Article
Oncology
Qianqian Zhang, Meng Zhang, Shaohua Hu, Lei Meng, Jing Xi, Aman Xu, Yanyan Zhang, Shihui Yu
Summary: This study found a relatively high prevalence of frailty among elderly inpatients with gastric and colorectal cancer, with risk factors including older age, low handgrip strength, no regular exercise habit, and poor nutritional status.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Geriatrics & Gerontology
Emma Yun Zhi Huang, Jasmine Cheung, Justina Yat Wa Liu, Rick Yiu Cho Kwan, Simon Ching Lam
Summary: This study validates the use of GFI-C as a reliable and valid instrument for screening pre-frailty and frailty among older Chinese individuals in communities. The optimal cut-off values for frailty and pre-frailty are recommended to be 3 and 2, respectively.
Article
Oncology
Shao-Ming Yu, Chih-Chung Hsu, Shun-Wen Hsueh, Chia-Yen Hung, Chang-Hsien Lu, Kun-Yun Yeh, Hung-Ming Wang, Shinn-Yn Lin, Yu-Shin Hung, Wen-Chi Chou
Summary: This study evaluated the performance of two modern frailty screening tools, fTRST and mFI-5, in non-elderly patients with head and neck cancer. The results showed that fTRST and mFI-5 are valuable for predicting treatment-related adverse events, treatment tolerance, and quality of life. Incorporating frailty assessment into the management of non-elderly cancer patients can aid in the identification of high-risk individuals.
Article
Medicine, General & Internal
Sang-Wook Lee, Jae-Sik Nam, Ye-Jee Kim, Min-Ju Kim, Jeong-Hyun Choi, Eun-Ho Lee, Kyoung-Woon Joung, In-Cheol Choi
Summary: Developing and validating a predictive model for pre-operative frailty risk of elderly patients through diagnostic and operation codes can assist in evaluating peri-operative frailty risk before emergency surgery efficiently. The Operation Frailty Risk Score (OFRS) showed robust performance in both the temporal validation cohort and two external validation cohorts.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Otorhinolaryngology
S. Rothman, S. Zabarqa, J. Pitaro, H. Gavriel, T. Marom, L. Muallem Kalmovich
Summary: This study aimed to investigate whether risk models, frailty indexes, patients' comorbidities, or demographic characteristics are correlated with postoperative morbidity in elderly patients with head and neck cancer. The study found that there was no higher postoperative morbidity rate among elderly patients compared to younger age groups, indicating that the current evaluation system cannot accurately identify elderly patients at risk. However, assessing operative risk based on physiological reserve or frailty remains an important tool for evaluating elderly patients with head and neck cancer.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Dermatology
Joon Min Jung, Hanju Yoo, Dong Jun Lim, Chong Hyun Won, Sung Eun Chang, Mi Woo Lee, Woo Jin Lee
Summary: This study aimed to evaluate the association of head and neck involvement on the clinicoprognostic features of Mycosis Fungoides (MF). The results showed that head and neck involvement at diagnosis was associated with advanced-stage disease, MF progression, extracutaneous dissemination, and large-cell transformation. It also had a negative impact on the overall survival and progression-free survival of patients with MF.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Oncology
Hemali P. Shah, Oded Cohen, Jordan Sukys, Jacqueline Dibble, Saral Mehra
Summary: This study found that frailty is associated with a decreased likelihood of timely initiation and completion of adjuvant treatment in patients with head and neck cancers after free flap reconstruction.
Article
Surgery
N. Gallagher, J. Berger, H. B. Jones, C. J. Lloyd
Summary: The aim of this study was to determine if the Rockwood Frailty Index is predictive of complications following excision of NMSC. The results showed that frailty is not predictive of postoperative complications following excision of NMSC on the head and neck. Postoperative complications are significantly more associated with full thickness skin graft.
