Article
Cell Biology
Diogo Ferreira-Martins, Emily Walton, Rolf O. Karlstrom, Mark A. Sheridan, Stephen D. McCormick
Summary: The study examines the effects of the growth hormone (GH)/insulin-like growth factor (IGF) system on osmoregulation in basal vertebrates. Results show that during metamorphosis, there are increases in gill ion transporters and salinity tolerance, accompanied by increases in components of the GH/IGF axis. Exposure to seawater (SW) after metamorphosis leads to slight increases in plasma chloride concentrations, indicating high SW tolerance, but no major changes in gill ion transporters or GH/IGF axis. The study suggests that metamorphosis plays a critical role in stimulating the GH/IGF axis and promoting metamorphosis and SW tolerance.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2023)
Article
Fisheries
Ze-Bin Zhou, Meng-Jie Zhang, Yuan-Yuan He, Shi-Cheng Bao, Xiang-Yang Zhang, Weiming Li, Qing-Hua Zhang
Summary: In this study, a homologous adaptor molecule TRIF, named LmTRIF, was identified in Northeast Chinese lamprey (Lethenteron morii). The results indicated that LmTRIF plays an important role in the innate immune signal transduction process of lamprey and provides a basis for the origin and evolution of the TLR signaling pathway in vertebrates.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Fisheries
Zhaosheng Sun, Yuting Qin, Danjie Liu, Bangjie Wang, Zhao Jia, Junya Wang, Qian Gao, Jun Zou, Yue Pang
Summary: Chemokines are soluble peptides that guide cell migration in development and immune defense. The CXC chemokine system in lamprey has been found to have diversified, showing variations in gene organization and expression patterns in different tissues, indicating an evolutionary adaptation in jawless fish.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yoshinao Katsu, Xiaozhi Lin, Ruigeng Ji, Ze Chen, Yui Kamisaka, Koto Bamba, Michael E. Baker
Summary: Recent studies have found that the corticoid receptors (CR1 and CR2) in modern lampreys show a strong response to 11-deoxycorticosterone and 11-deoxycortisol, and they are close to the mineralocorticoid receptor (MR) in sharks. In HEK293 cells, the integrity of the lamprey CR sequence is crucial for steroid-mediated transcriptional activation.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Article
Chemistry, Medicinal
Rita Sigueiro, Laurent Bianchetti, Carole Peluso-Iltis, Sandra Chalhoub, Annick Dejaegere, Judit Osz, Natacha Rochel
Summary: This study reveals the structural differences between VDR from the basal vertebrate sea lamprey and VDR from higher vertebrates through crystal structure comparison, and analyzes the impact of these differences on transcriptional responses.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Cell Biology
Shreyas M. Suryanarayana, Juan Perez-Fernandez, Brita Robertson, Sten Grillner
Summary: In lampreys, two separate afferent channels from olfactory glomeruli to different targets in the brain have been identified. Mitral-like cells project directly to the piriform cortex, while smaller tufted-like cells project exclusively to the dorsomedial telencephalic nucleus. The tufted-like cells exhibit short-latency activation and terminate with mossy fibers on dmtn cells, eliciting large unitary EPSPs without concurrent inhibition.
Article
Multidisciplinary Sciences
Pei-Yi Lin, Lulu Y. Chen, Man Jiang, Justin H. Trotter, Erica Seigneur, Thomas C. Sudhof
Summary: Contrary to neurexin-1 and neurexin-3, neurexin-2 restricts synapse formation in the hippocampus. Deleting neurexin-2 increases the strength and release probability of excitatory synapses, while having no effect on inhibitory synapses. Superresolution microscopy reveals that the deletion of neuron-specific neurexin-2 doubles the density of excitatory synapses in the CA1 region.
