Article
Medicine, General & Internal
Einat Shmueli, Yulia Gendler, Patrick Stafler, Hagit Levine, Guy Steuer, Ophir Bar-On, Hannah Blau, Dario Prais, Meir Mei-Zahav
Summary: The study aims to evaluate if dynamic hyperinflation (DH) can predict pulmonary deterioration in cystic fibrosis (CF) patients and explore its association with peak VO2. The results showed a significant decline in lung function (FEV1%) trend in the DH group, and the DH group had a higher frequency of intravenous antibiotic treatment in the 4 years after CPETs. Peak VO2 was also correlated with lung function deterioration and intravenous antibiotic treatment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Plant Sciences
Azam Alavinezhad, Vahideh Ghorani, Omid Rajabi, Mohammad Hossein Boskabady
Summary: Zataria multiflora extract showed significant therapeutic effects on asthma patients by reducing respiratory symptoms, improving pulmonary function, and suppressing inflammation.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
R. A. Faria, C. L. Goulart, P. B. Santos, R. S. Marinho, S. M. Firmino, F. P. G. Rizzatti, R. G. Mendes, A. Borghi-Silva, M. G. Roscani
Summary: The dilation of the right ventricle is associated with unfavorable prognostic markers in COPD, including worsening functional capacity and more frequent exacerbations. The study found correlations between RVDD and forced vital capacity and distance in the 6MWT in patients with exacerbation.
Article
Respiratory System
Cyndi Henry, Magali Boucher, Marie-Eve Boulay, Andreanne Cote, Louis-Philippe Boulet, Ynuk Bosse
Summary: This study used oscillometry to assess the cumulative effect of methacholine on large and small airways in the absence of deep inspirations. The results showed that methacholine has a cumulative effect on small airways but not on large airways.
Review
Medicine, General & Internal
Leona Dowman, Catherine J. Hill, Anthony May, Anne E. Holland
Summary: This study aims to determine the benefits and safety of pulmonary rehabilitation for ILD patients. The results show that pulmonary rehabilitation may improve exercise capacity, dyspnea, and quality of life in ILD patients, especially in those with IPF.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Medicine, General & Internal
Oh-Beom Kwon, Chang-Dong Yeo, Hwa-Young Lee, Hye-Seon Kang, Sung-Kyoung Kim, Ju-Sang Kim, Chan-Kwon Park, Sang-Haak Lee, Seung-Joon Kim, Jin-Woo Kim
Summary: Chronic obstructive pulmonary disease (COPD) is frequently seen in patients with non-small cell lung cancer (NSCLC), and lung hyperinflation is associated with postoperative lung function. This study found that a preoperative residual volume/total lung capacity of >= 40% is an independent predictor of preserved lung function after lung cancer surgery.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Geriatrics & Gerontology
Haoyu Zou, Yuelan Qin, Fanghua Gong, Juan Liu, Jie Zhang, Liuyi Zhang
Summary: The ABCDEF pulmonary rehabilitation program has positive effects on improving lung function, exercise tolerance, and postoperative recovery in patients with lung cancer who have undergone thoracoscopic pneumonectomy.
Article
Multidisciplinary Sciences
Oystein Rasch-Halvorsen, Erlend Hassel, Ben M. Brumpton, Haldor Jenssen, Martijn A. Spruit, Arnulf Langhammer, Sigurd Steinshamn
Summary: This study aimed to assess the association of FEV1Z-score with VO2peak in COPD and investigate whether this association differs between emphysema (E-COPD) and non-emphysema (NE-COPD) phenotypes. The results showed that FEV1Z-score is positively associated with VO2peak, with a stronger association seen in E-COPD but no statistically significant difference by phenotype.
Article
Multidisciplinary Sciences
Jyotika Erram, Monica Bari, Antoinette Domingo, Daniel T. Cannon
Summary: Expiratory loading reduced FEV1, FVC, and PEF in healthy adults, but did not significantly affect FEV1/FVC, FRC, or RAR. This suggests that threshold loading may be a useful strategy to alter work of breathing without major impacts on key pulmonary function parameters.
Article
Computer Science, Interdisciplinary Applications
Grzegorz Mikolajowski, Malgorzata Palac, Pawel Linek
Summary: The study aims to present a newly developed and automatic measurement procedure to directly control airflow and simultaneously collect ultrasound images at the programmed breathing phase. The experiment was conducted on 10 healthy individuals, comparing the measurements obtained manually with an external device controlling the peak phases of tidal inspiration and expiration. Results suggest that the measurement procedure may affect the interpretation of results, with the TrA shear modulus being the most vulnerable to errors related to the measurement procedure.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Apurba Barman, Mithilesh K. Sinha, Jagannatha Sahoo, Debasish Jena, Vikas Patel
Summary: The study evaluated the efficacy and safety of respiratory rehabilitation in patients recovering from SARS. Results showed that respiratory rehabilitation significantly improved exercise capacity and pulmonary function test parameters in SARS patients, with no significant adverse events reported. However, the improvement in activities of daily living and quality of life outcomes were limited. Further clinical trials are needed to determine the optimal respiratory rehabilitation program for SARS patients.
