Article
Plant Sciences
Wen Yu, Yannan Wang, Di Jiang, Jie Shang, Miao Liu, Thomas Efferth, Chun-Bo Teng
Summary: This study discovered a novel strategy to induce pancreatic ductal progenitors to differentiate into insulin-producing cells using isoastragaloside I. This approach has the potential to be applied in islet transplantation for diabetes therapies.
Article
Medicine, General & Internal
Barbara Wlodarczyk, Lukasz Durko, Przemyslaw Wlodarczyk, Renata Talar-Wojnarowska, Ewa Malecka-Wojciesko
Summary: Differentiating between pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP) poses a challenge. This study assessed the usability of IGF-1, IGFBP-2, and IGF-1/IGFBP-2 ratio in differentiating PDAC and CP. The results indicate that CA 19-9 demonstrates high potential as a marker for PDAC and CP differentiation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cell Biology
Tingting Cui, Jiaxin Huang, Yingning Sun, Bolin Ning, Fang Mu, Xin You, Yaqi Guo, Hui Li, Ning Wang
Summary: KLF2 inhibits chicken preadipocyte differentiation at least in part through direct downregulation of PPAR gamma 1 expression. This mechanism involves KLF2 regulation of the P1 promoter of the PPAR gamma gene and effects on histone modifications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Gastroenterology & Hepatology
Soledad A. Camolotto, Veronika K. Belova, Luke Torre-Healy, Jeffery M. Vahrenkamp, Kristofer C. Berrett, Hannah Conway, Jill Shea, Chris Stubben, Richard Moffitt, Jason Gertz, Eric L. Snyder
Summary: The study found that HNF4α regulates the growth and molecular subtype of PDAC by activating the classical gene expression program and repressing SIX4 and SIX1.
Article
Chemistry, Multidisciplinary
Qian-Zhi Ni, Bing Zhu, Yan Ji, Qian-Wen Zheng, Xin Liang, Ning Ma, Hao Jiang, Feng-Kun Zhang, Yu-Rong Shang, Yi-Kang Wang, Sheng Xu, Er-Bin Zhang, Yan-Mei Yuan, Tian-Wei Chen, Fen-Fen Yin, Hui-Jun Cao, Jing-Yi Huang, Ji Xia, Xu-Fen Ding, Xiao-Song Qiu, Kai Ding, Chao Song, Wen-Tao Zhou, Meng Wu, Kang Wang, Rui Lui, Qiu Lin, Wei Chen, Zhi-Gang Li, Shu-Qun Cheng, Xiao-Fan Wang, Dong Xie, Jing-Jing Li
Summary: This study reveals that PPDPF functions as an important regulator of SOS1 and promotes tumor development in pancreatic ductal adenocarcinoma (PDAC) through the PPDPF-SOS1 axis. This finding provides a potential therapeutic target for PDAC.
Article
Oncology
Mundla Srilatha, Ramarao Malla, Megha Priya Adem, Jeremy B. Foote, Ganji Purnachandra Nagaraju
Summary: Obesity is closely associated with pancreatic health, and obese individuals have an increased risk for developing pancreatic ductal adenocarcinoma (PDAC). Factors such as chronic inflammation, insulin resistance, metabolic dysfunction, immune suppression, hormone level changes, and genetic mutations contribute to the development and progression of PDAC in obese individuals.