Article
Immunology
Yan Chen, Lingjie Luo, Lisi Deng, Xiaoxue Tian, Shangwu Chen, Anlong Xu, Shaochun Yuan
Summary: The AID/APOBEC family expands in primates to resist viruses and retrotransposons. Recently, expansion of AID/APOBEC-like genes has also been observed in lamprey. The study suggests that the arms race between host and pathogens, along with VLR assembly, may contribute to the expansion and diversification of the lamprey AID/APOBEC family.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Joshua M. Lorenz-Guertin, Nadya Povysheva, Caitlyn A. Chapman, Matthew L. Macdonald, Marco Fazzari, Aparna Nigam, Jessica L. Nuwer, Sabyasachi Das, Megan L. Brady, Katarina Vajn, Matthew J. Bambino, Susan T. Weintraub, Jon W. Johnson, Tija C. Jacob
Summary: Benzodiazepine drugs treat seizures, anxiety, insomnia, and alcohol withdrawal by enhancing GABA-A receptors containing γ2 subunits. However, their clinical use is hindered by tolerance and withdrawal symptoms. This study found that long-term treatment with benzodiazepines reduces sedative effects, alters GABA-A receptor distribution, decreases inhibitory tone, and increases glutamatergic neurotransmission.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Immunology
Zebin Zhou, Shaoqing Ding, Yaqian Wang, Janfeng Ren, Xiangyang Zhang, Weiming Li, Qinghua Zhang
Summary: The study identified and characterized LmTLR14d gene in Northeast Chinese lamprey, which was found to be expressed in various tissues and up-regulated during infection. The results suggest that LmTLR14d may play a crucial role in the innate immune signaling of lamprey.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jochen Kuhse, Femke Groeneweg, Stefan Kins, Karin Gorgas, Ralph Nawrotzki, Joachim Kirsch, Eva Kiss
Summary: Alzheimer's disease (AD) is characterized by synaptic failure and neuronal loss. Artemisinins have been shown to restore key protein levels of inhibitory GABAergic synapses in the hippocampus of APP/PS1 mice. This study demonstrates that the protein levels and subcellular localization of alpha 2 and alpha 3 subunits of GlyRs are altered in different regions and stages of AD, and can be modulated by treatment with artesunate.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Fisheries
Kyle L. Rekedal, Khan M. A. Hassan, Chris T. Amemiya
Summary: Research suggests that Lampetra hubbsi, a freshwater lamprey species from the Kings River of California, could be a feasible alternative for studying the adaptive immune system of lampreys, showing high homology with VLRB molecules of the parasitic sea lamprey Petromyzon marinus.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Biology
Remy A. Yovanno, Tsung Han Chou, Sarah J. Brantley, Hiro Furukawa, Albert Y. Lau
Summary: This study investigated the mechanisms of D-serine in receptor activation and found that D-serine competes with glutamate for binding to GluN2A. The inhibitory effect of D-serine at high concentrations was confirmed through electrophysiology experiments.
Article
Biochemistry & Molecular Biology
Chris N. Glover, Greg G. Goss
Summary: Hagfish exposed to hypoxia showed a more rapid accumulation of calcium, especially in the gills. This effect was most pronounced after 24 hours of exposure and may be related to enhancing hypoxia tolerance in hagfishes.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2021)
Article
Biology
Emily M. Dong, W. Ted Allison
Summary: The eyes of hagfish are basic compared to other vertebrates, lacking various structures typically found in vertebrate eyes. Research shows that hagfish retina grows throughout life and exhibits distinct characteristics, such as a layer of photoreceptor cells expressing a single opsin. Despite lacking a distinct layer of interneurons, the hagfish retina still contains multiple cell populations expressing markers of vertebrate retinal interneurons.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Lei Sun, Arabella Wan, Zhuolong Zhou, Dongshi Chen, Heng Liang, Chuwei Liu, Shijia Yan, Yi Niu, Ziyou Lin, Siyue Zhan, Shanfeng Wang, Xianzhang Bu, Weiling He, Xiongbin Lu, Anlong Xu, Guohui Wan
Summary: The study identified an RNA-binding protein RALY as a critical regulator in colorectal cancer metabolism, promoting the post-transcriptional processing of miRNAs that downregulate metabolism-associated genes and reprogram mitochondrial metabolism in cancer cells. Increased levels of RALY were associated with poor prognosis in CRC patients expressing low levels of mitochondrion-associated genes, and this effect was facilitated by N6-methyladenosine switch under reactive oxygen species stress. Inhibition of m6A methylation abolished RALY recognition of pri-miRNAs, leading to inhibition of colorectal tumor growth and progression both in vivo and in organoid models.
