Article
Cell Biology
Zhaoze Guo, Han Zhang, Yiming Fu, Junjie Kuang, Bei Zhao, LanFang Zhang, Jie Lin, Shuhui Lin, Dehua Wu, Guozhu Xie
Summary: Cancer-associated fibroblasts (CAFs) are the most common stromal cells in breast cancer, and they play a role in disease progression and chemoresistance. This study found that CAF-derived conditioned media can promote breast cancer cell growth and radioresistance. The secretion of interleukin 6 (IL-6) by CAFs activates the STAT3 signaling pathway, leading to the growth and radioresistance of breast cancer cells. Inhibition of STAT3 or neutralizing IL-6 can block the effects induced by CAFs. In mouse models, the IL-6 receptor monoclonal antibody tocilizumab can reverse CAF-induced growth and radioresistance. Additionally, poor response to radiotherapy in breast cancer is associated with the expression of IL-6 and p-STAT3. These findings highlight the importance of the IL-6/STAT3 signaling pathway as a potential therapeutic target in breast cancer radiotherapy.
CELL DEATH DISCOVERY
(2023)
Article
Medicine, General & Internal
Greta Balciuniene, Violeta Gulbiniene, Irena Dumalakiene, Rita Viliene, Daiva Bartkeviciene, Ingrida Pilypiene, Grazina S. Drasutiene, Diana Ramasauskaite
Summary: This study evaluated IL-6, TNF-alpha, and MMP-8 levels in vaginally obtained amniotic fluid as predictors for chorioamnionitis in patients with preterm premature rupture of membranes. The noninvasive technique of sampling amniotic fluid could be an alternative method to invasive amniocentesis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Jose L. Arias, Samanta C. Funes, Rodrigo Blas, Eduardo Callegari, Ricardo J. Elicabe, Maria D. Paez, Alicia Munarriz, Rodolfo Pardo-Hidalgo, Hector Tamashiro, Maria S. Di Genaro
Summary: The study found a significant relationship between S100A8 alarmin and IL-6 and MMP-9 secretion in the synovial microenvironment of peripheral SpA, revealing the involvement of S100A8 in the pathogenesis of peripheral SpA.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Cell Biology
Magdalena Raskova, Lukas Lacina, Zdenek Kejik, Anna Venhauerova, Marketa Skalickova, Michal Kolai, Milan Jakubek, Daniel Rosel, Karel Jr Jr Smetana, Jan Brabek
Summary: This review summarizes the role of interleukin 6 (IL-6) in cancer biology, highlighting the potential of targeting IL-6 signaling pathways, particularly in metastasis suppression.
Article
Medicine, Research & Experimental
Guofang Lu, Siyuan Tian, Yi Sun, Jiaqiang Dong, Na Wang, Jiaoxia Zeng, Yongzhan Nie, Kaichun Wu, Ying Han, Bin Feng, Yulong Shang
Summary: Inflammatory stimuli in the tumor microenvironment play vital roles in cancer progression, with the mechanism of inflammation-induced cancer metastasis in gastric cancer still poorly understood. NEK9 directly regulates cell motility and RhoA activation in gastric cancer by phosphorylating ARHGEF2. The IL-6-mediated suppression of miR-520f-3p leads to an increase in NEK9, GP130, and STAT3 levels, contributing to reduced overall survival of GC patients. Targeting the IL-6-STAT3-NEK9 pathway may offer a new strategy for treating gastric cancer.
Article
Oncology
Keizo Takenaga, Takahiro Ochiya, Hideya Endo
Summary: The NBD peptide inhibits invasiveness and metastasis of highly metastatic human mammary carcinoma cells by suppressing MMP-14 expression through Sp1 downregulation. The peptide also has potential as a promising cancer therapeutic drug for targeting both endothelial cells and tumor cells.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Review
Oncology
Sara G. Manore, Daniel L. Doheny, Grace L. Wong, Hui-Wen Lo
Summary: Breast cancer, the most commonly diagnosed cancer in women, often metastasizes due to the IL-6-mediated signaling pathway. Abnormal activation of this pathway promotes breast cancer metastasis while suppressing the anti-tumor immune response. Components of the IL-6 pathway are potential targets for cancer therapeutics.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhendong Liu, Ruizhou Liu, Rui Wang, Jihang Dai, Hui Chen, Jingcheng Wang, Xiaolei Li
Summary: Sinensetin (SIN), a natural flavonoid, has anti-inflammatory and antioxidant properties, which can reduce the production of inflammatory mediators in human osteoarthritis chondrocytes and protect the degradation of extracellular matrix. It also inhibits the activation of NF-κB and delays the progression of osteoarthritis in rats, protecting cartilage.
