Review
Endocrinology & Metabolism
Davide Gerardi, Nicolo Santostasi, Diana Torge, Fabiola Rinaldi, Sara Bernardi, Serena Bianchi, Maurizio Piattelli, Giuseppe Varvara
Summary: This systematic review evaluates the efficacy of Platelet-rich Fibrin (PRF) in sinus lift procedures, compared and/or in addition to Deproteinized Bovine Bone Materials (DBBM). The results suggest that PRF associated with DBBM is a valid alternative in bone regeneration, but further research is needed to explore the potential of platelet concentrates and the inductivity properties of DBBM in sinus lift techniques.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Medicine, General & Internal
Biagio Rapone, Alessio Danilo Inchingolo, Stefano Trasarti, Elisabetta Ferrara, Erda Qorri, Antonio Mancini, Nicola Montemurro, Antonio Scarano, Angelo Michele Inchingolo, Gianna Dipalma, Francesco Inchingolo
Summary: This study evaluated the long-term clinical outcomes of bone regeneration procedures using algae-derived plant hydroxyapatite compared with demineralized anorganic bovine bone, in combination with autologous blood-derived PRP. The results showed that both biomaterials are suitable for sinus grafting in severely atrophic maxillae.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Chemistry, Physical
Bruno Coelho Mendes, Rodrigo dos Santos Pereira, Carlos Fernando de Almeida Barros Mourao, Pietro Montemezzi, Anderson Maikon de Souza Santos, Jessica Monique Lopes Moreno, Roberta Okamoto, Eduardo Hochuli-Vieira
Summary: This study compared two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting, and evaluated osteoblast precursor cells and vascular formation using immunolabeling. The results showed that the evaluated bone substitutes had suitable outcomes for bone regeneration.
Article
Dentistry, Oral Surgery & Medicine
Lukas A. A. van Dijk, Nard G. G. Janssen, Silke J. J. Nurmohamed, Marvick S. M. Muradin, Alessia Longoni, Robbert C. C. Bakker, Florence G. de Groot, Joost D. D. de Bruijn, Debby Gawlitta, Antoine J. W. P. Rosenberg
Summary: The aim of this study was to evaluate the use of osteoinductive calcium phosphate with submicron surface topography as a bone graft substitute for maxillary sinus floor augmentation (MSFA). A preclinical sheep model and a small clinical trial were conducted to compare the performance of different calcium phosphates and autologous bone grafts. The results showed that the calcium phosphate with submicron needle-shaped topography demonstrated better bone formation compared to other materials, and was comparable to autologous bone graft in terms of implant stability and clinical outcome.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Thomas Starch-Jensen, Soren Schou, Hendrik Terheyden, Niels Henrik Bruun, Hanna Aludden
Summary: This study tested the hypothesis of no difference in bone regeneration after maxillary sinus floor augmentation using different ratios of iliac or mandibular autograft and deproteinized bovine bone mineral. The results showed that the percentage of bone regeneration significantly increased with a higher ratio of autograft, regardless of the origin of the graft.
CLINICAL ORAL IMPLANTS RESEARCH
(2023)
Article
Biology
Karoline Maria Reich, Florian Beck, Patrick Heimel, Stefan Lettner, Heinz Redl, Christian Ulm, Stefan Tangl
Summary: This study aimed to evaluate the spatial distribution and compaction of bone graft particles in the maxillary sinus after maxillary sinus floor augmentation and their association with bone regeneration. The study found that excessive compaction of bone graft particles can negatively affect their integration with the native bone, highlighting the importance of avoiding excessive compaction to optimize the macrostructural environment for bone regeneration.
Article
Engineering, Biomedical
Yiqian Ying, Beibei Li, Changying Liu, Zuochun Xiong, Wei Bai, Jun Li, Pan Ma
Summary: The study compared the bone regeneration potential of nanostructured sponges (NS-Sponge) with other materials in rabbit sinus augmentation, showing that NS-Sponge had better outcomes in terms of new bone area and dimensional stability.
JOURNAL OF BIOMATERIALS APPLICATIONS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Pablo Galindo-Moreno, Dario Abril-Garcia, Ana Belen Carrillo-Galvez, Federico Zurita, Natividad Martin-Morales, Francisco O'Valle, Miguel Padial-Molina
Summary: This study compared the effectiveness of two xenografts for maxillary sinus floor augmentation. The results showed that anorganic bovine bone and porcine bone mineral combined with maxillary autogenous cortical bone had similar biological and radiological features.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Kuo Feng Hung, Liu Ling Hui, Yiu Yan Leung
Summary: This study developed prediction models based on CBCT to estimate the bone graft volume needed for sinus floor elevation (SFE) based on the augmentation site, elevation height, and sinus width. The prediction models showed high consistency with the measured values.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Mengdie Fu, Zhiwei Jiang, Lingfei Ren, Jin He, Danji Zhu, Guoli Yang
Summary: This retrospective study compared the volumetric changes in hard and soft tissues between antral pseudocyst removal and retainment before maxillary sinus floor augmentation and immediate implant placement. The results showed that the removal of the pseudocyst resulted in higher bone graft volumetric stability and fewer postoperative complications.
