Article
Food Science & Technology
Weidong Liu, Cihua Zheng, Qiang Li, Tian Xu, Wenjie Cao, Meng Shi, Feng Huang, Lulin Liu, Yufeng Luo, Wenming Zhang, Qun Xiao, Zhaoxia Liu, Xiaorong Deng
Summary: Probiotics used before gastrectomy can alleviate postoperative inflammation, improve metabolic disorders, reduce insulin resistance, and decrease the incidence of infectious complications. Probiotics also regulate the balance of gut microbiota, promoting early recovery of patients.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biochemistry & Molecular Biology
Marzieh Salehi, Ralph DeFronzo, Amalia Gastaldelli
Summary: This study investigated the effect of weight loss surgery on insulin kinetics. The results showed that the altered insulin clearance rate after surgery is mainly attributed to the liver rather than other organs. In addition, the endogenous insulin clearance rate is more sensitive to the increase in circulating insulin levels, while peripheral insulin sensitivity is similar among the three groups. After a meal, the weight loss surgery group had higher insulin secretion, independent of glycemic levels. Compared to sleeve gastrectomy, gastric bypass surgery resulted in greater post-meal insulin secretion and a reduction in post-meal insulin clearance rate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
HyunJin Oh, Byung-Ho Yoon, Jung-Wee Park, Ye Jhin Jeon, Bit-Na Yoo, Jean Kyung Bak, Yong-Chan Ha, Young-Kyun Lee
Summary: This study investigated the cumulative incidence of osteoporotic fracture in gastric cancer survivors according to treatment modality. The results showed that total gastrectomy increased the risk of osteoporotic fracture compared to subtotal gastrectomy and endoscopic mucosal dissection and resection. Further research is needed to establish an optimal strategy for each type of surgery.
Article
Endocrinology & Metabolism
Marzieh Salehi, Amalia Gastaldelli, Ralph DeFronzo
Summary: Roux-en Y gastric bypass surgery and sleeve gastrectomy alter postprandial glucose metabolism, increasing the risk of hypoglycemia. After surgery, there is a reduced hepatic glucose production response during insulin-induced hypoglycemia. However, the counterregulatory response to hypoglycemia is similar among individuals with surgery and without surgery.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Cihua Zheng, Tingtao Chen, Jiachen Lu, Kehong Wei, Huakai Tian, Weidong Liu, Tian Xu, Xinyu Wang, Shuai Wang, Rong Yang, Yulu Yang, Zhaoxia Liu, Hong Wei, Xiaorong Deng
Summary: Probiotic compounds treatment can help to reduce postoperative inflammation, enhance immunity, restore gut microbiota composition, and promote recovery after gastrectomy.
Article
Immunology
Wenjie Cao, Cihua Zheng, Xuan Xu, Rui Jin, Feng Huang, Meng Shi, Zhipeng He, Yufeng Luo, Lulin Liu, Zhaoxia Liu, Jing Wei, Xiaorong Deng, Tingtao Chen
Summary: This study demonstrates that oral administration of C. butyricum after gastrectomy can reduce postoperative inflammation, enhance immune function, restore intestinal microbiota balance, increase short-chain fatty acid levels, reduce the occurrence of postoperative complications, and promote early recovery in patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Lyrialle W. Han, Yuanyuan Shi, Alison Paquette, Lu Wang, Theo K. Bammler, Qingcheng Mao
Summary: Pregnancy and the microbiome have complex interactions that affect host metabolism, particularly in hepatic metabolic processes. Research has shown that the presence or absence of the microbiome can impact specific metabolic pathways in pregnant mice, providing new insights into the role of the microbiome in modulating metabolic processes during pregnancy.
Article
Gastroenterology & Hepatology
Toshiyasu Ojima, Masaki Nakamura, Keiji Hayata, Junya Kitadani, Akihiro Takeuchi, Hiroki Yamaue
Summary: This single-center retrospective study compared outcomes of robotic subtotal gastrectomy (RsTG) and robotic total gastrectomy (RTG) in treating gastric cancer patients. RsTG had shorter operation time, less intraoperative blood loss, lower complication rate, higher serum albumin levels, and better postoperative bodyweight recovery compared to RTG.
JOURNAL OF GASTROINTESTINAL SURGERY
(2021)
Article
Gastroenterology & Hepatology
Andriy Myronovych, Bailey C. E. Peck, Mingrui An, Jianhui Zhu, Anna Warm, Aleksander Kupe, David M. Lubman, Randy J. Seeley
Summary: The study revealed that extracellular vesicles in the intestines of mice after VSG were enriched, with a significantly different protein composition compared to before VSG. VSG-derived extracellular vesicles exhibited cytotoxic effects on intestinal epithelial cells and reduced proliferation of intestinal progenitor cells in mice.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Han-Na Kim, Min-Jeong Kim, Jonathan. P. P. Jacobs, Hyo-Joon Yang
Summary: This study investigated the microbial changes and host inflammatory cytokine responses in H. pylori-negative gastric cancer patients. The results showed that the gastric mucosal microbiota in GC patients had reduced diversity and a different composition compared to controls. Lacticaseibacillus was enriched, while Haemophilus and Campylobacter were depleted in the cancer group. Furthermore, the combined abundance of these taxa correlated significantly with gastric mucosal IL1B expression.
