Review
Biochemistry & Molecular Biology
Selvaraj Vimalraj
Summary: Angiogenesis is the formation of new blood vessels from existing ones. Abnormal angiogenesis, seen in tumor microenvironments, is characterized by distorted and leaky blood vessels with various shapes and high perfusion efficiency. Tumor angiogenesis plays a crucial role in cancer growth, invasion, and metastasis, and is tightly regulated by signaling networks. Targeting multiple signaling pathways involved in angiogenesis is important for effective antiangiogenic therapy. New therapeutic approaches, such as blocking specific proteins or genes, are being explored to dissect alternative angiogenesis mechanisms in tumor microenvironments.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Article
Biotechnology & Applied Microbiology
Alessandro Certelli, Paolo Valente, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Rosalinda D'Amico, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: In diabetic mouse skin, controlled co-delivery of TG-VEGF and TG-PDGF-BB recombinant proteins effectively induces angiogenesis and arteriogenesis, with similar efficacy to normal littermate control mice at therapeutically relevant doses. This approach also prevents abnormal vascular enlargement caused by high TG-VEGF levels and promotes effective arteriogenesis in the dermal layer.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
William Lory, Bridgette Wellslager, Chao Sun, Ozlem Yilmaz, Hong Yu
Summary: S1PR2 antagonist JTE013 enhances expression of VEGFA, PDGFA, and GDF15 genes, activates TGFβ/Smad and Akt signaling, and promotes angiogenesis and alveolar bone regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Rosalinda D'Amico, Camilla Malucelli, Andrea Uccelli, Andrea Grosso, Nunzia Di Maggio, Priscilla S. Briquez, Jeffrey A. Hubbell, Thomas Wolff, Lorenz Gurke, Edin Mujagic, Roberto Gianni-Barrera, Andrea Banfi
Summary: Chronic wounds in type-2 diabetic patients often have severe local skin ischemia despite normal blood flow. By using fibrin hydrogels decorated with engineered growth factors, wound closure and microvascular growth can be promoted.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Cell Biology
Hiroyuki Ogawa, Kosuke Kaji, Norihisa Nishimura, Hirotetsu Takagi, Koji Ishida, Hiroaki Takaya, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Takemi Akahane, Hitoshi Yoshiji
Summary: Lenvatinib shows potential as a novel therapeutic strategy for liver fibrosis by inhibiting hepatic stellate cell proliferation and promoting apoptosis, as well as reducing protein expression levels and intrahepatic neovascularization.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Filipa Lopes-Coelho, Filipa Martins, Sofia A. Pereira, Jacinta Serpa
Summary: Anti-angiogenic therapy aims to fight cancer by disrupting the nutrient and oxygen supply to tumor cells, mainly by targeting vascular endothelial growth factor (VEGF). While some drugs in this category can enhance immune therapy, they often fall short in terms of efficacy. Researchers believe that targeting alternative angiogenic pathways in combination could be a promising solution.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Zhenbo Shi, Jian Tu, Ying Ying, Yunlian Diao, Ping Zhang, Shu Liao, Zhijuan Xiong, Shibo Huang
Summary: CCL2, a proinflammatory chemokine, plays a crucial role in regulating the migration and infiltration of inflammatory cells and promoting tumorigenesis in the tumor microenvironment. Recent studies have shown its involvement in the development of resistance to various anticancer agents, and its mechanisms include inhibiting drug-induced apoptosis, antiangiogenesis, and antitumor immunity. Understanding the role and mechanisms of CCL2 in anticancer drug resistance may lead to new therapeutic targets for overcoming cancer resistance.
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Medicine, Research & Experimental
Nima Beheshtizadeh, Maliheh Gharibshahian, Mohammad Bayati, Reza Maleki, Hannah Strachan, Sarah Doughty, Lobat Tayebi
Summary: The utilization of growth factors in tissue regeneration has been extensively researched, but satisfactory outcomes have been elusive. Trials with regulated administration of growth factors have produced the most satisfactory results. The delivery of delicate growth factors like Vascular Endothelial Growth Factor (VEGF) remains challenging. The objective of this review is to present and assess different VEGF administration mechanisms and evaluate appropriate dosages for various applications.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Kesavan R. Arya, Ramachandran P. Bharath Chand, Chandran S. Abhinand, Achuthsankar S. Nair, Oommen V. Oommen, Perumana R. Sudhakaran
Summary: The study reanalyzed gene expression data of bevacizumab-resistant glioblastoma multiforme (GBM) tumors and identified differentially expressed genes (DEGs) enriched in processes such as angiogenesis, cell proliferation, and apoptosis. Protein-protein interaction network analysis revealed 21 hub genes associated with cancer pathways and survival analysis showed three upregulated hub genes linked to poor survival, suggesting potential therapeutic targets and biomarkers for anti-VEGF resistance in GBM.
