Article
Nutrition & Dietetics
Zumin Shi, Xinyu Shi, Alice F. Yan
Summary: This study found that early exposure to the Chinese Great Famine increased the risk of fractures in adulthood, particularly among individuals living in urban areas and with a modern diet.
Article
Multidisciplinary Sciences
Panna Hegedus, Julia Heckenast, Balazs Hangya
Summary: The ventral pallidum (VP) acts as an interface between striatopallidal and limbic circuits, conveying information crucial to behavior adjustment. The study showed that VP neuron populations respond to punishment, reward, and outcome-predicting cues, with non-bursting, non-rhythmic neurons being most sensitive to reinforcement signals. Different responses of bursts and single spikes in some neurons suggest a multiplexed coding scheme in the VP.
Article
Ecology
Craig D. Perl, Zanna B. Johansen, Zahra Moradinour, Marie Guiraud, C. E. Restrepo, Vun Wen Jie, A. Miettinen, Emily Baird
Summary: Heatwaves have detrimental impacts on animal morphology and behavior, especially during development. This study tested the effects of exposure to elevated temperatures during the late development stage on the behavior and morphology of adult worker bumblebees. The results showed that exposure to high temperatures during a portion of late development impaired the initial behavioral responses of workers to sensory stimuli, but did not significantly impact body or organ size.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2022)
Article
Psychiatry
Maria del Mar Cajiao-Manrique, Veronica Casado-Anguera, Alejandra Garcia-Blanco, Rafael Maldonado, Elena Martin-Garcia
Summary: This study investigates the development of cannabis addiction-like behavior in adult mice after adolescent exposure to THC. The results show that adolescent THC exposure does not affect the reinforcement of WIN 55,212-2 or the development of cannabis addiction-like behavior. However, THC pre-exposed mice display impulsive-like behavior in adulthood, especially in those that develop addiction-like criteria. Additionally, downregulated expression of drd2 and adora2a genes in NAc and HPC is observed in THC pre-exposed mice.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Environmental Sciences
Hui Liu, Wenyu Jiang, Yafen Ye, Bei Yang, Xin Shen, Siying Lu, Jun Zhu, Mengling Liu, Chuanzhen Yang, Haibin Kuang
Summary: Tributyltin (TBT) is a persistent organotin pollutant widely used as agricultural and wood biocides, exhibiting well-documented toxicity to reproductive functions in aquatic organisms. Studies on pregnant mice showed that TBT exposure led to an increase in absorbed embryos and abnormal placental development.
ENVIRONMENTAL TOXICOLOGY
(2021)
Article
Psychology, Experimental
Thomas Armstrong, Jeremy G. Stewart, Edwin S. Dalmaijer, Megan Rowe, Siri Danielson, Mira Engel, Brooklynn Bailey, Matthew Morris
Summary: Disgust motivates avoidance of stimuli associated with pathogens. Research shows that while these disgusting images were not visually avoided, the frequency of viewing them decreased over time and with repeated exposure, which was correlated with participants' disgust ratings of the images.
Article
Nutrition & Dietetics
Edoardo Pisa, Alberto Martire, Valentina Chiodi, Alice Traversa, Viviana Caputo, Jonas Hauser, Simone Macri
Summary: Research has shown that early exposure to breast milk lacking 3′SL can lead to decreased attention, spatial and working memory, as well as altered long-term potentiation in the hippocampal region in adulthood.
Article
Environmental Sciences
Anna Zettergren, Niklas Andersson, Kristin Larsson, Inger Kull, Erik Melen, Antonios Georgelis, Marika Berglund, Christian Lindh, Anna Bergstrom
Summary: This study suggests that exposure to DiNP during preschool age may be associated with subsequent obesity development. Specific metabolites were found to be correlated with body weight and body fat percentage.
ENVIRONMENTAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Dae D. Chung, Marisa R. Pinson, Lokeshwar S. Bhenderu, Michael S. Lai, Rhea A. Patel, Rajesh C. Miranda
Summary: Prenatal alcohol exposure can have toxic and teratogenic effects on fetal development and individual health, with potential lifelong consequences. Current research focuses on understanding the mechanisms behind the immediate and long-term impacts of alcohol on health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Behavioral Sciences
April M. Arquilla, Kerianne M. Wilson, Khaleel A. Razak, Wendy Saltzman
Summary: When becoming parents, female mammals undergo changes that facilitate parental care. In biparental species like the California mouse, new fathers also become more attracted to neonates but the mechanisms are not clear. This study found that fathers spent more time in proximity to and in contact with pup-related stimuli compared to control stimuli, regardless of the sensory modality. Virgin males, on the other hand, did not show any differential responses to pup-related stimuli.
