Article
Cardiac & Cardiovascular Systems
Toshikazu Sano, Tatsuo Ito, Shuta Ishigami, Srinivas Bandaru, Shunji Sano
Summary: This study aimed to enhance the cardiomyogenic efficiency of cardiosphere-derived cells (CDCs) using an intrinsic activation system, resulting in improved regenerative potential and functional benefits in a rat model of acute myocardial infarction. The CRISPR/dCas9 system showed promise in regulating the activation of Tnnt2 gene within stem cells, which could lead to better therapeutic outcomes for patients with ischemic heart disease.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Biotechnology & Applied Microbiology
Xuejun He, Yimin Huang, Yuan Liu, Xincheng Zhang, Quanji Wang, Yanchao Liu, Xiaopeng Ma, Xiaobing Long, Yang Ruan, Hongxia Lei, Chao Gan, Xiaochuan Wang, Xin Zou, Bo Xiong, Kai Shu, Ting Lei, Huaqiu Zhang
Summary: This study revealed that an exosomal long non-coding RNA from astrocytes attenuates microglial activation after traumatic brain injury by up-regulating Smad7, providing a potential therapeutic target.
Article
Biotechnology & Applied Microbiology
Liang Mao, Yun-Da Li, Ruo-Lan Chen, Gang Li, Xiao-Xia Zhou, Fei Song, Chan Wu, Yu Hu, Yi-Xiang Hong, Xitong Dang, Gui-Rong Li, Yan Wang
Summary: The study demonstrates the potential of heart homing peptide (HHP) displayed exosomes from human cardiosphere-derived cells (CDCs) to enhance the therapeutic effect on myocardial hypertrophy. The HHP-exosomes showed higher accumulation in the heart and improved cardiac function and remodeling in mouse models. This beneficial effect is likely mediated through the miRNA-148a-mediated suppression of GP130 signaling pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Editorial Material
Cell & Tissue Engineering
Hassan Rashidi, David C. Ha
Summary: In this study, Ma et al. demonstrate that activating the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells.
Article
Cardiac & Cardiovascular Systems
Progyaparamita Saha, MinJung Kim, Antariksh Tulshyan, Yin Guo, Rachana Mishra, Deqiang Li, Curt I. Civin, Sunjay Kaushal, Sudhish Sharma
Summary: Objective: Cell-based therapies have shown promise in restoring and remodeling injured myocardium after cardiac injury. This study aimed to enhance the therapeutic potential of cardiosphere-derived cells by modulating hypoxia-inducible factor-1a, a regulator of paracrine factors.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Oncology
Min Wu, Lingxiang Wu, Wei Wu, Mengyan Zhu, Jianyu Li, Ziyu Wang, Jie Li, Rong Ding, Yuan Liang, Liangyu Li, Tingting Zhang, Bin Huang, Yun Cai, Kening Li, Lu Li, Rui Zhang, Baoli Hu, Fan Lin, Xiuxing Wang, Siyuan Zheng, Jian Chen, Yongping You, Tao Jiang, Junxia Zhang, Hongshan Chen, Qianghu Wang
Summary: Tumor-associated macrophages (TAM) play a crucial role in immunosuppression, but how TAMs are transformed and influence the tumor microenvironment (TME) is not fully understood. In this study, researchers identified a subset of TAMs termed double-positive TAMs that co-expressed macrophage and tumor markers. These double-positive TAMs had immunosuppressive phenotypes and were transformed into M2-like macrophages, expressing immune-checkpoint proteins and suppressing T cell proliferation. This study sheds light on the processes driving TAM-mediated immunosuppression in glioblastoma.
Article
Pharmacology & Pharmacy
Laura Paz-Artigas, Kaoutar Ziani, Clara Alcaine, Claudia Baez-Diaz, Virginia Blanco-Blazquez, Jose Luis Pedraz, Ignacio Ochoa, Jesus Ciriza
Summary: This study evaluated the effects of long-term cryopreservation on CDCs, as well as the mechanical stability of microcapsules. The results suggest that cryopreservation may better ensure the stability of both CDCs and microcapsules, making it a suitable technique for long-term storage of encapsulated cells.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Cell Biology
Isotta Chimenti, Vittorio Picchio, Francesca Pagano, Leonardo Schirone, Sonia Schiavon, Luca D'Ambrosio, Valentina Valenti, Maurizio Forte, Flavio di Nonno, Speranza Rubattu, Mariangela Peruzzi, Francesco Versaci, Ernesto Greco, Antonella Calogero, Elena De Falco, Giacomo Frati, Sebastiano Sciarretta
Summary: This study evaluated the impact of autophagy modulation on the viability and phenotype of murine cardiac stromal cells (CSCs) under different stress conditions. The results showed that autophagy induction preserved CSC viability and function, suggesting its potential in cardiac repair mechanisms.
