Article
Biochemistry & Molecular Biology
Hong Chen, Qilin Pei, Linfen Tao, Jing Xia, Guocai Lu, Ying Zong, Wenhua Xie, Wanqing Li, Chenglong Huang, Ting Zeng, Xinyu Yu, Weixuan Wang, Gaojun Chen, Song Yang, Rui Cheng, Xi Li
Summary: Obesity poses a significant threat to human health due to chronic inflammation and metabolic diseases. Apoptosis-associated speck-like protein (ASC) acts as a critical link between inflammasome and apoptosis-inducing proteins. This study reveals that ASC deficiency promotes lipid accumulation by increasing lipogenesis and decreasing lipolysis in subcutaneous adipose tissue, aggravating obesity and metabolic imbalance. In addition, ASC regulation of p53/AMPKα axis contributes to the dysregulation of lipid metabolism. The findings suggest that ASC could be a potential therapeutic target for obesity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Yao-Hao Xu, Yu-Tao Hu, Shu-Min Xu, Bing-Bing Song, Hao Yuan, Dan-Dan Zhao, Shi-Yao Guo, Zhi Jiang, Li-Yuan Wei, Yong Rao, Jia-Heng Tan, Shi-Liang Huang, Qing-Jiang Li, Shuo-Bin Chen, Zhi-Shu Huang
Summary: In this study, we designed and synthesized a new series of bouchardatine derivatives and identified one derivative, 18a, with high antiproliferation activities against colorectal cancer cells. 18a inhibited cell proliferation by modulating oxidative phosphorylation and activating AMPK. These findings suggest that 18a could be a promising candidate for colorectal cancer treatment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Goon-Tae Kim, Kyung-Hee Cho, Amitesh Sharma, Shivani Devi, Tae-Sik Park
Summary: Graviola leaf extracts can alleviate chronic diseases by downregulating fatty acid oxidation and synthesis genes. In vivo experiments in mice fed a high-fat diet showed significant weight loss and improvement in liver condition in response to treatment with graviola leaf extracts, particularly ethanol extract.
Article
Biochemistry & Molecular Biology
Hang-Hee Cho, Sun-Hee Jang, Chungkil Won, Chung-Hui Kim, Hong-Duck Kim, Tae Hoon Kim, Jae-Hyeon Cho
Summary: DM inhibits adipogenesis and lipid accumulation by downregulating adipogenic transcription factors and inactivating adipogenesis signaling factor.
Article
Biochemistry & Molecular Biology
Jie Cai, Gu Qiong, Chanjuan Li, Lulu Sun, Yuhong Luo, Shengheng Yuan, Frank J. Gonzalez, Jun Xu
Summary: MNSB isolated from Saururus chinensis has been identified as a potent inhibitor of adipogenesis/lipogenesis by increasing phosphorylation of AMPK. In animal studies, MNSB showed preventive and therapeutic effects on obesity, along with decreasing adipocyte size. Additionally, MNSB was found to increase AMPK phosphorylation in subcutaneous white adipose tissue and brown adipose tissue in vivo.
Article
Food Science & Technology
Jaeeun Jung, Jeongjin Park, Minhee Lee, Jinhak Kim, Dongchan Oh, Woojin Jun, Ok-Kyung Kim, Jeongmin Lee
Summary: In this study, the potential anti-obesity effects of Salacia reticulata extracts (SC) were explored in obese mice and 3T3-L1 adipocytes, revealing that SC supplementation led to significant reductions in body weight gain, adipose tissue weight, adipose tissue mass, and adipocyte size. SC treatment also exerted inhibitory effects on adipogenesis and lipogenesis, while promoting lipolysis and thermogenesis pathways. These findings suggest that SC has a direct influence on lipid metabolism of adipocytes, making it a promising candidate for weight loss interventions.
Article
Biochemistry & Molecular Biology
Hyo-Shim Han, Ilavenil Soundharrajan, Mariadhas Valan Arasu, Dahye Kim, Ki-Choon Choi
Summary: This study investigated the effects of Leuconostoc citreum (LSC) cell-free metabolites on adipogenesis, lipogenesis, and lipolysis in 3T3-L1 adipocytes. The results showed that LSC treatment reduced lipid droplet accumulation and the expression of key adipogenic and lipogenic markers while increasing lipolysis. Additionally, LSC treatment elevated adiponectin levels, suggesting its potential as a novel probiotic strain for treating obesity and metabolic disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nicklas Pihlstrom, Yang Jin, Zeynep Nenseth, Omer F. Kuzu, Fahri Saatcioglu
Summary: Prostate cancer is one of the most common non-skin cancers among men, with no curative treatment currently available. STAMP2, an important factor for prostate cancer growth and survival, is regulated by inflammatory signaling which may affect disease progression. Inflammatory events and dysregulated cytokine expression are implicated in prostate cancer, and STAMP2 knockdown increases the sensitivity of prostate cancer cells to cytokine treatment.
