Review
Oncology
Xishan Chen, Renba Liang, Lin Lai, Kaihua Chen, Xiaodong Zhu
Summary: The meta-analysis showed that high expression of EGFR was significantly associated with poor overall survival (OS) and disease-free survival (DFS) in patients with nasopharyngeal carcinoma. However, it was not significantly associated with other survival indicators. High expression of p-EGFR did not show significant correlation with OS and distant metastasis-free survival (DMFS).
FRONTIERS IN ONCOLOGY
(2021)
Review
Pharmacology & Pharmacy
Jieun Bang, Mihyeon Jun, Soyun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: Hepatocellular carcinoma (HCC) is a significant global health concern, with its incidence steadily increasing. Recent progress has been made in understanding the molecular signaling pathways, particularly the EGFR/PI3K/AKT/mTOR pathway, which plays a central role in HCC. Preclinical studies have shown the effectiveness of targeting this signaling pathway for HCC therapy, offering potential therapeutic options for patients.
Article
Biochemistry & Molecular Biology
Peiying Huang, Mengmeng Li, Qinglai Tang, Kang Jiang, Yuchao Luo
Summary: This study investigated the biological functions and mechanisms of circular RNA_0000523 (circ_0000523) in nasopharyngeal carcinoma (NPC). The results showed that circ_0000523 facilitates NPC progression through regulating the miR-1184/COL1A1 axis.
Article
Medicine, Research & Experimental
Enni Chen, Jiajia Huang, Miao Chen, Jiawei Wu, Puyun Ouyang, Xiaonan Wang, Dingbo Shi, Zhiqiao Liu, Wancui Zhu, Haohui Sun, Shanshan Yang, Baoyu Zhang, Wuguo Deng, Huijuan Qiu, Fangyun Xie
Summary: This study reveals that FLI1 regulates radiotherapy resistance in nasopharyngeal carcinoma (NPC) through the TIE1-mediated PI3K/AKT signaling pathway, suggesting that targeting the FLI1/TIE1 signaling pathway could be a potential therapeutic strategy to enhance the efficacy of radiotherapy in NPC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Li-Zhi Wu, You Zou, Bin-Ru Wang, Hai-Feng Ni, Yong-Gang Kong, Qing-Quan Hua, Shi-Ming Chen
Summary: Investigating the impact of CENP-N on the radiosensitivity of NPC cells, this study found that knockdown of CENP-N can enhance NPC radiosensitivity by inhibiting the AKT/mTOR pathway. The combination of CENP-N knockdown and radiotherapy showed significant suppression of proliferation, induction of apoptosis, and G2/M phase arrest in NPC cells, with increased levels of Bax and gamma H2AX proteins and decreased levels of Cyclin D1 protein.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Xiaohua Hong, Guangyao Wang, Guanglan Xu, Wei Shi, Tongbiao Wang, Zhen Rong, Chunmei Mo
Summary: The article evaluated the prognostic effect and clinical significance of epidermal growth factor receptor and its phosphorylated form (EGFR/p-EGFR) in nasopharyngeal carcinoma through a systematic review and meta-analysis. The results showed that EGFR overexpression could be used as a biomarker for poor overall survival (OS) and disease-free survival (DFS) in nasopharyngeal carcinoma, but not for progression-free survival (PFS) and distant metastasis-free survival (DMFS). The overexpression of p-EGFR was not associated with the prognosis of nasopharyngeal carcinoma patients.
Article
Integrative & Complementary Medicine
Xiao-Ying Li, Feng Gao, Xiao-Cong Wang, Lu-Lu Liu, Yu Gan, Shuang-Ze Han, Li Zhou, Wei Li, Ming Li
Summary: The dysfunction of EGFR signaling is crucial in the development of OSCC, and this study confirms the overexpression of EGFR in OSCC tumor tissues. Depletion of EGFR inhibits OSCC cell growth, while the natural compound curcumol shows anti-tumor effects by downregulating Mcl-1. Curcumol inhibits the EGFR-Akt signal pathway, resulting in Mcl-1 phosphorylation and degradation. Furthermore, curcumol effectively suppresses tumor growth in vivo and Mcl-1 expression correlates with p-EGFR and p-Akt in OSCC tumor tissues.
AMERICAN JOURNAL OF CHINESE MEDICINE
(2023)
Review
Microbiology
Xintong Peng, Yanling Zhou, Yongguang Tao, Shuang Liu
Summary: This article summarizes the relationship between EBV, EGFR, and LMP1 in NPC, highlighting the importance of EGFR in the occurrence and development of NPC. EGFR-targeted drugs are discussed as potential newly developed anti-tumor drugs for NPC patients, as activation of EGFR signaling affects various aspects of NPC cell behavior and contributes to poor outcomes.
Article
Oncology
Renba Liang, Xiaodong Zhu
Summary: UC2288 inhibited the growth of NPC by suppressing the EGFR/ERK pathway and may be a promising therapeutic option for NPC.