Article
Biology
Daniel Borda-Molina, Hanna Iffland, Markus Schmid, Regina Mueller, Svenja Schad, Jana Seifert, Jens Tetens, Werner Bessei, Joern Bennewitz, Amelia Camarinha-Silva
Summary: This study found significant differences in the microbial communities between laying hen lines selected for high and low feather pecking behavior, but the microbial composition did not affect feather pecking behavior or agonistic behavior.
Article
Surgery
Jason P. Robertson, Hans Van der Wall, Gregory L. Falk
Summary: This study evaluated the safety and efficacy of subtotal gastrectomy with Roux-en-Y reconstruction as a remedial procedure for patients with gastroparesis and recurrent reflux after previous fundoplication. The results showed that this procedure is a moderately safe and effective option for patients with post-fundoplication reflux and delayed gastric emptying symptoms.
ANZ JOURNAL OF SURGERY
(2022)
Article
Surgery
Chia- Wei, Tsung-Jung Liang, Chia-Yuan Hsu, Chung-Yu Tsai, I-Shu Chen
Summary: This study retrospectively analyzed data from 134 patients who underwent subtotal D2 gastrectomy for locally advanced gastric cancer and compared the short-term and surgical outcomes between laparoscopic and open gastrectomy procedures. The results showed that laparoscopic surgery had shorter surgical time, less blood loss, faster postoperative recovery, and shorter hospital stay compared to open gastrectomy. There were no differences in surgical morbidity and mortality rates, as well as disease-free survival and overall survival rates, between the two groups. Therefore, laparoscopic gastrectomy is a feasible and safe treatment option for locally advanced gastric cancer.
ASIAN JOURNAL OF SURGERY
(2023)
Review
Oncology
Feng Xia, Zhen Sun, Jian-Hong Wu, You Zou
Summary: The article discusses the occurrence and treatment of intussusception after gastric surgery, focusing mainly on the anastomosis sites following Billroth II and Roux-en-Y reconstruction, while also mentioning cases after bariatric surgery.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Immunology
Zhaolai Hua, Le Xu, Jiahui Zhu, Ling Xiao, Bin Lu, Jianping Wu, Zhenfeng Wu, Qihai Zhou, Junfeng Zhang
Summary: Objective of this study was to investigate the effect of Helicobacter pylori (Hp) infection on gastric mucosal microbiota in patients with chronic gastritis. The study found that virulent Hp infection alters gastric microbiota, reduces microbial diversity, and enhances the symbiotic relationship between Helicobacter bacteria and non-Helicobacter bacteria in patients with chronic gastritis. These findings provide new evidence for treating Hp infection by improving gastric microbiota.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Letter
Gastroenterology & Hepatology
Chun-Ying Wu, Hsiu J. Ho, Chen-Yi Wu, Yi-Ju Chen, Teng-Yu Lee, Yao-Chun Hsu, Jaw-Town Lin
Article
Gastroenterology & Hepatology
Jason J. Liu, Chuan-Yu Chen, Edward Giovannucci, Chun-Ying Wu
Summary: The study found that survivors of childhood and adolescent cancers diagnosed from 1975 to 2015 have significantly elevated risks of developing digestive system cancers compared to the general population in the US. Among the 41,249 cancer survivors, 133 developed subsequent primary digestive system cancer, with bone cancer, lymphoma, and neuroblastoma survivors having the highest risks. The findings suggest the need for surveillance recommendations for childhood and adolescent cancer survivors and further studies to understand the mechanisms behind the increased risks of digestive system cancers.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Endocrinology & Metabolism
Chen-Yi Wu, Chun-Ying Wu, Chung-Pin Li, Yiing-Jenq Chou, Yi-Hsian Lin, Yun-Ting Chang
Summary: This study found that diabetic patients treated with DPP4 inhibitors had a significantly increased risk of bullous pemphigoid, especially when used concurrently with insulin.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2021)
Article
Dermatology
Yi-Ju Chen, Hsiu J. Ho, Chen-Yi Wu, Chao-Kuei Juan, Chun-Ying Wu
Summary: The study found that skin infections at an early age, especially viral, bacterial, and fungal infections in the first 2 years of life, were significantly associated with the development of pediatric psoriasis. Results also showed that atopic dermatitis and family history of psoriasis, particularly from the mother or other first-degree relatives, were independently associated with pediatric psoriasis.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2021)
Article
Microbiology
Yi-Ting Lin, Ting-Yun Lin, Szu-Chun Hung, Po-Yu Liu, Ping-Hsun Wu, Yun-Shiuan Chuang, Wei-Chun Hung, Yi-Wen Chiu, Mei-Chuan Kuo, Chun-Ying Wu
Summary: This study investigated the differences in gut microbiota composition among hemodialysis patients receiving different anti-acid drugs, revealing that PPI significantly altered the gut microbiota compared to H-2 blocker users or controls. Importantly, there was a significant enrichment of the genus Streptococcus in PPI users.
