Article
Chemistry, Multidisciplinary
Phuc Van Hoang, Thy Dang Uyen Phan, Phuong Vu Quynh Duong, Anh Thi Van Tran, Khoi Tan Nguyen, Nam Van Ho Phan
Summary: This study developed a green method of ultrasound-assisted extraction coupled with gas bubble flotation for extracting fi-amyrin from Dischidia major. The solvent system used was water:ethanol (9:1) and cationic surfactants were employed to improve the adsorption of fi-amyrin onto the air/liquid interface during flotation. High-performance liquid chromatography with spectrophotometric detection was applied to quantify the fi-amyrin content in D. major and its extracts. The foam layer collected from flotation showed high selectivity toward fi-amyrin, and the product content increased significantly after removing surfactants from the solution.
Article
Biochemistry & Molecular Biology
Jose Sanchez-Collado, Jose J. Lopez, Isaac Jardin, Alejandro Berna-Erro, Pedro J. Camello, Carlos Cantonero, Tarik Smani, Gines M. Salido, Juan A. Rosado
Summary: The two variants of the Orai1 subunit, Orai1 alpha and Orai1 beta, exhibit different functional characteristics and interactions in mammalian cells. Orai1 alpha is essential for the activation and membrane location of TRPC1, while Orai1 beta plays a role in maintaining Ca2+ oscillations.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Mathematics, Applied
Supriya Bhunia, Ganesh Ghorai, Qin Xin
Summary: (English Summary:)
This paper introduces the concept of (alpha, beta)-Pythagorean fuzzy order of elements, including relative subgroup, normalizer, centralizer, and a fuzzy version of Lagrange's theorem, providing an efficient tool for handling vagueness in a fuzzy environment.
Article
Veterinary Sciences
Cairsty DePasquale, Nicole Kemerer, Nathan White, Monica Yost, Jordan Wolfkill, Jennifer Sturgill, X. Li
Summary: Environmental enrichment enhances animals' cognitive abilities by providing opportunities for them to recognize and discriminate between different stimuli in their environment, which is crucial for survival and overall well-being.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Nan Yan, Shuai Wang, Haotian Gao, Jiaqi Chen, Jiahui Cao, Pengsheng Wei, Xue Li, Ying Yu, Yan Wang, Yalin Niu, Yijie Wang, Shuyuan Liu, Ge Jin
Summary: Aloe emodin, derived from aloe or rhubarb, has various therapeutic effects including anti-renal fibrosis, anti-atherosclerosis, anti-cancer, and neuroprotective effects in ischemic stroke. In this study, aloe emodin was found to improve motor coordination and attenuate visual recognition impairment in HD R6/1 transgenic mice. It achieved this by inhibiting the phosphorylation of CaMKII and TGF-beta 1/Smad signaling, downregulating mutant huntingtin protein levels, and inhibiting neuronal apoptosis. These findings suggest that aloe emodin may be a potential therapeutic option for HD.
Article
Multidisciplinary Sciences
Cesar Garcia-Cruz, Candelaria Merino-Jimenez, Jorge Aragon, Victor Ceja, Brenda Gonzalez-Assad, Juan Pablo Reyes-Grajeda, Cecilia Montanez
Summary: The overexpression of Dp40 can promote neuronal differentiation in PC12 cells, while overexpression of Dp40(L170P) has the opposite effect. The altered protein expression profile in PC12-Dp40(L170P) cells suggests that Dp40 may play a role in regulating cytoskeletal structure and synaptic vesicle exocytosis.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Nicolas Captier, Jane Merlevede, Askhat Molkenov, Ainur Seisenova, Altynbek Zhubanchaliyev, Petr Nazarov, Emmanuel Barillot, Ulykbek Kairov, Andrei Zinovyev
Summary: BIODICA is an integrated computational environment for analyzing bulk and single-cell molecular profiles, allowing non-experts to perform ICA-based omics data analysis and communicate with biology experts through interactive graphical user interface.
