Review
Clinical Neurology
Samantha-Su Taylor, Nazir Noor, Ivan Urits, Antonella Paladini, Monica Sri Sandhu, Clay Gibb, Tyler Carlson, Dariusz Myrcik, Giustino Varrassi, Omar Viswanath
Summary: CRPS is a chronic pain condition with hyperalgesia and allodynia of the extremities. It is divided into CRPS-I and CRPS-II. Risk factors include female gender, fibromyalgia, and rheumatoid arthritis. Pathogenesis is not yet clarified but may involve neuropathic inflammation and autonomic nervous system involvement. Treatment options range from physical therapy to pharmacotherapy with varying levels of effectiveness. More research is needed to better understand and treat this multifactorial condition.
Article
Medicine, General & Internal
Abdelkarim S. Aloweidi, Sami A. Abu Halaweh, Mahmoud M. Al-Mustafa, Islam M. Massad, Ibraheem Y. Qudaisat, Aws M. Khanfar, Jihad M. Ajlouni, Shaher T. Alhadidi, Ahmad I. El-Share, Mohammad A. Jarbeh, Anas A. Al-Oweidi
Summary: This study investigated the reduction in pain scores after treatment with a combination of IVRA and SGB for CRPS patients. It was found that the combination treatment was effective for most patients, with higher success rates in patients with previous plaster of Paris application.
SAUDI MEDICAL JOURNAL
(2022)
Article
Anesthesiology
Christelle D. K. Samen, Olivia M. Sutton, Ambrose E. Rice, Munfarid A. Zaidi, Ingharan J. Siddarthan, Stephanie D. Crimmel, Steven P. Cohen
Summary: The study found a weak correlation between temperature increase after sympathetic block and immediate pain relief. Patients with greater temperature increases reported more significant immediate pain reduction. There was no significant correlation between temperature increase and intermediate-term pain score reduction, as well as between immediate and intermediate-term pain relief.
Article
Chemistry, Multidisciplinary
Larisa Ryskalin, Giulia Ghelarducci, Chiara Marinelli, Gabriele Morucci, Paola Soldani, Nicolo Bertozzi, Paolo Annoscia, Andrea Poggetti, Marco Gesi
Summary: This study retrospectively reviewed the effectiveness of a rehabilitative treatment algorithm for CRPS and found that the rehabilitation protocol significantly improved pain and quality of life scores. Early and skilled rehabilitation intervention is of paramount importance for managing CRPS type 1.
APPLIED SCIENCES-BASEL
(2022)
Article
Anesthesiology
R. Norman Harden, Candida S. McCabe, Andreas Goebel, Michael Massey, Tolga Suvar, Sharon Grieve, Stephen Bruehl
Summary: There have been modest advancements in Complex Regional Pain Syndrome research, but the overall quantity and quality of work in this field remains low. The rarity of the disease makes it difficult to gather a sufficient sample size for statistical significance using traditional approaches. However, researchers are using semi-systematic reviews and including data from various sources to tailor treatment regimes for patients.
Review
Medicine, General & Internal
Antimo Moretti, Francesca Gimigliano, Marco Paoletta, Matteo Bertone, Sara Liguori, Giuseppe Toro, Giovanni Iolascon
Summary: Complex regional pain syndrome type I, also known as algodystrophy, is a rare disease characterized by severe pain, functional limitations, and sensory and vasomotor alterations. While some cases may not have an obvious trigger event, comprehensive clinical evaluations and patient history analysis are crucial for accurate diagnosis.
Review
Clinical Neurology
Gerard Limerick, Dana K. K. Christo, Jennifer Tram, Roya Moheimani, John Manor, Krishnan Chakravarthy, Jay Karri, Paul J. J. Christo
Summary: This review presents the most current information about the epidemiology, classification, diagnostic criteria, pathophysiology, treatments, and preventive strategies of complex regional pain syndrome (CRPS).
CURRENT PAIN AND HEADACHE REPORTS
(2023)
Article
Anesthesiology
Steven P. Cohen, Chachrit Khunsriraksakul, Yongjae Yoo, Evan Parker, Christelle D. K. Samen-Akinsiku, Nirav Patel, Seffrah J. Cohen, Xiaoning Yuan, Jianguo Cheng, Jee Youn Moon
Summary: This study aimed to determine factors associated with response to ketamine infusion. The results showed that pain relief after sympathetic blocks and post-block temperature increase were positively associated with response to ketamine infusion, while psychiatric factors were not associated with treatment response.
Article
Anesthesiology
Johann Lambeck, Eva M. Kesenheimer, Barbara Kleinmann, Matthias Reinhard
Summary: The tourniquet ischemia test has high positive predictive value for the diagnosis of CRPS, but low sensitivity, making it useful as a confirmatory assay rather than a screening test in patients with suspected CRPS.
Article
Multidisciplinary Sciences
Jae-Ik Lee, Soon-Woo Kwon, Ahry Lee, Woo-suk Tae, Sung-Bom Pyun
Summary: The study found that the head of the caudate nucleus, putamen, and white matter complexes in the corona radiata were significantly associated with the development of poststroke CRPS. Clinical characteristics of patients in the poststroke CRPS group included lower muscle strength and impaired cognitive and sensory function, which may aid in the prevention and early treatment of poststroke CRPS.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Jayantee Kalita, Prakash C. Pandey, Ruchi Shukla, Usha K. Misra
Summary: The efficacy and safety of 20 mg prednisolone is comparable to 40 mg prednisolone in treating CRPS-I, and it is safe for diabetic patients.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Review
Anesthesiology
Amol Soin, Yasmeen Soin, Tammy Dann, Ricardo Buenaventura, Kris Ferguson, Sairam Atluri, Harsh Sachdeva, Gururau Sudarshan, Humam Akbik, Jordan Italiano
Summary: The systematic qualitative review evaluated the evidence for the use of low-dose naltrexone in treating chronic pain syndromes, showing a positive association with symptom relief. Additional prospective and interventional studies are needed due to the limited number of available articles on treating complex regional pain syndrome with low-dose naltrexone.
Review
Medicine, Research & Experimental
Mark A. Chmiela, Mark Hendrickson, Jason Hale, Chen Liang, Phillip Telefus, Afrin Sagir, Michael Stanton-Hicks
Summary: The study demonstrates that implantable PNS systems are effective in treating CRPS patients, improving function and reducing long-term pain. While a portion of patients require surgical revisions or implantation of a second PNS system, the majority are able to continue using the PNS system within the institution.
Review
Pharmacology & Pharmacy
Thomas J. P. Mangnus, Krishna D. Bharwani, Maaike Dirckx, Frank J. P. M. Huygen
Summary: This article provides an overview of current and future pharmacotherapeutic options for Complex Regional Pain Syndrome (CRPS) and emphasizes the importance of understanding the underlying mechanisms of CRPS in order to target treatment approaches effectively. The use of objective biomarkers may aid in selecting mechanism-based drugs for improved treatment outcomes in the future.
Review
Clinical Neurology
Yu Liu, Ying Liang, Min Gao, Yingchun Li, Tingting Zhao, Yani Zhao
Summary: CRPS is a chronic pain disorder with unclear pathogenesis, but effective animal models are helpful in research and treatment. Multiple CRPSI animal models have been established, with ongoing improvements in modeling methods.
JOURNAL OF PAIN RESEARCH
(2021)