SEMINARS IN CANCER BIOLOGY
(2023)
Review
Cell & Tissue Engineering
Isaura Beatriz Borges Silva, Camila Harumi Kimura, Vitor Prado Colantoni, Mari Cleide Sogayar
Summary: Type 1 diabetes is characterized by the destruction of insulin-producing beta cells by the immune system. Current treatment strategies struggle to maintain glycemic control, leading to research into expanding beta-cell cultures for pancreatic islet replacement therapy using stem cell differentiation protocols. Challenges remain in efficiently producing functional beta cells for long-term euglycemia maintenance in clinical translation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Mohamed A. Ghoneim, Mahmoud M. Gabr, Ayman F. Refaie, Sawsan M. El-Halawani, Mohga M. Al-issawi, Batoul L. Elbassiouny, Mai A. Abd El Kader, Amani M. Ismail, Mona F. Zidan, Mary S. Karras, Raghda W. Magar, Sherry M. Khater, Sylvia A. Ashamallah, Mahmoud M. Zakaria, Malgorzata Kloc
Summary: This study investigated allogenic immune responses following the transplantation of insulin-producing cells (IPCs) differentiated from human adipose tissue-derived stem cells (hAT-MSCs) into humanized mice. The results showed that the engrafted cells were not affected by allogenic immune response, suggesting potential for cell therapy for insulin-dependent diabetes without immunosuppression or encapsulation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Multidisciplinary Sciences
Giulio Innamorati, Thomas M. Wilkie, Giorgio Malpeli, Salvatore Paiella, Silvia Grasso, Borislav Rusev, Biagio Eugenio Leone, Maria Teresa Valenti, Luca dalle Carbonare, Samuele Cheri, Alice Giacomazzi, Marco Zanotto, Vanessa Guardini, Michela Deiana, Donato Zipeto, Michela Serena, Marco Parenti, Francesca Guzzi, Rita Teresa Lawlor, Giovanni Malerba, Antonio Mori, Giuseppe Malleo, Luca Giacomello, Roberto Salvia, Claudio Bassi
Summary: The GNA15 gene is ectopically expressed in human pancreatic ductal adenocarcinoma cancer cells and is associated with poor prognosis. Elevated GNA15 expression in pancreatic cancer can affect signaling and cell motility during progression.
SCIENTIFIC REPORTS
(2021)
Review
Cell & Tissue Engineering
Marzieh Nemati, GolamHossein Ranjbar Omrani, Bahareh Ebrahimi, Aliakbar Alizadeh
Summary: The use of stem cells in treating diseases, especially diabetes, is a promising new avenue. Among different types of stem cells, mesenchymal stem cells (MSCs) are commonly used for differentiation into insulin-producing cells. Various studies have shown the potential of stem cells in diabetes recovery, but further research is needed to evaluate their efficacy and safety.
STEM CELLS INTERNATIONAL
(2021)
Review
Biochemistry & Molecular Biology
Seema Parte, Rama Krishna Nimmakayala, Surinder K. Batra, Moorthy P. Ponnusamy
Summary: Pancreatic cancer is a deadly neoplastic malignancy with high mortality rates. Acinar to ductal cell metaplasia plays a crucial role in tumor initiation, making it important for understanding the pathogenesis and early diagnosis of pancreatic cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biochemistry & Molecular Biology
Je Lin Sieow, Hweixian Leong Penny, Sin Yee Gun, Ling Qiao Tan, Kaibo Duan, Joe Poh Sheng Yeong, Angela Pang, Diana Lim, Han Chong Toh, Tony Kiat Hon Lim, Edgar Engleman, Olaf Rotzschke, Lai Guan Ng, Jinmao Chen, Suet Mien Tan, Siew Cheng Wong
Summary: A large number of neutrophils infiltrate tumors and contribute to the inflammatory tumor microenvironment. The metabolic status of these neutrophils and their role in tumor progression were investigated in a mouse model of pancreatic ductal adenocarcinoma (PDAC). Tumor-infiltrating neutrophils showed enhanced glycolytic activity compared to neutrophils from the bone marrow and blood of the same mouse. Deletion of hypoxia-inducible factor 1-alpha (HIF-1 alpha) in neutrophils reduced tumor burden and improved survival in the mouse model, indicating a potential target for metabolic modulation in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Seung-Ah Lee, Subin Kim, Seog-Young Kim, Jong Yoen Park, Jinyan Nan, Ho Seon Park, Hyunsuk Lee, Yong Deok Lee, Hakmo Lee, Shinae Kang, Hye Seung Jung, Sung Soo Chung, Kyong Soo Park
Summary: Researchers developed a simple protocol to differentiate bone marrow-derived stem cells into mature insulin-producing cells, which could potentially be used for cell-based therapy in diabetes mellitus.