Article
Endocrinology & Metabolism
Anna Mikolajczak, Nada A. Sallam, Radha D. Singh, Taylor B. Scheidl, Emma J. Walsh, Sebastian Larion, Carol Huang, Jennifer A. Thompson
Summary: This study demonstrated that accelerated adipogenesis during the perinatal period predisposes offspring to hypertrophic adipocyte dysfunction later in life, compromising the buffering function of subcutaneous fat depot.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Oncology
Jorgen Sikkeland, Matthew Yoke Wui Ng, Hatice Zeynep Nenseth, Bilal Unal, Su Qu, Yang Jin, Anne Simonsen, Fahri Saatcioglu
Summary: STAMP2 suppresses autophagy through modulation of the integrated stress response axis and regulates mitochondrial respiration, both of which have significant metabolic effects and support PCa growth.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Chemistry, Organic
Fang-Yu Yuan, Yue-Hua Pan, Ai-Ping Yin, Wei Li, Dong Huang, Xue-Long Yan, Shu-Qi Wu, Gui-Hua Tang, Rong Pu, Sheng Yin
Summary: Euphorstranoids A and B, isolated from Euphorbia stracheyi, are highly rearranged ingenane diterpenoids that inhibit the triglyceride level in 3T3-L1 adipocytes by retarding cell adipogenesis at the early stage.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Nutrition & Dietetics
Hee-Seop Lee, Adina L. Santana, Jaymi Peterson, Umut Yucel, Ramasamy Perumal, Joaquin De Leon, Seong-Ho Lee, Dmitriy Smolensky
Summary: Obesity is a serious public health problem that can lead to various chronic diseases. This study suggests that extracts from high-polyphenol sorghum bran may have potential anti-obesity effects.
Article
Biochemistry & Molecular Biology
Ji Woo Hong, Ha Young Park, Han A. Kim, Yun Seon Hwang, Eun Jae Lee, Jin Woo Kim
Summary: The study aimed to investigate the effect of Canavalia gladiata extract (CGE) on AMP-activated protein kinase (AMPK) in 3T3-L1 preadipocytes and evaluate the mechanisms of adipogenesis and lipogenesis. CGE treatment at different concentrations suppressed lipid accumulation and differentiation in 3T3-L1 preadipocytes. The mRNA expressions of AMPK and carnitine palmitoyl transferase-1 (CPT-1) increased, while the expressions of adipogenesis transcription factors decreased, suggesting the inhibitory effect of CGE on adipogenesis and lipogenesis. Gallic acid was identified as the main component of CGE. These findings suggest that CGE can be used as an anti-obesity food additive or medication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Qiongyu Lu, Ziting Liu, Luyao Zhao, Linru Xu, Chu Liu, Ling Li, Yiren Cao, Fengchan Li, Lili Wu, Lei Wang, Ting Chen, Tao You, Lijie Ren, Guixue Wang, Chaojun Tang, Li Zhu
Summary: The study found that Sema7A plays an inhibitory role in obesity and hepatic steatosis, suggesting it as a potential new therapeutic target for obesity and metabolic diseases.
MOLECULAR METABOLISM
(2023)
Review
Genetics & Heredity
Javier A. Benavides-Aguilar, Andrea Torres-Copado, Jose Isidoro-Sanchez, Surajit Pathak, Asim K. Duttaroy, Antara Banerjee, Sujay Paul
Summary: Obesity is a major health concern worldwide and can lead to various chronic diseases. MiRNAs play a significant role in the onset and progression of obesity and related ailments, and their expression can be influenced by chemical compounds in food and treatments.
Article
Multidisciplinary Sciences
Karianne Giller Fleten, J. Johannes Eksteen, Brynjar Mauseth, Ketil Andre Camilio, Terje Vasskog, Baldur Sveinbjornsson, Oystein Rekdal, Gunhild M. Maelandsmo, Kjersti Flatmark
Summary: The study found that oncolytic peptides showed promising activity in treating CRC and produced good therapeutic effects in mouse models. Experimental evidence demonstrated that these oncolytic peptides can trigger lasting anticancer immune responses and prevent the occurrence of liver metastases, making them potentially promising drugs for the treatment of colorectal cancer in the future.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Multidisciplinary
Abhilash D. Pandya, Tore-Geir Iversen, Siver Moestue, Maria T. Grinde, Yrr Morch, Sofie Snipstad, Andreas K. O. Aslund, Geir F. Oy, Wanja Kildal, Olav Engebraten, Kirsten Sandvig, Tore Skotland, Gunhild M. Maelandsmo
Summary: PEBCA nanoparticles showed the highest uptake in breast cancer xenografts and lymph nodes, making them the most promising for drug delivery. They also increased infiltration of anti-tumorigenic M1 macrophages in tumors and shifted the M1/M2 macrophage ratio, suggesting potential for modulating immune responses for enhanced therapeutic effects.
