Article
Oncology
Lewei Yang, Qi Zeng, Yun Deng, Yeqing Qiu, Wei Yao, Yifeng Liao
Summary: The high expression of cysteine cathepsin V (CTSV) in lung cancer is associated with poor prognosis, and glycosylated CTSV is involved in lymph node metastasis. Glycosylated CTSV promotes lung cancer metastasis by being secreted into the extracellular matrix. Additionally, the level of CTSV in serum can distinguish lung cancer patients from healthy individuals.
FRONTIERS IN ONCOLOGY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Shuning Zhang, Yuqing Dong, Shuangyuan Zhao, Fei Bi, Ming Xuan, Guiquan Zhu, Weihua Guo, Zhuang Zhang
Summary: In oral tongue squamous cell carcinoma, CXCL1 promotes tumor cell proliferation through the PI3K/AKT pathway, and also mediates cell migration by regulating the activation of Rho GTPases and the rearrangement of cytoskeleton. The level of plasma CXCL1 can predict the possibility of early lymphatic metastasis, and has prognostic value in progression-free survival and overall survival.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Ganji Seeta Rama Raju, Eluri Pavitra, Sai Samyuktha Bandaru, Ganji Lakshmi Varaprasad, Ganji Purnachandra Nagaraju, Rama Rao Malla, Yun Suk Huh, Young-Kyu Han
Summary: HOTAIR is an oncogenic non-coding RNA that is strongly associated with tumor grade and prognosis in various carcinomas, including breast cancer (BC). It regulates target genes through sponging and epigenetic mechanisms and controls oncogenic cellular and signaling mechanisms, such as metastasis and drug resistance. In BC cells, HOTAIR expression is regulated by transcriptional and epigenetic mechanisms. This review discusses the regulatory mechanisms of HOTAIR during cancer development and explores its role in BC development, metastasis, and drug resistance. The review also highlights the potential therapeutic applications of HOTAIR in BC management, treatment, and prognosis.
Article
Oncology
Yuqing Dong, Shuning Zhang, Shuangyuan Zhao, Ming Xuan, Guiquan Zhu, Zhuang Zhang, Weihua Guo
Summary: Increased CCL2 concentration is associated with short-term progress-free survival and predicts patient prognosis. CCL2 may be a preferable biomarker for predicting the prognosis of patients with tongue cancer.
CANCER BIOLOGY & THERAPY
(2023)
Article
Oncology
Jian-Hua Hong, Sung-Tzu Liang, Alexander Sheng-Shin Wang, Chia-Ming Yeh, Hsiang-Po Huang, Chia-Dong Sun, Zong-Han Zhang, Shih-Yu Lu, Yen-Hsiang Chao, Chung-Hsin Chen, Yeong-Shiau Pu
Summary: Prostate cancer is common among men in the Western world, but there are currently no reliable biomarkers to differentiate between aggressive and indolent cancer. Studies have shown that LMNB1 may play a role in the progression of prostate cancer, but the results have been inconsistent.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Jian-Hua Hong, Sung-Tzu Liang, Alexander Sheng-Shin Wang, Chia-Ming Yeh, Hsiang-Po Huang, Chia-Dong Sun, Zong-Han Zhang, Shih-Yu Lu, Yen-Hsiang Chao, Chung-Hsin Chen, Yeong-Shiau Pu
Summary: LMNB1 may play a role in early prostate cancer progression, but additional molecular alterations may be needed to confer full malignancy potential to initiated cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Oncology
Xi Yang, Lu Fang, Chenping Zhang
Summary: The study revealed that the differential expression of TNFRSF10C in the immune-related pathway is associated with lymph node metastasis and disease-free survival in tongue cancer patients. This suggests TNFRSF10C CNV log2 ratio may serve as an indicator of good prognosis for patients with non-LNM after neck dissection.
Review
Multidisciplinary Sciences
Linlin Li, Xiaoyu Shen, Yuan Liang, Binru Li, Yiwei Si, Rui Ma
Summary: This study aimed to investigate the diagnostic and prognostic value of N-telopeptide of type I collagen (NTx) for bone metastasis in human cancers. The results showed that NTx combined with other markers had a higher diagnostic efficacy, especially in Asian people with lung cancer, breast cancer, and prostate cancer. Furthermore, a high NTx level was associated with poor overall survival in cancer patients with bone metastasis. Therefore, serum NTx combined with other markers can serve as a feasible biomarker for the diagnosis and prognosis prediction of bone metastasis in different cancers.