Article
Neurosciences
Kainan S. Wang, Mauricio R. Delgado
Summary: The ability to perceive and exercise control significantly influences mental and physical wellbeing. Controllability can protect against the negative impact of uncontrollable aversive stimuli and potentially reverse passive behavior. Experimental findings showed that exposure to controllability increased avoidance behavior among participants, and this effect was associated with increased activation in the ventromedial prefrontal cortex, suggesting its role in encoding the value of control.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Engineering, Civil
Dominique Bohrmann, Anna Bruder, Klaus Bengler
Summary: While autonomous vehicles are expected to bring several advantages, they also increase the likelihood of motion sickness. This study examined the effects of dynamic visual stimuli on motion sickness development and found that a LED feedback system showed potential benefits in mitigating motion sickness.
IEEE TRANSACTIONS ON INTELLIGENT TRANSPORTATION SYSTEMS
(2022)
Article
Environmental Sciences
Yi-Ming Xiong, Yuan -Yuan Li, Lin Lv, Xuan-Yue Chen, Xing -Hong Li, Zhan- Fen Qin
Summary: There is increasing evidence that certain environmental chemicals can make individuals more vulnerable to stress or injuries, contributing to clinical and subclinical diseases. Tetrabromobisphenol A (TBBPA), a commonly used flame retardant, has been found to impact testis development at the molecular and cellular levels. This study aimed to investigate whether developmental exposure to TBBPA could increase testicular susceptibility to stress in adulthood. The results show that historical exposure to TBBPA increased the susceptibility of mouse testes to spermatogenic stress, leading to severe reproductive problems.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Horticulture
Adam Duerr Karl, Gregory Michael Peck
Summary: This study explores how sunlight affects the quality of cider apple fruit and juice. The findings indicate that sunlight increases polyphenol concentrations in fruit, resulting in larger fruit and improved juice quality. Fruit harvested from the top of the tree canopy has higher polyphenol concentrations and soluble solid concentrations. Shading and bagging fruit have inconsistent effects on polyphenol concentrations.
Article
Public, Environmental & Occupational Health
Masayuki Teramoto, Hiroyasu Iso, Kenji Wakai, Akiko Tamakoshi
Summary: In this study, secondhand smoke exposure during childhood was associated with an increased risk of pancreatic cancer mortality in adulthood, but not with the overall cancer risk or risk of other smoking-related cancers.
AMERICAN JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Clinical Neurology
Aron T. Hill, Reza Zomorrodi, Itay Hadas, Faranak Farzan, Daphne Voineskos, Alanah Throop, Paul B. Fitzgerald, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: Magnetic seizure therapy (MST) is emerging as a safe and effective experimental intervention for treatment resistant major depressive disorder (MDD) with minimal cognitive side-effects. Resting-state brain dynamics show widespread changes following MST in MDD patients, with theta connectivity potentially serving as a physiological marker of treatment response. Future prospective studies are needed to confirm these initial findings.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Cory R. Weissman, Itay Hadas, Dengdeng Yu, Brett Jones, Dehan Kong, Benoit H. Mulsant, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: The study analyzed STAR*D trial data and found that factors such as history of suicide attempts, comorbid medical illness, and family history of drug abuse can impact changes in suicidal ideation. Treatment with bupropion and buspirone was associated with reduction in suicidal ideation. Improvement in suicidal ideation was correlated with improvement in overall depression symptoms.
NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Aron T. Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul B. Fitzgerald, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: This study utilized TMS-EEG to investigate the differences in neural oscillatory dynamics between subjects with major depressive disorder (MDD) and healthy controls (HC), revealing increased oscillatory power in the DLPFC area in MDD subjects before treatment, and decreased power after convulsive therapy. These findings suggest that convulsive therapy may modulate neural oscillatory activity in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Jeanette Hui, Reza Zomorrodi, Pantelis Lioumis, Elnaz Ensafi, Daphne Voineskos, Aristotle Voineskos, Itay Hadas, Tarek K. Rajji, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: Altered interhemispheric connectivity is found in both schizophrenia and major depressive disorder patients, indicating disruptions of interhemispheric signaling processes. There was increased interhemispheric signal propagation in patient groups compared to healthy controls, but no difference between SCZ and MDD groups. These results enhance our understanding of physiological mechanisms underlying interhemispheric imbalances in SCZ and MDD.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Mohsen Poorganji, Reza Zomorrodi, Colin Hawco, Aron T. Hill, Itay Hadas, Tarek K. Rajji, Robert Chen, Daphne Voineskos, Anastasios A. Daskalakis, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: The study compared the neurophysiological responses of active and sham transcranial magnetic stimulation (TMS) in both single pulse (SP) and paired pulse (PP) paradigms using TMS-EEG, demonstrating significant differences in excitatory and inhibitory responses between active and sham stimulation. This reaffirms the effectiveness of TMS-EEG in evaluating cortical neurophysiology with high fidelity.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Itay Hadas, Aviad Hadar, Avi Lazarovits, Zafiris J. Daskalakis, Abraham Zangen
Summary: This study introduces a neurophysiological diagnostic tool based on brain region relevant to ADHD, revealing a correlation between right PFC excitability and ADHD severity. Results show reduced brain responses in ADHD patients and a diagnostic model based on cortical activity.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Medicine, Research & Experimental
Zafiris J. Daskalakis, Shawn M. McClintock, Itay Hadas, Elisa Kallioniemi, Reza Zomorrodi, Alanah Throop, Lucy Palmer, Faranak Farzan, Kevin E. Thorpe, Carol Tamminga, Daniel M. Blumberger
Summary: This study aims to investigate the therapeutic effects of magnetic seizure therapy on treatment-resistant depression by evaluating biomarkers for predicting remission of suicidal ideation and cognitive impairment. The study will use TMS-EEG to assess cortical inhibition and multiscale entropy analysis to evaluate cognitive adverse effects.
Article
Clinical Neurology
Manon Desforges, Itay Hadas, Brian Mihov, Yan Morin, Mathilde Rochette Braun, Pantelis Lioumis, Reza Zomorrodi, Hugo Theoret, Martin Lepage, Zafiris J. Daskalakis, Sara Tremblay
Summary: This study investigates the effect of three doses of intermittent theta-burst stimulation (iTBS) on cortical activity in the left dorsolateral prefrontal cortex using concurrent transcranial magnetic stimulation (TMS) and electroencephalography (EEG). The results show that doubling or tripling the number of iTBS pulses does not result in stronger potentiation of prefrontal activity.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Neurosciences
Peiwei Liu, Tian Lin, David Feifel, Natalie C. Ebner
Summary: Growing evidence suggests that the neuropeptide oxytocin plays a role in promoting social cognition and prosocial behavior by modulating the salience of social information. This study found that self-administered intranasal oxytocin reduced resting-state functional connectivity within the salience network, with a stronger effect observed in older participants.