Review
Medicine, General & Internal
Shuangtao Xing, Shijie Feng, Dan Zeng
Summary: This study compared the effects of different types of exercise on pulmonary function in adult patients with asthma through Network Meta-analysis. The results showed that breathing training, aerobic training, relaxation training, yoga training, and breathing combined with aerobic training significantly improved Forced Expiratory Volume in the first second (FEV1) levels; aerobic training, breathing training, yoga training, and breathing combined with aerobic training improved Forced Vital Capacity (FVC) levels; breathing training, aerobic training, relaxation training, yoga training, and breathing combined with aerobic training improved Peak Expiratory Flow (PEF) levels; breathing training, aerobic training, and yoga training improved Forced Expiratory Volume in the first second/Forced Vital Capacity (FEV1/FVC) levels.
ANNALS OF MEDICINE
(2023)
Review
Chemistry, Medicinal
Katarzyna Kaczynska, Monika Jampolska, Piotr Wojciechowski, Dorota Sulejczak, Kryspin Andrzejewski, Dominika Zajac
Summary: Lactoferrin (LF) is a versatile glycoprotein with various properties that can be used to treat lung diseases. Although in vitro and in vivo studies show significant potency of LF in treating lung diseases, its effectiveness in human studies is only confirmed for respiratory tract infections. For other diseases such as lung cancer, COVID-19, and sepsis, the reports are conflicting, and there is a lack of conclusive human studies on the beneficial effects of LF.
Review
Medicine, General & Internal
Annamaria Bosi, Roberto Tonelli, Ivana Castaniere, Enrico Clini, Bianca Beghe
Summary: Patients with acute asthma attack often present to the emergency room with severe functional impairment despite low symptom perception. Early functional assessment focusing on vital parameters, respiratory function, and perceived dyspnea is crucial. Treatment planning and patient education are equally important, significantly impacting long-term outcomes of asthma.
Article
Cardiac & Cardiovascular Systems
Habibe Durdu, Rengin Demir, Melih Zeren, Pinar Basturk, Hidayet Ozan Arabaci, Umit Yasar Sinan, Mehmet Serdar Kucukoglu
Summary: Accessory respiratory muscles, especially the serratus anterior, are significantly weakened in patients with pulmonary arterial hypertension (PAH), which affects exercise capacity. A model including serratus anterior, sternocleidomastoid, and maximal inspiratory pressure is the best predictor for exercise tolerance. Respiratory muscles cannot predict dyspnea, but the strength of the pectoralis muscles and serratus anterior is correlated with daily activity and dyspnea.
Article
Physiology
Timothy J. Fulton, Marissa N. Baranauskas, Robert F. Chapman
Summary: This study aims to determine whether participation and/or advancement at an athlete's first World Championship/Olympic Games affect the likelihood of winning medals in the future. The results suggest that advancing out of the initial round in the first competition is associated with increased odds of future medaling.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2022)
Article
Sport Sciences
Curtis S. Goss, Joel T. Greenshields, Tyler J. Noble, Robert F. Chapman
Summary: This study analyzed the finishing time trends of the top 100 performers in men's and women's marathon, half-marathon, and road 10-km races from 2001 to 2019. The results suggest that recent world record performances are influenced by overall circumstances rather than individual runners' outstanding physiology.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Physiology
Ren-Jay Shei, Hunter L. Paris, Abigail S. Sogard, Timothy D. Mickleborough
Summary: Inspiratory muscle training (IMT) is a method aimed at improving respiratory muscle strength and endurance. However, its effects vary between different populations. The use of standardized IMT protocols may overlook individual characteristics and training needs. Therefore, a more personalized approach to IMT training, based on individual goals and desired outcomes, may be more effective.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Michael A. Coyle, Curtis S. Goss, Wesley J. Manz, Joel T. Greenshields, Robert F. Chapman, Joel M. Stager
Summary: This study found that histamine plays a role in the development of exercise-induced arterial hypoxemia (EIAH) during intense exercise in highly trained athletes. The use of the mast cell stabilizer nedocromil sodium (NS) and H-1-receptor antagonist diphenhydramine HCL (DH) can improve EIAH and increase arterial oxyhemoglobin saturation (SaO2).
