Article
Multidisciplinary Sciences
AhmadReza Rezaeian, Fatemeh Khatami, Saeed Heidari Keshel, Mohammad Reza Akbari, Akram Mirzaei, Keykavos Gholami, Reza Mohammadi Farsani, Seyed Mohammad Kazem Aghamir
Summary: This study demonstrates that MSC-exosomes have certain anti-tumor effects on prostate, bladder, and kidney cancer cells. These effects are mainly achieved by inducing apoptosis and inhibiting cancer cell proliferation.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Yuzhi Wang, Yu Zou, Yi Zhang, Chengwen Li
Summary: This study identified specific immune-related lncRNAs as clinically significant markers for diagnosis and prognosis of gastric cancer, and improved the prognosis of patients through a risk scoring system. Analyzing immune infiltrates and lncRNAs helps clinicians develop personalized treatment strategies for GC patients.
BIOSCIENCE REPORTS
(2021)
Article
Medicine, Research & Experimental
Yutong Zhang, Lijuan Zhao, Yaping Bi, Jinyuan Zhao, Chao Gao, Xiaojie Si, Honglin Dai, Moges Dessale Asmamaw, Qiurong Zhang, Wenchao Chen, Hongmin Liu
Summary: Tumor metastasis is a major cause of cancer-related death, and new tumor metastasis regulators are needed for diagnosis and treatment. Long non-coding RNA (lncRNA) plays a role in promoting tumor metastasis through various mechanisms. Additionally, lncRNA can be found in exosomes and may serve as potential biomarkers and therapeutic targets for cancer metastasis.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Medicine, Research & Experimental
Cecilia Bica, Alexandru Tirpe, Andreea Nutu, Cristina Ciocan, Sergiu Chira, Eugen S. Gurzau, Cornelia Braicu, Ioana Berindan-Neagoe
Summary: This article presents an integrative review on the implications of semaphorins in cancer, specifically discussing their role in cell proliferation/survival, angiogenesis, invasion, metastasis, stemness, and chemo-resistance/response. It highlights the heterogeneity of semaphorins as a family and their interaction with the tumor microenvironment components in driving cancer progression. The differences observed in the biological structure of semaphorins and the specificities of each cancer type necessitate viewing each semaphorin as a unique entity and conducting research accordingly. A deeper understanding of the molecular mechanisms promoting and sustaining the malignant behavior of cancer cells is crucial.
Review
Oncology
Boyang Fan, Qian Zhang, Ning Wang, Guiyu Wang
Summary: This review evaluates the role of lncRNAs in regulating CRCSC signaling pathways and their involvement in promoting and suppressing colorectal cancer. The potential clinical applications of lncRNAs as diagnostic and prognostic biomarkers and therapeutic targets for colorectal cancer are also discussed, providing new ideas and protocols for the prevention and treatment of this disease.
FRONTIERS IN ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuquan Huang, Wu Zhang, Qingxia Li, Zhe Wang, Xianghong Yang
Summary: RNA methylation, including m6A, m5C, and m1A, plays a critical role in cancer. Methylation-associated lncRNAs are involved in various biological processes in cancer, and our analysis identified 39 lncRNAs strongly associated with prognosis in pancreatic cancer. Using a combination of clinical characteristics, we developed a risk model comprising seven lncRNAs that accurately predicted the survival probability of patients. This study highlights the potential of m6A/m5C/m1A-associated lncRNAs as biomarkers for early diagnosis, prognosis estimation, and response prediction to immunotherapy in pancreatic cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Guo Huang, Hong Cao, Guowen Liu, Juan Chen
Summary: This study aimed to investigate the effects of androgen receptor signaling pathway-related long non-coding RNAs (ARSP-related lncRNAs) on breast cancer subtype classification and tumor microenvironment (TME). By screening ARSP-related lncRNAs, a risk model was constructed and found to be an independent prognostic factor for breast cancer patients. The risk score also had an impact on immune cell infiltration in the TME.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Qi Huang, Xue-mei Li, Jing-ping Sun, Yan Zhou
Summary: In this study, the role of endomucin (EMCN) in colorectal cancer (CRC) progression was explored. It was found that EMCN was overexpressed in tumor tissues and could promote CRC proliferation and metastasis. Additionally, 178 potential EMCN-binding proteins were identified, and functional annotation analysis suggested their enrichment in carcinogenic-related functions and pathways.