Article
Oncology
Nicklas Pihlstrom, Yang Jin, Zeynep Nenseth, Omer F. Kuzu, Fahri Saatcioglu
Summary: Prostate cancer is one of the most common non-skin cancers among men, with no curative treatment currently available. STAMP2, an important factor for prostate cancer growth and survival, is regulated by inflammatory signaling which may affect disease progression. Inflammatory events and dysregulated cytokine expression are implicated in prostate cancer, and STAMP2 knockdown increases the sensitivity of prostate cancer cells to cytokine treatment.
Article
Biochemistry & Molecular Biology
Mateusz A. Krzyscik, Malgorzata Zakrzewska, Vigdis Sorensen, Geir Frode Oy, Skjalg Brunheim, Ellen M. Haugsten, Gunhild M. Maelandsmo, Antoni Wiedlocha, Jacek Otlewski
Summary: Despite being the second leading cause of death worldwide, cancer still lacks a fully effective therapy, highlighting the urgent need for new targeted anticancer drugs. Researchers have developed novel protein-drug conjugates that successfully inhibit tumor growth in a mouse model of human breast cancer.
Article
Oncology
Sigurdur Trausti Karvelsson, Arnar Sigurdsson, Kotryna Seip, Maria Tunset Grinde, Qiong Wang, Freyr Johannsson, Gunhild Mari Maelandsmo, Siver Andreas Moestue, Ottar Rolfsson, Skarphedinn Halldorsson
Summary: The study reveals that the epithelial-to-mesenchymal transition induces metabolic changes in breast epithelial cells, including re-routing of the TCA cycle, increased lipid biosynthesis, and decreased glycolytic rates. The alterations in GSH synthesis modulate the sensitivity of breast epithelial cells to mTOR inhibitors.
MOLECULAR CANCER RESEARCH
(2021)
Article
Endocrinology & Metabolism
Caroline E. Nunes-Xavier, Wanja Kildal, Andreas Kleppe, Havard E. Danielsen, Hakon Waehre, Roberto Llarena, Gunhild M. Maelandsmo, Oystein Fodstad, Rafael Pulido, Jose I. Lopez
Summary: This study identified distinct clinical relevance of the two immune checkpoint proteins PD-L1 and B7-H3 in prostate cancer, with B7-H3 potentially serving as a significant therapeutic target.
Article
Pharmacology & Pharmacy
Gan Wang, Min Zhang, Ping Meng, Chengbo Long, Xiaodong Luo, Xingwei Yang, Yunfei Wang, Zhiye Zhang, James Mwangi, Peter Muiruri Kamau, Zhi Dai, Zunfu Ke, Yi Zhang, Wenlin Chen, Xudong Zhao, Fei Ge, Qiumin Lv, Mingqiang Rong, Dongsheng Li, Yang Jin, Xia Sheng, Ren Lai
Summary: Unlike healthy cells, cancer cells heavily rely on the molecular chaperone protein TRiC, particularly its subunit CCT4, for protein folding and maintenance of proteostasis. In this study, we demonstrate that targeting CCT4 with the compound anticarin-beta can effectively inhibit osteosarcoma cell survival and impede STAT3 maturation. Anticarin-beta shows high selectivity for cancer cells and exhibits remarkable antitumor efficacy in orthotopic and patient-derived xenograft models of osteosarcoma.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Multidisciplinary Sciences
Marta Nyakas, Karianne Giller Fleten, Mads Haugland Haugen, Nikolai Engedal, Christina Sveen, Inger Nina Farstad, Vivi Ann Florenes, Lina Prasmickaite, Gunhild Mari Maelandsmo, Kotryna Seip
Summary: This study investigated the therapeutic potential of combining an AXL inhibitor (AXLi) and a clinically relevant BRAF inhibitor (BRAFi) for the treatment of metastatic melanoma. The results showed that AXL was expressed in the majority of melanoma lymph node metastases. In vitro experiments demonstrated that the combination of AXLi and BRAFi resulted in the largest reduction in cell viability. Moreover, pre-clinical studies using AXL(high) melanoma models showed a therapeutic benefit of adding AXLi to the BRAF-targeted therapy. Mechanistic insights revealed that AXLi potentiated BRAFi-induced apoptosis, stimulated ferroptosis, and inhibited autophagy. Overall, this study suggests that combining AXLi with standard therapy could improve the therapeutic outcome in metastatic melanoma.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Multidisciplinary
Rourou Xiao, Lixin You, Li Zhang, Xichen Guo, Ensong Guo, Faming Zhao, Bin Yang, Xi Li, Yu Fu, Funian Lu, Zizhuo Wang, Chen Liu, Wenju Peng, Wenting Li, Xiaohang Yang, Yingyu Dou, Jingbo Liu, Wei Wang, Tianyu Qin, Yaoyuan Cui, Xiaoxiao Zhang, Fuxia Li, Yang Jin, Qingping Zeng, Beibei Wang, Gordon B. Mills, Gang Chen, Xia Sheng, Chaoyang Sun
Summary: The WEE1 inhibitor AZD1775 induces endoplasmic reticulum stress and activates the PERK and IRE1 alpha branches of the unfolded protein response in TP53 mutant ovarian cancer models. Inhibition of the IRE1 alpha-XBP1s pathway may enhance the efficacy of AZD1775.