Article
Genetics & Heredity
Zhiyong Tan, Shi Fu, Yinglong Huang, Xianzhong Duan, Yigang Zuo, Xiaorui Zhu, Haifeng Wang, Jiansong Wang
Summary: By analyzing data from bladder cancer patients, it was found that HSPB8 has significantly different expression levels between cancer and normal samples. This study further revealed the clinicopathological characteristics and prognostic value of HSPB8 in bladder cancer, indicating its potential as a biomarker for treatment.
FRONTIERS IN GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Ai Sato, Kiyoshi Takagi, Ayano Yoshimura, Wakana Tsukamoto, Mio Yamaguchi-Tanaka, Yasuhiro Miki, Akiko Ebata, Minoru Miyashita, Takashi Suzuki
Summary: This study explores the clinical significance of KLK12 in breast cancer. The results show that KLK12 is strongly associated with low-grade malignancy and has favorable prognostic effects. Knockdown of KLK12 enhances proliferation and migration of breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Yuhao Zou, Chenming Zhong, Zekai Hu, Shiwei Duan
Summary: miR-873, located on chromosome 9p21.1, is a microRNA family consisting of miR-873-5p and miR-873-3p. The expression level of miR-873-5p varies in different cancers and impacts cancer development through multiple signaling pathways.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fei Wang, Rukeng Tan, Kun Feng, Jing Hu, Zehang Zhuang, Cheng Wang, Jinsong Hou, Xiqiang Liu
Summary: Radiomics analysis with a 10-mm peritumoral extension on MRI showed excellent predictive power for lymph node metastasis and prognosis in tongue cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Biochemistry & Molecular Biology
Ireneusz Dziuba, Agata M. Gawel, Pawel Tyrna, Jedrzej Machtyl, Monika Olszanecka, Andrzej Pawlik, Cezary Wojcik, Lukasz P. Bialy, Izabela Mlynarczuk-Bialy
Summary: Homotypic entotic figures, a potential prognostic marker in various cancers, have unclear biological roles. This study aimed to explore and compare the frequency of entosis in primary breast tumors and their lymph node metastases. Additionally, we investigated the correlation between entosis and classical breast cancer biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Jiehua Deng, Wei Xiao, Zheng Wang
Summary: The expression level of FAM46C is correlated with the prognosis of tumors, and low expression suggests a poor prognosis. FAM46C is positively correlated with immune cell abundance in the tumor microenvironment and has associations with immunomodulatory pathways, factors, and markers. Additionally, FAM46C expression is related to certain tumor characteristics.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, General & Internal
Jinqi Xue, Xudong Zhu, Xinbo Qiao, Yulun Wang, Jiawen Bu, Xiaoying Zhang, Qingtian Ma, Lu Liang, Lisha Sun, Caigang Liu
Summary: This study evaluated the role of CEMIP in the survival outcome of breast cancer (BC) patients and explored its regulatory mechanism. The results showed that CEMIP expression was higher in BC tissues and was associated with a worse prognosis. CEMIP and its coexpressed genes were found to participate in the progression of BC. Therefore, CEMIP may serve as a potential biomarker for the treatment of BC patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2022)
Review
Dentistry, Oral Surgery & Medicine
Ying Liu, Bao-hua Fan, Yi-ran Tan, Dong-wang Zhu, Min-jun Dong, Li-zhen Wang, Jiang Li, Jian Sun, Chen-ping Zhang, Tong Ji, Wen-jun Yang, Ahmed Abdelrehem, Yi-qun Wu, Lai-ping Zhong
Summary: This study retrospectively analyzed the clinical characteristics, surgical treatment, and prognosis of patients with D-TGCT involving the TMJ and the skull base. The results showed a recurrence rate of 4.5% after complete resection, and tumor recurrence rates of 9.1% and 15.8% for surgery alone and postoperative radiotherapy, respectively. Overall, D-TGCT involving the TMJ and the skull base is locally aggressive but has a good prognosis.
ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY
(2021)
Letter
Oncology
Wu-tong Ju, Ying Liu, Li-zhen Wang, Jiang Li, Guo-xing Ren, Jian Sun, Wen-yong Tu, Yong-jie Hu, Tong Ji, Wen-jun Yang, Jun Li, Yue He, Yan-an Wang, Chen-ping Zhang, Lai-ping Zhong, Zhi-yuan Zhang
CANCER COMMUNICATIONS
(2021)
Article
Oncology
Claire Petit, Benjamin Lacas, Jean-Pierre Pignon, Quynh Thu Le, Vincent Gregoire, Cai Grau, Allan Hackshaw, Bjorn Zackrisson, Mahesh K. B. Parmar, Ju-Whei Lee, Maria Grazia Ghi, Giuseppe Sanguineti, Stephane Temam, Maurice Cheugoua-Zanetsie, Brian O'Sullivan, Marshall R. Posner, Everett E. Vokes, Juan J. Cruz Hernandez, Zbigniew Szutkowski, Eric Lartigau, Volker Budach, Rafal Suwinski, Michael Poulsen, Shaleen Kumar, Sarbani Ghosh Laskar, Jean-Jacques Mazeron, Branislav Jeremic, John Simes, Lai-Ping Zhong, Jens Overgaard, Catherine Fortpied, Pedro Torres-Saavedra, Jean Bourhis, Anne Auperin, Pierre Blanchard
Summary: The network meta-analysis suggests that intensifying chemoradiotherapy, using hyperfractionated radiotherapy with concomitant chemotherapy or induction chemotherapy followed by chemoradiotherapy, could improve outcomes for locally advanced head and neck cancer patients.
Article
Oncology
Benjamin Lacas, Alexandra Carmel, Cecile Landais, Stuart J. Wong, Lisa Licitra, Jeffrey S. Tobias, Barbara Burtness, Maria Grazia Ghi, Ezra E. W. Cohen, Cai Grau, Gregory Wolf, Ricardo Hitt, Renzo Corvo, Volker Budach, Shaleen Kumar, Sarbani Ghosh Laskar, Jean-Jacques Mazeron, Lai-Ping Zhong, Werner Dobrowsky, Pirus Ghadjar, Carlo Fallai, Branko Zakotnik, Atul Sharma, Rene-Jean Bensadoun, Maria Grazia Ruo Redda, Severine Racadot, George Fountzilas, David Brizel, Paolo Rovea, Athanassios Argiris, Zoltan Takacsi Nagy, Ju-Whei Lee, Catherine Fortpied, Jonathan Harris, Jean Bourhis, Anne Auperin, Pierre Blanchard, Jean-Pierre Pignon
Summary: The updated results of the study demonstrate the significant improvement in overall survival for head and neck cancer patients with the addition of concomitant chemotherapy, particularly for those with stage III or IV disease. Induction or adjuvant chemotherapy showed less benefit in increasing overall survival. Additionally, efficacy decreases with age progression.
RADIOTHERAPY AND ONCOLOGY
(2021)
Meeting Abstract
Oncology
Lai-Ping Zhong, Wu-tong Ju, Rong-hui Xia, Qi Zhu, Guopei Zhu, Shengjin Dou, Jiang Li, Min-jun Dong
JOURNAL OF CLINICAL ONCOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
Wenwen Sun, Tongchao Zhao, Timothy O. Aladelusi, Wutong Ju, Zhiyuan Zhang, Laiping Zhong, Dongwang Zhu
Summary: In patients with oral squamous cell carcinoma, reduced expression of Annexin A1 was found to enhance sensitivity to TPF chemotherapy by promoting caspase-dependent apoptosis. This indicates that Annexin A1 may have prognostic value in patients undergoing TPF chemotherapy for locally advanced OSCC.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Oncology
Tong-Chao Zhao, Zhi-Hang Zhou, Wu-Tong Ju, Si-Yuan Liang, Xiao Tang, Dong-Wang Zhu, Zhi-Yuan Zhang, Lai-Ping Zhong
Summary: This study found that OSCC cells overexpressing GDF15 are sensitive to TPF chemotherapy through a caspase-9-dependent pathway. GDF15 overexpression promotes OSCC cell proliferation through erbB2 phosphorylation. Therefore, ErbB2 inhibitors could be potential targeted drugs or alternative therapy for OSCC patients with GDF15 overexpression.
