Article
Oncology
Greta Ali, Iose Di Stefano, Anello Marcello Poma, Stefano Ricci, Agnese Proietti, Federico Davini, Marco Lucchi, Franca Melfi, Gabriella Fontanini
Summary: Research showed high prevalence of DLL3 expression in high-grade lung NET patients, associated with aggressive clinicopathological features, suggesting its potential as a useful biomarker for target therapy in high-grade tumors.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Wei Guo, Qilin Huai, Guochao Zhang, Lei Guo, Peng Song, Xuemin Xue, Fengwei Tan, Qi Xue, Shugeng Gao, Jie He
Summary: High expression of HNRNPC is significantly associated with poor overall survival in patients with LUAD, indicating that HNRNPC may be a cancer-promoting factor and a potential prognostic biomarker in LUAD.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei Guo, Qilin Huai, Huan Wan, Lei Guo, Peng Song, Shugeng Gao, Jie He
Summary: Through analysis of multiple datasets, it is found that IGF2BP3 is abnormally highly expressed in LUAD, leading to worse prognosis. This suggests that IGF2BP3 may be an oncogene and potential prognostic biomarker for LUAD.
DNA AND CELL BIOLOGY
(2021)
Article
Oncology
Daniel J. Serie, Amanda A. Myers, Daniela A. Haehn, Alexander S. Parker, Essa M. Bajalia, Giovanni A. Gonzalez, Qiongyu Li, Maurice Yu Wong, Kaitlynn C. Moser, Bo Zhou, David D. Thiel
Summary: By using high-throughput glycoproteomics, we identified differential expression of certain glycopeptides associated with progression-free survival in patients with clear cell renal cell carcinoma (ccRCC). These findings suggest that glycoprotein-isoforms may serve as novel biomarkers for clinical diagnosis and prognosis of ccRCC.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2022)
Article
Cell Biology
Yingan Zhao, Yingjue Zhang, Chen Dai, Kai Hong, Yangyang Guo
Summary: This study established a 13-gene signature and robust nomogram to predict the prognosis of breast cancer patients. The research showed that patients with high-risk breast cancer had poorer survival and the signature was an independent prognostic factor. This can be beneficial for the diagnosis and treatment of breast cancer.
Article
Oncology
Kazuya Takamochi, Kieko Hara, Takuo Hayashi, Shinji Kohsaka, Fumiyuki Takahashi, Yoshiyuki Suehara, Kenji Suzuki
Summary: This study investigated the associations between PD-L1 expression and clinicopathological features, prognosis, and driver oncogene alterations in 1,005 surgically resected lung adenocarcinoma specimens. The results showed that PD-L1 positivity was more common in male smokers and tumors with specific pathological features. Although PD-L1 positivity was associated with poor survival outcomes, it was not statistically significant in multivariate analysis.
Article
Surgery
Hiroshi Saeki, Tomoko Jogo, Tetsuro Kawazoe, Tomohiro Kamori, Yu Nakaji, Yoko Zaitsu, Minako Fujiwara, Yoshifumi Baba, Tetsu Nakamura, Naoki Iwata, Akinori Egashira, Tomonori Nakanoko, Masaru Morita, Yoshihiro Tanaka, Yasue Kimura, Tomotaka Shibata, Yuichiro Nakashima, Yasunori Emi, Akitaka Makiyama, Eiji Oki, Shoji Tokunaga, Mototsugu Shimokawa, Masaki Mori
Summary: This study identifies RAD51 expression as a useful biomarker to predict resistance to preoperative therapy and poor prognosis in patients with esophageal squamous cell carcinoma (ESCC). Preoperative chemotherapy may be warranted for patients with positive RAD51 expression.
Article
Oncology
Makoto Sakai, Makoto Sohda, Shintaro Uchida, Arisa Yamaguchi, Takayoshi Watanabe, Hideyuki Saito, Yasunari Ubukata, Nobuhiro Nakazawa, Kengo Kuriyama, Akihiko Sano, Hiroomi Ogawa, Takehiko Yokobori, Ken Shirabe, Hiroshi Saeki
Summary: This study found that even in non-obese patients, the synergic effects of muscle mass reduction and excess body adiposity have a negative impact on the prognosis of surgically resected esophageal cancer patients. The V/P ratio, as a marker of relative muscle mass reduction and fat accumulation, has prognostic value in EC patients.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Wuguang Chang, Hongmu Li, Wei Ou, Si-Yu Wang
Summary: A zinc metabolism-related gene signature was constructed to predict prognosis and immunotherapy response for lung adenocarcinoma (LUAD). Six key zinc metabolism-related genes were included in the signature, which showed good predictive performance for LUAD patients. The low-risk group exhibited immune activation and had higher response rates to immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jii Bum Lee, Min Hee Hong, Seong Yong Park, Sehyun Chae, Daehee Hwang, Sang-Jun Ha, Hyo Sup Shim, Hye Ryun Kim
Summary: Targeting the T-Cell Immunoreceptor with Ig and ITIM domain-poliovirus receptor (PVR) pathway is a potential therapeutic strategy in lung cancer. Overexpression of PVR is associated with poor prognosis in surgically resected squamous cell lung carcinoma (SQCC). Patients with high levels of both PVR and PD-L1 expression had the shortest recurrence-free survival (RFS).