Review
Immunology
Wenbin Liu, Guangrui Huang, Hongliang Rui, Jie Geng, Haikun Hu, Yujiao Huang, Guiyang Huo, Baoli Liu, Anlong Xu
Summary: Membranous nephropathy (MN) is a common pattern of glomerular injury in multiple autoimmune responses. Detecting autoantibodies can lead to personalized precision medicine. Further identification of autoantibodies and biomarkers is needed to accurately predict disease prognosis and therapeutic response.
AUTOIMMUNITY REVIEWS
(2022)
Article
Biochemical Research Methods
Yuxiu Sun, Chen Li, Wanchen Yu, Guiyang Huo, Mengmeng Zhu, Pengfei Zhao, Ting Wang, Guangrui Huang, Anlong Xu
Summary: Analyzing the serum proteomic profile of SAPHO patients revealed multiple proteins associated with SAPHO syndrome, with inhibitors of the complement system such as CFH and C4BP up-regulated in the syndrome, potentially playing crucial roles in its pathogenesis.
JOURNAL OF PROTEOMICS
(2022)
Article
Allergy
Jianhua Zhen, Pengfei Zhao, Yini Li, Yanan Cai, Wanchen Yu, Wei Wang, Lu Zhao, Hesong Wang, Guangrui Huang, Anlong Xu
Summary: This study explored changes in the gut microbiota, urine metabolome, and plasma proteome in individuals with allergies. Indole derivatives from tryptophan metabolism may play a key role in the progression of allergies and could be potential therapeutic targets.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Article
Immunology
Yan Chen, Lingjie Luo, Lisi Deng, Xiaoxue Tian, Shangwu Chen, Anlong Xu, Shaochun Yuan
Summary: The AID/APOBEC family expands in primates to resist viruses and retrotransposons. Recently, expansion of AID/APOBEC-like genes has also been observed in lamprey. The study suggests that the arms race between host and pathogens, along with VLR assembly, may contribute to the expansion and diversification of the lamprey AID/APOBEC family.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Xin Tao, Ziwen Huang, Fan Chen, Xinli Wang, Tingting Zheng, Shaochun Yuan, Anlong Xu
NATIONAL SCIENCE REVIEW
(2022)
Article
Biochemistry & Molecular Biology
Liutao Chen, Yonggui Fu, Zhijie Hu, Ke Deng, Zili Song, Susu Liu, Mengxia Li, Xin Ou, Runze Wu, Mian Liu, Rui Li, Shuiying Gao, Lin Cheng, Shangwu Chen, Anlong Xu
Summary: The N6-methyladenosine (m(6)A) modification and alternative polyadenylation (APA) are important regulators of gene expression. YTHDC1, an m(6)A reader, was found to suppress proximal APA sites and produce longer 3' UTR transcripts by binding to upstream m(6)A sites. The interaction between YTHDC1 and FIP1L1, as well as the liquid-liquid phase separation promoted by m(6)A binding, may play a crucial role in APA regulation.
