Article
Multidisciplinary Sciences
Nicolas Millet, Norma Solis, Diane Aguilar, Michail S. Lionakis, Robert T. Wheeler, Nicholas Jendzjowsky, Marc Swidergall
Summary: This study reveals the role of the beta-glucan receptor EphA2 in modulating renal immunopathology during disseminated candidiasis through IL-23 signaling and ferroptotic cell death.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Jean-Claude Lecron, Sandrine Charreau, Jean-Francois Jegou, Nadjet Salhi, Isabelle Petit-Paris, Emmanuel Guignouard, Christophe Burucoa, Laure Favot-Laforge, Charles Bodet, Anne Barra, Vincent Huguier, Jiad Mcheik, Laure Dumoutier, Julien Garnier, Francois-Xavier Bernard, Bernhard Ryffel, Franck Morel
Summary: This study found that the proinflammatory cytokines IL-22 and IL-17 induced by bacterial infection delay the healing process of skin wounds, regardless of the presence of bacteria. This discovery reveals the underlying mechanisms of bacterial infection on wound healing.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Berengere Villeret, Reem Ghinnagow, Saade Kheir, Maelys Born-Bony, Jay K. Kolls, Ignacio Garcia-Verdugo, Jean-Michel Sallenave
Summary: This study reveals the importance of lymphocytes in fighting against Pseudomonas aeruginosa infection. The bacterium down-regulates IL-23 and IL-22 protein accumulation in the lungs, but up-regulates their RNA production. Adenovirus-mediated over-expression of IL-1, IL-23, and IL-7 can rescue mice from Pseudomonas aeruginosa-induced lethality, suggesting its potential value in locally immunosuppressed individuals like cystic fibrosis patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Adrian Gomez-Nguyen, Nikhilesh Gupta, Harsha Sanaka, Dennis Gruszka, Alaina Pizarro, Luca DiMartino, Abigail Basson, Paola Menghini, Abdullah Osme, Carlo DeSalvo, Theresa Pizarro, Fabio Cominelli
Summary: The study found that psychological stress can induce the formation of colonic TLOs through intrinsic alterations in IL-23 signaling, rather than through extrinsic influence from the microbiome. Furthermore, chronic stress is protective against secondary insult from colitis, suggesting that TLOs may improve mucosal barrier function.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Immunology
Nu Z. N. Nguyen, Vuvi G. Tran, Jiyeon Baek, Younghee Kim, Eun H. Youn, Seung W. Na, Sang J. Park, Su-Kil Seo, Byungsuk Kwon
Summary: Invasive candidiasis has high mortality rates in immunocompromised patients. IL-33 regulates innate immune response to Candida albicans infection in vivo, initiating a defense mechanism by stimulating IL-23 production in dendritic cells and GM-CSF secretion by NK cells.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Amanda Goulart, Medeton Mahoussi Michael Boko, Nubia Sabrina Martins, Ana Flavia Gembre, Romulo Silva de Oliveira, Sandra Patricia Palma-Albornoz, Thais Bertolini, Paulo Eduardo Martins Ribolla, Leandra Naira Zambelli Ramalho, Thais Fernanda de Campos Fraga-Silva, Vania Luiza Deperon Bonato
Summary: IL-22 plays a pro-inflammatory role in allergic asthma, contributing to the recruitment and activation of eosinophils. The absence of IL-22 reduces eosinophil number and cytokine production, as well as mucus production and pulmonary inflammation. Transfer of Th17 cells from IL-22 deficient mice also affects eosinophil frequency in the airways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Microbiology
Bhawna Yadav, Charles A. Specht, Chrono K. Lee, Maria Pokrovskii, Jun R. Huh, Dan R. Littman, Stuart M. Levitz
Summary: Exposure to mold, Aspergillus, is generally harmless to healthy individuals but can lead to invasive and allergic aspergillosis in immunocompromised and atopic individuals. In murine models of pulmonary aspergillosis, lung eosinophils express IL-17, ROR gamma t, and IL-23R. However, IL-23 is not necessary for the production of IL-17 and ROR gamma t in this context.
Article
Multidisciplinary Sciences
Rakesh Pandey, Yusur Al-Nuaimi, Rajiv Kumar Mishra, Sarah K. Spurgeon, Marc Goodfellow
Summary: Psoriasis is a chronic inflammatory skin disease associated with a complex signaling network involving cytokines, immune cells, and skin cells.
