Article
Biochemistry & Molecular Biology
Louise M. Arildsen Jakobsen, Weiwei He, Nicholas Ditzel, Marianne Danielsen, Trine K. Dalsgaard, Niklas Rye Jorgensen, Peter Bollen, Hanne C. Bertram
Summary: This study investigated the effects of whey protein complexation of vitamin D-3 supplements on bone health in rats. The results showed that complexation did not improve the bioavailability of vitamin D-3 or have any significant impact on bone strength or microstructure.
Article
Endocrinology & Metabolism
Joseph L. Roberts, Giovanni Mella-Velazquez, Hamid Y. Dar, Guanglu Liu, Hicham Drissi
Summary: This study suggests that IL-17ra signaling in preosteoclasts can contribute to osteoclast formation and subsequent bone loss. The deletion of IL-17ra in osteoclast precursors may lead to increased trabecular bone microarchitecture and decreased osteoclast number.
Article
Endocrinology & Metabolism
Sophia N. Ziemian, Olufunmilayo O. Ayobami, Amanda M. Rooney, Natalie H. Kelly, Derek T. Holyoak, F. Patrick Ross, Marjolein C. H. van der Meulen
Summary: The study found that the loss of estrogen receptor-alpha in bone cells resulted in reduced subchondral bone mass, exacerbating load-induced OA pathology. Changes in bone specific to estrogen loss may contribute to the increased incidence of OA in post-menopausal women.
Article
Endocrinology & Metabolism
Yuxuan Zheng, Jiren Yan, Xiaofu Zhang, Hailong Cui, Zhenyuan Wei, Xiaoying Li, Qiuyu Wang, Biao Zhong
Summary: This study investigated the pathogenesis of obesity-induced impaired bone mass accrual and the impact of dietary intervention on bone density. The results showed that dietary intervention led to weight loss and decreased intrahepatic lipid accumulation. High-fat diet induced bone mass accrual, while diet intervention restrained trabecular bone density. Additionally, diet intervention increased osteogenesis and decreased adipogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Biagio Palmisano, Mara Riminucci, Gerard Karsenty
Summary: Aerobic exercise has been found to positively influence bone remodeling, and the study aimed to investigate the role of interleukin-6 (IL-6) signaling in bone during exercise. The study showed that IL-6 receptor expression in bones increased with aerobic exercise. However, mice lacking the IL-6 receptor in osteoblasts showed impaired bone mass, remodeling, and formation when subjected to aerobic exercise, indicating the importance of IL-6 signaling in promoting bone turnover during exercise.
Article
Endocrinology & Metabolism
Ziyuan Ma, Christiane Ruedl
Summary: The study reveals that pancreatic resident macrophages have different turnover kinetics and sources during aging and obesity, but obesity and type 2 diabetes do not affect the turnover kinetics of any macrophage subpopulation residing in the pancreas.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Franziska Lademann, Elena Tsourdi, Lorenz C. Hofbauer, Martina Rauner
Summary: Thyroid hormones regulate bone metabolism through the transporter protein MCT8. Knocking out the MCT8 gene in mice leads to both bone gain and bone loss, depending on the age of the mice. Young mice lacking MCT8 show increased trabecular bone at the spine, while adult mice show decreased trabecular bone in both the femur and vertebrae. Additionally, deleting MCT8 in osteoblasts and osteocytes has different effects on bone volume.
Article
Biochemistry & Molecular Biology
Patricia Llamas-Granda, Laura Martin-Rodriguez, Raquel Largo, Gabriel Herrero-Beaumont, Aranzazu Mediero
Summary: The study suggests that tenofovir may increase bone loss by activating the Sema4D/PlexinB1 signaling pathway, inhibiting osteoblast differentiation. Agents that increase local adenosine concentrations, such as dipyridamole, may prevent bone loss following the inhibition of this pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Christine Swanson
Summary: Recent studies have shown a relationship between sleep/circadian disruptions and bone health. Both short and long sleep durations are associated with low bone mineral density (BMD), and women with short sleep have an increased risk of fracture. Age, sex, weight change, and concurrent circadian misalignment may modify the effects of sleep restriction on bone metabolism. Night shift work, which disrupts circadian rhythms, can lead to alterations in bone metabolism and structure, increasing the risk of fractures. Sleep and circadian disruptions during adolescence may have long-term consequences on bone modeling. In conclusion, short sleep and night shift work have negative impacts on bone metabolism and health.
CURRENT OSTEOPOROSIS REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Krystyna Pawlak, Beata Sieklucka, Dariusz Pawlak
Summary: The activation of the KYN pathway in trabecular bone during CKD development intensified genes related to osteogenesis, resulting in a stiffer femoral neck. Conversely, reduction of the KYN pathway in cortical bone allowed for PTH-dependent anabolic effects, leading to better bone turnover and strength in the course of CKD development. This highlights the potential interference of the paracrine KYN pathway in bone with the anabolic effects of PTH through disrupting PTH-dependent molecular signaling.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Endocrinology & Metabolism
Xiaoyu Xu, Haisheng Yang, Whitney A. Bullock, Maxim A. Gallant, Claes Ohlsson, Teresita M. Bellido, Russell P. Main
Summary: Age-related bone loss is caused by imbalanced bone turnover and decreased skeletal mechanoadaptation. Estrogen receptors, ER alpha and ER beta, play crucial roles in osteoprotective regulation. Previous studies focused on ER alpha but the role of Ot-ER beta in bone mass regulation is still unknown. This study found that Ot-ER beta regulates bone (re)modeling and mechanical signal response differently in males and females.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biology
Jiancheng Yang, Shaojie Zhou, Huanhuan Lv, Min Wei, Yanwen Fang, Peng Shang
Summary: The study found that 4 weeks of static magnetic field exposure significantly promoted the recovery of hindlimb unloading-induced decrease in bone mineral density and content, deterioration of bone microarchitecture, and reduction in bone strength. The results suggest that static magnetic fields may be a promising biophysical countermeasure for maintaining bone health in astronauts after landing.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Endocrinology & Metabolism
Frank C. Ko, Margaret M. Kobelski, Wanlin Zhang, Gina M. Grenga, Janaina S. Martins, Marie B. Demay
Summary: Phosphate restriction leads to decreased bone formation and increased bone marrow adipose tissue by affecting cellular signaling pathways and gene expression.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Physiology
Hanan Aljohani, Linda T. Senbanjo, Mohammed Al Qranei, Joseph P. Stains, Meenakshi A. Chellaiah
Summary: The study demonstrated the ability of MSM to induce osteoblast formation and function in vivo, resulting in increased bone formation in the mandible.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Toshio Matsumoto, Teruki Sone, Akiko Yamashita, Tetsuo Inoue
Summary: This study aimed to determine the efficacy of abaloparatide in increasing bone mineral density (BMD) and its safety in postmenopausal Japanese women with osteoporosis. The results showed that abaloparatide significantly increased BMD in the lumbar spine, total hip, and femoral neck, with mild adverse effects.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)