Article
Oncology
Caroline E. Nunes-Xavier, Janire Mingo, Maite Emaldi, Karine Flem-Karlsen, Gunhild M. Maelandsmo, Oystein Fodstad, Roberto Llarena, Jose I. Lopez, Rafael Pulido
Summary: This study revealed heterogeneous expression of PDH complex components in PCa tumors, with PDH complex components being related to AR signaling and PDK2 expression associated with poor PCa prognosis. These findings highlight the potential of targeting PDH complex components for intervention in PCa.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Chengcheng Shi, Faming Zhao, Tingting Zhang, Denghui Xu, Zhuangyu Hao, Fengzhen Cui, Ji-Hua Shi, Yang Jin, Ningning Li, Caihong Yang, Yi Zhang, Xia Sheng
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Yixin Jin, Kristina Berg Lorvik, Yang Jin, Carole Beck, Adam Sike, Irene Persiconi, Emilie Kvaloy, Fahri Saatcioglu, Claire Dunn, Jon Amund Kyte
Summary: This study describes a CAR T cell targeting STEAP1 and demonstrates its potential clinical application in prostate cancer. The CAR T cells showed specific response against STEAP1 and effectively inhibited tumor growth and prolonged survival in vivo.
MOLECULAR THERAPY-ONCOLYTICS
(2022)
Article
Oncology
Vigdis Nygaard, Anne Hansen Ree, Vegar Johansen Dagenborg, Anne-Lise Borresen-Dale, Bjorn Edwin, Asmund Avdem Fretland, Krzysztof Grzyb, Mads H. Haugen, Gunhild M. Maelandsmo, Kjersti Flatmark
Summary: A mesenchymal subgroup with an immunosuppressive phenotype, characterized by high expression of immune checkpoints HAVCR2/TIM-3 and VISTA, as well as the M2 macrophage marker CD163, was identified in colorectal cancer liver metastases. These findings suggest potential novel opportunities for immune-based therapy approaches in microsatellite stable colorectal cancer.
CANCER RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Margherita Ambrosini, Marzia Del Re, Paolo Manca, Andrew Hendifar, Alexander Drilon, Guilherme Harada, Anne Hansen Ree, Samuel Klempner, Gunhild Mari Maelandsmo, Kjersti Flatmark, Hege G. Russnes, James M. Cleary, Harshabad Singh, Elisa Sottotetti, Antonia Martinetti, Giovanni Randon, Andrea Sartore-Bianchi, Iolanda Capone, Massimo Milione, Maria Di Bartolomeo, Filippo Pietrantonio
Summary: This study collected data from patients with GI cancers and ALK rearrangements, showing remarkable responses and clinical benefit with ALK inhibitors. Despite the low frequency, ALK rearrangements play an important role in personalized treatment for GI cancers.
JCO PRECISION ONCOLOGY
(2022)
Article
Oncology
Jorgen Sikkeland, Matthew Yoke Wui Ng, Hatice Zeynep Nenseth, Bilal Unal, Su Qu, Yang Jin, Anne Simonsen, Fahri Saatcioglu
Summary: STAMP2 suppresses autophagy through modulation of the integrated stress response axis and regulates mitochondrial respiration, both of which have significant metabolic effects and support PCa growth.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