CLINICAL ORAL IMPLANTS RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Xianxian Zhuang, Jiating Lin, Hao Dong, Yin Wen, Ruoting Xian, Lu Cheng, Jingyi Wu, Shaobing Li
Summary: The study evaluated the clinical outcome of the transalveolar approach with the small segmentation method for inclined maxillary sinus floor elevation. The results showed promising results with successful osseointegration of implants and significant bone height changes achieved using this method.
CLINICAL IMPLANT DENTISTRY AND RELATED RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Pe-Yi Kuo, Cho-Ying Lin, Chi-Ching Chang, Yuan-Min Wang, Whei-Lin Pan
Summary: The study found that synthetic biphasic calcium phosphate used in transcrestal sinus floor elevation undergoes shrinkages and graft remodeling, leading to a reduction in graft height, which is closely correlated with the vertical amount of implant protrusion, vertical elevation height, and the ratio of vertical to horizontal elevation of the grafted space, but not correlated with sinus width and other dimensions of the grafted space.
BIOMEDICAL JOURNAL
(2021)
Article
Medicine, General & Internal
Takamitsu Koga, Yuya Nakatani, Seigo Ohba, Masahito Hara, Yoshinori Sumita, Kazuhiro Nagai, Izumi Asahina
Summary: The clinical study aimed to evaluate the safety and preliminary efficacy of autologous freeze-drying platelet-rich plasma (FD-PRP) on bone regeneration in maxillary sinus floor augmentation. The results indicated the safety of x3FD-PRP in surgery and the progress of bone regeneration in patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Environmental Sciences
Eugenio Velasco-Ortega, Angela Sierra-Baztan, Alvaro Jimenez-Guerra, Antonio Espana-Lopez, Ivan Ortiz-Garcia, Enrique Nunez-Marquez, Jesus Moreno-Munoz, Jose Luis Rondon-Romero, Jose Lopez-Lopez, Loreto Monsalve-Guil
Summary: This study demonstrates that implant-supported restorations with MFSA using beta-TCP is a successful approach, leading to favorable long-term clinical outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Review
Dentistry, Oral Surgery & Medicine
Xin Li, Shi-chen Lin, Shao-yu Duan
Summary: The objective of this study was to evaluate the effectiveness of large granular bovine bone compared to small granular bovine bone in maxillary sinus floor elevation. The systematic review and meta-analysis of four studies showed that there was no significant difference in histological performance between the two types of bovine bone. However, more clinical evidence is needed to support this conclusion.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ahmed S. Sultan, Maryam Jessri, Camile S. Farah
Summary: The evidence on the potential detrimental effects of electronic nicotine delivery systems (ENDS) on systemic and oral health is scarce, and their role in oral carcinogenesis remains unclear. However, with the increasing use of ENDS by the general public, dental healthcare providers are more likely to face questions on their safety in the oral cavity and their effectiveness as a smoking cessation tool.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Review
Dentistry, Oral Surgery & Medicine
Majdy Idrees, Omar Kujan, Kate Shearston, Camile S. Farah
Summary: The analysis conducted using strict criteria showed that the malignant transformation rate of oral lichen planus is exaggerated and does not reflect the actual clinical course. Patients who smoke, consume alcohol, are seropositive for HCV, or display the red subtype of OLP have a higher risk of malignant transformation.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Orthopedics
Hayman Lui, Cedryck Vaquette, Janet M. Denbeigh, Randy Bindra, Sanjeev Kakar, Andre J. van Wijnen
Summary: This study aimed to assess a multiphasic scaffold for reconstruction of the dorsal scapholunate interosseous ligament, which showed tissue integration and maturation leading to increased mechanical strength of the operated joint. Bone and ligament tissues were regenerated in their respective compartments with properties approaching those reported for the human dorsal SLIL ligament.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Materials Science, Biomaterials
Greeshma Ratheesh, Mengchao Shi, Patrick Lau, Yin Xiao, Cedryck Vaquette
Summary: This study demonstrated that a hierarchical scaffold with dual pore sizes significantly improved scaffold properties, enhancing specific surface area, initial cell adhesion, cell proliferation, and in vitro osteogenesis by providing an environment conducive to cell condensation and osteogenic differentiation.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Review
Oncology
Farzaneh Kordbacheh, Camile S. Farah
Summary: Head and neck cancer poses a significant burden on global health systems and patients, with traditional treatments including surgery, radiation, and chemotherapy. Targeted immunotherapies have shown significant progress, but rely on understanding molecular pathways. Developing a broader range of targeted therapies is crucial for improving outcomes in head and neck oncology.
