Article
Oncology
Leqian Guo, Guilan Xie, Ruiqi Wang, Liren Yang, Landi Sun, Mengmeng Xu, Wenfang Yang, Mei Chun Chung
Summary: This study found that for TNBC patients, the survival benefit of breast-conserving surgery with radiotherapy was higher than or similar to that of total mastectomy.
Article
Health Care Sciences & Services
Alba Di Leone, Antonio Franco, Francesca Zotta, Lorenzo Scardina, Margherita Sicignano, Enrico Di Guglielmo, Virginia Castagnetta, Stefano Magno, Daniela Terribile, Alejandro Martin Sanchez, Gianluca Franceschini, Riccardo Masetti
Summary: Triple-negative breast cancer (TNBC) refers to a subtype of breast cancer that lacks the expression of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). A population-based study was conducted to compare the outcomes of breast-conserving surgery (BCS) and mastectomy (M) in 289 TNBC patients. The study found no significant differences in locoregional disease-free survival, distant disease-free survival, and overall survival between the two surgical treatments. These findings suggest that TNBC should not be considered a contraindication for breast-conserving surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Song Wang, Yiyuan Zhang, Fangxu Yin, Xiaohong Wang, Zhenlin Yang
Summary: In women with early-stage IMPC, breast-conserving treatment was found to be at least equivalent to mastectomy in terms of survival outcomes. BCT should be recommended as the standard surgical treatment, especially for patients with T2 disease, when both procedures are feasible.
FRONTIERS IN ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Jinqian Mao, Jin Hu, Yanting Zhang, Jian Shen, Fang Dong, Ximeng Zhang, Jie Ming, Tao Huang, Xiaoqin Run
Summary: This study compared single hormone receptor-positive breast cancer to other subtypes and found clinically and biologically distinct features. The prognosis of single hormone receptor-positive tumors was similar to hormone receptor-negative and hormone receptor-positive tumors in patients with or without HER2 overexpression.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Surgery
Ye-Wei Yuan, Peng-Cheng Liu, Fang-Fang Li, Ya-Han Yang, Wei Yang, Li Fan, De-Wu Mou, Hong-Wei Yang, Mao-Shan Chen
Summary: This study found that breast-conserving therapy (BCT) is an acceptable and preferable alternative to mastectomy for patients with centrally located breast cancer (CLBC).
Article
Oncology
Weimin Xie, Min Cao, Zhen Zhong, Zongshuai Huang, Xiaqiu Gao, Zicheng Li
Summary: The study aimed to compare the efficacy of breast conserving surgery (BCS) and mastectomy in elderly breast cancer patients, and found that the two surgical procedures were comparable in overall survival rate after being matched by clinicopathologic features.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Tingting Han, Mingwei Shi, Qiwei Chen, Dongbo Chen, Jiqing Hao
Summary: This study found that adjuvant radiation therapy after breast-conserving surgery can improve both breast cancer-specific survival and overall survival in elderly patients with early-stage breast cancer. The results of subgroup analysis also support this conclusion.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Hakyoung Kim, Sae Byul Lee, Seok-Jin Nam, Eun Sook Lee, Byeong-Woo Park, Ho Yong Park, Hyouk Jin Lee, Jisun Kim, Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn
Summary: This study evaluated the long-term outcomes of Korean women with early breast cancer undergoing breast-conserving surgery plus radiotherapy or total mastectomy. Findings showed that the breast-conserving surgery plus radiotherapy group had better overall survival and breast cancer-specific survival than the total mastectomy group in both the Korean Breast Cancer Registry and Asan Medical Center cohorts. The results suggest that breast-conserving surgery plus radiotherapy is at least equivalent to total mastectomy in terms of overall survival and may influence treatment decisions for early breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Endocrinology & Metabolism
Qitong Chen, Limeng Qu, Yeqing He, Yueqiong Deng, Qin Zhou, Wenjun Yi
Summary: This study compared the long-term prognosis of nipple-sparing mastectomy (NSM) and breast-conserving surgery (BCS) and found no significant differences in overall survival and breast cancer-specific survival between the two procedures. Subgroup analysis showed that the majority of patients had a similar prognosis regardless of whether they underwent NSM or BCS.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Jun Wang, Shi-Ping Yang, Ping Zhou, Chen-Lu Lian, Jian Lei, Li Hua, Zhen-Yu He, San-Gang Wu
Summary: The study evaluated the value of locoregional treatment in patients with de novo stage IV breast cancer, and found that postoperative radiotherapy can improve breast cancer-specific survival in these patients.
Article
Oncology
Shi-Ping Yang, Lu-Lu Tan, Ping Zhou, Chen-Lu Lian, San-Gang Wu, Zhen-Yu He
Summary: The study aimed to evaluate the association between adjuvant radiotherapy (RT) after breast-conserving surgery (BCS) and survival among elderly breast cancer patients. The results showed that patients who received adjuvant RT had better breast cancer-specific survival (BCSS) and overall survival (OS) compared to those without RT.
FRONTIERS IN ONCOLOGY
(2022)
Review
Surgery
Maria Paz Galeano Machuca, Shelly Chien-Chien Cheng, Tony Hong-Ting Jou, Chih-Tao Cheng
Summary: Factors influencing the choice of breast-conserving therapy (BCT) for early-stage breast cancer treatment in Eastern and Southeastern Asian population include sociodemographic factors, clinicopathological factors, and healthcare provider factors. Personal factors such as fear of recurrence and avoidance of further treatment are associated with not selecting BCT. Decisions about surgery type are complex and involve multiple influencing factors.
WORLD JOURNAL OF SURGERY
(2021)
Article
Oncology
Yu-Chun Song, Zhou Huang, Hui Fang, Yu Tang, Hao Jing, Yong-Wen Song, Jing Jin, Yue-Ping Liu, Bo Chen, Yuan Tang, Shu-Nan Qi, Ning-Ning Lu, Ning Li, Ye-Xiong Li, Shu-Lian Wang
Summary: This study compares the recurrence and survival outcomes between breast-conserving surgery (BCS) and mastectomy after neoadjuvant chemotherapy (NACT). The results show that there is no significant difference in the 5-year locoregional recurrence rate, distant metastasis rate, and disease-free survival rate between the BCS and mastectomy groups. However, the BCS group has significantly higher 5-year breast cancer-specific survival rate and overall survival rate compared to the mastectomy group. Multivariate analysis also demonstrates that BCS significantly improves breast cancer-specific survival and overall survival.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Alexander Bartram, Fiona Gilbert, Alastair Thompson, G. Bruce Mann, Amit Agrawal
Summary: The utility of MRI in predicting tumor size accurately in DCIS patients is noted, with no significant difference in surgical outcomes between pre-operative MRI and conventional imaging groups. However, there is a lack of data on the usefulness of pre-operative MRI in oncoplastic breast surgery.
CANCER TREATMENT REVIEWS
(2021)
Article
Oncology
Junsheng Zhang, Ciqiu Yang, Chuqian Lei, Yi Zhang, Fei Ji, Hongfei Gao, Mei Yang, Liulu Zhang, Jieqing Li, Teng Zhu, Weiping Li, Xiaosheng Zhuang, Kun Wang
Summary: This study demonstrated that early-stage MBC patients who underwent BCT had significantly improved overall survival and breast cancer-specific survival compared to those who underwent mastectomy. The improvement was consistent across almost all different T and N stages subgroups.