Article
Plant Sciences
Peng Tian, Lili Wu, Maya Kudo, Misa Hayashi, Lingling Qin, Ming Gao, Anlong Xu, Tonghua Liu
Summary: TNK can reduce obesity by regulating intestinal flora and is associated with fatty acid metabolism.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Cell Biology
Zhijie Hu, Mengxia Li, Zhanfeng Huo, Liutao Chen, Susu Liu, Ke Deng, Xin Lu, Shangwu Chen, Yonggui Fu, Anlong Xu
Summary: Alternative splicing and alternative polyadenylation (APA) are crucial for gene regulation in eukaryotic cells. While the U1 snRNP complex can suppress proximal APA sites, the free proteins of this complex actually promote the usage of these sites, indicating a contrasting role.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2022)
Article
Immunology
Jin Li, Shumin Liu, Yang Zhang, Qiuyun Huang, Hao Zhang, Jihua OuYang, Fan Mao, Huiping Fan, Wenjie Yi, Meiling Dong, Anlong Xu, Shengfeng Huang
Summary: The Apextrin C-terminal (ApeC) domain is a protein domain largely specific to aquatic invertebrates. This study examined 130 ACPs from gastropods and bivalves, classifying them into different groups based on their phylogenetics and architectures. The study found that the selected ACPs from bivalves and gastropods showed high affinities to certain types of peptidoglycan, but weak or no affinities to other microbial cell wall components. Furthermore, the ACP from the bivalve had the highest expression in the gill and could be up-regulated after bacterial challenge, similar to the findings in amphioxus ACPs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Wan-di Feng, Yao Wang, Tong Luo, Xin Jia, Cui-qin Cheng, Hao-jia Wang, Mei-qi Zhang, Qi-qi Li, Xue-jiao Wang, Yi-ying Li, Jin-yong Wang, Guang-rui Huang, Ting Wang, An-long Xu
Summary: Recent evidence suggests that targeting NLRP3 inflammasome activation is important for treating inflammasome-driven diseases. Scoparone, a natural compound from the Chinese herb Artemisia capillaris Thunb, has anti-inflammatory activity. This study investigated the effect of scoparone on NLRP3 inflammasome activation in inflammatory diseases.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Oncology
Ying Shi, Xiaopu Sang, Jiali Deng, Yihang Wang, Xiaoni Chen, Shan Lin, Fenfang Wu, Anlong Xu
Summary: This study found that cell cycle-related genes play a key role in the development and prognosis of hepatocellular carcinoma (HCC), and are significantly correlated with immune cell infiltration. The expression levels of CDK1, CDC20, CCNA2, CCNB1, and CCNB2 may be involved in the regulation of monocytes and tumor-associated macrophages (TAMs) in HCC. These findings suggest that cell cycle-related genes can be used as novel biomarkers for exploring the prognosis and immune cell infiltration of HCC.
Article
Cell & Tissue Engineering
Ying Shi, Jiali Deng, Xiaopu Sang, Yihang Wang, Fei He, Xiaoni Chen, Anlong Xu, Fenfang Wu
Summary: By including BMP4 in the hepatic differentiation medium, we have achieved co-differentiation of endoderm-derived hepatocytes and mesoderm-derived nonparenchymal cells, which has a beneficial effect on hepatocyte maturation and lifespan in vitro.
STEM CELLS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Zirui Yue, Zhaoyu Fan, Hao Zhang, Buhan Feng, Chengyi Wu, Shenghui Chen, Jihua Ouyang, Huiping Fan, Panwei Weng, Huixiong Feng, Shangwu Chen, Meiling Dong, Anlong Xu, Shengfeng Huang
Summary: The chitin-based peritrophic matrix (PM), which was traditionally believed to be lost in vertebrates, has been discovered in fishes as a chitinous membrane (CM). In zebrafish, the CM plays a role in ingestion behavior, microbial homeostasis, epithelial renewal, digestion, growth, and longevity. Although not essential for gut immunity, the CM may provide insights into the understanding of vertebrate gut physiology and human intestinal diseases.
Article
Biochemistry & Molecular Biology
Hongmei Li, Fenfang Wu, Guangrui Huang, Di Wu, Ting Wang, Xiashuang Wang, Kai Wang, Yuyin Feng, Anlong Xu
Summary: Recent studies have shown that transplantation of hiPS-CMs is a promising approach for treating heart failure, but the immature nature and secreted proteins of hiPS-CMs involved in cardiomyocyte repair are not well understood. In this study, a saponin(+) compound induced system was established to generate stable and functional hiPS-CMs in vitro and transplanted into heart failure mice. The results demonstrated that the optimally induced hiPS-CMs had enhanced therapeutic effects by reducing cardiac remodeling and dysfunction, decreasing cardiomyocyte death, and promoting angiogenesis. The reparative effect was likely mediated by the secretion of PDGF-BB and the activation of the PI3K/Akt pathway.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
