Article
Chemistry, Physical
Alessandra Marega Motta, Maressa Donato, Giovanna Mobbili, Paolo Mariani, Rosangela Itri, Francesco Spinozzi
Summary: This study investigates the mechanisms of interaction between Rhamnolipids (RLs) and simulated plasma membrane models. The results show that mono-RL primarily interacts with the outer leaflet of the membrane through insertion without pore formation, but induces lipid mixing. On the other hand, di-RLs initially interact through insertion and later undergo pore formation.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Dongmei Li, Weiyi Tao, Dinghua Yu, Shuang Li
Summary: The composition of rhamnolipid products from different sources varies significantly, which can hinder their application. In this study, rhamnolipid products with known structural components were tested for their emulsifying properties and antifungal activities. The results showed that the different components had no significant effect on emulsifying performance, but increased di-rhamnolipid content in the products exhibited stronger antifungal activity. This work helps to promote the application of rhamnolipids as pesticide adjuvants.
Article
Biochemistry & Molecular Biology
Marie Joncquel, Julie Labasque, Julie Demaret, Marie-Adelaide Bout, Aghiles Hamroun, Benjamin Hennart, Mathieu Tronchon, Magali Defevre, Isabelle Kim, Alain Kerckhove, Laurence George, Mylene Gilleron, Anne-Frederique Dessein, Farid Zerimech, Guillaume Grzych
Summary: FK506 is an immunosuppressant with globally dose-dependent side effects. This targeted metabolomic analysis using LC-MS on plasma samples from FK506-treated patients identified a potential link between FK506 and the enzyme PIPOX, as well as pipecolic acid as a potential biomarker for early nephrotoxicity in FK506 patients.
Article
Biotechnology & Applied Microbiology
Jean-Frederic Dubern, Manuel Romero, Anne Mai-Prochnow, Marco Messina, Eleftheria Trampari, Hardeep Naghra-van Gijzel, Kok-Gan Chan, Alessandro M. Carabelli, Nicolas Barraud, James Lazenby, Ye Chen, Shaun Robertson, Jacob G. Malone, Paul Williams, Stephan Heeb, Miguel Camara
Summary: Pseudomonas aeruginosa uses multiple protein regulators, including ToxR, to control the production of virulence factors and adapt to different environments. This study reveals the previously unknown role of ToxR in surface-associated motility and its impact on the Rhl quorum sensing system and biofilm formation in P. aeruginosa.
NPJ BIOFILMS AND MICROBIOMES
(2022)
Article
Biotechnology & Applied Microbiology
Achmad Rifky Alfian, Kwanrutai Watchaputi, Chayaphathra Sooklim, Nitnipa Soontorngun
Summary: The study characterized the functional properties and antifungal activities of sophorolipids produced by the newly identified strain Starmerella riodocensis GT-SL1R sp. nov. The strain produced mixed forms of lactonic and acidic sophorolipids and displayed antifungal activity against Candida albicans, showcasing potential industrial and biomedical applications as a green surfactant and antifungal agent. Sophorolipids offer a promising alternative to current antimicrobials for treating infectious diseases in humans, animals, and plants, using renewable bioresources and industrial wastes to reduce production costs.
MICROBIAL CELL FACTORIES
(2022)
Article
Infectious Diseases
Ashwani Kumar, Hemanth Kumar, A. M. Manonmani, G. Prabakaran, B. Vijayakumar, A. Mathivanan, I Geetha, P. Jambulingam
Summary: The efficacy, application dosage, residual activity, and frequency of application of two mosquitocidal biosurfactants, surfactin (VCRC B471) and di-rhamnolipid (VCRC B426), in controlling Anopheles stephensi immatures in selected sites in Goa, India, were evaluated. The results showed that both biosurfactants were effective in reducing the density of immature mosquitoes for a duration of 14-18 days, with optimum application dosages of 51 mL/m(2) and 27 mL/m(2) for surfactin and di-rhamnolipid, respectively.
JOURNAL OF VECTOR BORNE DISEASES
(2022)
Article
Biotechnology & Applied Microbiology
Karuppiah Vijayakumar, Seralathan MuhilVannan
Summary: Streptococcus mutans is a common pathogen in the oral cavity causing dental caries, and 3,5-DTBP shows potential as a therapeutic agent by inhibiting virulence factors and reducing the bacteria's acid tolerance. This study provides insights into the potential use of 3,5-DTBP in controlling S. mutans infections.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2021)
Article
Chemistry, Physical
M. A. Hegazy, M. M. Hegazy, A. Labena, M. Shawky
Summary: In this study, previously synthesized di-cationic amphiphiles surfactants demonstrated excellent surface properties in formation water during gas and oil production. These surfactants were found to be effective corrosion inhibitors for carbon steel and showed broad antimicrobial activity against bacterial and candida strains.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