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Shinkichi Takamori, Mototsugu Shimokawa, Taichi Matsubara, Naoki Haratake, Ryo Toyozawa, Naoko Miura, Masafumi Yamaguchi, Takashi Seto, Tetsuzo Tagawa, Tatsuro Okamoto, Mitsuhiro Takenoyama, Yoshihiko Maehara, Masaki Mori
Summary: The study analyzed 1134 NSCLC patients with smoking history who underwent curative lung resection at a single center in Japan between 2000 and 2016, finding that smoking period was an independent predictor of DFS and OS, with superior AUC values compared to number of packs smoked per day. Patients with a smoking period >= 40 years had significantly shorter DFS and OS than those with a smoking period of < 40 years.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Lingjiao Chen, Guiyuan Xie, Juan Feng, Qiuyuan Wen, Hongjing Zang, Junmi Lu, Yuting Zhan, Songqing Fan
Summary: The study found that Bcl-XS expression was significantly increased in lung squamous cell carcinoma (SCC), while patients with overexpression of FADD in lung adenocarcinoma (ADC) and low expression of Bcl-XS in lung SCC had lower overall survival rates. Elevated expression of FADD was identified as an independent poor prognostic factor for patients with surgically resected lung ADC, however, increased expression of Bcl-XS was an independent good prognostic biomarker for patients with surgically resected lung SCC.
Article
Oncology
Kazuya Takamochi, Kieko Hara, Takuo Hayashi, Shinji Kohsaka, Fumiyuki Takahashi, Yoshiyuki Suehara, Mototsugu Shimokawa, Kenji Suzuki
Summary: An analysis of 980 surgically resected LUAD specimens revealed that PD-L2 expression was associated with clinicopathological features and driver oncogene alterations, but not with overall survival or relapse-free survival. Additionally, the prognostic impact of PD-L2 tended to vary based on PD-L1 expression status.
Article
Oncology
Jiahao Han, Xiangyu Wang, Chong Zhang, Qian Wu, Xiaochen Ma, Yitong Li, Zhenmei Chen, Rui Zhang, Guo Zhang, Jing Lin, Lu Lu, Wenwei Zhu, Huliang Jia, Jubo Zhang, Jie Fan, Jinhong Chen
Summary: This study found that HER2 amplification is associated with younger age, left-sided RAS/RAF wild-type, and bilobar involvement in colorectal liver metastases (CRLMs). Additionally, HER2 amplification predicts a poorer prognosis, particularly in left-sided RAS/RAF wild-type CRLMs.
JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Immunology
Joao Gorgulho, Christoph Roderburg, Fabian Beier, Carsten Bokemeyer, Tim H. Bruemmendorf, Tom Luedde, Sven H. Loosen
Summary: CD3+HLADR+ cells in peripheral blood can serve as a biomarker for immune checkpoint inhibitor (ICI) therapy, and their association with specific gut microbiome species can indicate individual treatment outcomes.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Surgery
Jian-Xun Chen, Ting-Yu Lu, Hsin-Yuan Fang, Yu-Sen Lin, Jang-Ming Lee
WORLD JOURNAL OF SURGERY
(2020)
Article
Oncology
Pei-Wen Yang, Mei-Chun Lin, Pei-Ming Huang, Cheng-Ping Wang, Tseng-Cheng Chen, Chun-Nan Chen, Mong-Hsun Tsai, Jason Chia-Hsien Cheng, Eric Y. Chuang, Min-Shu Hsieh, Pei-Jen Lou, Jang-Ming Lee
Summary: This study found that elderly EC patients have an increased risk of gastrointestinal cancer but a reduced risk of head and neck cancer. Betel nut chewing and variations in certain genes may be associated with MPC risk.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Ke-Cheng Chen, I-Hui Wu, Chih-Yang Chang, Pei-Ming Huang, Mong-Wei Lin, Jang-Ming Lee
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Ke-Cheng Chen, I-Hui Wu, Chih-Yang Chang, Pei-Ming Huang, Mong-Wei Lin, Jang-Ming Lee
Summary: TEVAR is a feasible procedure for esophageal cancers invading the aorta and can be used for curative-intent resection to improve local tumor control and PFS.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Luo-Sheng Yong, Mong-Wei Lin, Ke-Cheng Chen, Pei-Ming Huang, Jang-Ming Lee
Summary: Drainless, minimally invasive lobectomy appears to be feasible for selected lung cancer patients, with no major surgical complications noted during the perioperative period. Further evaluation is needed to assess its impact on short- and long-term surgical outcomes in the future.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Oncology
Yi-Ling Tsou, Jang-Ming Lee, Chia-Chun Tang
Summary: Cancer-related fatigue intensifies significantly for esophageal cancer patients throughout the treatment process, reaching its peak after surgery. Concerns about physician invalidation and marital status are associated with CRF. Clinicians need to be aware of the intensifying trend of CRF and provide timely intervention to alleviate patients' fatigue.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sian-Han Lin, Jang-Ming Lee, I-Hui Wu
Summary: The study evaluated the management of AEF with elective TEVAR over salvage TEVAR, and found that elective TEVAR provided better survival rates and fewer complications, allowing more patients to receive subsequent treatments.