Article
Medicine, Research & Experimental
Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang, Qiu Li
Summary: This study analyzed EMT-related genes in CRC using bioinformatics methods, identified nine EMT-related genes that impact CRC prognosis, metastasis, drug efficacy, and immunity, and constructed a risk prognosis model.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Junfeng Qiu, Mingzhou Li, Cailin Su, Yihao Liang, Ruizhang Ou, Xiaoning Chen, Chengmei Huang, Yaxin Zhang, Yaping Ye, Wenting Liao, Chao Zhang
Summary: This study found that in colorectal cancer (CRC), the expression of FOXS1 is upregulated and is positively correlated with poor survival. FOXS1 promotes malignant behavior of CRC cells, including proliferation, invasion, and angiogenesis, both in vitro and in vivo. Mechanistically, FOXS1 upregulates the transcriptional level of CXCL8 to regulate tumor growth and metastasis. These findings suggest that the FOXS1/CXCL8 axis may serve as a potential therapeutic target for the treatment of metastatic CRC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yixin Xu, Jia Liu, Tao Jiang, Linsen Shi, Liang Shang, Jun Song, Leping Li
Summary: Research has shown that the up-regulation of PDRG1 in colorectal cancer is associated with worse clinical pathological stage and poorer survival outcome, and its silencing can inhibit tumor growth, metastasis, and induce apoptosis, demonstrating its role as a novel oncogene. PDRG1 is involved in the malignant progression of colorectal cancer by regulating the p21-mediated signal pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Review
Oncology
Luchang Wang, Kaijiong Zhang, Jia Feng, Dongsheng Wang, Jinbo Liu
Summary: Breast cancer is a common and deadly disease for women, affecting their quality of life. Platelets, fragments derived from megakaryocytes, have been a focus of tumor researchers due to their anticoagulant function. They play a crucial role in tumor angiogenesis, vascular integrity, tumor microenvironment, tumor cell proliferation, metastasis, and cancer treatment. This review provides a better understanding of the role of platelets in these processes.
CANCER MANAGEMENT AND RESEARCH
(2023)
Article
Medicine, Research & Experimental
Weijie Liang, Jie Wu, Xinguang Qiu
Summary: This study revealed that LINC01116 is overexpressed in CRC tissues and its high expression is negatively correlated with postoperative survival. In vitro experiments demonstrated that LINC01116 can enhance CRC progression by regulating EZH2 to inhibit TPM1 promoter, leading to increased cell proliferation, migration, and angiogenesis. Further in vivo experiments validated the findings from the in vitro study.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Oncology
Bin Wang, Hanfei Guo, Hongquan Yu, Yong Chen, Haiyang Xu, Gang Zhao
Summary: EGR1, a transcription factor, plays a role in tissue injury, immune responses, and fibrosis. Recent studies suggest EGR1's involvement in cancer initiation and progression, potentially affecting tumor cell proliferation, invasion, metastasis, and angiogenesis. The specific mechanisms by which EGR1 modulates these processes are still under investigation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Shuyun Wang, Limin Nie, Yuxiao Song, Fang Zhang, Xiaozheng Chen, Wenjing Shi, Zijiang Yang, Yuping Sun, Qi Dang, Aiqin Gao
Summary: The study found that NRTN is enriched in colorectal cancer cells and predicts poor patient outcomes. Upregulated NRTN enhances cancer cell motility and angiogenesis, promoting tumor invasion and metastasis.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Cardiac & Cardiovascular Systems
Tayoot Chengsupanimit, Baskaran Sundaram, Wayne Bond Lau, Scott W. Keith, Gregory C. Kane
RESPIRATORY MEDICINE
(2018)
Article
Clinical Neurology
Akash A. Shah, Huiliang Yang, Paul T. Ogink, Joseph H. Schwab
Article
Cell Biology
