Review
Chemistry, Analytical
Yulin Ren, Lei Cao, Minli You, Jingcheng Ji, Yan Gong, Hui Ren, Feng Xu, Hui Guo, Jie Hu, Zedong Li
Summary: Liquid biopsy based on detection of circulating nucleic acid (NA) biomarkers has emerged as a promising strategy for lung cancer monitoring. Digital NA amplification technologies, such as digital polymerase chain reaction and digital isothermal amplification, show high sensitivity and specificity for early diagnosis, minimal residual disease detection, prognosis prediction, and companion diagnosis of lung cancer. This paper summarizes the evolution of digital NA amplification technologies and proposes SMART digital NA amplification technologies for wider applications in lung cancer monitoring. Moreover, it summarizes the existing NA biomarkers at different stages of lung cancer and introduces the existing digital NA amplification methods for detecting these biomarkers. Conclusions and future perspectives are also provided.
TRAC-TRENDS IN ANALYTICAL CHEMISTRY
(2022)
Article
Oncology
Zixuan Song, Yangzi Zhou, Xue Bai, Dandan Zhang
Summary: This study established a reliable nomogram through big data analysis to predict early death in patients with advanced ovarian cancer, which is helpful for screening high-risk patients and tailoring treatment plans.
FRONTIERS IN ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Satoru Hagiwara, Takeshi Yoshida, Naoshi Nishida, Hiroshi Ida, Kazuomi Ueshima, Yasunori Minami, Masahiro Takita, Tomoko Aoki, Masahiro Morita, Hirokazu Cishina, Yoriaki Komeda, Akihiro Yoshida, Hidetoshi Hayashi, Kazuhiko Nakagawa, Masatoshi Kudo
Summary: This case report describes a rare case of immune-related cholangitis in a patient with squamous cell lung cancer. The patient did not respond to conventional treatment for liver dysfunction but showed improvement with the introduction of immunotherapy.
HEPATOLOGY RESEARCH
(2022)
Article
Clinical Neurology
Mario Fichera, Anna Castaldo, Alessia Mongelli, Gloria Marchini, Cinzia Gellera, Lorenzo Nanetti, Caterina Mariotti
Summary: The incidence of disease-related medical conditions varies according to the duration of FA disease. In patients with long disease duration, visual and auditory pseudo-hallucinations were unexpectedly high.
NEUROLOGICAL SCIENCES
(2022)
Article
Oncology
Naoya Kemmotsu, Kiichiro Ninomiya, Kei Kunimasa, Takamasa Ishino, Joji Nagasaki, Yoshihiro Otani, Hiroyuki Michiue, Eiki Ichihara, Kadoaki Ohashi, Takako Inoue, Motohiro Tamiya, Kazuko Sakai, Youki Ueda, Hiromichi Dansako, Kazuto Nishio, Katsuyuki Kiura, Isao Date, Yosuke Togashi
Summary: Intracranial metastases are common in NSCLC patients with poor prognosis. We analyzed clinical data and found that the frequency of intracranial progression in advanced NSCLC patients treated with PD-1 blockade therapies was significantly lower than that in patients treated with cytotoxic chemotherapies. Our results indicate that cancer immunotherapies can prevent intracranial progression, maintaining long-term effects both intracranially and systemically.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Katarina Davalieva, Sanja Kiprijanovska, Ognen Ivanovski, Aleksandar Trifunovski, Skender Saidi, Aleksandar Dimovski, Zivko Popov
Summary: The high recurrence rate and invasive diagnostic methods in bladder cancer clinical management require the development of new non-invasive molecular tools for early detection and risk stratification. This study identified potential non-invasive diagnostic and prognostic markers using a new analysis method, expanding the field of bladder cancer research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Francisco Aya, Mariana Benegas, Nuria Vinolas, Roxana Reyes, Ivan Vollmer, Ainara Arcocha, Marcelo Sanchez, Noemi Reguart
Summary: The study aimed to explore the capacity of Perfusion-Computed Tomography (pCT) in detecting early changes in tumor vascularization in non-small cell lung cancer (NSCLC) patients treated with antiangiogenic therapy, confirming the feasibility of pCT in capturing early changes in tumor vasculature and suggesting the potential of blood volume (BV) in identifying differential tumor responses to antiangiogenic therapy at an early stage.