CELL DEATH DISCOVERY
(2022)
Article
Multidisciplinary Sciences
Kenji Miki, Kohei Deguchi, Misato Nakanishi-Koakutsu, Antonio Lucena-Cacace, Shigeru Kondo, Yuya Fujiwara, Takeshi Hatani, Masako Sasaki, Yuki Naka, Chikako Okubo, Megumi Narita, Ikue Takei, Stephanie C. Napier, Tsukasa Sugo, Sachiko Imaichi, Taku Monjo, Tatsuya Ando, Norihisa Tamura, Kenichi Imahashi, Tomoyuki Nishimoto, Yoshinori Yoshida
Summary: The study reveals that an estrogen-related receptor gamma (ERR gamma) agonist and an S-phase kinase-associated protein 2 inhibitor enhance the maturation of cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) by promoting larger cell size, longer sarcomere length, the presence of transverse tubules, and improved metabolic, contractile, and electrical properties.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Avner Adini, Irit Adini, Etty Grad, Yuval Tal, Haim D. Danenberg, Peter M. Kang, Benjamin D. Matthews, Robert J. D'Amato
Summary: Myocardial infarction (MI) remains a leading cause of death in the western world, with current interventions being limited due to comorbidities or lack of resources. Non-invasive approaches to enhance angiogenesis in ischemic tissues have been ineffective in humans, prompting researchers to develop PR1P, a VEGF binding peptide that improves heart function post-MI in rodents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Martha E. Floy, Sophie E. Givens, Oriane B. Matthys, Taylor D. Mateyka, Charles M. Kerr, Alexandra B. Steinberg, Ana C. Silva, Jianhua Zhang, Ying Mei, Brenda M. Ogle, Todd C. McDevitt, Timothy J. Kamp, Sean P. Palecek
Summary: The study explores the developmental lineage and functional properties of cardiac fibroblasts derived from human pluripotent stem cells, highlighting their potential in modeling fibrotic diseases and regenerative therapies in the context of heart function. The differences in characteristics between epicardial and second heart field cardiac fibroblasts provide insights for in vitro model selection and therapeutic applications.
Article
Cardiac & Cardiovascular Systems
Daile Jia, Siqin Chen, Peiyuan Bai, Chentao Luo, Jin Liu, Aijun Sun, Junbo Ge
Summary: This study reveals the importance of cardiac resident macrophages in the efficient clearance and degradation of apoptotic cardiomyocytes during myocardial infarction, which is crucial for inflammation resolution and tissue repair. The researchers identified Lgmn as a key gene involved in this process and demonstrated its functional significance through various experiments.
Article
Cardiac & Cardiovascular Systems
Ardiansah Bayu Nugroho, Nicholas Stafford, Min Zi, Sukhpal Prehar, Ryan Potter, Dowan Kwon, Yulia Suciati Kohar, Efta Triastuti, Thuy Anh Bui, Elizabeth J. Cartwright, Delvac Oceandy
Summary: Induction of endogenous regenerative capacity has emerged as a promising approach to repair damaged hearts following myocardial infarction. In this study, miR-411 was identified as a potent inducer of cardiomyocyte proliferation, likely by modulating the Hippo/YAP pathway. Overexpression of miR-411 in the heart significantly increased cardiomyocyte proliferation and survival in a myocardial infarction model.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Youming Zhang, Wei Gao, Jie Yuan, Xin Zhong, Kang Yao, Rong Luo, Haibo Liu
Summary: This study found that the expression of CCR7 increased in DEXs derived from inflammatory cells after myocardial infarction (MI). Overexpression of CCR7 enhanced the migration of DEXs to the spleen and improved cardiac function by activating CD4(+) T cells and secreting IL-4 and IL-10.
Article
Immunology
Miriam Aarsund, Tuula Anneli Nyman, Maria Ekman Stensland, Yunjie Wu, Marit Inngjerdingen
Summary: NK cells release extracellular vesicles (EVs) containing cytolytic proteins to target and kill cancer cells. A fractionation scheme enriched cytolytic NK-EVs, leading to the identification of distinct EV populations. Immunoaffinity pulldowns further enriched EVs containing cytolytic granule markers.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Cell & Tissue Engineering
Claudia Cozzolino, Vittorio Picchio, Erica Floris, Francesca Pagano, Wael Saade, Mariangela Peruzzi, Giacomo Frati, Isotta Chimenti
Summary: Smoking habits have a significant impact on cardiovascular health by damaging differentiated and functional cells, as well as impairing reparative mechanisms. The introduction of modified tobacco risk products (MRPs) as alternative smoking devices has raised concerns regarding their effects on cardiovascular repair and regenerative cells. This review critically evaluates the limited available data on the molecular and cellular effects of MRPs on cardiovascular repair and regeneration.
CURRENT STEM CELL RESEARCH & THERAPY
(2023)
Review
Cardiac & Cardiovascular Systems
Grace Lee, Joanna Chikwe, Milan Milojevic, Harindra C. Wijeysundera, Giuseppe Biondi-Zoccai, Marcus Flather, Mario F. L. Gaudino, Stephen E. Fremes, Derrick Y. Tam
Summary: This review compares the latest European and American guidelines on the management of aortic stenosis (AS) and identifies three areas of divergence: timing of intervention, valve selection, and surgical vs. transcatheter aortic valve replacement criteria. Gaps in the literature for specific aspects of AS treatment are also highlighted.
EUROPEAN HEART JOURNAL
(2023)
Article
Nutrition & Dietetics
Alessandra D'Amico, Chiara Fossati, Fabio Pigozzi, Paolo Borrione, Mariangela Peruzzi, Simona Bartimoccia, Filippo Saba, Annachiara Pingitore, Giuseppe Biondi-Zoccai, Luigi Petramala, Fabrizio De Grandis, Daniele Vecchio, Luca D'Ambrosio, Sonia Schiavon, Luigi Sciarra, Cristina Nocella, Elena Cavarretta
Summary: This study aimed to investigate the effects of a mixture containing three compounds on muscle injury biomarkers in endurance athletes. The results showed that the intake of this mixture significantly reduced oxidative stress and positively modulated autophagy, resulting in a significant decrease in muscle injury biomarkers.
Review
Pharmacology & Pharmacy
Adelaide Iervolino, Luigi Spadafora, Cristiano Spadaccio, Valentina Iervolino, Giuseppe Biondi Zoccai, Felicita Andreotti
Summary: Cardiotoxic therapies pose a burden on patients, who may have to interrupt life-saving treatment due to serious complications. Nanotechnologies offer the possibility to modify toxic drugs and eliminate off-target side effects, showing promising applications in pharmacology and cardio-oncology. The future of nanotechnologies lies in improving therapeutic safety and expanding the range of pharmacological agents.
Editorial Material
Cardiac & Cardiovascular Systems
Luigi Spadafora, Gabriele Crimi, Italo Porto, Giuseppe Biondi-Zoccai
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Marco Giuseppe Del Buono, Juan Ignacio Damonte, Francesco Moroni, Juan Guido Chiabrando, Roshanak Markley, Jeremy Turlington, Cory R. Trankle, Le Kang, Giuseppe Biondi-Zoccai, Michael C. Kontos, Charlotte S. Roberts, Benjamin W. Van Tassell, Antonio Abbate
Summary: IL-1 blockade with anakinra reduces inflammation and prevents heart failure events in patients with STEMI. The efficacy of anakinra is not influenced by time-to-treatment, as it significantly reduces systemic inflammation and incidence of heart failure regardless of when it is administered.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
(2023)
Review
Health Care Sciences & Services
Francesco Perone, Annachiara Pingitore, Edoardo Conte, Geza Halasz, Marco Ambrosetti, Mariangela Peruzzi, Elena Cavarretta
Summary: Obesity is associated with an increased risk of cardiovascular disease events and mortality, as well as other complications such as pre-type 2 diabetes and non-alcoholic fatty liver diseases. While physical activity and diet are important in reducing cardiovascular risk, they are not always successful strategies. Pharmacological treatments and bariatric surgery show promise in improving cardiovascular outcomes, but safety issues and cost restrict their use. Cardiac rehabilitation programs have been shown to improve cardiovascular disease risk factors, quality of life, and exercise capacity in obese patients. A multidisciplinary approach is needed to effectively reduce cardiovascular disease risk and mortality.
