Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep20112
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Funding
- Department of Energy, Office of Basic Energy Sciences [DE-SC00112704]
- ERC [227711]
- European Research Council (ERC) [227711] Funding Source: European Research Council (ERC)
- Biotechnology and Biological Sciences Research Council [BB/L026260/1, BB/H022597/1] Funding Source: researchfish
- Engineering and Physical Sciences Research Council [EP/I022562/1] Funding Source: researchfish
- BBSRC [BB/L026260/1, BB/H022597/1] Funding Source: UKRI
- EPSRC [EP/I022562/1] Funding Source: UKRI
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We developed a scanning hard x-ray microscope using a new class of x-ray nano-focusing optic called a multilayer Laue lens and imaged a chromosome with nanoscale spatial resolution. The combination of the hard x-ray's superior penetration power, high sensitivity to elemental composition, high spatial-resolution and quantitative analysis creates a unique tool with capabilities that other microscopy techniques cannot provide. Using this microscope, we simultaneously obtained absorption-, phase-, and fluorescence-contrast images of Pt-stained human chromosome samples. The high spatial-resolution of the microscope and its multi-modality imaging capabilities enabled us to observe the internal ultra-structures of a thick chromosome without sectioning it.
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