Journal
SCIENTIFIC REPORTS
Volume 6, Issue -, Pages -Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/srep22554
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Funding
- National Basic Research Program of China (973 Program) [2012CB933300, 2015AA042602]
- Fund for Creative Research of National Natural Science Foundation of China [61321492]
- Project of National Natural Science Foundation of China [91323304, 81402468, 61327811]
- Shanghai Youth Science and Technology Talent Sailing project [14YF1407200]
- Project for Shanghai Outstanding Academic leaders [15XD1504300]
- Youth Innovation Promotion Association, CAS
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For point-of-care (POC) applications, robust, ultrasensitive, small, rapid, low-power, and low-cost sensors are highly desirable. Here, we present a novel biosensor based on a complementary metal oxide semiconductor (CMOS)-compatible silicon nanowire tunneling field-effect transistor (SiNW-TFET). They were fabricated top-down with a low-cost anisotropic self-stop etching technique. Notably, the SiNW-TFET device provided strong anti-interference capacity by applying the inherent ambipolarity via both pH and CYFRA21-1 sensing. This offered a more robust and portable general protocol. The specific label-free detection of CYFRA21-1 down to 0.5 fgml(-1) or similar to 12.5 aM was achieved using a highly responsive SiNW-TFET device with a minimum sub-threshold slope (SS) of 37 mVdec(-1). Furthermore, real-time measurements highlighted the ability to use clinically relevant samples such as serum. The developed high performance diagnostic system is expected to provide a generic platform for numerous POC applications.
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