Article
Medicine, Research & Experimental
Jonathan A. Harounian, Nicole Molin, Thomas J. Galloway, Drew Ridge Facs, Jessica Bauman, Jeffrey Farma, Sanjay Reddy, Miriam N. Lango
Summary: This study found that Merkel cell carcinoma patients with lymphovascular invasion (LVI) and positive sentinel lymph node (SLN) had worse prognostic outcomes. Sentinel lymph node biopsy assists in risk stratification and radiation treatment planning in MCC.
Article
Oncology
Stacy B. Sanders, Tanya L. Hoskin, Arielle P. Stafford, Judy C. Boughey
Summary: This study evaluated the rate of non-sentinel lymph node (NSLN) positivity and factors influencing this in patients with a positive sentinel lymph node (SLN) following neoadjuvant chemotherapy (NAC). The results showed a high rate of nodal positivity on completion axillary lymph node dissection (cALND) in the setting of positive SLN after NAC, supporting the current standard of routine cALND. In patients with cN+ disease, NSLN positivity varied based on tumor biology, multicentricity/multifocality, number of positive SLNs, and SLN metastasis size.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Isaac Cebrecos, Eduard Mension, Inmaculada Alonso, Helena Castillo, Esther Sanfeliu, Sergi Vidal-Sicart, Sergi Ganau, Maria Vidal, Francesco Schettini
Summary: In early stage breast cancer patients without lymph node metastasis, the presence of positive sentinel lymph nodes after primary systemic treatment directs axillary lymph node dissection. This study aimed to identify factors associated with non-sentinel lymph node involvement and develop a predictive score. The results showed that non-sentinel lymph node involvement was infrequent (22.2%) and associated with progesterone receptor levels and macrometastatic sentinel lymph nodes. The developed predictive score accurately predicted the absence of non-sentinel lymph node involvement, suggesting that unnecessary axillary lymph node dissection could be safely avoided in most patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Kevin L. Ma, Cimarron E. Sharon, Gabriella N. Tortorello, Nikhita J. Perry, Luke J. Keele, John N. Lukens, Giorgos C. Karakousis, John T. Miura
Summary: This retrospective cohort study analyzed data from the National Cancer Database from 2012 to 2019. The study found that there was no significant difference in survival benefits between radiation therapy and completion lymph node dissection for regional lymph node micrometastasis in Merkel cell carcinoma (MCC) patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Richard J. Straker, Michael J. Carr, Andrew J. Sinnamon, Adrienne B. Shannon, James Sun, Karenia Landa, Kirsten M. Baecher, Christian Wood, Kevin Lynch, Harrison G. Bartels, Robyn Panchaud, Michael C. Lowe, Craig L. Slingluff, Mark J. Jameson, Kenneth Tsai, Mark B. Faries, Georgia M. Beasley, Vernon Sondak, Giorgos C. Karakousis, Jonathan S. Zager, John T. Miura
Summary: The study revealed that in clinically localized Merkel cell carcinoma, males, patients over 75 years old, and those with lymphovascular invasion are more likely to have false negative SLNB results. Patients with false negative SLNB experienced shorter time to nodal recurrence and significantly worse survival rates.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Alexander C. J. van Akkooi, Dirk Schadendorf, Alexander M. M. Eggermont
Summary: Sentinel lymph node biopsy (SLNB) was introduced in the 1990s to identify patients who may benefit from completion lymph node dissection. SLNB staging has been found to be the best for staging melanoma. Adjuvant systemic therapy and biomarkers are emerging, which might reduce the need for SLNB staging in the future.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Medical Laboratory Technology
Rebecca Czaja, Ruizhe Wu, Julie M. Jorns
Summary: In recent years, there has been a trend towards less aggressive surgical management of axillary lymph nodes in breast cancer. This study evaluated the effectiveness of evaluating axillary sentinel lymph nodes and found that serial sectioning at 2-mm intervals reduced false negatives due to macrometastatic disease. Discordant cases were mostly false negatives detected on the first permanent section level due to sampling errors.
ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE
(2021)
Article
Medicine, General & Internal
Neil Carleton, Jian Zou, Yusi Fang, Stephen E. Koscumb, Osama Shiraz Shah, Fangyuan Chen, Sushil Beriwal, Emilia J. Diego, Adam M. Brufsky, Steffi Oesterreich, Steven D. Shapiro, Robert Ferris, Leisha A. Emens, George Tseng, Oscar C. Marroquin, Adrian V. Lee, Priscilla F. McAuliffe
Summary: This study found that receiving SLNB or RT did not improve LRFS or DFS in older patients with ER-positive, clinically node-negative breast cancer. The study supports the continued deimplementation of both SLNB and RT in accordance with the Choosing Wisely and National Comprehensive Cancer Network guidelines.