Article
Oncology
Wei-Li Ma, Chia-Chi Lin, Feng-Ming Hsu, Jang-Ming Lee, Jin-Shing Chen, Yen-Lin Huang, Yih-Leong Chang, Chin-Hao Chang, James Chih-Hsin Yang
Summary: Front-line platinum-based chemotherapy for advanced thymoma and TC can improve resectability and prolong OS. Different front-line regimens, including CAP, EP, and TP, show similar outcomes in terms of PFS and OS for patients with advanced thymoma and TC. The TC pathology subtype and presence of liver metastasis are associated with poor OS, highlighting the need for further prognostic factor studies.
Review
Oncology
Yu-Kwang Lee, Ke-Cheng Chen, Pei-Ming Huang, Shuenn-Wen Kuo, Mong-Wei Lin, Jang-Ming Lee
Summary: Minimally invasive esophagectomy has become an accepted treatment option for esophageal cancer, but there is no consensus on the specific procedures for thoracic and abdominal phases, including anastomosis and various techniques. Further research is needed to investigate the roles of these novel techniques in treating different patient populations.
Article
Medicine, General & Internal
Yung-Hsin Chen, Ke-Cheng Chen, Pei-Ming Huang, Shuenn-Wen Kuo, Mong-Wei Lin, Jang-Ming Lee
Summary: This study presents the perioperative and long-term clinical outcomes of robotic-assisted thoracoscopic enucleation for esophageal tumors and cysts. The results show that this surgical approach is technically feasible and effective for treating submucosal benign tumors of the esophagus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Gastroenterology & Hepatology
Satoru Matsuda, Takahiro Tsushima, Ken Kato, Chih-Hung Hsu, Jang Ming Lee, Ian Yu-Hong Wong, Hu-Lin Christina Wang, Chang Hyun Kang, Xufeng Guo, Shun Yamamoto, Takayuki Tsuji, Hirofumi Kawakubo, Hiroya Takeuchi, Simon Law, Yuko Kitagawa
Summary: A multimodality treatment conference was held with experts from East Asia to establish a consensus on conversion therapy. It was agreed that conversion therapy refers to surgery or chemoradiotherapy aimed at curing initially unresectable tumors.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Oncology
Min-Chen Tsai, Yu-Ching Chou, Yu-Kwang Lee, Wan-Lun Hsu, Chin-Sheng Tang, Shiow-Ying Chen, Shih-Pei Huang, Yong-Chen Chen, Jang-Ming Lee
Summary: Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), has significantly increased in Taiwan over the past thirty years. This increase may be attributed to changes in risk factors such as smoking, alcohol consumption, and betel nut chewing. Early detection and prevention are crucial for high-risk patients.
Editorial Material
Oncology
Yi-Ling Tsou, Jang-Ming Lee, Chia-Chun Tang
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Masaaki Sato, Shun-Mao Yang, Dong Tian, Nakajima Jun, Jang-Ming Lee
Summary: This article discusses the controversial issues and conditions surrounding subsolid pulmonary nodules commonly seen in Asia, including lack of guidelines, roles of preoperative biopsy and imaging, lesion location, selection of localization techniques, dissection and sampling of frozen sections and lymph nodes, multifocal lesions, and non-surgical treatment modalities. The aim is to provide updated evidence and opinions to assist surgeons and physicians in managing ground glass nodules in a balanced manner and encourage further discussion for better guidelines and algorithms.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
Pei-Wen Yang, Ya-Han Chang, Li-Fan Wong, Ching-Ching Lin, Pei-Ming Huang, Min-Shu Hsieh, Jang-Ming Lee
Summary: This study revealed the significant prognostic role of SOCS5 gene in ESCC, with its genetic polymorphisms and expression levels serving as potential therapeutic biomarkers for improving the prognosis of ESCC.