Article
Oncology
F. Deodato, D. Pezzulla, S. Cilla, M. Ferro, R. Giannini, C. Romano, M. Boccardi, M. Buwenge, V. Valentini, A. G. Morganti, G. Macchia
Summary: This study reports the final results of a dose-escalation study of VMAT-SRS boost in patients with spine metastases. The study found that a 12 Gy dose of SRS boost after 25 Gy to the affected and adjacent vertebrae resulted in excellent local control and survival rates without significant toxicity.
Article
Oncology
Thomas B. Brunner, Dominik Bettinger, Michael Schultheiss, Lars Maruschke, Lukas Sturm, Nico Bartl, Ivana Koundurdjieva, Simon Kirste, Hannes P. Neeff, Christian Goetz, Nils Henrik Nicolay, Gabriele Ihorst, Fabian Bamberg, Robert Thimme, Anca-Ligia Grosu, Eleni Gkika
Summary: The study findings indicate that SBRT is an effective and well-tolerated local treatment for patients with hepatocellular carcinoma, providing high rates of local control and maintaining quality of life for patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Yuting Wang, Qiaoqiao Li, Li Zhang, Shiliang Liu, Jinhan Zhu, Yadi Yang, Mengzhong Liu, Yaojun Zhang, Mian Xi
Summary: This study investigates the treatment efficacy of stereotactic body radiotherapy and evaluates the influence of radiation dose on local control and survival in patients with abdominal lymph node metastases from hepatocellular carcinoma. The results show that SBRT achieves satisfactory local control and survival with a dose-response relationship between radiation dose and treatment efficacy.
Article
Oncology
Yuting Wang, Qiaoqiao Li, Li Zhang, Shiliang Liu, Jinhan Zhu, Yadi Yang, Mengzhong Liu, Yaojun Zhang, Mian Xi
Summary: This study aimed to investigate the treatment efficacy of stereotactic body radiotherapy (SBRT) for abdominal lymph node metastases (LNM) from hepatocellular carcinoma (HCC) and evaluate the influence of radiation dose on local control and survival. The results showed that SBRT achieved satisfactory local control and survival with a dose-response relationship between local control and radiation dose.
Review
Oncology
Won Il Jang, Sunmi Jo, Ji Eun Moon, Sun Hyun Bae, Hee Chul Park
Summary: This study is the first systematic review and meta-analysis on the advantages of IMRT for hepatocellular carcinoma. Despite most patients being in advanced stages and using combined treatment, IMRT for HCC showed similar survival rates to existing radiotherapy modalities and relatively low toxicity.
Article
Medicine, General & Internal
Ren Ji, Kelvin K. Ng, Wenqi Chen, Weihong Yang, Hongtao Zhu, Tan-To Cheung, Chi-Leung Chiang, Tiffany C. L. Wong, Feng-Ming Kong, G. Wu, Chung-Mau Lo
Summary: This study compared the clinical outcomes of SBRT and RFA for patients with unresectable HCC. The results showed that there was no significant difference in the short-term and long-term clinical outcomes between SBRT and RFA, including the complete remission rate and local tumor control rate. Both treatments had a low incidence of complications. Therefore, SBRT can be considered as an alternative to RFA for the treatment of unresectable HCC.
Article
Oncology
Ting-Shi Su, Qiu-Hua Liu, Xiao-Fei Zhu, Ping Liang, Shi-Xiong Liang, Lin Lai, Ying Zhou, Yong Huang, Tao Cheng, Le-Qun Li
Summary: This study found that higher radiotherapy doses are associated with better outcomes for HCC patients, with SaRT and SbRT showing better improvement in OS, PFS, and intrahepatic control compared to ScRT.