Article
Dermatology
Shu-Hao Chang, Chun-Ying Wu, Kai-Cheng Chuang, Shi-Wei Huang, Zheng-Yi Li, Sin-Ting Wang, Zi-Lun Lai, Cheng-Chung Chang, Yi-Ju Chen, Tak-Wah Wong, Jun-Kai Kao, Jeng-Jer Shieh
Summary: This study found that IMQ induced lysosomal membrane permeabilization and dysfunction, as well as increased lysosome biogenesis for lysosomal adaptation in cancer cells. The induction of lysosomal adaptation by IMQ occurred through lysosomal calcium ion release and activation of the calcineurin/TFEB axis to promote lysosome biogenesis.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Letter
Gastroenterology & Hepatology
Teng-Yu Lee, Chun-Ying Wu
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Dermatology
Chen-Yi Wu, Chun-Ying Wu, Chung-Pin Li, Yi-Hsian Lin, Yun-Ting Chang
Summary: The use of immunosuppressants was found to be associated with a reduced risk of mortality in patients with bullous pemphigoid. The mortality rate over five years was significantly lower in the group using immunosuppressants compared to those using only corticosteroids. The most substantial decrease in mortality risk was observed in patients under 70 years of age.
Article
Dermatology
Teng-Li Lin, Chun-Ying Wu, Chao-Kuei Juan, Yun-Ting Chang, Yi-Ju Chen
Summary: CLE-alone patients have an increased risk of developing non-SLE autoimmune diseases in the future, with females and those on long-term systemic corticosteroids being more susceptible to this outcome.
Article
Infectious Diseases
Yao-Chun Hsu, Chi-Yi Chen, I-Wei Chang, Chi-Yang Chang, Chun-Ying Wu, Teng-Yu Lee, Ming-Shiang Wu, Ming-Jong Bair, Jyh-Jou Chen, Chieh-Chang Chen, Cheng-Hao Tseng, Chi-Ming Tai, Yen-Tsung Huang, Wen-Hui Ku, Lein-Ray Mo, Jaw-Town Lin
Summary: The study investigated the efficacy and safety of tenofovir disoproxil fumarate in reducing disease progression in patients with non-cirrhotic chronic hepatitis B and minimally raised ALT. The results showed that tenofovir disoproxil fumarate can reduce the risk of liver fibrosis progression, but its effect on necroinflammation is not significant.
LANCET INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
Li-Lin Liang, Hsu-Sung Kuo, Hsiu J. Ho, Chun-Ying Wu
Summary: The study found that an increase in COVID-19 vaccine coverage is associated with a reduction in the case fatality ratio, especially in countries with more effective governments and higher transport infrastructure quality. There is a dose-dependent relationship between vaccine coverage and reduction in case fatality ratio.
JOURNAL OF GLOBAL HEALTH
(2021)
Article
Dermatology
Ching-Li Chen, Chun-Ying Wu, Ying-Syuan Lyu, Yiing-Jenq Chou, Yun-Ting Chang, Chen-Yi Wu
Summary: This study examined the risk of venous thromboembolism (VTE) among bullous pemphigoid (BP) patients in Taiwan and found that BP patients had a significantly higher rate of VTE compared to non-BP patients. BP was identified as a significant risk factor for VTE, along with cancer, chronic liver disease and cirrhosis, and female sex.
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
T-L Lin, C-M Kuo, Y-L Chang, H. J. J. Ho, Y-J Chen, C-Y Wu
Summary: This study aimed to assess the psychiatric hazards in psoriasis patients prescribed acitretin compared with those prescribed disease-modifying antirheumatic drugs (DMARDs). The study found that acitretin was associated with higher risks of psychiatric disorders compared to DMARDs.
Article
Medicine, General & Internal
Teng-Yu Lee, Yao-Chun Hsu, Hsiu J. Ho, Jaw-Town Lin, Yi-Ju Chen, Chun-Ying Wu
Summary: Aspirin therapy is significantly associated with a reduced risk of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) patients.
Article
Dermatology
Po-Chien Wu, Chun-Ying Wu, Ying-Syuan Lyu, Yun-Ting Chang, Chen-Yi Wu
Summary: This population-based case-control study investigated the association between bullous pemphigoid (BP) and atopic dermatitis (AD) in Taiwan. The study found that AD was independently associated with BP, increasing the risk of developing BP by 76%. Other significant risk factors for BP included psoriasis, hypertension, diabetes mellitus, chronic kidney disease, chronic obstructive pulmonary disease, neuropsychiatric diseases, and autoimmune connective tissue disease.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
