Article
Medicine, General & Internal
Zhipeng Du, Zhongchao Zhang, Xu Han, Huaping Xie, Wei Yan, Dean Tian, Mei Liu, Caijun Rao
Summary: This study reveals the upregulation of SFXN4 in hepatocellular carcinoma (HCC) and its correlation with poor prognosis. SFXN4 is associated with oxidative phosphorylation, metabolic pathways, and several cancer-related pathways. It is regulated by multiple transcription factors and miRNAs. Knockdown of SFXN4 inhibits HCC proliferation, migration, and invasion in vitro, and suppresses tumor growth in vivo.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Cell Biology
Yening Xiao, Jiamei Ma, Chunliu Guo, Danni Liu, Jing Pan, Xiaoxi Huang
Summary: This study demonstrates that silencing of the CCNB2 gene can inhibit tumor formation and proliferation in nude mice. CCNB2 may accelerate the proliferation and metastasis of hepatocellular carcinoma cells by increasing JAG1 expression.
Article
Medicine, General & Internal
Kedan Cen, Caide Lu
Summary: Our study found that TALDO1 mRNA level was higher in HCC tissues and associated with histologic grade. High TALDO1 mRNA expression was an independent risk factor for poor prognosis in HCC patients. Furthermore, TALDO1 negatively regulates immune response and its knockdown suppressed the proliferation and migration ability of HCC cells by activating the MAPK pathway and enhancing VEGF expression.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Xiaoting Huang, Leyang Xiang, Wei Liu, Mingyi Li, Anbang Ren, Zide Chen, Chu Zheng, Chen Chengcong, Jinquan Liu, Yawei Yuan
Summary: The study revealed that overexpression of DMBX1 in HCC is associated with metastasis and poor prognosis, suggesting that DMBX1 may be a therapeutic target for HCC.
ANNALS OF HEPATOLOGY
(2021)
Article
Cell Biology
Pablo Carabias, Maria Espelt, Maria L. Bacigalupo, Paola Rojas, Luciana Sarrias, Ayelen Rubin, Nicolas A. Saffioti, Maria T. Elola, Juan P. Rossi, Carlota Wolfenstein-Todel, Gabriel A. Rabinovich, Maria F. Troncoso
Summary: GAL1, abundantly expressed in the tumor microenvironment, may promote chemoresistance in HCC cells by modulating P-gp protein expression.
CELL DEATH & DISEASE
(2022)
Article
Oncology
Jie Sun, Zheng Dong, Zhengyao Chang, Hongfei Liu, Qiyu Jiang, Deyuan Zhang, Shanshan Lu, Xiaodong Jia, Dawei Wu, Aaron Ge, Pan Zhao, Jing Wang, Yinying Lu
Summary: The study found that the expression of MARCH6 was elevated in human HCC samples and was associated with poor prognosis. Over-expression of MARCH6 promoted cell growth and migration of HCC cells, while its knockdown suppressed these functions. Additionally, MARCH6-mediated up-regulation of ATF2 contributed to HCC development, suggesting MARCH6 may be a promising target for HCC diagnosis and treatment.
Article
Oncology
Dawei Yuan, Rulan Ma, Tuanhe Sun, Kun Zhu, Chengxue Dang, Haixia Ye, Kang Li
Summary: The high expression of RSPH14 in hepatocellular carcinoma (HCC) is associated with poor prognosis. Knockdown of RSPH14 can inhibit cell proliferation, migration, and invasion, and promote apoptosis of HCC cells by inhibiting the expression of RelA. RSPH14 may be a potential new treatment target for HCC.
CANCER CELL INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Liping Sun, Shuguang Liu, Xiaopai Wang, Xuefeng Zheng, Ya Chen, Hong Shen
Summary: The study demonstrated that eIF6 expression was significantly increased in HCC and correlated with its pathological progression. eIF6 served as a new diagnostic biomarker and an independent risk factor for OS in HCC patients. Functional studies showed that deletion of eIF6 exhibited tumor-suppressor activity in HCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Xiao-Wei Dang, Qi Pan, Zhen-Hai Lin, Hao-Hao Wang, Lu-Hao Li, Lin Li, Dong-Qi Shen, Pei-Ju Wang
Summary: This study confirmed that DEPDC1B knockdown restricts tumor growth in vitro and in vivo, and it interacts with CDK1, being a potential therapeutic target involved in HCC growth and progression. The results suggest that DEPDC1B plays a key role in HCC and may be a promising target for therapeutic interventions.