RADIATION ONCOLOGY
(2021)
Article
Oncology
Luca Boldrini, Angela Romano, Silvia Mariani, Davide Cusumano, Francesco Catucci, Lorenzo Placidi, Gian Carlo Mattiucci, Giuditta Chiloiro, Francesco Cellini, Maria Antonietta Gambacorta, Luca Indovina, Vincenzo Valentini
Summary: Hepatocellular carcinoma in early stages can benefit from local ablative treatments such as radiofrequency ablation or transarterial chemoembolization. Radiotherapy has shown promising results for HCC treatment. Magnetic resonance-guided radiotherapy may represent a significant improvement in stereotactic body radiotherapy for liver tumors.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Oncology
Isaure Roquette, Emilie Bogart, Thomas Lacornerie, Massih Ningarhari, Jean-Emmanuel Bibault, Marie-Cecile Le Deley, Eric F. Lartigau, David Pasquier, Xavier Mirabel
Summary: This study describes the treatment efficacy and safety of stereotactic body radiation therapy (SBRT) in patients with hepatocellular carcinoma (HCC). The analysis of data from 318 patients showed that SBRT is efficient for the management of HCC with a favorable toxicity profile.
Article
Oncology
Hongzhi Wang, Xianggao Zhu, Yuting Zhao, Dezuo Dong, Lijuan Li, Yong Cai, Yongheng Li, Weihu Wang
Summary: This study aimed to investigate the maximum tolerated dose of apatinib administered during and after radiotherapy for unresectable hepatocellular carcinoma (HCC). The results showed that the combination of apatinib at a daily dose of 250 mg with radiotherapy could be recommended for the treatment of unresectable HCC, and it exhibited encouraging antitumor activity.
Review
Oncology
Aruz Mesci, Naghmeh Isfahanian, Ian Dayes, Himu Lukka, Theodoros Tsakiridis
Summary: This article reviews the changes in radiotherapy for high-risk prostate cancer and discusses the principles of dose escalation, hypo- and ultra-hypo-fractionated radiotherapy boost treatments. It focuses on clinical trials using stereotactic body radiation therapy (SBRT) as a sole radiation modality or as boost therapy.
CLINICAL GENITOURINARY CANCER
(2022)
Article
Gastroenterology & Hepatology
Li-Qing Li, Ying Zhou, Yong Huang, Ping Liang, Shi-Xiong Liang, Ting-Shi Su
Summary: This study compared the long-term outcomes of robotic stereotactic body radiotherapy (SBRT) with intensity-modulated radiotherapy (IMRT) in advanced hepatocellular carcinoma (HCC) with portal vein tumor thrombosis (PVTT). The results showed no significant difference in overall survival, progression-free survival, intrahepatic control, and local control between SBRT and IMRT groups. SBRT may be a safe and more time-efficient treatment for local advanced HCC with PVTT when high-precision tracking technology is available.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Oncology
Boldizsar Kovacs, Michael Mayinger, Stefanie Ehrbar, Debra Fesslmeier, Maiwand Ahmadsei, Lorraine Sazgary, Robert Manka, Hatem Alkadhi, Frank Ruschitzka, Firat Duru, Alexandros Papachristofilou, Christian Sticherling, Slawomir Blamek, Krzysztof S. Golba, Matthias Guckenberger, Ardan M. Saguner, Nicolaus Andratschke
Summary: This study is an innovative prospective phase II trial aiming to evaluate the optimal radiation dose for stereotactic arrhythmia radioablation (STAR) in patients with therapy-refractory sustained ventricular arrhythmias (sVA). The trial has obtained IRB approval and focuses on determining the safe and effective radiation dose to be employed in the STAR procedure.
RADIATION ONCOLOGY
(2023)
Review
Biology
Chai Hong Rim, Hye Yoon Lee, Jung Sun Kim, Hakyoung Kim
Summary: Both radiofrequency ablation (RFA) and stereotactic body radiotherapy (SBRT) have demonstrated efficacy in treating early hepatocellular carcinoma (HCC), but their effectiveness has yet to be compared in randomized studies. Research has described the characteristics and indications of both treatment modalities and discussed recent comparative studies between them.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
(2021)
Article
Oncology
Hanna Grzbiela, Elzbieta Nowicka, Marzena Gawkowska, Dorota Tarnawska, Rafal Tarnawski
Summary: This study evaluated the efficacy and safety of dose de-escalation using robotic stereotactic CyberKnife radiotherapy in patients with intracranial meningiomas. The results showed that delivering a total dose of 18 Gy in three fractions had comparable efficacy to treatment schedules with higher doses, suggesting the feasibility of dose de-escalation in the treatment of meningiomas.