ANNALS OF THE ROYAL COLLEGE OF SURGEONS OF ENGLAND
(2023)
Article
Otorhinolaryngology
Seung Hoon Han, Deuktae Cho, Ramla Mohammad, Young Ho Jung, Soon-Hyun Ahn, Wonjae Cha, Woo-Jin Jeong
Summary: Preoperative Comprehensive Geriatric Assessment (CGA) can predict postoperative complications in elderly patients undergoing head and neck cancer surgery, with frailty status, operation time, and estimated blood loss significantly associated with major complications. Age was not found to be a risk factor for complications.
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2022)
Article
Otorhinolaryngology
Ajay T. Bakas, Harmke A. Polinder-Bos, Fleur Streng, Francesco U. S. Mattace-Raso, Gijsbertus Ziere, Rob J. Baatenburg de Jong, Aniel Sewnaik
Summary: This study found that the G8 is a valid screening tool to identify frail patients in younger patients with head and neck cancer, and it is associated with mortality.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Health Care Sciences & Services
Aurelio Lo Buglio, Francesco Bellanti, Cristiano Capurso, Gianluigi Vendemiale
Summary: The Controlling Nutritional Status (CONUT) score is a simple screening tool that can detect nutritional status and predict adverse clinical outcomes in specific populations. This study aimed to investigate the predictive role of the CONUT score on mortality and length of stay (LOS) in frail patients admitted to an Internal Medicine Department. The results showed that high CONUT scores were associated with longer LOS, but did not significantly predict mortality.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Jing-Yang Tian, Xin-Yu Hao, Fu-Yang Cao, Jing-Jing Liu, Yan-Xiang Li, Yong-Xin Guo, Wei-Dong Mi, Li Tong, Qiang Fu
Summary: The study investigated the predictive value of the 5-factor modified frailty index (mFI-5) for postoperative mortality, delirium, and pneumonia in elderly patients undergoing lung cancer surgery. The results showed that frail patients had higher rates of postoperative delirium, pneumonia, and 1-year mortality, as well as longer hospitalization. Therefore, mFI-5 has potential clinical utility in predicting these outcomes in elderly lung cancer surgery patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Oumar Billa, Franck Bonnetain, Jerome Chamois, Angeline Ligey, Valerie Ganansia, Sophie Renard, Sophie Maillard, Magali Quivrin, Noemie Vulquin, Pierre Truntzer, Georges Noel, Philippe Maingon, Tienhan Sandrine Dabakuyo-Yonli
Summary: This study aimed to assess whether baseline health-related quality of life (HRQoL) scores could predict the occurrence of radiotherapy-related toxicities. Data from 200 patients enrolled in a randomized study were analyzed. Multivariable analyses showed that a 10-point improvement in physical, role, and social functioning was associated with a lower hazard of major toxicity, while a 10-point increase in dyspnea and loss of appetite was associated with an increased hazard of major toxicity.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Otorhinolaryngology
Thanaphone Banh Chong, Pascale Grosclaude, Emilien Chabrillac, Stephanie Lozano, Sebastien Vergez, Loic Mourey, Agnes Dupret-Bories
Summary: This study aimed to assess the survival benefit of optimal vs suboptimal management in elderly patients with upper aerodigestive tract cancer and to determine if comprehensive geriatric assessment (CGA) was a prognostic factor for survival. The results showed that optimal treatment was associated with better overall survival, and receiving CGA seemed to provide benefits for patients with lower G8 scores.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Teresa Magnes, Sandro Wagner, Dominik Kiem, Lukas Weiss, Gabriel Rinnerthaler, Richard Greil, Thomas Melchardt
Summary: Head and neck squamous cell carcinoma is a heterogeneous disease arising from the mucosa of the upper aerodigestive tract, with only about one third of patients responding to checkpoint inhibitors. HPV status and combined positive score are the main biomarkers used in clinical practice, while other factors like tumor mutational burden and immune microenvironment show promise but require validation in prospective trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Otorhinolaryngology
Jeroen E. van Schaik, Anna C. Muller Kobold, Bernard F. A. M. van der Laan, Bert van der Vegt, Bettien M. van Hemel, Boudewijn E. C. Plaat
Summary: The diagnostic value of measuring SCC-Ag and CA15-3 concentrations in FNA samples for the detection of SCC metastases in cervical lymph nodes was evaluated. SCC-Ag measurement showed comparable sensitivity to FNAC and could be used as a cost-effective screening tool in samples with nondiagnostic or indeterminate FNAC results or when multiple lymph nodes are sampled. However, SCC-Ag in FNA samples had lower specificity compared to FNAC assessed by experienced pathologists in head and neck oncology. The addition of CA15-3 measurement did not enhance accuracy.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Dermatology