Article
Cell Biology
Takatsune Shimizu, Eiji Sugihara, Hideyuki Takeshima, Hiroyuki Nobusue, Rui Yamaguchi, Sayaka Yamaguchi-Iwai, Yumi Fukuchi, Toshikazu Ushijima, Akihiro Muto, Hideyuki Saya
Summary: Mutant p53 in osteosarcoma cells does not suppress the activity of wild-type p53. Targeting mutant p53 R270C (equivalent to human R273C) has limited therapeutic potential, as it does not prevent invasion and metastasis in cells.
Article
Biochemistry & Molecular Biology
Yixuan Wu, Qi Qu, Zhiting Wan, Shaogang Qu
Summary: The widely used pesticide fenpropathrin can increase the expression of Mdm2 and reduce the expression of p53, leading to the stimulation of Nedd4L and the secretion of IL-6 through the Mdm2-p53 pathway. Nedd4L mediates the degradation of GLT-1, resulting in glutamate accumulation and excitotoxicity aggravation. These findings provide insight into the pathogenic mechanism of fenpropathrin toxicity and contribute to the development of guidance for pesticide control and environmental protection.
ACS CHEMICAL NEUROSCIENCE
(2023)
Review
Oncology
Lidia Rodriguez Calleja, Melanie Lavaud, Robel Tesfaye, Benedicte Brounais-Le-Royer, Marc Baud'huin, Steven Georges, Francois Lamoureux, Franck Verrecchia, Benjamin Ory
Summary: The p53 protein family and the TGFb pathway play important roles in tumor growth and metastatic spread. Various isoforms of the p53 protein family, as well as interactions between the p53 protein family and the TGFb pathway, have been found to contribute to the complexity of tumor development.
Article
Chemistry, Analytical
D. Vieira, J. Barralet, E. J. Harvey, G. Merle
Summary: This study presents a new approach to enhance the electrochemical interaction of MMP-14 with the electrode surface using a specific commercial molecule called NSC-405020. By grafting NSC-405020 onto carbon nanotubes, MMP-14 can be detected and quantified with a wide linear detection range and low detection limit.
Article
Immunology
Rita Haldar, Lee Shaashua Berger, Ella Rossenne, Arielle Radin, Anabel Eckerling, Elad Sandbank, Erica K. Sloan, Steve W. Cole, Shamgar Ben-Eliyahu
Summary: We demonstrated that minimally-invasive removal of primary tumors (PTs) and elimination of secreted factors can induce regression of micro-metastases in breast cancer. However, laparotomy during the procedure leads to an outbreak of micro-metastases. Administration of propranolol and etodolac can maintain metastatic dormancy following laparotomy.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Xi Yan, Lina Han, Riyang Zhao, Sumaya Fatima, Lianmei Zhao, Feng Gao
Summary: The study found that IL-6 and IL-8 could be promising molecular biomarkers for the diagnosis and prediction of lung cancer metastasis, regardless of pathological types, when combined with CEA.
Review
Cell Biology
Noritaka Tanaka, Takeharu Sakamoto
Summary: MT1-MMP is a member of the metalloproteinase family, which degrades extracellular matrix components directly and can indirectly degrade type IV collagen through the activation of MMP-2 with TIMP-2. MT1-MMP is initially expressed as an inactive form in the ER and is activated through truncation processing by furin. Upon trafficking from the ER to the cell surface membrane, MT1-MMP exhibits proteolytic activities on surrounding molecules.