Journal
CLINICAL OBSTETRICS AND GYNECOLOGY
Volume 58, Issue 4, Pages 814-826Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GRF.0000000000000156
Keywords
neonate; gut microbiota; human milk oligosaccharides; prebiotic; innate immune signaling; enteric infection
Categories
Funding
- National Institutes of Health [HD013021, AI075563, HD061930, HD059140]
Ask authors/readers for more resources
Glycans of the intestinal mucosa and oligosaccharides of human milk influence the early colonization of the infant gut and establishment of mucosal homeostasis, and differences in colonization of the gut influence the ontogeny of glycans on the surface of the intestinal mucosa, proinflammatory signaling, homeostasis, and resilience to insult. This interkingdom reciprocal interaction is typical of a mutualistic symbiotic relationship. The period in which the infant gut most needs protection from hypersensitive inflammation overlaps with the recommended period of exclusive nursing; electively substituting artificial formula that lacks human milk protective glycans seems ill advised, especially for premature infants.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available