SCIENTIFIC REPORTS
(2021)
Article
Microbiology
Lindsay M. Snyder, Claire M. Doherty, Heather L. Mercer, Eric Y. Denkers
Summary: Our study identified MyD88-independent intestinal immune pathways induced by T. gondii, including myeloid cell-derived IL-12 production, downstream type I immunity, and IFN-gamma production by ILC1, ILC3, and T lymphocytes. This reveals an underlying network of immune responses that do not involve signaling through MyD88.
Article
Immunology
Dominika Borowska, Samantha Sives, Lonneke Vervelde, Kate M. Sutton
Summary: This study analyzes chicken macrophages and dendritic cells, revealing differences in phenotype, function, and transcription. The BM cultures with CSF2 and IL-4 tend to represent cells of the macrophage lineage rather than conventional dendritic cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yaohan Xu, Jiang Zhu, Jingyi Hu, Ziqi Zou, Yueling Zhao, Lihua Lai, Ping Xu, Yinjing Song, Hao Cheng
Summary: The study demonstrated that L-Theanine can significantly reduce the levels of IL-23 and chemokines, inhibit the activation of NF-kappa B and IL-17A signaling pathways, and promote propanoate metabolism, thereby alleviating IMQ-induced psoriasis-like skin inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dominik Aschenbrenner, Maria Quaranta, Soumya Banerjee, Nicholas Ilott, Joanneke Jansen, Boyd Steere, Yin-Huai Chen, Stephen Ho, Karen Cox, Carolina V. Arancibia-Carcamo, Mark Coles, Eamonn Gaffney, Simon Pl Travis, Lee Denson, Subra Kugathasan, Jochen Schmitz, Fiona Powrie, Stephen N. Sansom, Holm H. Uhlig
Summary: Dysregulated immune responses are the cause of IBDs, with IL-10 and IL-1 identified as critical regulators of monocyte IL-23 production. The study differentiates between homeostatic IL-23 production and hyperinflammation-associated IL-23 production in patients with severe ulcerating active Crohn's disease and anti-TNF treatment non-responsiveness. Subgroups of patients with IBD that might benefit from IL-23p19 and/or IL-1 alpha/IL-1 beta-targeting therapies upstream of IL-23 are identified.
Article
Microbiology
Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajana, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats
Summary: Gram-positive bacterial infections can cause organ failure and death in sepsis. Bacillus anthracis PGN, a component shed during bacterial replication, can promote sepsis-like pathology. This study found that purified Bacillus anthracis PGN can activate human dendritic cells (DCs), promote the production of proinflammatory cytokines, and induce the differentiation of T(H)17 cells.
Article
Biochemistry & Molecular Biology
Yan Qi, Bin Liao, Jiawei Chen, Chunling Liang, Zesong Chen, Baozhen Xie
Summary: This study investigated the roles of IL-17, IL-22, and IL-23 in the diagnosis of NKTCL, and found that their serum levels were significantly increased in NKTCL patients, indicating their potential as diagnostic biomarkers.
CELLULAR AND MOLECULAR BIOLOGY
(2023)
Article
Medicine, Research & Experimental
Philipp Novoszel, Martin Holcmann, Gabriel Stulnig, Cristiano De Sa Fernandes, Victoria Zyulina, Izabela Borek, Markus Linder, Alexandra Bogusch, Barbara Drobits, Thomas Bauer, Carmen Tam-Amersdorfer, Patrick M. Brunner, Georg Stary, Latifa Bakiri, Erwin F. Wagner, Herbert Strobl, Maria Sibilia
Summary: This study found that c-Jun/AP-1 protein regulates CCL2 and IL-23 production in DCs following TLR7 activation, affecting psoriasis-like skin inflammation. The expression of CCL2 and IL-23 in human psoriatic skin co-localize with c-Jun in type-2/inflammatory DCs, and inhibition of JNK-AP-1 can reduce the expression of these targets in TLR7/8-stimulated human DCs.
