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Oncology
Young-Il Kim, Robert Luke Pecha, Tara Keihanian, Michael Mercado, S. Valeria Pena-Munoz, Kailash Lang, George Van Buren, Sadhna Dhingra, Mohamed O. Othman
Summary: The expression of MUC1 is closely associated with aggressive pathological features of gastric cancer and can serve as a prognostic marker in US gastric cancer patients.
Article
Multidisciplinary Sciences
Lang Li, Qiusheng Guo, Gaochen Lan, Fei Liu, Wenwu Wang, Xianmei Lv
Summary: In this study, a survival-associated competing endogenous RNA network and a multi-mRNA-based prognostic signature model were constructed to better understand the complexity and genetic characteristics of cervical squamous cell carcinoma and endocervical adenocarcinoma. The study provides a new perspective for cancer pathogenesis research.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Yuehong Cui, Qian Li, Wei Li, Yan Wang, Fang Lv, Xinying Shi, Zhaoqing Tang, Zhenbin Shen, Yingyong Hou, Henghui Zhang, Beibei Mao, Tianshu Liu
Summary: The study uncovered a new mechanism by which NOTCH3 participates in immune tolerance in GC, indicating its potential as a therapeutic target or predictive marker for GC patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Genetics & Heredity
Xiaomin Li, Ning Qiu, Qijuan Li
Summary: 13 S100s members were upregulated in PAAD tissues. 15 S100s members were associated with TP53 mutation. Expression levels of S100A3/A5/A6/A10/A11/A14/A16/B/P/Z were significantly correlated with the pathological stage.
FRONTIERS IN GENETICS
(2021)
Review
Cell Biology
Zihao Zhang, Hao Wu, Wei Chong, Liang Shang, Changqing Jing, Leping Li
Summary: Gastric cancer is a high-incidence cancer worldwide, and early diagnosis and precise treatment are crucial. Liquid biopsy, especially the detection of circulating tumor cells, circulating tumor DNA, and circulating free DNA, has shown promising potential in monitoring gastric cancer occurrence and recurrence, evaluating prognosis, and assessing treatment response.
CELL DEATH & DISEASE
(2022)
Article
Multidisciplinary Sciences
Shangshang Hu, Huaifeng Liu, Jinyan Zhang, Shujing Li, Huadong Zhou, Yu Gao
Summary: In this study, the down-regulated expression of miR-30c-5p in gastric cancer tissues and the up-regulation of target genes ADAM12, EDNRA, and CPNE8 were identified. These genes were found to be related to various clinicopathological factors in gastric cancer patients and may play a role in the progression of gastric cancer through cancer-related pathways. They could serve as potential prognostic markers for poor survival in gastric cancer patients.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Haiya Bai, Youliang Wang, Huimin Liu, Junyang Lu
Summary: By analyzing RNA sequencing data of CM, a four-mRNA signature including CD276, UQCRFS1, HAPLN3, and PIP4P1 was identified to effectively predict patients' prognosis with potential clinical application value. The signature showed better efficiency in survival prediction compared to other clinical variables such as melanoma Clark level and tumor stage.
FRONTIERS IN GENETICS
(2021)
Article
Endocrinology & Metabolism
Yongjun Zhu, Bingbing Zou, Mingyi Wu, Jing He
Summary: This study investigates the effect of Notch pathway genes on clinical survival and the immune microenvironment in gastric cancer. A risk score model and a nomogram model were constructed to predict the survival rates of gastric cancer patients based on the expression of six Notch signaling pathway genes. The different risk groups showed significant differences in mutation frequency, immune cell infiltration, drug sensitivity, and response to immune checkpoint blockade.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Oncology
Chenglong He, Liping He, Qiaowei Lu, Jianjun Xiao, Wenjing Dong
Summary: This study explored the role of chemokine and chemokine receptors (CCRs) in gastric cancer (GC) by analyzing datasets from the TCGA database. It found that CCRs play a significant role in tumor infiltration, angiogenesis, and metastasis in GC. A prediction model based on four CCRs (CCL15, CCL21, CCR3, and ACKR3) was constructed and showed potential as an independent prognostic factor for GC. The study also revealed the correlation between CCRs and immune-cell infiltration in the GC immune microenvironment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Chenglong He, Liping He, Qiaowei Lu, Jianjun Xiao, Wenjing Dong
Summary: This study explored the role of CCRs in gastric cancer through analyzing mutations and differential expression of CCRs, constructing a prediction model based on four CCRs, and investigating immune responses and signaling pathways associated with risk groups.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Bingdong Zhang, Yuerui Li, Liu Yang, Yongbing Chen
Summary: The study explored the prognostic value of mutation patterns in gastric adenocarcinoma using data from TCGA. A four-gene-based risk score was developed to predict overall survival, with significant associations identified between mutated genes and survival. The four-gene-based risk score was validated in an independent cohort, suggesting potential implications for prognostic prediction and therapeutic guidance in gastric adenocarcinoma.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Jae-Ho Cheong, Sam C. Wang, Sunho Park, Matthew R. Porembka, Alana L. Christie, Hyunki Kim, Hyo Song Kim, Hong Zhu, Woo Jin Hyung, Sung Hoon Noh, Bo Hu, Changjin Hong, John D. Karalis, In-Ho Kim, Sung Hak Lee, Tae Hyun Hwang
Summary: The ability to predict the survival and response to treatment of gastric cancer patients can be improved by generating a 32 gene signature. This study identifies four prognostic molecular subtypes through genomic profiling and shows that the 32-gene signature is a promising prognostic and predictive biomarker for guiding the clinical care of gastric cancer patients.
NATURE COMMUNICATIONS
(2022)
Article
Genetics & Heredity
Li Wang, Shan Cao, Rujun Zhai, Yang Zhao, Guodong Song
Summary: This study systematically analyzed the expression, prognostic values, mutations, and functional networks of the lysyl oxidase (LOX) family in gastric cancer (GC) using various databases. The results suggested that LOX and LOXL2 may play crucial roles in the oncogenesis of GC and could potentially serve as biomarkers for predicting tumor prognosis and targets for therapy.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Lucy X. Ma, Osvaldo Espin-Garcia, Yvonne Bach, Hiroko Aoyama, Michael J. Allen, Xin Wang, Gail E. Darling, Jonathan Yeung, Carol J. Swallow, Savtaj Brar, Patrick Veit-Haibach, Sangeetha Kalimuthu, Rebecca Wong, Eric X. Chen, Grainne M. O'Kane, Raymond W. Jang, Elena Elimova
Summary: This study compared the accuracy of four prognostic scores to predict early death and overall survival in patients with metastatic gastric and esophageal cancer. The GRIm-Score showed the highest predictive discrimination and ability to predict early death.
Article
Oncology
Ding-Ping Sun, Yu-Feng Tian, Chih-Chan Lin, Shih-Ting Hung, Yih-Huei Uen, You-Cheng Hseu, Chia-Lin Chou, Li-Chin Cheng, Wen-Ching Wang, Yi-Yu Kuang, Chia-Lang Fang, Kai-Yuan Lin
Summary: The study highlights the significant role of KLF16 in gastric cancer, demonstrating its association with patient prognosis and its impact on cell activities, cell cycle regulation, and epithelial-mesenchymal transition to either accelerate or suppress cancer cell proliferation and metastasis.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