Article
Endocrinology & Metabolism
Gustavo M. Amaro, Alana D. T. da Silva, Guilherme H. Tamarindo, Celina de A. Lamas, Sebastiao R. Taboga, Valeria Helena Alves Cagnon, Rejane M. Goes
Summary: In vitro studies have shown that omega-3 polyunsaturated fatty acids ([n-3] PUFAs) have antitumor effects, but their effects on prostate cancer remain controversial in epidemiological studies. This study found that a(n-3) PUFA-enriched diet could delay tumor progression in the early stages of prostate cancer in mice and reduce cell proliferation and hormone receptor expression.
Article
Biology
Mirna Jovanovic, Tijana Stankovic, Sonja Stojkovic Buric, Jasna Bankovic, Jelena Dinic, Mila Ljujic, Milica Pesic, Miodrag Dragoj
Summary: Tspan14, a member of the tetraspanin protein family, plays an important role in non-small cell lung cancer (NSCLC) progression. The inactivation of TSPAN14 gene is associated with low survival rate and aggressive tumor types in NSCLC patients.
Article
Materials Science, Multidisciplinary
Y. Ikeda, R. Yuan, A. Chakraborty, H. Ghassemi-Armaki, J. M. Zuo, R. Maass
Summary: The study revealed the presence of nano-scale intermetallic phase G-phase in uncracked grain boundaries, suggesting it as one of the primary nanoscopic drivers for grain-boundary weakening and crack initiation. These findings shift the focus of LME research to the very early stages immediately following Zn diffusion, where secondary phase nucleation and growth emerge as the root-cause for failure.
MATERIALS TODAY ADVANCES
(2022)
Article
Medicine, General & Internal
Geovanne Pedro Mauro, Carolina Trindade Mello Medici, Lucas Coelho Casimiro, Eduardo Weltman
Summary: The study evaluated the efficacy of radiotherapy for follicular lymphoma under different management scenarios. Results showed good overall survival and progression-free survival rates for patients treated with radiation, although some patients may experience transformation into aggressive lymphomas, which can be effectively managed with rituximab-based systemic treatment.
Article
Oncology
Jesper van Breeschoten, Alfons J. M. van den Eertwegh, Doranne L. Hilarius, John B. Haanen, Christian U. Blank, Maureen J. B. Aarts, Franchette W. P. J. van den Berkmortel, Jan Willem B. de Groote, Geke A. P. Hospers, Ellen Kapiteijn, Djura Piersma, Rozemarijn S. van Rijnan, Marion A. Stevense-den Boer, Astrid A. M. van der Veldt, Gerard Vreugdenhil, Marye J. Boers-Sonderen, Damjan Manevski, Karijn P. M. Suijkerbuijk, Michel W. J. M. Wouters, Liesbeth C. de Wreede
Summary: This study aimed to assess population mortality in advanced melanoma patients in the Netherlands after different response states and analyze the contribution of disease and population mortality across different age groups. The results showed that, despite improvements in survival outcomes for advanced melanoma patients over the past decade, the majority still die from melanoma-related mortality.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Nuclear Science & Technology
Mostafa Hamza, Mihai A. Diaconeasa
Summary: This paper presents a framework to include human reliability analysis (HRA) during the early stages of nuclear power plant design, aiming to guide the design and evaluate the reliance on human actions. The framework is demonstrated using X-energy's pre-conceptual Xe-100 high-temperature gas-cooled pebble-bed reactor (HTGR-PB) design, showing the safety and reliability of the design even without considering human actions.
PROGRESS IN NUCLEAR ENERGY
(2022)
Article
Oncology
Ruishan Wen, Ying Chen, Jinyu Long, Xiulian Huang, Yuxin Guo, Baoquan Lin, Zongyang Yu
Summary: This study analyzed potential influencing factors in 1073 non-small cell lung cancer (NSCLC) patients with EGFR mutation, including clinical features, biomarkers, and concomitant mutations. The results showed that concomitant mutations including AXIN2, P2CG, and RAD51C occurred only in the aggressively progressive group. The Ki-67 index was significantly correlated with aggressive progression in the first-line TKI therapy. In the second-line therapy, the PFS of chemotherapy in combination with other treatments was better than single TKIs.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Michael Steiner, Ben Yang, Simon Hohl, Da Li, Philip Donoghue
Summary: In Mongolia, researchers have discovered a new assemblage of Cambrian eggs, embryos, and early postembryonic stages, shedding light on the development and evolution of ancient bilaterian animals.
NATURE COMMUNICATIONS
(2021)