Review
Cardiac & Cardiovascular Systems
Mattia Petrungaro, Liuba Fusco, Elena Cavarretta, Antonio Scara, Alessio Borrelli, Silvio Romano, Renata Petroni, Flavio D'Ascenzi, Luigi Sciarra
Summary: Atrial fibrillation (AF) is a common sustained arrhythmia with high morbidity, disability, and mortality. Physical activity has been shown to reduce the risk of cardiovascular disease and all-cause mortality, and it may also reduce the risk of AF while improving overall well-being. However, intense physical activity has been associated with an increased risk of AF.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Mariangela Peruzzi, Karin Covi, Matteo Saccucci, Annachiara Pingitore, Wael Saade, Luigi Sciarra, Maria P. Cristalli, Fabio Miraldi, Giacomo Frati, Elena Cavarretta
Summary: Periodontal disease (PD) and cardiovascular diseases (CVD) have been extensively studied and are among the most common pathologies in the world. This umbrella review aimed to evaluate the association between these two conditions. A comprehensive literature search was conducted, and 31 systematic reviews and 8 meta-analyses were included. The results suggested that PD is associated with a higher risk of developing CVD and cerebrovascular diseases, but further research is needed to investigate the potential effects of periodontitis treatment on CVD events.
MINERVA CARDIOLOGY AND ANGIOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Angela Buonpane, Giuseppe Biondi-Zoccai, Francesco Versaci
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Marco Borgi, Mariangela Peruzzi, Giuseppe Biondi-Zoccai, Francesco Versaci
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Giuliano Tocci, Giuseppe Biondi-Zoccai, Maurizio Forte, Giovanna Gallo, Giulia Nardoianni, Emiliano Fiori, Luca D'Ambrosio, Riccardo Di Pietro, Giulio Stefanini, Francesco Cannata, Erica Rocco, Beatrice Simeone, Gianmarco Sarto, Leonardo Schirone, Alessandra D'Amico, Mariangela Peruzzi, Cristina Nocella, Massimo Volpe, Speranza Rubattu
Summary: This study evaluated the effects of a mixture of trehalose, spermidine, nicotinamide, and polyphenols on outpatients with grade 1 uncomplicated essential hypertension. The results showed that the mixture reduced oxidative stress, stimulated autophagy, increased NO bioavailability, and counteracted hypertension-related arterial stiffness through regulation mechanisms.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Nutrition & Dietetics
Cristina Nocella, Elena Cavarretta, Chiara Fossati, Fabio Pigozzi, Federico Quaranta, Mariangela Peruzzi, Fabrizio De Grandis, Vincenzo Costa, Carwyn Sharp, Massimo Manara, Antonia Nigro, Vittoria Cammisotto, Valentina Castellani, Vittorio Picchio, Sebastiano Sciarretta, Giacomo Frati, Simona Bartimoccia, Alessandra D'Amico, Roberto Carnevale
Summary: This study assessed intestinal permeability in elite football players and found that intense exercise can increase intestinal permeability. However, intake of cocoa polyphenols in dark chocolate can decrease intestinal permeability. In vitro experiments also showed that polyphenols can improve intestinal damage.
Article
Cardiac & Cardiovascular Systems
Henner Hanssen, Trine Moholdt, Martin Bahls, Alessandro Biffi, Monika Siegrist, Adam J. Lewandowski, Giuseppe Biondi-Zoccai, Elena Cavarretta, Ane Kokkvoll, Maja-Lisa Lochen, Viviana Maestrini, Rita Salvador Pinto, Stefano Palermi, David Thivel, Malgorzata Wojcik, Dominique Hansen, Emeline M. Van Craenenbroeck, Daniel Weghuber, Nicolle Kraenkel, Monica Tiberi
Summary: There is an urgent need to optimize cardiovascular risk management and primary prevention of childhood obesity to combat the health threat and socioeconomic burden of cardiovascular disease. Lifestyle interventions have high potential to change disease trajectories by optimizing screening programs and risk management strategies for obesity-related cardiovascular risks.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Zefferino Palama, Antonio Gianluca Robles, Matteo Paoletti, Martina Nesti, Ermenegildo De Ruvo, Antonio Scara, Alessio Borrelli, Gabriele De Masi De Luca, Mariano Rillo, Leonardo Calo, Elena Cavarretta, Silvio Romano, Luigi Sciarra
Summary: The study assessed the inducibility of supraventricular tachycardia (SVT) in patients referred for atrial fibrillation (AF) ablation and the effects of SVT ablation on AF recurrences. It found that 19% of patients had inducible SVT, and SVT ablation had a preventive effect on AF recurrences.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)