Article
Hematology
Eugenia Biguzzi, Simona Maria Siboni, Saskia le Cessie, Luciano Baronciani, Frits R. Rosendaal, Astrid van Hylckama Vlieg, Flora Peyvandi
Summary: The study evaluated the differential increase of VWF and FVIII:C with age among different ages and types of VWD.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Justine H. Ryu, Kenneth A. Bauer, Sol Schulman
Summary: This report describes the successful perioperative management of a patient with type 2N VWD using the recombinant FVIII product efanesoctocog alfa. By decoupling the FVIII-VWF interaction, efanesoctocog alfa achieves prolonged FVIII circulation and mitigates potential cardiovascular risks.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Review
Cell Biology
Angelika Mojzisch, Maria A. Brehm
Summary: Von Willebrand factor (VWF) is synthesized exclusively in endothelial cells and megakaryocytes, and plays multiple roles in cellular processes such as angiogenesis, leukocyte adhesion, and tumor cell metastasis. Its dysregulation can lead to various pathophysiological consequences.
Article
Biochemistry & Molecular Biology
Yuanyuan Wang, Xiaobo Liu, Tobias Obser, Alexander T. Bauer, Martin Heyes, Sarah Starzonek, Mina Zulal, Karena Opitz, Leonie Ott, Sabine Riethdorf, Tobias Lange, Klaus Pantel, Gerd Bendas, Stefan W. Schneider, Marion Kusche-Gullberg, Christian Gorzelanny
Summary: In this study, it was found that the exposure of HS on the surface of blood circulating melanoma cells recruited a significant amount of plasmatic vWF, forming a tight molecular complex. The length of HS chains or the absence of HS was associated with reduced vWF encapsulation. The vWF-HS complex prevented vascular adhesion and promoted the repulsion of circulating cancer cells from the blood vessel wall. Cancer cells with low HS levels evaded recognition by vWF and were prone to form metastases.
Article
Hematology
Wenjing Cao, Aria R. Trask, Antonia I. Bignotti, Lindsey A. George, Bhavya S. Doshi, Denise E. Sabatino, Noritaka Yada, Liang Zheng, Rodney M. Camire, X. Long Zheng
Summary: This study aims to determine the effect of FVIII on VWF proteolysis and homeostasis. Through mouse models, recombinant FVIII infusion, and patients with hemophilia A, the study concludes that FVIII plays a pivotal role in regulating VWF proteolysis and homeostasis under various conditions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Hematology
Sukhraj Pal Singh Dhami, Sean Patmore, Claire Comerford, Ciara M. Byrne, Brenton Cavanagh, John Castle, Cliona C. Kirwan, Martin Kenny, Ingmar Schoen, James S. O'Donnell, Jamie M. O'Sullivan
Summary: Breast cancer patients with elevated plasma VWF levels are associated with poorer survival. Breast cancer cells induce ECs to secrete VWF and other substances, and this effect is enhanced by the presence of platelets. VEGF-A plays a crucial role in modulating breast cancer-induced VWF release, and VEGF-A released by breast tumor cells also promotes angiogenesis in ECs. LMWH can inhibit VWF-breast tumor adhesion and transendothelial migration.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Cardiac & Cardiovascular Systems
Carlo R. Bartoli, Samson Hennessy-Strahs, Robert D. Dowling, J. William Gaynor, Andrew C. Glatz
Summary: Children with a bidirectional superior cavopulmonary (Glenn) circulation show abnormalities in global angiogenic signaling, vWF metabolism, and angiopoietins, which may contribute to the development of pulmonary AVMs. Targeting the vWF-angiopoietin axis could potentially correct angiogenic imbalance in Glenn patients, for whom no targeted therapy currently exists.