Article
Medicine, Research & Experimental
Giri Krishnan, Nynke S. van den Berg, Naoki Nishio, Georgina Juniper, Jaqueline Pei, Quan Zhou, Guolan Lu, Yu-Jin Lee, Kimberly Ramos, Andrei H. Iagaru, Fred M. Baik, Alexander D. Colevas, Brock A. Martin, Eben L. Rosenthal
Summary: The study showed that intravenous infusion of a tumor-targeted tracer could accurately identify sentinel and metastatic lymph nodes, potentially improving the practice of SLNB surgery.
Article
Oncology
Maria Cristina Leonardi, Camilla Arrobbio, Sara Gandini, Stefania Volpe, Francesca Colombo, Eliana La Rocca, Viviana Galimberti, Sabrina Kahler-Ribeiro-Fontana, Cristiana Fodor, Samantha Dicuonzo, Damaris Patricia Rojas, Maria Alessia Zerella, Anna Morra, Emilia Montagna, Marco Colleoni, Giovanni Mazzarol, Laura Lavinia Travaini, Mattia Zaffaroni, Paolo Veronesi, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Summary: This study aimed to evaluate the rate of positive non-sentinel lymph nodes in breast cancer patients after neoadjuvant systemic therapy following positive sentinel lymph node biopsy. Positive non-SLNs were found in 62.3% of cases and were significantly associated with older age, clinically positive lymph nodes, SLN extracapsular extension, and a higher ratio of positive SLNs/total SLNs. ECE and higher nodal ratio were independent predictors of III axillary level positivity.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Cell Biology
Billy Shui-Wun Lai, Julia Y. Tsang, Joshua J. Li, Ivan K. Poon, Gary M. Tse
Summary: This study aimed to evaluate predictive factors for axillary lymph node (ALN) metastasis and the clinical value of sentinel lymph node (SLN) features. The study found that only 31.8% of SLN+ cases had ALN metastasis. The level of tumor invasion in SLN and tumor size in SLN were found to be useful predictors for ALN metastasis and breast cancer outcome. Additionally, the presence of isolated tumor cells (ITC) with deeper invasion in SLN was associated with worse prognosis.
Article
Oncology
Enver Ozkurt, Stephanie Wong, Esther Rhei, Mehra Golshan, Jane Brock, Thanh U. Barbie
Summary: The study found that patients with T1 tubular carcinoma (TC) have low rates of axillary lymph node (LN) involvement, comparable to patients with ductal carcinoma in situ (DCIS) and lower than other types of ER-positive invasive ductal carcinoma (IDC) patients. There was no significant difference in 5-year and 10-year overall survival rates between TC patients with or without LN involvement. Therefore, tubular histology is independently associated with improved survival.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Dimitrios Nasioudis, Maureen Byrne, Emily M. Ko, Robert L. Giuntoli, Ashley F. Haggerty, Lori Cory, Sarah H. Kim, Mark A. Morgan, Nawar A. Latif
Summary: The study found that performing SLNBx on patients with endometrioid endometrial carcinoma did not have a negative impact on survival rates. After controlling for confounders, SLNBx showed similar survival outcomes compared to systematic lymphadenectomy. This research provides a minimally invasive option for treating these patients.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Chi-Chang Yu, Yun-Chung Cheung, Chuen Hsueh, Shin-Cheh Chen
Summary: IC tumor size and the presence of LVI are independent risk predictors of SLN metastasis. With the absence of any predictors, the incidence of positive SLNs is very low, suggesting that SLNB may be omitted in patients who initially underwent BCS without risk predictors identified on final pathological assessment. Further prospective studies are needed before clinical application.
Article
Radiology, Nuclear Medicine & Medical Imaging
Juanito Gebruers, Laura Elst, Marcella Baldewijns, Liesbeth De Wever, Koen Van Laere, Maarten Albersen, Karolien Goffin
Summary: This study investigated the role of dynamic sentinel lymph node biopsy (DSNB) in cN0 penile cancer patients without palpable inguinal lymph node metastases. The results showed that DSNB had a high detection rate and negative predictive value, making it a valuable tool for early detection of inguinal lymph node metastases.