EMBO MOLECULAR MEDICINE
(2021)
Article
Immunology
Alessia Piermattei, Giuseppe Migliara, Gabriele Di Sante, Maria Foti, Soren Bohos Hayrabedyan, Angela Papagna, Maria Concetta Geloso, Maddalena Corbi, Mariagrazia Valentini, Alessandro Sgambato, Giovanni Delogu, Gabriela Constantin, Francesco Ria
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Cell Biology
Chiara Ripamonti, Angela Papagna, Claudio Storini, Daniela Miglietta, Maria Foti
JOURNAL OF LEUKOCYTE BIOLOGY
(2017)
Article
Biotechnology & Applied Microbiology
Lara Colleoni, Barbara Galbardi, Claudia Barzago, Silvia Bonanno, Sara Franzi, Rita Frangiamore, Giorgia Camera, Maria Foti, Donatella Biancolini, Eleonora Canioni, Lorenzo Maggi, Carlo Antozzi, Renato Mantegazza, Pia Bernasconi, Dimos Kapetis
PHARMACOGENETICS AND GENOMICS
(2017)
Article
Oncology
Heleen H. Van Acker, Ottavio Beretta, Sebastien Anguille, Lien De Caluwe, Angela Papagna, Johan M. Van den Bergh, Yannick Willemen, Herman Goossens, Zwi N. Berneman, Viggo F. Van Tendeloo, Evelien L. Smits, Maria Foti, Eva Lion
Article
Immunology
Melanie A. Cron, Solene Maillard, Fabien Delisle, Nolwenn Samson, Frederique Truffault, Maria Foti, Elie Fadel, Julien Guihaire, Sonia Berrih-Aknin, Rozen Le Panse
AUTOIMMUNITY REVIEWS
(2018)
Article
Medicine, Research & Experimental
Angeline Gradolatto, Dani Nazzal, Maria Foti, Jacky Bismuth, Frederique Truffault, Rozen Le Panse, Sonia Berrih-Aknin
MYASTHENIA GRAVIS AND RELATED DISORDERS I
(2012)
Article
Oncology
Rebecca Favaro, Irene Appolloni, Serena Pellegatta, Alexandra Badiola Sanga, Pierfrancesco Pagella, Eleonora Gambini, Federica Pisati, Sergio Ottolenghi, Maria Foti, Gaetano Finocchiaro, Paolo Malatesta, Silvia K. Nicolis
Article
Geriatrics & Gerontology
Bojana Jakic, Mattias Carlsson, Maja Buszko, Giuseppe Cappellano, Christian Ploner, Elisabeth Onestingel, Maria Foti, Hubert Hackl, Egon Demetz, Hermann Dietrich, Cecilia Wick, Georg Wick
Article
Immunology
Angeline Gradolatto, Dani Nazzal, Frederique Truffault, Jacky Bismuth, Elie Fadel, Maria Foti, Sonia Berrih-Aknin
JOURNAL OF AUTOIMMUNITY
(2014)
Article
Multidisciplinary Sciences
Francesca Pontiroli, Olivier Dussurget, Ivan Zanoni, Matteo Urbano, Ottavio Beretta, Francesca Granucci, Paola Ricciardi-Castagnoli, Pascale Cossart, Maria Foti
Article
Cell Biology
Francesca Martorana, Maria Foti, Assunta Virtuoso, Daniela Gaglio, Federica Aprea, Tiziana Latronico, Rocco Rossano, Paolo Riccio, Michele Papa, Lilia Alberghina, Anna Maria Colangelo
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Review
Biochemistry & Molecular Biology
Ilenia Savinetti, Angela Papagna, Maria Foti
Summary: Monocytes are crucial in immunity and disease progression, being heterogeneous in morphology and marker expression, potentially playing a role in neurodegenerative diseases.
Article
Multidisciplinary Sciences
Maria Tredicine, Chiara Camponeschi, Davide Pirolli, Matteo Lucchini, Mariagrazia Valentini, Maria Concetta Geloso, Massimiliano Mirabella, Marco Fidaleo, Benedetta Righino, Camilla Moliterni, Ezio Giorda, Mario Rende, Maria Cristina De Rosa, Maria Foti, Gabriela Constantin, Francesco Ria, Gabriele Di Sante
Summary: The modulation of leukocyte trafficking, specifically the effect of TLR2 ligands on the reshuffling of CD44 isoforms repertoire in T helper cells, plays a crucial role in the pathogenesis of autoimmune disorders. The strain background and TLR2 haplotype also affect the Wnt/β-catenin signaling pathway and expression of splicing factors. This study suggests that TLRs regulation of CD44 isoform repertoire may control the distribution of lesions in the central nervous system.
Article
Biochemical Research Methods
Dimos Kapetis, Ferdinando Clarelli, Federico Vitulli, Nicole Kerlero de Rosbo, Ottavio Beretta, Maria Foti, Paola Ricciardi-Castagnoli, Francesca Zolezzi