Article
Peripheral Vascular Disease
Khushbu Rauniyar, Honey Bokharaie, Michael Jeltsch
Summary: This study comprehensively analyzed the evolutionary relationships of PDGF/VEGF growth factors and proposed a phylogenetic tree. Whole-genome duplications in vertebrates contribute to the diversity of PDGF/VEGF, but limited duplications are necessary to explain the emergence pattern. The oldest phylogenetically PDGF/VEGF-like growth factor likely had a BR3P signature in the C-terminus, similar to modern lymphangiogenic growth factors. Some younger VEGF genes are absent in specific vertebrate clades, while PDGF/VEGF gene duplications frequently occur in fish on top of fish-specific whole-genome duplications.
Article
Cell Biology
Marina Katsman, Aviva Azriel, Guy Horev, Yitzhak Reizel, Ben-Zion Levi
Summary: The study reveals the crucial role of N-VEGF as an autoregulatory arm of VEGF-A in angiogenesis and cell survival under hypoxic conditions.
Review
Oncology
Fatema Tuz Zahra, Md. Sanaullah Sajib, Constantinos M. Mikelis
Summary: Anti-angiogenic therapies targeting VEGF signaling have shown temporary benefits in cancer treatment, with resistance often developing due to the upregulation of other growth factors like bFGF. Recent efforts have focused on developing multi-target anti-angiogenic drugs to overcome resistance mechanisms and improve outcomes in clinical practice.
Article
Medicine, Research & Experimental
Xue Dong, Yi Lei, Zeyang Yu, Tian Wang, Yi Liu, Gang Han, Xiaodan Zhang, Yiming Li, Yinting Song, Heping Xu, Mei Du, Haifang Yin, Xiaohong Wang, Hua Yan
Summary: The study utilized exosomes (EXOs) as carriers for delivering the anti-angiogenic peptide KV11 via retro-orbital injection, showing enhanced suppression of neovascularization and vascular leakage in the retina. This system has the potential to treat proliferative retinopathy in a less invasive manner compared to intravitreal injection.
Article
Medicine, Research & Experimental
Jin Yao, Li-Li Hu, Xiu-Miao Li, Kun Shan, Rong-Mei Zhou, Hui-Min Ge, Mu-Di Yao, Qin Jiang, Chen Zhao, Biao Yan
BIOMEDICINE & PHARMACOTHERAPY
(2019)
Article
Multidisciplinary Sciences
Chang Liu, Hui-Min Ge, Bai-Hui Liu, Rui Dong, Kun Shan, Xue Chen, Mu-Di Yao, Xiu-Miao Li, Jin Yao, Rong-Mei Zhou, Shu-Jie Zhang, Qin Jiang, Chen Zhao, Biao Yan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Medicine, Research & Experimental
Qin Jiang, Chang Liu, Chao-Peng Li, Shan-Shan Xu, Mu-Di Yao, Hui-Min Ge, Ya-Nan Sun, Xiu-Miao Li, Shu-Jie Zhang, Kun Shan, Bai-Hui Liu, Jin Yao, Chen Zhao, Biao Yan
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Article
Ophthalmology
Sida Xi, Jing Yao, Shujie Zhang, Rui Liu, Lianqun Wu, Xinpei Ye, Peng Zhang, Wen Wen, Chen Zhao
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2020)
Article
Ophthalmology
Jiancheng Huang, Jamie Schaefer, Yekai Wang, Lauren Gioia, Ying Pei, Xiaofei Shi, Shanawar Waris, Chen Zhao, John Nguyen, Jianhai Du
EXPERIMENTAL EYE RESEARCH
(2020)
Article
Ophthalmology
Kai Xu, Bo Li, Shujie Zhang, Fangyuan Hu, Zhijian Xu, Lei Li, Yihan Zhang, Weiliang Zhu, Chen Zhao
EXPERIMENTAL EYE RESEARCH
(2020)
Article
Medicine, Research & Experimental
Lianqun Wu, Yu Liang, Nan Song, Xiying Wang, Chao Jiang, Xinxin Chen, Bing Qin, Xiantao Sun, Guohua Liu, Chen Zhao
Summary: Thyroid-associated ophthalmopathy is characterized by autoimmune involvement of orbital tissues. This study identified differential expression transcripts and alternative splicing genes in patients with this condition, revealing their association with immune modulation, extracellular matrix remodeling, and adipogenesis. Further research into alternative splicing mechanisms may help identify potential therapeutic targets for thyroid-associated ophthalmopathy.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Ophthalmology
Wenqing Zhu, Xiying Wang, Chao Jiang, Ling Ling, Lianqun Wu, Chen Zhao