Article
Neurosciences
Yuan Ji, Xue Zhang, Zirui Wang, Wen Qin, Huaigui Liu, Kaizhong Xue, Jie Tang, Qiang Xu, Dan Zhu, Feng Liu, Chunshui Yu
Summary: This study identified 98 genes associated with GMV changes in schizophrenia, which were functionally enriched for chemical synaptic transmission, central nervous system development, and cell projection. These genes could be used as candidate genes to explore biological mechanisms underlying the structural impairments in schizophrenia.
Article
Neurosciences
Elizabeth R. Chrastil, Caroline Rice, Mathias Goncalves, Kylie N. Moore, Syanah C. Wynn, Chantal E. Stern, Erika Nyhus
Summary: This study investigates the effects of active and passive navigation on spatial cognition using electroencephalography. The results suggest that active decision-making during learning leads to better spatial knowledge and is associated with increased theta power during exploration.
Article
Computer Science, Information Systems
Supriya Bhunia, Ganesh Ghorai, Qin Xin, Muhammad Gulzar
Summary: In this article, the effectiveness of (alpha, beta)-Pythagorean fuzzy set in dealing with uncertainty is discussed. The concepts of (alpha, beta)-Pythagorean fuzzy subring and (alpha, beta)-Pythagorean fuzzy ideal of a ring are introduced, along with various related results and the level subring. The direct product and ring homomorphism of (alpha, beta)-Pythagorean fuzzy subrings are also studied.
Article
Multidisciplinary Sciences
Ayaka Hoshi, Yuya Hirayama, Fumihiro Saito, Tatsuji Ishiguro, Hiromichi Suetani, Keiichi Kitajo
Summary: Population preferences for video advertisements vary across individuals, and this variation is influenced by the consistent spatiotemporal patterns of neural activity produced through repetitive viewing of video clips. The degree of engagement and memory in individual viewers is associated with this consistency. The observed consistency in a smaller group of viewers can predict population preferences and can be identified through EEG responses to repeated television commercials.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Rebecca A. Keogh, Amanda L. Haeberle, Christophe J. Langouet-Astrie, Jeffrey S. Kavanaugh, Eric P. Schmidt, Garrett D. Moore, Alexander R. Horswill, Kelly S. Doran
Summary: In this study, a murine model of Group B Streptococcus (GBS) diabetic wound infection was developed and it was demonstrated through dual RNA sequencing that GBS infection triggers an inflammatory response. GBS adapts to this hyperinflammatory environment by up-regulating virulence factors and mutations in the covR gene were found to affect GBS hemolysin/pigmentation production. This foundational study provides insight into the pathogenesis of GBS diabetic wound infections.
Article
Multidisciplinary Sciences
Sangkyu Kim, Jessica Fuselier, Anna Latoff, Justin Manges, S. Michal Jazwinski, Andrea Zsombok
Summary: Various risk factors, such as age, genetic variants, toxic amyloid-beta accumulation, and unhealthy lifestyle, contribute to the development of Alzheimer's disease. The heritability of AD is estimated to be between 0.13 and 0.25, indicating a significant contribution of non-genetic factors. DNA methylation, an epigenetic mechanism, plays a role in the interaction between the genome and these non-genetic factors. Using the Tg2576 mouse model, researchers found transcriptional upregulation of genes involved in extracellular matrix structures and functions, as well as differential methylation of genes involved in extracellular protein secretion and localization. The integrative analysis revealed enrichment of GO terms related to memory and synaptic functionability, suggesting a potential role of DNA methylation in AD neuropathology.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Saniya Khullar, Daifeng Wang
Summary: Neuroinflammation and immune dysregulation are important in Alzheimer's disease (AD), Covid-19, and neurological symptoms. By analyzing population data, we predicted gene regulatory networks in major brain regions related to AD. Comparative network analysis revealed conservation and specificity in regulatory networks, with many immunological genes. Additionally, we identified AD-Covid genes and prioritized candidate genes for predicting Covid severity. Our study also uncovered potential mechanistic insights of disease risk variants. Our open-source analysis provides a functional genomic resource for AD-Covid research at the brain region level.
HUMAN MOLECULAR GENETICS
(2023)
Article
Mathematics, Applied
Zonghao Zou, Yuexin Liu, Alan C. H. Tsang, Y. -N Young, On Shun Pak
Summary: This study explores the integration of deep RL with context detection for micro-robotic locomotion in a dynamically changing environment. Experimental results demonstrate that this approach can effectively detect environmental changes and adjust locomotory gaits accordingly, leading to significantly improved locomotion performance.
COMMUNICATIONS IN NONLINEAR SCIENCE AND NUMERICAL SIMULATION
(2024)
Article
Immunology
Chunxia Huang, Michael Garnet Irwin, Gordon Tin Chun Wong, Raymond Chuen Chung Chang
JOURNAL OF NEUROINFLAMMATION
(2018)
Review
Clinical Neurology
A. K. L. Liu, E. J. Lim, I. Ahmed, R. C. -C. Chang, R. K. B. Pearce, S. M. Gentleman
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2018)
Review
Clinical Neurology
Cindy Chi-Ching Pang, Clemens Kiecker, John T. O'Brien, Wendy Noble, Raymond Chuen-Chung Chang
Article
Toxicology
Ran You, Yuen-Shan Ho, Clara Hiu-Ling Hung, Yan Liu, Chun-Xia Huang, Hei-Nga Chan, See-Lok Ho, Sheung-Yeung Lui, Hung-Wing Li, Raymond Chuen-Chung Chang
PARTICLE AND FIBRE TOXICOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Zhaofei Yang, Tianbai Li, Song Li, Min Wei, Hongqian Qi, Bairong Shen, Raymond Chuen-Chung Chang, Weidong Le, Fengyuan Piao
ACS CHEMICAL NEUROSCIENCE
(2019)
Review
Medicine, Research & Experimental
Yan Liu, Tim Yan, John Man-Tak Chu, Ying Chen, Sophie Dunnett, Yuen-Shan Ho, Gordon Tin-Chun Wong, Raymond Chuen-Chung Chang
LABORATORY INVESTIGATION
(2019)
Review
Cell Biology
Zi-xian Chen, Qing-qing Xu, Chun-shuo Shan, Yi-hua Shi, Yong Wang, Raymond Chuen-Chung Chang, Guo-qing Zheng
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2019)
Article
Multidisciplinary Sciences
Ran You, Yan Liu, Raymond Chuen-Chung Chang
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2019)
Review
Neurosciences
Novem Ching-Yee Lam, Hoi-Yan Yeung, Wai-Kiu Li, Ho-Yin Lo, Chun-Fong Yuen, Raymond Chuen-Chung Chang, Yuen-Shan Ho
Article
Plant Sciences
Henry Ho-Lung Chan, Hang-i Lam, Kai-yip Choi, Serena Zhe-chuang Li, Yamunadevi Lakshmanan, Wing-yan Yu, Raymond Chuen-chung Chang, Jimmy Shiu-ming Lai, Kwok-fai So
JOURNAL OF ETHNOPHARMACOLOGY
(2019)
Article
Neurosciences
Anuri Shah, Jianfei Chao, Cristina Legido-Quigley, Raymond Chuen-Chung Chang
Summary: The study demonstrates that oxyresveratrol has protective effects against ER stress in two different PD cell models, acting through diverse mechanisms and presenting as a promising candidate for PD treatment.
NUTRITIONAL NEUROSCIENCE
(2021)
Article
Neurosciences
Chunxia Huang, Olivia Tsz-Wa Ng, John Man-Tak Chu, Michael Garnet Irwin, Xianwen Hu, Shoufeng Zhu, Raymond Chuen-Chung Chang, Gordon Tin-Chun Wong
NEUROSCIENCE LETTERS
(2019)
Review
Cell Biology
Yuen-Shan Ho, Fei-Yi Zhao, Wing-Fai Yeung, Gordon Tin-Chun Wong, Hong-Qi Zhang, Raymond Chuen-Chung Chang
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2020)
Article
Biochemistry & Molecular Biology
Anuri Shah, Pei Han, Mung-Yee Wong, Raymond Chuen-Chung Chang, Cristina Legido-Quigley
Article
Chemistry, Physical
Ze Gong, Chao Fang, Ran You, Xueying Shao, Xi Wei, Raymond Chuen-Chung Chang, Yuan Lin