PHYSIOLOGICAL REPORTS
(2022)
Review
Physiology
Ren-Jay Shei, Ian G. Holder, Alicia S. Oumsang, Brittni A. Paris, Hunter L. Paris
Summary: Wearable devices are popular in the health and fitness field, but there are inconsistencies in their accuracy and reliability. Further evaluation is needed to assess their efficacy and standardize validation metrics and algorithms.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ren-Jay Shei, Marissa N. Baranauskas
Summary: Inhaled nitric oxide (iNO) is a potent vasodilator that has been approved for use in certain conditions, but its use in coronavirus disease 2019 (COVID-19) related acute respiratory distress syndrome (ARDS) is not supported by randomized controlled trial data. Presently, the available data are mainly derived from retrospective and cohort studies.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2022)
Article
Physiology
Annika Astrand, Emily Falk Libby, Ren-Jay Shei, Jacelyn E. Peabody Lever, Niroop Kaza, Adegboyega Timothy Adewale, Evan Boitet, Lloyd Edwards, Martin Hemmerling, James Root, Botilda Lindberg, Cecilia Wingren, Anna Malmgren, Juan Sabater, Steven M. Rowe
Summary: Airway dehydration in cystic fibrosis (CF) leads to mucus stasis and bacterial overgrowth, causing recurrent respiratory infections. Inhibition of the epithelial sodium channel (ENaC) can improve mucociliary clearance and reduce the risk of lung function decline. This study evaluated the effects of AZD5634, an ENaC inhibitor, in healthy and CF preclinical models. The results showed that AZD5634 effectively increased airway surface liquid volume and improved mucociliary transport rate. However, nebulization of AZD5634 did not significantly improve airway hydration or mucus clearance in CF rats.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2022)
Article
Physiology
Olivier Girard, Benjamin D. Levine, Robert F. Chapman, Randall Wilber
Summary: Altitude training is crucial for the success of elite endurance athletes. The Live High-Train Low (LHTL) model, which combines acclimatization to hypoxia with high-intensity training at low altitude, has been widely used since 1997. This review discusses important considerations for successfully implementing LHTL camps in elite athletes, including optimal dose, individual responses, iron status, training-load monitoring, and the timing of intervention.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Article
Physiology
Olivier Girard, Sebastien Racinais
Summary: The purpose of this study was to compare the effects of graded hypoxia on subsequent rapid and maximal torque-production capacity during exhaustive intermittent cycling. The results showed that both normoxia and moderate to severe hypoxia significantly reduced the rate of torque development of the knee extensors during intense intermittent cycling. Rating: 7 out of 10.
INTERNATIONAL JOURNAL OF SPORTS PHYSIOLOGY AND PERFORMANCE
(2023)
Review
Sport Sciences
Qian Yu, Zhaowei Kong, Liye Zou, Robert Chapman, Qingde Shi, Jinlei Nie
Summary: This study compared the efficacy of seven common hypoxic training paradigms on maximal oxygen consumption (VO2max) and explored related moderating factors. The results showed that the optimal hypoxic training paradigms differed between athletes and non-athletes, with intermittent hypoxia interval training (IHIT) being most effective for athletes and intermittent hypoxic training (IHT) being most promising for non-athletes. Saturation hours were found to be a significant factor affecting the improvements in VO2max induced by IHT.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Biochemistry & Molecular Biology
Rachel Tan, Marissa N. Baranauskas, Sean T. Karl, Joaquin Ortiz de Zevallos, Ren-Jay Shei, Hunter L. Paris, Chad C. Wiggins, Stephen J. Bailey
Summary: There is evidence to suggest that dietary nitrate supplementation can increase muscular power output during skeletal muscle contractions. However, more research is needed to understand the impact of different nitrate dosing regimens on nitric oxide bioavailability and its potential effects across different populations. This review discusses the potential influence of different dietary nitrate supplementation strategies on nitric oxide bioavailability and muscular power output in various population groups and suggests further research areas.
NITRIC OXIDE-BIOLOGY AND CHEMISTRY
(2023)
Article
Biophysics
Marissa N. Baranauskas, Timothy J. Fulton, Alyce D. Fly, Bruce J. Martin, Timothy D. Mickleborough, Robert F. Chapman
Summary: This study found that there is a high intraindividual variability in the response of serum erythropoietin to multiple simulated altitude exposures. Athletes who regularly use simulated altitude methods should expect inconsistent EPO responses to intermittent exposures lasting <= 12 hours.
HIGH ALTITUDE MEDICINE & BIOLOGY
(2022)
Article
Psychology, Developmental
Madeleine K. Nowak, Keisuke Ejima, Patrick D. Quinn, Jeffrey J. Bazarian, Timothy D. Mickleborough, Jaroslaw Harezlak, Sharlene D. Newman, Keisuke Kawata
Summary: This study aimed to examine whether individuals with ADHD have reduced tolerance to subconcussive head impacts induced by soccer headings. The results showed that verbal memory declined transiently in the ADHD group after ten controlled soccer headings, while the non-ADHD group improved both verbal and visual memory functions. Blood biomarker levels were sensitive to the stress of ten headings in the ADHD group. These findings suggest that ADHD may decrease brain tolerance to repetitive subconcussive head impacts.
JOURNAL OF ATTENTION DISORDERS
(2022)
Article
Nutrition & Dietetics
Matthew J. Barenie, Jessica A. Freemas, Marissa N. Baranauskas, Curtis S. Goss, Kadie L. Freeman, Xiwei Chen, Stephanie L. Dickinson, Alyce D. Fly, Keisuke Kawata, Robert F. Chapman, Timothy D. Mickleborough
Summary: The study aimed to compare the effects of green-lipped mussel oil and krill oil on exercise-induced muscle damage, with ESPO-572(R) showing at least as good results as PCSO-524(R) in reducing DOMS increase and protecting joint ROM.
JOURNAL OF DIETARY SUPPLEMENTS
(2022)