STEM CELLS TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Min Kyung Kang, Fen Jiang, Ye Ji Kim, Kyoungjin Ryu, Atsushi Masamune, Shin Hamada, Yun-Yong Park, Sang Seok Koh
Summary: CTHRC1, a protein highly expressed in tumors, is predominantly secreted by cancer stroma in pancreatic cancer. It activates pancreatic stellate cells (PSCs) to remodel the cancer extracellular matrix (ECM) and has stronger pro-tumoral effects through PSC activation than through autocrine action. This study unveils PSC activation as the central mechanism underlying the pro-tumoral effects of CTHRC1 and suggests its potential as a therapeutic target for pancreatic cancer.
Article
Oncology
Yunzhen Qian, Yitao Gong, Xuan Zou, Yu Liu, Yusheng Chen, Ruijie Wang, Zhengjie Dai, Yesiboli Tasiheng, Xuan Lin, Xu Wang, Guopei Luo, Xianjun Yu, He Cheng, Chen Liu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a lethal and heterogeneous disease. This study investigates the significance of APOBEC3C gene in PDAC and found that high APOBEC3C expression is associated with increased mutations in specific genes and enhanced immune activity. APOBEC3C is substantially upregulated in PDAC and predicts shorter survival. These findings suggest that APOBEC3C could serve as a potential therapeutic target for PDAC and guide immunotherapy.
Article
Endocrinology & Metabolism
Yunjung Cho, Kyungdo Han, Da Hye Kim, Yong-Moon Park, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
Summary: The study found that there is an association between cumulative exposure to metabolic disturbances, such as metabolic syndrome and its components, and the risk of dementia. The more exposure, the higher the risk, and even minimal exposure to metabolic disturbances can significantly impact the risk of dementia.
ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Cell & Tissue Engineering
Tomohiro Yoneda, Byung H. Choi, Pawan K. Gupta, Chih-Yuan Ho, Yat P. Tsui, Ling-Mei Wang, Yukari Fujiwara, Hiroshi Karasawa, Yuu Moriya, Kiyoko Bando, Yoshiteru Kamiyama, Masayuki Kanki, Kou Omura, Takeshi Watanabe, Yohan Bae, Feng-Cheng Chou, Dong-sik Ham, Joo Y. Lee, Guangyang Liu, Yongjun Liu, James Ooi, Yoshie Tsurumaki
Summary: The study compared the non-clinical prerequisites for initiating clinical studies in five Asian countries/regions from an industry viewpoint. The findings revealed differences in regulations and development experiences, leading to variations in the non-clinical study package and its corresponding study design. Sharing experiences among Asian countries/regions could expedite cross-border IND approval and contribute to early delivery of innovative CTPs to patients.
Article
Cell & Tissue Engineering
Tomohiro Yoneda, Toshimitsu Tanaka, Kiyoko Bando, Byung Hyune Choi, Ryan Chang, Yukari Fujiwara, Pawan Kumar Gupta, Dong-sik Ham, Hiroshi Karasawa, Shinobu Kuwae, Shing-mou Lee, Yuu Moriya, Koji Takakura, Yoshie Tsurumaki, Takeshi Watanabe, Keiji Yoshimura, Masayuki Nomura
Summary: The 4th Asia Partnership Conference of Regenerative Medicine aimed to promote regulatory harmonization of regenerative medicine products in Asia. The conference facilitated dialogue between regulatory agencies and industry experts, sharing updates on the field and specific regulatory schemes.