Article
Oncology
Yeon Joo Kim, Yeon-Joo Kim, Yong Bae Kim, Ik Jae Lee, Jeanny Kwon, Kyubo Kim, Jihye Cha, Myungsoo Kim, In Young Jo, Jung Hoon Kim, Jaehyeon Park, Jin Hee Kim, Juree Kim, Kyung Hwan Shin, Su Ssan Kim
Summary: This study aimed to investigate the impact of postoperative radiotherapy in de novo metastatic breast cancer patients undergoing planned primary tumor resection and to identify the subgroup of patients who would most benefit. The results showed that postoperative radiotherapy was associated with a significantly better progression-free survival in patients with de novo metastatic breast cancer who underwent primary tumor resection. Patients with clinical T1/2 category and non-triple-negative breast cancer benefited most from postoperative radiotherapy, while those with triple-negative breast cancer showed little benefit.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Hwa Kyung Byun, Jae Sik Kim, Jee Suk Chang, Yeona Cho, Sung-Ja Ahn, Jung Han Yoon, Haeyoung Kim, Nalee Kim, Euncheol Choi, Hyeli Park, Kyubo Kim, Shin-Hyung Park, Chai Hong Rim, Hoon Sik Choi, Yoon Kyeong Oh, Ik Jae Lee, Kyung Hwan Shin, Yong Bae Kim
Summary: The study externally validated a nomogram for predicting the risk of breast cancer-related lymphedema, demonstrating good predictive accuracy and the ability to predict the risk of lymphedema occurrence effectively.
BREAST CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
Mi Sun Kim, Woong Sub Koom, Jae Ho Cho, Se-Young Kim, Ik Jae Lee
Summary: This study evaluated the outcomes and prognostic factors of salvage and palliative radiotherapy (RT) in patients with upper tract urothelial carcinoma (UTUC). The results showed that salvage and palliative RT are feasible and effective treatments for UTUC. Patients who responded to RT using intensity-modulated RT (IMRT) may have a survival benefit. Additionally, positive PD-L1 status might be associated with radiosensitivity.
RADIATION ONCOLOGY
(2022)
Article
Oncology
Yeona Cho, Yejin Kim, Ibrahim Chamseddine, Won Hee Lee, Hye Ryun Kim, Ik Jae Lee, Min Hee Hong, Byung Chul Cho, Chang Geol Lee, Seungryong Cho, Jin Sung Kim, Hong In Yoon, Clemens Grassberger
Summary: This study investigated the dynamics of lymphocyte depletion and recovery in non-small cell lung cancer patients undergoing chemoradiotherapy, and their correlation with regional dose. The findings suggest that the recovery from lymphopenia is strongly associated with improved survival in patients receiving maintenance immunotherapy.
RADIOTHERAPY AND ONCOLOGY
(2022)
Article
Multidisciplinary Sciences
Jiwon Sung, Yeonho Choi, Jun Won Kim, Ik Jae Lee, Ho Lee
Summary: This study evaluated the effect of the 1.5 T magnetic field of the MR-Linac on radiation leakage doses. The results showed that the special shielding design achieved a significant reduction in leakage doses.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Sung Jun Ahn, Hyeokjin Kwon, Jun Won Kim, Goeun Park, Mina Park, Bio Joo, Sang Hyun Suh, Yoon Soo Chang, Jong-Min Lee
Summary: This study aims to investigate the association between the risk of brain metastases (BM) in the hippocampal-avoidance region (HAR) and the stage and molecular status of non-small cell lung cancer (NSCLC) patients. The results suggest that patients with extra-cranial metastases are more likely to have BM in the HAR.
FRONTIERS IN ONCOLOGY
(2022)
Article
Gastroenterology & Hepatology
Hye Won Lee, Esl Kim, Kyung Joo Cho, Hye Jung Park, Jieun Seo, Hyeonah Lee, Eunha Baek, Jong Rak Choi, Kwang-Hyub Han, Seung-Tae Lee, Jun Yong Park
Summary: Molecular barcode sequencing in liquid biopsy has the potential to detect hepatocellular carcinoma and provide personalized information about tumor biology, guiding clinical diagnosis, management, and prognostic stratification.