Dajun Zhao, Pan Feng, Yang Sun, Zhigang Qin, Zhengbin Zhang, Yanzhen Tan, Erhe Gao, Wayne Bond Lau, Xinliang Ma, Jian Yang, Shiqiang Yu, Xuezeng Xu, Dinghua Yi, Wei Yi
CELL DEATH & DISEASE
(2018)
Article
Clinical Neurology
Bowen Hu, Xi Yang, Huiliang Yang, Limin Liu, Peiran Chen, Linnan Wang, Ce Zhu, Chunguang Zhou, Yueming Song
WORLD NEUROSURGERY
(2018)
Article
Medicine, Research & Experimental
Zheyi Yan, Rui Guo, Lu Gan, Wayne Bond Lau, Xiaoming Cao, Jianli Zhao, Xinliang Ma, Theodore A. Christopher, Bernard L. Lopez, Yajing Wang
Review
Biochemistry & Molecular Biology
Qilian Yang, Yuqing Yang, Nianxin Zhou, Kexin Tang, Wayne Bond Lau, Bonnie Lau, Wei Wang, Lian Xu, Zhengnan Yang, Shuang Huang, Xin Wang, Tao Yi, Xia Zhao, Yuquan Wei, Hongjing Wang, Linjie Zhao, Shengtao Zhou
Article
Clinical Neurology
Huiliang Yang, Akash A. Shah, Sandra B. Nelson, Joseph H. Schwab
Article
Clinical Neurology
Akash A. Shah, Huiliang Yang, Mitchel B. Harris, Joseph H. Schwab
CLINICAL SPINE SURGERY
(2019)
Article
Cardiac & Cardiovascular Systems
Yunhui Du, Xiao Li, Haicun Yu, Li Yan, Wayne Bond Lau, Shihan Zhang, Yanwen Qin, Wen Wang, Xinliang Ma, Huirong Liu, Michael Fu
CARDIOVASCULAR DRUGS AND THERAPY
(2019)
Article
Biochemistry & Molecular Biology
Huiliang Yang, Liang Wang, Kathleen Turajane, Lijun Wang, Wentian Yang
Summary: A method has been developed to simultaneously detect and colocalize fluorescent lineage tracing reporter signals and RNAscope signals in skeletal tissue without compromising fidelity, sensitivity, and specificity. The method allows for versatile applications such as determining gene knockout efficacy at the mRNA level, detecting alterations in target gene transcripts in reporter-positive cells caused by specific gene mutations, and studying disease pathology by examining transcript-level expression of genes in a specific cell lineage in vivo.
Article
Cell Biology
Jinyang Zhao, Xiaolong Lin, Haoxuan Sun, Donghui Zhao, Qin Ma, Wayne Bond Lau, Zichao Cheng, Fanqi Li, Jinghua Liu, Qian Fan
Summary: This study found that long non-coding RNAs play key roles as regulatory molecules in aging-related apoptosis effects. Additionally, besides promoting apoptosis, aging also inhibits myocardial apoptosis after hypoxia/reoxygenation.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Cardiac & Cardiovascular Systems
Gan Lu, Demin Liu, Dina Xie, Wayne Bond Lau, Jing Liu, Theodore A. Christopher, Bernard Lopez, Lian Liu, Hang Hu, Peng Yao, Yarong He, Erhe Gao, Walter J. Koch, Jianli Zhao, Xin-Liang Ma, Yu Cao, Yajing Wang
Summary: Acute myocardial infarction causes endoplasmic reticulum stress and endocrine dysfunction in adipocytes, possibly mediated by the release of small extracellular vesicles enriched with the miR-23-27-24 cluster, to communicate with cardiomyocytes.
CIRCULATION RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Zhijun Meng, Zhen Zhang, Jianli Zhao, Caihong Liu, Peng Yao, Ling Zhang, Dina Xie, Wayne Bond Lau, Jumpei Tsukuda, Theodore A. Christopher, Bernard Lopez, Di Zhu, Demin Liu, John Ry Zhang, Erhe Gao, Harry Ischiropoulos, Walter Koch, Xinliang Ma, Yajing Wang
Summary: Insulin resistance in the heart is a characteristic of diabetic cardiac injury. The molecular mechanisms underlying this resistance are not yet understood. Recent studies have shown that the diabetic heart is also resistant to other cardioprotective interventions. The role of Cav3 in diabetic impairment of cardiac protective signaling and diabetic ischemic heart failure needs further investigation.
Meeting Abstract
Cardiac & Cardiovascular Systems
Yajing Wang, Lu Gan, Dina Xie, Wayne Bond Lau, Sisi Wu, Dajun Zhao, Erhe Gao, Walter J. Koch, Xinliang Ma
Meeting Abstract
Cardiac & Cardiovascular Systems
Wenjun Yan, Lu Gan, Yunlong Xia, Yongzhen Guo, Wayne B. Lau, Erhe Gao, Theodore Christopher, Bernard Lopez, Walter Koch, Yajing Wang, Xinliang Ma, Ling Tao
