Journal
ONCOTARGET
Volume 7, Issue 28, Pages 44763-44778Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8206
Keywords
apoptosis; autophagy; necroptosis; chemotherapy resistance; osteosarcoma
Categories
Funding
- National Natural Science Foundation of China [31300624]
- China Postdoctoral Science Foundation [2013M530473]
Ask authors/readers for more resources
Osteosarcoma is the most common primary bone tumor in children and adolescents. Although combined therapy including surgery and multi-agent chemotherapy have resulted in great improvements in the overall survival of patients, chemoresistance remains an obstacle for the treatment of osteosarcoma. Molecular targets or effective agents that are actively involved in cell death including apoptosis, autophagy and necroptosis have been studied. We summarized how these agents (novel compounds, miRNAs, or proteins) regulate apoptotic, autophagic and necroptotic pathways; and discussed the current knowledge on the role of these new agents in chemotherapy resistance in osteosarcoma.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available