Review
Oncology
Hannah Buckley, Charles Wilson, Thankamma Ajithkumar
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2017)
Review
Oncology
Thankamma Ajithkumar, Stephen Price, Gail Horan, Amos Burke, Sarah Jefferies
Article
Oncology
Enrica Seravalli, Mirjam Bosman, Yasmin Lassen-Ramshad, Anne Vestergaard, Foppe Oldenburger, Jorrit Visser, Efi Koutsouveli, Chryssa Paraskevopoulou, Gail Horan, Thankamma Ajithkumar, Beate Timmermann, Carolina-Sofia Fuentes, Gillian Whitfield, Thomas Marchant, Laetitia Padovani, Eloise Gamier, Lorenza Gandola, Silvia Meroni, Bianca A. W. Hoeben, Martijn Kusters, Claire Alapetite, Sandra Losa, Farid Goudjil, Henriette Magelssen, Morten Egeberg Evensen, Frank Saran, Gregory Smyth, Barbara Rombi, Roberto Righetto, Rolf-Dieter Kortmann, Geert O. Janssens
Article
Dermatology
G. W. M. Millington, A. Collins, C. R. Lovell, T. A. Leslie, A. S. W. Yong, J. D. Morgan, T. Ajithkumar, M. J. Andrews, S. M. Rushbook, R. R. Coelho, S. J. Catten, K. Y. C. Lee, A. M. Skellett, A. G. Affleck, L. S. Exton, M. F. Mohd Mustapa, N. J. Levell
BRITISH JOURNAL OF DERMATOLOGY
(2018)
Article
Oncology
A. Bowzyk Al-Naeeb, M. Murray, G. Horan, F. Harris, R. -D. Kortmann, J. Nicholson, T. Ajithkumar
Article
Oncology
T. Ajithkumar, A. -L. Mazhari, M. Stickan-Verfuerth, P. -H. Kramer, C. -S. Fuentes, J. Lambert, H. Thomas, H. Mueller, G. Fleischhack, B. Timmermann
Article
Oncology
Thankamma Ajithkumar, Gail Horan, Laetitia Padovani, Nicky Thorp, Beate Timmermann, Claire Alapetite, Lorenza Gandola, Monica Ramos, Karen Van Beek, Melissa Christiaens, Yasmin Lassen-Ramshad, Henriette Magelssen, Kristina Nilsson, Frank Saran, Barbara Rombi, Rolf Kortmann, Geert O. Janssens
RADIOTHERAPY AND ONCOLOGY
(2018)
Review
Oncology
Thankamma Ajithkumar, Naduni Imbulgoda, Elliott Rees, Fiona Harris, Gail Horan, Amos Burke, Sarah Jefferies, Stephen Price, Justin Cross, Kieren Allinson
Article
Oncology
T. Ajithkumar, R. Taylor, R. D. Kortmann
Article
Oncology
L. Padovani, G. Horan, T. Ajithkumar
Editorial Material
Oncology
T. Ajithkumar, R. D. Kortmann
Review
Oncology
Bianca A. Hoeben, Christian Carrie, Beate Timmermann, Henry C. Mandeville, Lorenza Gandola, Karin Dieckmann, Monica Ramos Albiac, Henriette Magelssen, Yasmin Lassen-Ramshad, Barbora Ondrova, Thankamma Ajithkumar, Claire Alapetite, Brian V. Balgobind, Stephanie Bolle, Alison L. Cameron, Raquel Davila Fajardo, Stefan Dietzsch, Delphine Dumont Lecomte, Marry M. van den Heuvel-Eibrink, Rolf D. Kortmann, Anne Laprie, Patrick Melchior, Laetitia Padovani, Barbara Rombi, Giovanni Scarzello, Rudolf Schwarz, Klaus Seiersen, Enrica Seravalli, Nicola Thorp, Gillian A. Whitfield, Tom Boterberg, Geert O. Janssens
Article
Oncology
P. J. Ross, H. S. Wasan, D. Croagh, M. Nikfarjam, N. Nguyen, M. Aghmesheh, A. M. Nagrial, D. Bartholomeusz, A. Hendlisz, T. Ajithkumar, C. Iwuji, N. E. Wilson, D. M. Turner, D. C. James, E. Young, M. T. Harris
Summary: This study suggests that combining P-32 microparticles with standard-of-care chemotherapy may have clinically relevant benefits for patients with unresectable locally advanced pancreatic cancer. The treatment has an acceptable safety profile and results in improved local disease control and overall survival.
Article
Oncology
S. Prewett, G. Horan, H. Hatcher, T. Ajithkumar
Letter
Ophthalmology
David Maskell, Konstantinos Geropantas, Michael Kouroupis, Andrew Glenn, Thankamma Ajithkumar
CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE
(2017)