Alet J. G. Leus, Marjolijn S. Haisma, Jorrit B. Terra, Grigory Sidorenkov, Suzanne Festen, Boudewijn E. C. Plaat, Gyoergy B. Halmos, Emoke Racz
Summary: This study evaluated the impact of frailty and life expectancy on treatment decision, outcomes, and quality of life in older patients with cutaneous squamous cell carcinoma. The results showed that deviating from guidelines towards less aggressive treatment did not negatively affect short-term outcomes or quality of life in frail patients with a limited life expectancy. Further studies with larger sample sizes and longer follow-up periods are needed to confirm these results.
Article
Emergency Medicine
Nick Assink, Joep Kraeima, Anne M. L. Meesters, Mostafa El Moumni, Eelke Bosma, Robert J. Nijveldt, Sven H. van Helden, Jean-Paul P. M. de Vries, Max J. H. Witjes, Frank F. A. IJpma
Summary: A novel 3D measurement method was developed to assess fracture displacement and its association with the risk of conversion to total knee arthroplasty (TKA). The study found that an initial 3D gap area ≥550 mm² was independently associated with conversion to TKA. Different prognostic groups based on the range of 3D gap area were identified, and the survival rate of the knee without conversion to TKA was assessed through Kaplan-Meier curves.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Otorhinolaryngology
Priya Dewansingh, Linda Bras, Lies ter Beek, Wim P. P. Krijnen, Jan L. N. Roodenburg, Cees P. P. van der Schans, Gyorgy B. B. Halmos, Harriet Jager-Wittenaar
Summary: Both malnutrition risk and frailty are common in patients with HNC, but their coexistence and association are not fully understood. Screening for both conditions is recommended.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Otorhinolaryngology
Karlijn van den Bovenkamp, Bert van der Vegt, Gyorgy B. Halmos, Lorian Slagter-Menkema, Johannes A. Langendijk, Boukje A. C. van Dijk, Ed Schuuring, Bernard F. A. M. van der Laan
Summary: This study examined the predictive value of various tumor markers in patients with advanced-stage laryngeal squamous cell carcinoma, and found that overexpression of HIF-1α was associated with locoregional recurrence.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aniek T. Zwart, Vitor J. Cavalheiro, Maria J. Lamers, Rudi A. J. O. Dierckx, Geertruida H. de Bock, Gyorgy B. Halmos, Anouk van der Hoorn
Summary: The study found that low-dose neck CT scans from [F-18]-FDG PET-CT can provide comparable results to diagnostic neck CT scans in head and neck cancer patients. This enables SMI analysis in patients without a diagnostic neck CT but with a [F-18]-FDG PET-CT scan.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Otorhinolaryngology
Manon A. Zwakenberg, Jeroen M. Westra, Gyorgy B. Halmos, Jan Wedman, Bernard F. A. M. van Der Laan, Boudewijn E. C. Plaat
Summary: This study aimed to assess whether the additional use of narrow-band imaging (NBI) in transoral laser surgery (TOLS) for early laryngeal cancer improves clinical outcomes. The results showed that the use of NBI significantly reduced the number of positive resection margins and potentially decreased the recurrence rate and improved recurrence-free survival in patients treated with NBI-supported TOLS. Further studies with larger patient groups are needed to confirm these findings.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Medicine, General & Internal
Aniek T. Zwart, Laurence M. C. Kok, Julius de Vries, Marloes S. van Kester, Rudi A. J. O. Dierckx, Geertruida H. de Bock, Anouk van der Hoorn, Gyorgy B. Halmos
Summary: The aim of this study was to assess the utility of radiologically defined sarcopenia, or a low skeletal muscle index (SMI), as a biomarker for frailty and postoperative complications (POC) in patients with head and neck skin cancer (HNSC). The study used retrospectively collected data and found that low SMIs were related to frailty and malnutrition. However, only frailty based on Geriatric 8 (G8) score was related to POC. The study concluded that low SMI is a practical biomarker for frailty and malnutrition in HNSC, and further research should focus on interventions based on low SMI scores.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Julius Veuger, Nona C. Kuipers, Stefan M. Willems, Gyorgy B. Halmos
Summary: This study aimed to assess potential prognostic markers for rare sinonasal intestinal-type adenocarcinoma. The results showed that there were 21 biomarkers associated with a significant negative effect on survival, but none had a positive effect. The findings can help specialists better understand the risks and prognosis of this disease, leading to improved treatment and patient outcomes.
