Journal
ONCOTARGET
Volume 7, Issue 38, Pages 61670-61678Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.11430
Keywords
KLRG1; senescence; memory T cells; antitumor immunity
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Funding
- National Natural Science Foundation of China (NSFC) [81402357, 81472740, 81272424]
- Chinese Ministry of Science and Technology (MOST) [14C26213601925, 2015CB554000]
- Health and Family Plan Committee of China Research Fund of Public welfare in Health industry [201402015]
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Killer cell lectin-like receptor subfamily G member 1 (KLRG1) has been found on human memory T lymphocytes. However, the roles of KLRG1 on human T cells especially in tumor microenvironment have not been fully understood. Our results showed KLRG1 expression on T cells significantly increased in tumor microenvironment. KLRG1+ T cells exhibited poor proliferative capacity with decreased effector cytokine production. Meanwhile, KLRG1+ T cells expressed abundant pro-inflammatory cytokines and demonstrated high level of Foxp3 expression. KLRG1+ T cells showed decreased expression of miRNA-101 and higher expression of CtBP2. Our results indicated KLRG1 might contribute to the impaired antitumor immunity of memory T cells in tumor microenvironment. Thus, repressing KLRG1 on human memory T cells might be a novel therapeutics against cancer.
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