Review
Biochemistry & Molecular Biology
Heinrich Botha, Camile S. Farah, Kendrick Koo, Nicola Cirillo, Michael McCullough, Rita Paolini, Antonio Celentano
Summary: Research shows that in oral squamous cell carcinoma, glucose transporter 1 (GLUT-1) and GLUT-3 expression levels are correlated with tumor stage, treatment resistance, and poor prognosis. Other glucose transporters (GLUTs) are relatively understudied and may have the potential to improve patient care with further analysis.
Review
Oncology
Farzaneh Kordbacheh, Camile S. Farah
Summary: Next-generation sequencing has identified new gene mutations in head and neck squamous cell carcinoma, leading to a growing number of potential drug targets. Clinical trials are exploring various pharmacotherapeutics, particularly for aggressive locally advanced head and neck cancer. While first-line surgical treatments have improved survival rates in developed countries, recurrent and metastatic disease remains a challenge. Precision medicine, based on genomic profiling, is showing promise in tailoring targeted therapies for individual patients.
Review
Oncology
Yuchen Bai, Jarryd Boath, Gabrielle R. White, Uluvitike G. I. U. Kariyawasam, Camile S. Farah, Charbel Darido
Summary: Oral cancer is a multi-step disease with limited treatment options. The processes of oral cell proliferation, differentiation, and terminal differentiation play crucial roles in maintaining the homeostasis of oral epithelial tissue.
Review
Engineering, Biomedical
Fanny Blaudez, Saso Ivanovski, Benjamin Fournier, Cedryck Vaquette
Summary: Recent advancements in regenerative medicine and biomaterial science have emphasized the importance of regulating immune cell phenotypes at the interface of biomaterials. One promising approach is the use of reparative biological cues called resolvins, which have shown to play a key role in the resolution of inflammation and tissue regeneration. This review provides a comprehensive overview of the mechanisms and pathways involving resolvins, their current utilization in pre-clinical and clinical settings, and their potential when combined with biomaterial constructs in tissue engineering applications.
ACTA BIOMATERIALIA
(2022)
Article
Biochemistry & Molecular Biology
Simon A. Fox, Michael Vacher, Camile S. Farah
Summary: Relapse after surgery for oral squamous cell carcinoma (OSCC) is a significant problem. The current histopathological diagnostic techniques are not sensitive enough for the detection of oral cancer and minimal residual disease in surgical margins. In this study, we used gene expression and noncoding RNA profiles to identify biomarker signatures for tumors and marginal tissue zones. These biomarkers could potentially improve the detection of tumor cells and enhance surgical outcomes.
Article
Biology
Li-Qiao R. Ling, Zichen Lin, Rita Paolini, Camile S. Farah, Michael McCullough, Mathew A. W. T. Lim, Antonio Celentano
Summary: Oral squamous cell carcinoma (OSCC) is a common type of cancer, and anticoagulant usage is increasing. This study aimed to investigate the effects of anticoagulants on OSCC cell lines and their interactions with the drug 5-fluorouracil (5-FU). The results showed that commonly prescribed anticoagulants have antiproliferative effects on OSCC cells and can reduce cell migration. However, most of the anticoagulants tested reduced the effectiveness of the chemotherapeutic agent 5-FU, suggesting potential flaws in current pharmacological management. Further research is needed to translate these findings to animal models.
Article
Engineering, Biomedical
Reuben Staples, Saso Ivanovski, Cedryck Vaquette
Summary: This study demonstrates the potential of a highly porous scaffold with 100 μm width channels manufactured by melt electrowriting to induce perpendicular alignment and attachment of the periodontal ligament, leading to enhanced periodontal tissue regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Engineering, Biomedical
Nimal Raveendran, Saso Ivanovski, Cedryck Vaquette
Summary: 3D bioprinting allows the incorporation of cells in a porous construct and enhances bone-related gene expression. The combination of pre-induction and post-differentiation regimens shows superior osteogenic potential of bioprinted constructs in vitro and in vivo. This study reveals the positive impact of bioprinting on osteogenic differentiation and the potential for bone regeneration.
ACTA BIOMATERIALIA
(2023)
Article
Biochemistry & Molecular Biology
Fanny Blaudez, Saso Ivanovski, Tulio Fernandez, Cedryck Vaquette
Summary: Recent research examined the impact of in vitro culture on the bioactivity of ECM-decorated scaffolds for bone regeneration. It was found that longer culture periods hindered cell infiltration and overall bone regeneration, possibly due to pore obstruction caused by prolonged culture. This study highlights the importance of culture length in the development of effective ECM-decorated scaffolds.
Review
Dentistry, Oral Surgery & Medicine
S. Ivanovski, O. Breik, D. Carluccio, J. Alayan, R. Staples, C. Vaquette
Summary: 3D printing technology offers great potential for large-volume bone regeneration, particularly in the oro-dental and craniofacial regions. This review discusses the main 3D printing technologies used for manufacturing patient-matched devices and explores their pre-clinical and clinical performance, including complications. The regulatory pathway for approval of these devices and future developments are also discussed.
PERIODONTOLOGY 2000
(2023)