Review
Biochemistry & Molecular Biology
Carlos M. Chiesa-Estomba, Miguel Mayo-Yanez, Orlando Guntinas-Lichius, Vincent Vander-Poorten, Robert P. Takes, Remco de Bree, Gyorgy B. Halmos, Nabil F. Saba, Sandra Nuyts, Alfio Ferlito
Summary: Radiomics is a promising tool for the diagnosis, treatment, and follow-up of patients with hypopharyngeal squamous cell carcinoma (HPSCC). Further large-scale prospective studies are needed to validate its effectiveness in this patient population.
Article
Emergency Medicine
Nick Assink, Miriam G. E. Oldhoff, Kaj ten Duis, Joep Kraeima, Job N. Doornberg, Max J. H. Witjes, Jean-Paul P. M. de Vries, Anne M. L. Meesters, Frank F. A. IJpma
Summary: This study aimed to assess whether patient-specific osteosyntheses could facilitate proper fracture reduction in medial tibial plateau fractures. Custom-made osteosynthesis plates with drilling guides were used to accurately place screws and improve fracture reduction and tibial alignment.
EUROPEAN JOURNAL OF TRAUMA AND EMERGENCY SURGERY
(2023)
Article
Multidisciplinary Sciences
Jaron G. de Wit, Jasper Vonk, Floris J. Voskuil, Sebastiaan A. H. J. de Visscher, Kees-Pieter Schepman, Wouter T. R. Hooghiemstra, Matthijs D. Linssen, Sjoerd G. Elias, Gyorgy B. Halmos, Boudewijn E. C. Plaat, Jan J. Doff, Eben L. Rosenthal, Dominic Robinson, Bert van der Vegt, Wouter B. Nagengast, Gooitzen M. van Dam, Max J. H. Witjes
Summary: Using tumor-specific fluorescent tracers, fluorescence molecular imaging (FMI) can accurately visualize tumor tissues. This study evaluated the diagnostic accuracy of an EGFR-targeted FMI for intraoperative margin assessment in oral squamous cell carcinoma patients. The results showed that FMI with cetuximab-800CW had high sensitivity and specificity in detecting tumor-positive margins, providing a safe method for intraoperative adjustment of surgical margins.
NATURE COMMUNICATIONS
(2023)
Article
Oncology
Martine Froukje van der Kamp, Eric Hiddingh, Julius de Vries, Boukje Annemarie Cornelia van Dijk, Ed Schuuring, Lorian Slagter-Menkema, Bert van der Vegt, Gyorgy Bela Halmos
Summary: There is often a discrepancy between the chronological and biological age of head and neck cancer patients. Treatment is based on chronological age, but biological age may be a more accurate predictor of treatment tolerability. This study examined the association between tumor characteristics and chronological and biological age, as well as their relation to survival. The findings suggest that biological age may have a stronger impact on the tumor microenvironment than chronological age, highlighting the importance of investigating treatment response based on biological age.
