therapy.
MATERIALS TODAY CHEMISTRY
(2022)
Article
Engineering, Biomedical
Yanjiang Shao, Zeying Wang, Yutong Hao, Xueli Zhang, Ning Wang, Kunlun Chen, Junbiao Chang, Qianhua Feng, Zhenzhong Zhang
Summary: The cascade catalytic nanoplatform based on glucose oxidase modified mesoporous iron oxide nanoparticles loaded with Artemisinin utilizes the tumor microenvironment to carry out a series of reactions for cancer therapy, including tumor starvation therapy, oxidation reactions, and chemodynamic therapy, resulting in enhanced immunotherapy effects.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Chuhan Lv, Xuewei Yang, Zongkang Wang, Ming Ying, Qingguo Han, Shuangfei Li
Summary: The research demonstrates that amination modification significantly improves the performance of bioelectrodes, leading to increased enzyme immobilization and activity, enhanced peak current intensity and transfer rate, as well as remarkable electro-activity and favorable reaction at the electrode.
Article
Chemistry, Analytical
Xiaotong Xu, Yuyu Ma, Shujiang Ding, Yinhuan Li
Summary: A chemiluminescence sensor was developed for one-step determination of glucose by encapsulating glucose oxidase into Zn-doped zeolitic imidazolate framework-67. The sensor showed linear response and low limit of detection for glucose measurement, with good selectivity and stability in real human serum samples.
Article
Chemistry, Multidisciplinary
Dulini Fernando, Motilal Mathesh, Jackie Cai, Wenrong Yang
Summary: A facile polymer-directed metal-organic framework (MOF)-based nanoarchitechtonics was developed to enhance the catalytic efficiency of multi-enzyme cascade reactions through substrate channeling. The new method involved the simultaneous synthesis of MOF and co-immobilization of enzymes, resulting in a closely packed nanoarchitecture with enhanced substrate channeling. The enzyme cascade reaction system showed a 3.5-fold increase in catalytic activity compared to free enzymes.
Article
Biophysics
Juan Han, Wenrui Huang, Man Zhao, Jiacong Wu, Yuanyuan Li, Yanli Mao, Lei Wang, Yun Wang
Summary: The composite 3-MPBA/GOx@ZIF-8 demonstrated high catalytic efficiency, loading efficiency, and enhanced stability, making it a potential candidate for biosensor preparation and diabetes screening.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