JACC-BASIC TO TRANSLATIONAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Juan A. De Pablo-Moreno, Luis Javier Serrano, Luis Revuelta, Maria Jose Sanchez, Antonio Liras
Summary: The vascular endothelium plays a crucial role in hemostasis, maintaining a delicate balance between procoagulant and anticoagulant proteins, as well as fibrinolytic and antifibrinolytic factors. Coagulation disorders can be caused by mutations in coagulation factors or disruptions in the regulatory mechanisms. Treatment options include replacement and nonreplacement therapies, as well as administration of antifibrinolytic agents. Targeted therapies, such as monoclonal antibodies and interfering RNA therapies, are also being developed. The treatment approach for thrombophilia, disseminated intravascular coagulation, and severe thrombophilia varies depending on the specific condition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Liang Zheng, Liyun Cao, X. Long Zheng
Summary: This study reveals the protective role of ADAMTS13 or lack of VWF in reducing irradiation and melanoma-induced thrombotic microangiopathy and mortality. The microenvironment created by plasma ADAMTS13 or lack of VWF may affect melanoma cell phenotypes through alteration of oxidation-reduction and lipid metabolic pathways.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Jerzy Windyga, Benoit Guillet, Lucia Rugeri, Alexandra Fournel, Ewa Stefanska-Windyga, Valerie Chamouard, Sonia Pujol, Celine Henriet, Francoise Bridey, Claude Negrier
Summary: This study evaluated the hemostatic efficacy and safety of continuous infusion of pdFVIII and pdVWF in patients with HA and VWD undergoing surgery.
THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Oncology
Xin Li, Zhong Lu
Summary: Lung adenocarcinoma (LUAD) is a highly prevalent and deadly disease globally, and its growth and metastasis rely on angiogenesis. Recent evidence suggests that Von Willebrand factor (VWF) inhibits angiogenesis through regulation of angiopoietin-2 and integrin alpha v beta 3. LUAD patients exhibit an increased plasma VWF/ADAMTS-13 ratio, indicating the potential of VWF as a diagnostic indicator and therapeutic target for LUAD.
Article
Health Care Sciences & Services
Chanukya K. Colonne, Emmanuel J. Favaloro, Leonardo Pasalic
Summary: von Willebrand factor (VWF) and ADAMTS13 play important roles in normal hemostasis and can be involved in abnormal hemostasis in malignancy. VWF may also contribute to inflammation, angiogenesis, tumor biology, and tumor metastasis. VWF and ADAMTS13 have been explored as tumor biomarkers, but their clinical utility is currently limited. Further studies are needed to understand the relationships between VWF, ADAMTS13, and malignancy.
Article
Hematology
Eugenia Biguzzi, Filippo Castelli, Willem M. Lijfering, Suzanne C. Cannegieter, Jeroen Eikenboom, Frits R. Rosendaal, Astrid van Hylckama Vlieg
Summary: VWF:Ag and FVIII:C levels increase with age, with carriers of non-O blood group showing a steeper increase that is mediated by acquired factors. Differences in increase between blood groups are annulled after adjustment for acquired factors.
THROMBOSIS RESEARCH
(2021)
Article
Physiology
Helena A. Turton, Josephine Pickworth, Gordon G. Paterson, Allan Lawrie, J. Kenneth Baillie, A. A. Roger Thompson
Summary: High altitude exposure leads to increased levels of plasma P-selectin and vWF, with a strong positive correlation between the two markers. These changes are not solely attributed to an increase in platelet count.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Po-Chia Chen, Fabian Kutzki, Angelika Mojzisch, Bernd Simon, Emma-Ruoqi Xu, Camilo Aponte-Santamaria, Kai Horny, Cy Jeffries, Reinhard Schneppenheim, Matthias Wilmanns, Maria A. Brehm, Frauke Graeter, Janosch Hennig
Summary: Von Willebrand disease is a bleeding disorder associated with mutations in the VWF gene. This study investigates the structure and dynamics of the C6 domain and the G2705R variant in C6, using nuclear magnetic resonance spectroscopy, molecular dynamics simulations and aggregometry. The findings show that the G2705R mutation destabilizes VWF by promoting hinging between the subdomains of C6.