Article
Cell Biology
Jin Su, Shousen Hu, Shiping Ding, Kun Feng
Summary: This study reveals the functional importance of proteasome 26 S subunit ATPase 2 (PSMC2) in nasopharyngeal carcinoma and demonstrates its positive regulatory role in the AKT signaling pathway.
Article
Oncology
Xiaoqin Fan, Xina Xie, Ming Yang, Yujie Wang, Hanwei Wu, Tingting Deng, Xin Weng, Weiping Wen, Guohui Nie
Summary: This study revealed the significant role of YBX3 in the metastasis of nasopharyngeal carcinoma, showing that it inhibits epithelial-to-mesenchymal transition and MMP1 activation by regulating the PI3K/AKT signaling pathway. These findings suggest that YBX3 could be a potential therapeutic target for patients with NPC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
Hai-Long Li, Nian-Hua Deng, Xiu-Sheng He, Yue-Hua Li
Summary: This article primarily discusses the interactions between PI3K/AKT/mTOR signaling pathway and miRNAs in the pathology of nasopharyngeal carcinoma (NPC), as well as explores potential diagnostic biomarkers and therapeutic targets.
BIOMARKER RESEARCH
(2022)
Article
Cell Biology
Yunfan Luo, Jie Wang, Fan Wang, Xiong Liu, Juan Lu, Xiaoxiao Yu, Xuemin Ma, Xiaohong Peng, Xiangping Li
Summary: In nasopharyngeal carcinoma, vasculogenic mimicry formation is positively correlated with Foxq1 and EGFR expression, as well as TNM staging, with poor prognosis for VM-positive patients. Foxq1 promotes NPC metastasis by inducing VM, and can be effectively inhibited by EGFR inhibitors. Anti-EGFR and anti-VEGF drugs show synergistic efficacy in NPC inhibition.
CELL DEATH & DISEASE
(2021)
Article
Biotechnology & Applied Microbiology
Li-Zhi Wu, Mao-Ling Huang, Cheng-Lin Qi, Li-Jun Shen, You Zou, Rui Yang, Jian-Fei Sheng, Shi-Ming Chen
Summary: Overexpression of Notch2 can increase the radiosensitivity of NPC cells by inhibiting the AKT/mTOR pathway, leading to enhanced apoptosis and cell cycle arrest in G2/M phase.
Article
Biochemistry & Molecular Biology
Zhi-Jie Liu, Li-Sheng Zheng, Chang-Zhi Li, Li-Xia Peng, Yan Mei, Yan-Hong Lang, Liang Xu, Dong-Fang Meng, Xing-Si Peng, Ming-Dian Wang, De-Huan Xie, Ling-Ling Guo, Liu-Yan Ding, Bi-Jun Huang, Chao-Nan Qian
Summary: In this study, it was found that downregulation of Cystatin A (CSTA) was associated with metastasis in nasopharyngeal carcinoma (NPC) tissues. Functional assays showed that CSTA inhibited the motility and metastasis of NPC cells. Mechanistically, CSTA interacted with METTL3 to promote the degradation of NKX3-1 and LHPP, thereby suppressing AKT signaling. Our findings suggest that targeting the CSTA-METTL3-NKX3-1/LHPP-AKT axis could be a potential therapeutic strategy for inhibiting NPC metastasis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Oncology
Rui-Mei Feng, Ellen T. Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Yu Zhang, Jingping Yun, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Ingemar Ernberg, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Hans-Olov Adami, Weimin Ye
Article
Nutrition & Dietetics
Donal Barrett, Alexander Ploner, Ellen T. Chang, Zhiwei Liu, Cai-Xia Zhang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Jian-Yong Shao, Wei-Hua Jia, Yuming Zheng, Jian Liao, Yufeng Chen, Longde Lin, Ingemar Ernberg, Hans-Olov Adami, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Weimin Ye
JOURNAL OF NUTRITION
(2019)
Article
Chemistry, Medicinal
Yushan Liang, Guofei Feng, Liang Wu, Suhua Zhong, Xiaoyu Gao, Yan Tong, Wanmeng Cui, Yongying Qin, WenQing Xu, Xue Xiao, Zhe Zhang, Guangwu Huang, Xiaoying Zhou
DRUG DESIGN DEVELOPMENT AND THERAPY
(2019)
Article
Medicine, Research & Experimental
Huimei Huang, Yuyun Qiu, Guitian Huang, Xiaohui Zhou, Xiaoying Zhou, Wenqi Luo
MEDICAL SCIENCE MONITOR
(2019)
Article
Biochemistry & Molecular Biology
Guofei Feng, Liting Qin, Zhipeng Liao, Xiling Xiao, Bo Li, Wanmeng Cui, Libin Liang, Yingxi Mo, Guangwu Huang, Ping Li, Xiaoying Zhou, Zhe Zhang, Xue Xiao
JOURNAL OF CELLULAR BIOCHEMISTRY
(2020)
Article
Oncology