LIVER INTERNATIONAL
(2022)
Article
Oncology
Jung Ho Im, Ik Jae Lee, Yeonho Choi, Jiwon Sung, Jin Sook Ha, Ho Lee
Summary: This study investigates the impact of using denoised CT images as input data for a deep learning-based auto-segmentation framework on the accuracy of organ segmentation. The results show that denoising-based auto-segmentation performs well for the lungs and spinal cord, but has limited performance for the esophagus. For liver segmentation, denoising-based auto-segmentation performs minimally but with significantly better Dice similarity coefficient (DSC) than AccuContour(TM)-based auto-segmentation.
Article
Medicine, General & Internal
Mi Youn Seol, Seo Hee Choi, Ik Jae Lee, Hyung Soon Park, Hye Ryun Kim, Sang Kyum Kim, Hong In Yoon
Summary: This study investigated whether selective inhibition of PI3K isoforms could enhance radiosensitivity in GBM. The results from cell experiments and a mouse model demonstrated that inhibition of PI3K-alpha isoform increased radiosensitivity in GBM cells, leading to tumor growth suppression and extended survival in vivo.
YONSEI MEDICAL JOURNAL
(2023)
Article
Oncology
Jun Won Kim, Joseph Marsilla, Michal Kazmierski, Denis Tkachuk, Shao Hui Huang, Wei Xu, John Cho, Jolie Ringash, Scott Bratman, Benjamin Haibe-Kains, Andrew Hope
Summary: This study used a new web application to evaluate the relationship between target delineation compliance with international guidelines and outcomes of radiation therapy for nasopharyngeal carcinoma. The results showed that noncompliance of certain anatomical sites, such as the sphenoid sinus and cavernous sinus, with international guidelines may be associated with increased rates of treatment failure.
PRACTICAL RADIATION ONCOLOGY
(2023)
Article
Medicine, General & Internal
Yeona Cho, Jun Won Kim, Hyung Sun Kim, Joon Seong Park, Ik Jae Lee
Summary: In this study, the safety, feasibility, and early treatment outcomes of intraoperative radiotherapy (IORT) using a low-energy X-ray source in patients with resectable pancreatic cancer were evaluated. The preliminary report suggests that IORT is well-tolerated and feasible, with a 1-year local control rate of 76.4%.
YONSEI MEDICAL JOURNAL
(2022)
Article
Oncology
Kyubo Kim, Jinhong Jung, Haeyoung Kim, Wonguen Jung, Kyung Hwan Shin, Ji Hyun Chang, Su Ssan Kim, Won Park, Jee Suk Chang, Yong Bae Kim, Sung Ja Ahn, Ik Jae Lee, Jong Hoon Lee, Hae Jin Park, Jihye Cha, Juree Kim, Jin Hwa Choi, Taeryool Koo, Jeanny Kwon, Jin Hee Kim, Mi Young Kim, Shin-Hyung Park, Yeon-Joo Kim
Summary: This study evaluates the role of postmastectomy radiation therapy in patients with node-negative breast cancer of 5cm or larger tumors. The results indicate that radiation therapy is significantly associated with improved disease-free survival.
CANCER RESEARCH AND TREATMENT
(2022)
Article
Oncology
In Young Jo, Hee Chul Park, Eun Seog Kim, Seung-Gu Yeo, Myungsoo Kim, Jinsil Seong, Jun Won Kim, Tae Hyun Kim, Won Sup Yoon, Bae Kwon Jeong, Sung Hwan Kim, Jong Hoon Lee
Summary: Hypofractionated radiotherapy for oligo pulmonary metastases of hepatocellular carcinoma showed favorable local tumor response rate and acceptable toxicity profiles. Good treatment response, absence of intrahepatic tumor, Child-Pugh class A, and progression-free interval of <6 months were significant prognostic factors for overall survival. Five patients (8.6%) experienced grade 2 or higher radiation pneumonitis after hypofractionated radiotherapy.
JAPANESE JOURNAL OF CLINICAL ONCOLOGY
(2022)
