Journal
ONCOTARGET
Volume 7, Issue 52, Pages 85728-85740Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.13828
Keywords
intrinsic subtype; competing endogenous RNA network; biomarker; lncRNA; ESCC; Pathology Section
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Funding
- National High Technology Research and Development Program of China [2015AA020104]
- National Key Research and Development Program on Precision Medicine [2016YFC0901700]
- National Basic Research Program of China [2011CB910204, 2011CB510102, 2010CB529200]
- National Key Technology Support Program [2013BAI101B09]
- National Key Scientific Instrument and Equipment Development Project [2012YQ03026108]
- Medical-Engineering Cross Project of Shanghai Jiao Tong University [YG2016MS33]
- National Grand Program on Key Infectious Diseases [2015ZX10004801]
- Youth Innovation Promotion Association CAS
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Increasing evidence has indicated that lncRNAs acting as competing endogenous RNAs (ceRNAs) play crucial roles in tumorigenesis, metastasis and diagnosis of cancer. However, the function of lncRNAs as ceRNAs involved in esophageal squamous cell carcinoma (ESCC) is still largely unknown. In this study, clinical implications of two intrinsic subtypes of ESCC were identified based on expression profiles of lncRNA and mRNA. ESCC subtype-specific differential co-expression networks between mRNAs and lncRNAs were constructed to reveal dynamic changes of their crosstalks mediated by miRNAs during tumorigenesis. Several well-known cancer-associated lncRNAs as the hubs of the two networks were firstly proposed in ESCC. Based on the ceRNA mechanism, we illustrated that the loss of miR-186-mediated PVT1-mRNA and miR-26b-mediated LINC00240-mRNA crosstalks were related to the two ESCC subtypes respectively. In addition, crosstalks between LINC00152 and EGFR, LINC00240 and LOX gene family were identified, which were associated with the function of response to wounding and extracellular matrix-receptor interaction. Furthermore, functional cooperation of multiple lncRNAs was discovered in the two differential mRNA-lncRNA crosstalk networks. These together systematically uncovered the roles of lncRNAs as ceRNAs implicated in ESCC.
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