Article
Endocrinology & Metabolism
Seung-Hwan Lee, Kyungdo Han, Hyuk-Sang Kwon, Mee Kyoung Kim
Summary: The study found that the frequency and intensity of impaired fasting glucose (IFG) exposure are associated with cardiovascular disease and mortality risk. Adjusting for hypertension and dyslipidemia attenuated the association between high IFG exposure scores and risk of myocardial infarction or stroke, but the risk of all-cause mortality remained significant.
ENDOCRINOLOGY AND METABOLISM
(2021)
Review
Endocrinology & Metabolism
Jin Yu, Seung-Hwan Lee, Mee Kyoung Kim
Summary: Guidelines for the management of diabetes have become crucial for clinical practice and evidence-based medicine. The recent updates emphasize the treatment of comorbid conditions and the use of newer technologies such as continuous glucose monitoring and insulin pump. These updates provide a valuable approach for clinicians dealing with diabetes.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Endocrinology & Metabolism
Ji-Yeon Park, Kyungdo Han, Hun-Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim, Seung-Hwan Lee
Summary: This study found a linear relationship between cumulative exposure to high gamma-GTP level and risk of diabetes, suggesting that monitoring and lowering gamma-GTP level should be considered for prevention of diabetes in the general population.
ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Mee Kyoung Kim, Kyungdo Han, Hun Sung Kim, Kun Ho Yoon, Seung Hwan Lee
Summary: This study aimed to identify the cutoff levels of lipid parameters for increased risk of cardiovascular disease (CVD) among nondiabetic young adults. The researchers found that even modest increases in lipid levels were associated with increased risk of CVD in this population.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Endocrinology & Metabolism
Mee Kyoung Kim, Kyungdo Han, Seung-Hwan Lee
Summary: The Korean National Health Information Database (NHID) is a representative big data with strengths and limitations, requiring carefully designed studies for valuable information. Research and publications based on NHID have increased rapidly, especially in the field of diabetes and metabolism.
DIABETES & METABOLISM JOURNAL
(2022)
Article
Endocrinology & Metabolism
Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
Summary: The impact of thyroid-stimulating hormone (TSH) levels on diabetes mellitus incidence remains controversial in euthyroid state, but increases in TSH levels were associated with decreased skeletal muscle mass and increased body fat mass. Moreover, increment in TSH levels correlated with significant increases in fasting blood glucose and body mass index.
JOURNAL OF DIABETES
(2022)
Article
Medicine, General & Internal
Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun-Sung Kim
Summary: This study examined the relationship between glycemic control and cardiovascular disease risk in patients with type 2 diabetes. The results suggest that controlling glucose levels during early diabetes may be more important than reducing glycemic variability.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Editorial Material
Endocrinology & Metabolism
Jin Yu, Jae-Hyoung Cho, Seung-Hwan Lee
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Endocrinology & Metabolism
Seung-Hwan Lee, Jin Yu, Kyungdo Han, Seung Woo Lee, Sang Youn You, Hun -Sung Kim, Jae-Hyoung Cho, Kun-Ho Yoon, Mee Kyoung Kim
Summary: A risk model for predicting insulin-requiring GDM before pregnancy in Korean women was developed using data from 417,210 women. Six risk factors were identified and incorporated into a risk nomogram. The model showed a concordance index of 0.783, indicating its accuracy in predicting insulin-requiring GDM.
ENDOCRINOLOGY AND METABOLISM
(2023)
Editorial Material
Endocrinology & Metabolism
Seung-Hwan Lee
DIABETES & METABOLISM JOURNAL
(2023)
Editorial Material
Endocrinology & Metabolism
Seung-Hwan Lee
ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Medicine, General & Internal
Hyunah Kim, Da Young Jung, Seung-Hwan Lee, Jae-Hyoung Cho, Hyeon Woo Yim, Hun -Sung Kim
Summary: The blood glucose control status within the first 3 months after hospital care can predict glycemic control for the next 7 years. For cases with poor initial blood glucose control, new or more active methods of blood glucose control should be sought.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2022)