Bo Li, Zhipeng Liao, Yingxi Mo, Weilin Zhao, Xiaohui Zhou, Xiling Xiao, Wanmeng Cui, Guofei Feng, Suhua Zhong, Yushan Liang, Chunping Du, Guangwu Huang, Ping Li, Xue Xiao, Xiaoying Zhou, Rensheng Wang, Zhe Zhang
BRITISH JOURNAL OF CANCER
(2020)
Article
Biotechnology & Applied Microbiology
Shanshan Ma, Chang Liu, Bo Li, Tingting Zhang, Li Jiang, Rensheng Wang
ONCOTARGETS AND THERAPY
(2020)
Article
Oncology
Shixing Zheng, Liudmila Matskova, Xiaoying Zhou, Xue Xiao, Guangwu Huang, Zhe Zhang, Ingemar Ernberg
MOLECULAR ONCOLOGY
(2020)
Article
Oncology
Li Jiang, Bo Li, Yong Zhang, Shanshan Ma, Chang Liu, Feifei Liang, Zhuxin Wei, Tingting Huang, Rensheng Wang
Summary: This study investigated the impact of treatment on the vaginal microbiome in patients receiving pelvic IMRT with concurrent cisplatin-based chemotherapy. Significant differences were found in the vaginal microbial composition between patients and healthy controls, and certain microbial abundances increased over time, suggesting a potential role of the vaginal microbiome in cervical cancer treatment outcomes. Further research into these effects could lead to new therapeutic strategies to enhance radiochemotherapy efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yufeng Chen, Ellen T. Chang, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Wei-Hua Jia, Yuming Zheng, Yancheng Li, Longde Lin, Ingemar Ernberg, Dongming Wang, Weihong Chen, Ruimei Feng, Guangwu Huang, Yi-Xin Zeng, Hans-Olov Adami, Weimin Ye
Summary: Occupational exposures to dusts, chemical vapors, exhausts/smokes, or acids/alkalis are associated with an excess risk of nasopharyngeal carcinoma (NPC) in high-incidence areas like southern China. The risk of NPC appears to increase linearly with duration of exposure, suggesting a causal relationship between occupational exposures and NPC development.
Article
Oncology
Li Jiang, Yong Zhang, Bo Li, Min Kang, Zhendong Yang, Chunyu Lin, Kai Hu, Zhuxin Wei, Meng Xu, Jinglin Mi, Rensheng Wang, Fang Wu
Summary: The study evaluated circulating sEV-derived miRNAs as potential biomarkers for the diagnosis of nasopharyngeal carcinoma (NPC). It identified a distinct set of differentially expressed miRNAs between NPC patients and healthy controls, with target genes mainly involved in cancer-associated signaling pathways. A 3 miRNA-based model showed good discriminating power in diagnosing NPC and had an excellent ability to distinguish NPC patients at different stages from healthy controls.
Article
Environmental Sciences
Yufeng Chen, Ellen T. Chang, Zhiwei Liu, Qing Liu, Yonglin Cai, Zhe Zhang, Guomin Chen, Qi-Hong Huang, Shang-Hang Xie, Su-Mei Cao, Wei-Hua Jia, Yuming Zheng, Yancheng Li, Longde Lin, Ingemar Ernberg, Hongwei Zhao, Ruimei Feng, Guangwu Huang, Yi Zeng, Yi-Xin Zeng, Hans-Olov Adami, Weimin Ye
Summary: This study found that living in cottages or boats, using wood, coal, or kerosene as cooking fuel, drinking well water, river water, or spring/pond/stream water, and living in houses with smaller-sized windows were associated with an increased risk of NPC.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Oncology
Yunliang Lu, Xiaohui Zhou, Weilin Zhao, Zhipeng Liao, Bo Li, Peipei Han, Yanping Yang, Xuemin Zhong, Yingxi Mo, Ping Li, Guangwu Huang, Xue Xiao, Zhe Zhang, Xiaoying Zhou
Summary: ACAT1, as a key enzyme in the ketone body metabolism pathway, plays a crucial role in the proliferation and metastasis of nasopharyngeal carcinoma (NPC), potentially acting as a tumor suppressor by regulating epithelial-mesenchymal transition.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Yufeng Chen, Wanxin Li, Ellen T. Chang, Justine W. Debelius, Lokeshwaran Manoharan, Yuming Zheng, Yancheng Li, Guangwu Huang, Hans-Olov Adami, Rob Knight, Yonglin Cai, Zhe Zhang, Weimin Ye
Summary: Dysbiosis of the oral mycobiome, characterized by a loss of fungal community diversity and overgrowth of several fungal organisms, is associated with a significantly increased risk of nasopharyngeal carcinoma (NPC).