JOURNAL OF STRUCTURAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
K. Nowak, F. Sandra-Petrescu, S. Post, K. Horisberger
COLORECTAL DISEASE
(2015)
Article
Urology & Nephrology
Urs Benck, Peter Schnuelle, Bernd Krueger, Kai Nowak, Thomas Riester, Heiko Mundt, Niklas Lutz, Matthias Jung, Rainer Birck, Bernhard K. Kraemer, Wilhelm H. Schmitt
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Anita Ongherth, Sebastian Pasch, Christina M. Wuertz, Karolin Nowak, Naim Kittana, Cleo A. Weis, Aline Jatho, Christiane Vettel, Malte Tiburcy, Karl Toischer, Gerd Hasenfuss, Wolfram-Hubertus Zimmermann, Thomas Wieland, Susanne Lutz
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2015)
Article
Immunology
J. Haas, T. Singer, K. Nowak, J. Brust, U. Goettmann, P. Schnuelle, B. Krueger, B. K. Kraemer, U. Benck
TRANSPLANTATION PROCEEDINGS
(2015)
Article
Medicine, General & Internal
Ulrich Ronellenfitsch, Antonia Dimitrakopoulou-Strauss, Jens Jakob, Bernd Kasper, Kai Nowak, Lothar R. Pilz, Ulrike Attenberger, Timo Gaiser, Gerlinde Egerer, Stefan Froehling, Hans-Guenter Derigs, Matthias Schwarzbach, Peter Hohenberger
Article
Oncology
Ioannis Karampinis, Elena Joas, Anna Dreyer, Ulrich Ronellenfitsch, Jens Jakob, Peter Hohenberger, Kai Nowak
Article
Oncology
Jens Jakob, Per-Ulf Tunn, Andrew J. Hayes, Lothar R. Pilz, Kai Nowak, Peter Hohenberger
JOURNAL OF SURGICAL ONCOLOGY
(2014)
Article
Oncology
Julia Valerie Rotert, Joerg Leupold, Peter Hohenberger, Kai Nowak, Heike Allgayer
JOURNAL OF SURGICAL ONCOLOGY
(2014)
Article
Oncology
Christos Sachpekidis, Ioannis Karampinis, Jens Jakob, Bernd Kasper, Kai Nowak, Lothar Pilz, Ulrike Attenberger, Timo Gaiser, Hans-Guenter Derigs, Matthias Schwarzbach, Peter Hohenberger, Antonia Dimitrakopoulou-Strauss, Ulrich Ronellenfitsch
Article
Medicine, General & Internal
Andreas L. H. Gerken, Kai Nowak, Alexander Meyer, Maximilian C. Kriegmair, Christel Weiss, Bernhard K. Kraemer, Pauline Glossner, Katharina Heller, Ioannis Karampinis, Frank Kunath, Nuh N. Rahbari, Kay Schwenke, Christoph Reissfelder, Werner Lang, Ulrich Rother
Summary: This study aimed to evaluate the predictive power of quantitative indocyanine green (ICG) fluorescence angiography and found that the ingress of ICG was associated with the occurrence of ureterovesical anastomosis complications. The proposed definition and grading of complications enable valid comparisons between studies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
U. Ronellenfitsch, M. Schwarzbach, R. Hofheinz, P. Kienle, K. Nowak, M. Kieser, T. E. Slanger, B. Butmeister, D. Kelsen, D. Niedzwiecki, C. Schuhmacher, S. Urba, C. van de Velde, T. N. Walsh, M. Ychou, K. Jensen
Article
Cardiac & Cardiovascular Systems
Ioannis Karampinis, Stefan Pfleger, Kai Nowak
JOURNAL OF INVASIVE CARDIOLOGY
(2013)
Article
Medicine, Research & Experimental
Kai Nowak, Roderich Boenninghoff, Michael Geiger, Stefan Post, Peter Schnuelle, Mathias Schwarzbach
Article
Medicine, Research & Experimental
Christine Dacho, Andreas Dacho, Antje Geissler, Charlotte Hauser, Kai Nowak, Grietje Beck