Article
Oncology
Jing Cui, Jingcheng Zhou, Weiqing He, Juan Ye, Timothy Westlake, Rogelio Medina, Herui Wang, Bhushan L. Thakur, Juanjuan Liu, Mingyu Xia, Zhonggui He, Fred E. Indig, Aiguo Li, Yan Li, Robert J. Weil, Mirit I. Aladjem, Laiping Zhong, Mark R. Gilbert, Zhengping Zhuang
Summary: In this study, a novel macrolide antibiotic ISP I was found to inhibit cancer cell growth and metastasis by targeting the nucleolar protein SELH, which is crucial for redox homeostasis and genome stability in cancer cells.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jiayong Zhong, Zhihang Zhou, Yuhua Hu, Tongchao Zhao, Yu Yao, Laiping Zhong, Dongwang Zhu
Summary: This study presented the diagnosis and management of hypoglossal nerve-derived schwannoma in the floor of mouth for the first time in Asia. It provides a recommendation for considering hypoglossal schwannoma as a possible diagnosis when a patient presents with a mass in the floor of mouth.
Article
Multidisciplinary Sciences
Wu-tong Ju, Rong-hui Xia, Dong-wang Zhu, Sheng-jin Dou, Guo-pei Zhu, Min-jun Dong, Li-zhen Wang, Qi Sun, Tong-chao Zhao, Zhi-hang Zhou, Si-yuan Liang, Ying-ying Huang, Yong Tang, Si-cheng Wu, Jing Xia, Shi-qing Chen, Yue-zong Bai, Jiang Li, Qi Zhu, Lai-ping Zhong
Summary: Neoadjuvant therapy with camrelizumab and apatinib is safe and shows a promising major pathological response rate for oral squamous cell carcinoma (OSCC).
NATURE COMMUNICATIONS
(2022)
Article
Surgery
Wutong Ju, Yiyi Zhang, Ying Liu, Jingjing Sun, Jiang Li, Minjun Dong, Qi Sun, Wentao Shi, Tongchao Zhao, Zhihang Zhou, Yingying Huang, Xinyu Zhou, Dongwang Zhu, Shengjin Dou, Zhiyuan Zhang, Yue He, Chenping Zhang, Ronghui Xia, Guopei Zhu, Laiping Zhong
Summary: This retrospective study compared the outcomes of adjuvant radiotherapy and nonradiotherapy in locally advanced resectable oral squamous cell carcinoma (LAROSCC) patients who received neoadjuvant therapy and surgery. The results showed no significant differences in overall survival (OS) or locoregional recurrence-free survival (LRFS) between the two cohorts. The study supports further evaluation of adjuvant radiotherapy omission and suggests de-escalation trials for LAROSCC surgery patients who received neoadjuvant therapy.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Oncology
Ying Liu, Yingying Huang, Dongwang Zhu, Jiang Li, Tongchao Zhao, Yining He, Ronghui Xia, Laiping Zhong
Summary: This study investigated the characteristics of tumor recurrence in diffused-tenosynovial giant cell tumor of the temporomandibular joint and developed a personalized prognostic model. The results showed that age was an independent risk factor for local recurrence-free survival, and the Ki-67 index varied significantly in different sites and tumor volumes. By establishing a prediction model, the likelihood of local recurrence-free survival in patients with this tumor can be accurately forecasted.
Meeting Abstract
Oncology
L-P. Zhong
ANNALS OF ONCOLOGY
(2022)
Meeting Abstract
Oncology
Lai-Ping Zhong, Ying-Ying Huang, Jing-Jing Sun, Jun Li, Min-Jun Dong, Guopei Zhu, Jiang Li, Wu-Tong Ju
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Tong-Chao Zhao, Si-Yuan Liang, Zhi-Hang Zhou, Wu-Tong Ju, Zhi-Yuan Zhang, Dong-Wang Zhu, Lai-Ping Zhong
Summary: The study showed that Apatinib can effectively inhibit the growth of oral squamous cell carcinoma through inducing apoptosis via the VEGFR2/AKT/mTOR pathway. Apatinib also synergized with SCH772984 to achieve a more significant suppression of tumor growth.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