Article
Psychology, Multidisciplinary
Tian Lin, Didem Pehlivanoglu, Maryam Ziaei, Peiwei Liu, Adam J. Woods, David Feifel, Hakan Fischer, Natalie C. Ebner
Summary: The study found that older adults show dampened response to faces with lower trustworthiness compared to young adults, supporting the idea of reduced sensitivity to cues of untrustworthiness in aging. Additionally, the results extend evidence of an age-related positivity effect to the evaluation of face trustworthiness.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Medicine, General & Internal
Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Peter C. Arden, Annie Baker, James C. Bennett, Catherine Bird, Renske E. Blom, Christine Brennan, Donna Brusch, Lisa Burke, Kete Campbell-Coker, Robin Carhart-Harris, Joseph Cattell, Aster Daniel, Charles DeBattista, Boadie W. Dunlop, Katherine Eisen, David Feifel, MacKenzie Forbes, Hannah M. Haumann, David J. Hellerstein, Astrid I. Hoppe, Muhammad I. Husain, Luke A. Jelen, Jeanine Kamphuis, Julie Kawasaki, John R. Kelly, Richard E. Key, Ronit Kishon, Stephanie Knatz Peck, Gemma Knight, Martijn H. B. Koolen, Melanie Lean, Rasmus W. Licht, Jessica L. Maples-Keller, Jan Mars, Lindsey Marwood, Martin C. McElhiney, Tammy L. Miller, Arvin Mirow, Sunil Mistry, Tanja Mletzko-Crowe, Liam N. Modlin, Rene E. Nielsen, Elizabeth M. Nielson, Sjoerd R. Offerhaus, Veronica O'Keane, Tomas Palenicek, David Printz, Marleen C. Rademaker, Aumer van Reemst, Frederick Reinholdt, Dimitris Repantis, James Rucker, Samuel Rudow, Simon Ruffell, A. John Rush, Robert A. Schoevers, Mathieu Seynaeve, Samantha Shao, Jair C. Soares, Metten Somers, Susan C. Stansfield, Diane Sterling, Aaron Strockis, Joyce Tsai, Lucy Visser, Mourad Wahba, Samuel Williams, Allan H. Young, Paula Ywema, Sidney Zisook, Ekaterina Malievskaia
Summary: Psilocybin may be effective in treating treatment-resistant depression, but dosage and adverse effects need further investigation.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Clinical Neurology
Guy M. Goodwin, Scott T. Aaronson, Oscar Alvarez, Merve Atli, James C. Bennett, Megan Croal, Charles DeBattista, Boadie W. Dunlop, David Feifel, David J. Hellerstein, Muhammad Ishrat Husain, John R. Kelly, Molly R. Lennard-Jones, Rasmus W. Licht, Lindsey Marwood, Sunil Mistry, Tomas Palenicek, Ozlem Redjep, Dimitris Repantis, Robert A. Schoevers, Batya Septimus, Hollie J. Simmons, Jair C. Soares, Metten Somers, Susan C. Stansfield, Jessica R. Stuart, Hannah H. Tadley, Nisha K. Thiara, Joyce Tsai, Mourad Wahba, Sam Williams, Rachel I. Winzer, Allan H. Young, Matthew B. Young, Sid Zisook, Ekaterina Malievskaia
Summary: This study explores the efficacy of COMP360, a synthetic formulation of psilocybin, in treating treatment-resistant depression (TRD). Results show that a single dose of psilocybin at 25 mg and 10 mg can significantly improve symptoms of depression. This study expands on previous research on the use of psilocybin in treating TRD.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Medicine, Research & Experimental
Abraham Zangen, Samuel Zibman, Aron Tendler, Noam Barnea-Ygael, Uri Alyagon, Daniel M. Blumberger, Geoffrey Grammer, Hadar Shalev, Tatiana Gulevski, Tanya Vapnik, Alexander Bystritsky, Igor Filipcic, David Feifel, Ahava Stein, Frederic Deutsch, Yiftach Roth, Mark S. George
Summary: This study investigates whether targeting the medial prefrontal cortex (MPFC) using the H7 coil in deep transcranial magnetic stimulation (Deep TMS) is noninferior to targeting the lateral prefrontal cortex (LPFC) using the H1 coil. The results show that both techniques have similar clinical efficacy and safety profiles, and electrical brain activity measured by EEG correlates with clinical outcomes.
Article
Chemistry, Analytical
Mohsen Poorganji, Reza Zomorrodi, Christoph Zrenner, Aiyush Bansal, Colin Hawco, Aron T. Hill, Itay Hadas, Tarek K. Rajji, Robert Chen, Brigitte Zrenner, Daphne Voineskos, Daniel M. Blumberger, Zafiris J. Daskalakis
Summary: Variability in cortical response to TMS can be influenced by the phase and power of pre-stimulus neuronal oscillations. However, in this study, no significant effect of pre-TMS phase on single-trial cortical evoked activity was found. It was observed that high-powered oscillations resulted in larger subsequent activity compared to low-powered oscillations, regardless of the presence of a TMS pulse.
Meeting Abstract
Neurosciences
Aron Hill, Itay Hadas, Reza Zomorrodi, Daphne Voineskos, Paul Fitzgerald, Daniel Blumberger, Zafiris Daskalakis
BIOLOGICAL PSYCHIATRY
(2021)