Article
Pathology
He Wang, Huiwen Wang, Wenyu Cui, Qiao Zhang, Jing Li, Qi Zhang
Summary: The study showed that miR-889 is upregulated in hepatocellular carcinoma tissues and cell lines, and its overexpression promotes cell proliferation, migration, and invasion in hepatocellular carcinoma cells, leading to an unfavorable prognosis.
DIAGNOSTIC PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Haiyuan Li, Lei Gao, Xiaojuan Kang, Xueyan Wang, Yang Yu, Yaqing Zhang, Hao Chen
Summary: This study explored the expression and function of 40S ribosomal protein S24 (RPS24) in hepatocellular carcinoma (HCC). Results showed that RPS24 was elevated in HCC samples and related to poor prognosis. Furthermore, RPS24 overexpression or promoter methylation correlated with unfavorable prognosis in HCC patients. High expression of RPS24 was associated with DNA replication, cell cycle, immune infiltration, and immunotherapy response. Experimental validation demonstrated that silencing of RPS24 suppressed HCC cell growth and tumor proliferation. Therefore, RPS24 may serve as a potential adverse biomarker for HCC prognosis, acting through cell proliferation facilitation and the formation of an immunosuppressive microenvironment, and targeting RPS24 could be a promising therapeutic option for HCC management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Yihui Ma, Wenwen Sun, Qiangnu Zhang, Bingfang Gao, Wen Cai, QinLiang Liu, Juan Liao, Xinli Wang
Summary: The study identified lncRNA BSG-AS1 as a novel hypoxia-responsive lncRNA in HCC, which promotes proliferation and migration by positively regulating BSG through enhancing mRNA stability. Overexpression of lncRNA BSG-AS1 and BSG are associated with poor prognosis in HCC.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Oncology
Chun-Ming Li, Jie Zhang, Wu Wu, Zhu Zhu, Feng Li, Di Wu, Xiao-Jun Wang, Chuan-Ming Xie, Jian-Ping Gong
Summary: This study investigated the biological function and potential mechanism of FBXO43 in hepatocellular carcinoma (HCC). The results showed that FBXO43 was upregulated in HCC patient tissues and correlated with poor clinicopathological features. Knockdown of FBXO43 inhibited HCC cell proliferation, migration, and epithelial-mesenchymal transition (EMT), which was mediated by its interaction with cyclin D1 (CCND1) and promotion of CCND1 stability. Targeting the FBXO43-CCND1 axis may provide a new potential strategy for HCC treatment.
FRONTIERS IN ONCOLOGY
(2023)
Article
Environmental Sciences
Liang Ye, Xu Zhang, Peng Wang, Ying Zhang, Shujiao He, Yang Li, Shao Li, Kangyan Liang, Shuguang Liao, Yi Gao, Shuqing Zhou, Qing Peng
Summary: The low concentration of triphenyl phosphate (TPP) may exacerbate the proliferation, invasion, and migration of hepatocellular carcinoma (HCC) cells, acting as a risk factor in the progression of HCC.
ENVIRONMENTAL TOXICOLOGY
(2022)
Article
Oncology
Yan Lu, Qihua Dang, Yin Bo, Xuejin Su, Liping Wang, Jiaqi Sun, Junyuan Wei, Chengshi Quan, Yanru Li
Summary: CLDN6 was found to be highly expressed in human hepatocellular carcinoma (hHCC) and promoted the development of the cancer. Silencing of CLDN6 in hHCC cells inhibited proliferation, migration, and invasion abilities, upregulated E-cadherin expression, and downregulated N-cadherin and Vimentin expression, suggesting that CLDN6 could be a potential target for hHCC treatment.