Structural insight into antibody-mediated antagonism of the Glucagon-like peptide-1 Receptor

Conformational states of the full-length glucagon receptor

(2015) Linlin Yang et al.   Nature Communications

GLP-1 Receptor Localization in Monkey and Human Tissue: Novel Distribution Revealed With Extensively Validated Monoclonal Antibody

(2014) Charles Pyke et al.   ENDOCRINOLOGY

A potentiator of orthosteric ligand activity at GLP-1R acts via covalent modification

(2014) Whitney M Nolte et al.   Nature Chemical Biology

Structural and Pharmacological Characterization of Novel Potent and Selective Monoclonal Antibody Antagonists of Glucose-dependent Insulinotropic Polypeptide Receptor

(2013) Peter Ravn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of class B GPCR corticotropin-releasing factor receptor 1

(2013) Kaspar Hollenstein et al.   NATURE

Structure of the human glucagon class B G-protein-coupled receptor

(2013) Fai Yiu Siu et al.   NATURE

GLP-1 Receptor Activation Indirectly Reduces Hepatic Lipid Accumulation But Does Not Attenuate Development of Atherosclerosis in Diabetic MaleApoE−/−Mice

(2012) Naim Panjwani et al.   ENDOCRINOLOGY

The Glucagon-Like Peptide-1 Receptor—or Not?

(2012) Charles Pyke et al.   ENDOCRINOLOGY

Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor

(2012) A. Kirkpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular basis for negative regulation of the glucagon receptor

(2012) C. M. Koth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lactam Constraints Provide Insights into the Receptor-Bound Conformation of Secretin and Stabilize a Receptor Antagonist

(2011) Maoqing Dong et al.   BIOCHEMISTRY

Molecular Basis of Secretin Docking to Its Intact Receptor Using Multiple Photolabile Probes Distributed throughout the Pharmacophore

(2011) Maoqing Dong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Refinement of Glucagon-like Peptide 1 Docking to Its Intact Receptor Using Mid-region Photolabile Probes and Molecular Modeling

(2011) Laurence J. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Residues within the Transmembrane Domain of the Glucagon-Like Peptide-1 Receptor Involved in Ligand Binding and Receptor Activation: Modelling the Ligand-Bound Receptor

(2011) K. Coopman et al.   MOLECULAR ENDOCRINOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Side Chain Cyclization Based on Serine Residues: Synthesis, Structure, and Activity of a Novel Cyclic Analogue of the Parathyroid Hormone Fragment 1−11†

(2010) Andrea Caporale et al.   JOURNAL OF MEDICINAL CHEMISTRY

Crystal Structure of Glucagon-like Peptide-1 in Complex with the Extracellular Domain of the Glucagon-like Peptide-1 Receptor

(2009) Christina Rye Underwood et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eleven Amino Acid Glucagon-like Peptide-1 Receptor Agonists with Antidiabetic Activity

(2009) Claudio Mapelli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular Recognition of Corticotropin-releasing Factor by Its G-protein-coupled Receptor CRFR1

(2008) Augen A. Pioszak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain

(2008) Steffen Runge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular recognition of parathyroid hormone by its G protein-coupled receptor

(2008) Augen A. Pioszak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA