Journal
ONCOTARGET
Volume 7, Issue 18, Pages 25769-25782Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.8265
Keywords
miRNAs; pathway crosstalk; glioma progression
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Funding
- National High Technology Research and Development Program of China [863 Program] [2014AA021102]
- National Program on Key Basic Research Project [973 Program] [2014CB910504]
- National Natural Science Foundation of China [91439117, 61473106]
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Glioma is a malignant nervous system tumor with a high fatality rate and poor prognosis. MicroRNAs (miRNAs) are important post-transcriptional modulators of glioma initiation and progression. Tumor progression often results from dysfunctional co-operation between pathways regulated by miRNAs. We therefore constructed a glioma progression-related miRNA-pathway crosstalk network that not only revealed some key miRNA-pathway patterns, but also helped characterize the functional roles of miRNAs during glioma progression. Our data indicate that crosstalk between cell cycle and p53 pathways is associated with grade II to grade III progression, while cell communications-related pathways involving regulation of actin cytoskeleton and adherens junctions are associated with grade IV glioblastoma progression. Furthermore, miRNAs and their crosstalk pathways may be useful for stratifying glioma and glioblastoma patients into groups with short or long survival times. Our data indicate that a combination of miRNA and pathway crosstalk information can be used for survival prediction.
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