Summary: IOBT surgery achieved satisfactory outcomes in patients with mild VD associated with unilateral IOOA, with high success rates and good efficacy across different levels of VD. The risk of postoperative complications was low.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Jing Yao, Weiyi Xia, Xiying Wang, Wenqing Zhu, Chao Jiang, Ling Ling, Lianqun Wu, Chen Zhao
Summary: This study reported the effect of two three-muscle surgeries (ISM and VM) in Chinese patients with large-angle esotropia caused by chronic sixth nerve palsy. Both surgeries were effective in improving esotropia and abduction limitation, but potential complications should be noted.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Peripheral Vascular Disease
Hongyu Kong, Rong Zhang, Qinghe Jing, Yu Liang, Qiao Zhuo, Bo Li, Shujie Zhang, Weiliang Zhu, Chen Zhao
Summary: The study showed that EV11 effectively impacted the viability, migration, and tube formation of HUVECs, and inhibited the formation of neovascularization in CNV in mice eyes induced by laser without toxicity. EV11 also blocked the AKT/ERK1/2 signaling pathway in HUVECs.
MICROVASCULAR RESEARCH
(2022)
Article
Cell Biology
Meng Chen, Zhaozhao Zhao, Lianqun Wu, Jiancheng Huang, Peng Yu, Jiang Qian, Ting Ni, Chen Zhao
Summary: This study discovered that the E2F1/CKS2/PTEN signaling axis regulates malignant phenotypes in pediatric retinoblastoma, and CKS2 may serve as a potential therapeutic target for this disease.
CELL DEATH & DISEASE
(2022)
Article
Ophthalmology
Yulian Zhou, Ling Ling, Xiying Wang, Chao Jiang, Wen Wen, Chen Zhao
Summary: This study compares the surgical amount of unilateral medial rectus recession and lateral rectus resection (RR) in patients with acute acquired comitant esotropia (AACE) versus common forms of esotropia, and provides dose-response reference for surgical planning in AACE. The study found that the surgical amount performed was significantly larger in AACE patients compared to those with common forms of esotropia, providing quantitative evidence for augmented-dose unilateral RR in AACE for favorable surgical outcomes.
Article
Neurosciences
Sida Xi, Yulian Zhou, Jing Yao, Xinpei Ye, Peng Zhang, Wen Wen, Chen Zhao
Summary: This study explored the neural mechanism underlying impaired stereopsis and possible functional plasticity after strabismus surgery. The findings revealed that preoperative patients showed hypoactivation in higher-level dorsal and ventral visual areas. While there was no significant difference in activation between pre- and postoperative patients overall, those with improved stereopsis exhibited stronger postoperative activation in specific brain regions. The study suggests that cortical deficits and functional plasticity may contribute to impaired and improved stereopsis, respectively.
NEUROSCIENCE BULLETIN
(2023)
Article
Cell Biology
Yuelu Zhang, Jiancheng Huang, Yu Liang, Jiaqiu Huang, Yuhua Fu, Ningxie Chen, Boxun Lu, Chen Zhao
Summary: Age-related macular degeneration (AMD) is a major cause of irreversible blindness in the elderly, and there is currently no clinical treatment specifically targeting its primary impairment. This study focuses on the excessive accumulation of lipid droplets (LDs) in AMD and its potential role in the development of the disease. The researchers utilized a new compound called LD center dot ATTEC to degrade LDs and observed a significant improvement in AMD-like phenotypes.
Article
Ophthalmology
Weiyi Xia, Lianqun Wu, Jing Yao, Wen Wen, Xiying Wang, Chao Jiang, Lei Li, Chen Zhao
Summary: The study shows that the SOSL procedure has comparable efficacy to SO tenotomy in correcting A pattern, normalizing SO overaction, and converting fundus intorsion, with a significantly higher success rate in A pattern collapse. The SOSL group did not experience SO palsy postoperatively, and the degree of correction of SO overaction strongly correlated with the suture lengthening dosage.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
