Forced co-expression of IL-21 and IL-7 in whole-cell cancer vaccines promotes antitumor immunity

The Common  -Chain Cytokines IL-2, IL-7, IL-15, and IL-21 Induce the Expression of Programmed Death-1 and Its Ligands

(2014) A. L. Kinter et al.   JOURNAL OF IMMUNOLOGY

Interleukin-21: a double-edged sword with therapeutic potential

(2014) Rosanne Spolski et al.   NATURE REVIEWS DRUG DISCOVERY

Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti–CTLA-4 therapy against melanoma

(2013) Tyler R. Simpson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

Tumor Protection by IL-7 Secreting Whole Cell Vaccine is Merely Mediated by NK1.1-positive Cells

(2012) Caroline Schroten et al.   JOURNAL OF IMMUNOTHERAPY

Regulatory T cells in melanoma: the final hurdle towards effective immunotherapy?

(2012) Joannes FM Jacobs et al.   LANCET ONCOLOGY

Increased antigen responsiveness of naive CD8 T cells exposed to IL-7 and IL-21 is associated with decreased CD5 expression

(2010) Julien Gagnon et al.   IMMUNOLOGY AND CELL BIOLOGY

PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors

(2010) M. A. Curran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vitiligo is an independent favourable prognostic factor in stage III and IV metastatic melanoma patients: results from a single-institution hospital-based observational cohort study

(2009) P. Quaglino et al.   ANNALS OF ONCOLOGY

Intraepithelial Effector (CD3+)/Regulatory (FoxP3+) T-Cell Ratio Predicts a Clinical Outcome of Human Colon Carcinoma

(2009) Frank A. Sinicrope et al.   GASTROENTEROLOGY

Blockade of CTLA-4 on both effector and regulatory T cell compartments contributes to the antitumor activity of anti–CTLA-4 antibodies

(2009) Karl S. Peggs et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies

(2009) Marc Pellegrini et al.   NATURE MEDICINE

IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy

(2008) C. S. Hinrichs et al.   BLOOD

Immunotherapy of neuroblastoma by an Interleukin-21-secreting cell vaccine involves survivin as antigen

(2008) Michela Croce et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-Specific T-Cell Memory: Clearing the Regulatory T-Cell Hurdle

(2008) A. L. Cote et al.   CANCER RESEARCH

Pathologic Complete Response to Neoadjuvant Chemotherapy of Breast Carcinoma Is Associated with the Disappearance of Tumor-Infiltrating Foxp3+ Regulatory T Cells

(2008) S. Ladoire et al.   CLINICAL CANCER RESEARCH

Human Leukocyte Antigen Class I, MHC Class I Chain-Related Molecule A, and CD8+/Regulatory T-Cell Ratio: Which Variable Determines Survival of Cervical Cancer Patients?

(2008) E. S. Jordanova et al.   CLINICAL CANCER RESEARCH