Article
Oncology
Li-Chun Chang, Chia-Tung Shun, Been-Ren Lin, Silvia Sanduleanu, Weng-Feng Hsu, Ming-Shiang Wu, Han-Mo Chiu
Summary: A study conducted at the National Taiwan University Hospital from 2005 to 2014 compared the disease-free survival of T1 cancer arising from the rectum versus the colon. The results showed that T1 rectal cancer had a higher risk of recurrence compared to T1 colon cancer, with rectal location being an independent risk factor for recurrence. Further research is needed to explore whether adjuvant therapy or closer surveillance can reduce the risk of recurrence in T1 rectal cancer.
Article
Oncology
Da Qin, Qingdong Guo, Rui Wei, Si Liu, Shengtao Zhu, Shutian Zhang, Li Min
Summary: This study proposed a new algorithm to quantitate plasma miRNA for colon cancer diagnosis. By establishing a miRNA-pair matrix and using various algorithms, a 4-miRNA pair model was successfully developed that showed good performance in differentiating CC from normal controls.
FRONTIERS IN ONCOLOGY
(2021)
Review
Oncology
J. Taieb, M. Karoui, D. Basile
Summary: The key in treatment decision-making for stage II colon cancer lies in classifying tumors based on molecular and clinico-pathological features, then choosing appropriate treatment methods including surveillance, adjuvant therapy, and drug treatment. New tools in the future may help to more accurately identify patients for a more personalized treatment approach.
Review
Oncology
Torhild Veen, Arezo Kanani, Dordi Lea, Kjetil Soreide
Summary: The role of neoadjuvant immune checkpoint inhibitors (ICI) in early-stage operable colorectal cancer (CRC) is still unclear. A scoping review identified 40 trials investigating neoadjuvant ICI in operable CRC, with heterogeneous trial designs and the need for harmonization.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Adam R. Markowski, Agnieszka U. Blachnio-Zabielska, Karolina Pogodzinska, Anna J. Markowska, Piotr Zabielski
Summary: Colorectal cancer is a heterogeneous group of tumors with varied clinical and pathological features based on anatomical location. Sphingolipids play a role in cancer formation and progression, and their changes are important in carcinogenesis. This study analyzed the sphingolipid profile in colorectal cancer and found differences in cellular sphingolipid amounts between rectal and colonic cancer. The study also revealed qualitative and quantitative disturbances in sphingolipid metabolism in colorectal cancer, indicating the complexity of changes during cancer development depending on the tumor's location.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Cigdem Gungormez, Emine Teker, Sema Atmanoglu, Ersin Borazan
Summary: Early diagnosis is crucial for the outcome of colon cancer, and studying microRNA expression profiles can help identify potential target genes and understand molecular mechanisms in colon cancer patients. By analyzing miRNA data, researchers can potentially use miRNAs as biomarkers for stage IIIA colon cancer.
BIOCHEMICAL GENETICS
(2022)
Article
Immunology
Lu Han, Shiyun Chen, Zhe Luan, Mengjiao Fan, Yanrong Wang, Gang Sun, Guanghai Dai
Summary: Colon cancer is a complex disease involving interactions between cancer cells and the immune microenvironment. Recent studies have shown that microRNAs (miRNAs) play a critical role in gene regulation in colon cancer, particularly in modulating the immune microenvironment. Identifying miRNAs associated with colon cancer and their regulation of immune function-related genes could provide insights into prognosis and guide personalized treatment strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Oncology
Justin C. C. Brown, Chao Ma, Qian Shi, Charles S. S. Fuchs, Jeffrey Meyer, Donna Niedzwiecki, Tyler Zemla, Felix Couture, Philip Kuebler, Pankaj Kumar, DeQuincy Lewis, Benjamin Tan, Smitha Krishnamurthi, Eileen M. M. O'Reilly, Anthony F. F. Shields, Jeffrey A. A. Meyerhardt
Summary: The purpose of this study was to determine the specific types, durations, and intensities of recreational physical activity that are associated with the greatest improvements in disease-free survival (DFS) for patients with colon cancer. The study found that engaging in larger volumes of recreational physical activity, longer durations of light-to-moderate-intensity aerobic exercise, or any vigorous-intensity aerobic exercise were significantly associated with improved DFS.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jiashu Huang, Shenghao Yu, Lei Ding, Lingyuan Ma, Hongjian Chen, Hui Zhou, Yayan Zou, Min Yu, Jie Lin, Qinghua Cui
Summary: Breast cancer and colon cancer, the two deadliest cancers in the world, share similar genetic backgrounds and regulatory genes. Current treatment measures have suboptimal outcomes, so there is a need for innovation. Studies suggest that circRNAs as miRNA sponges play important roles in malignant behaviors of BC and CRC.
Article
Oncology
Stephanie L. L. Alden, Harmeet Dhani, Charuta C. C. Palsuledesai, Shifra Krinshpun, Adham Jurdi, Eric Christenson, Ilene Browner, Samuel Rosner
Summary: This report presents a case of a patient with early-stage colon cancer, highlighting the importance of circulating tumor DNA monitoring and suggesting the need for further research to determine its clinical use.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Gastroenterology & Hepatology
Justin M. Greco, Jonathan S. Abelson
Summary: A 59-year-old man underwent a screening colonoscopy which detected a 2-cm rectal polyp, and surgical excision confirmed it to be a well-differentiated adenocarcinoma.
DISEASES OF THE COLON & RECTUM
(2021)
Article
Biology
Kevin Nathanael Ramanto, Kresnodityo Jatiputro Widianto, Stefanus Satrio Hadi Wibowo, David Agustriawan
Summary: This study investigates the impact of miRNA regulation in specific stages of breast cancer among non-Hispanic white and non-Hispanic black populations using the TCGA dataset. Analysis revealed that four miRNAs may have significantly detrimental effects on breast cancer diagnosis and prognosis.
COMPUTATIONAL BIOLOGY AND CHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Ying Gao, Jie Zhang, Jiexia Pan, Sanjun Ying, Bang Lou, Qingliang Yang, Weiyong Hong, Gensheng Yang
Summary: The aim of this study is to establish a FOF1-ATP synthase molecular motor biosensor for accurate identification of colon cancer miRNAs. The FOF1-ATP synthase molecular motor was extracted and connected to the colon cancer-specific miR-17 capture probe. Signal probes were designed for dual-signal characterization to increase detection accuracy. The FOF1-ATPase rotation rate decreases when the signaling and capture probes combine with the target miRNA, resulting in a decrease in ATP synthesis.
Article
Oncology
Cecilia Margareta Lund, Anne Dyhl-Polk, Dorte Lisbeth Nielsen, Lene Buhl Riis
Summary: This study found no significant association between Wnt5a expression and prognosis in patients with stage II/III colon cancer. Patients with low Wnt5a expression had worse disease free survival and overall survival rates. Poor performance status was linked to lower DFS and OS.
TRANSLATIONAL ONCOLOGY
(2021)
Review
Cell Biology
Mirolyuba Ilieva, Riccardo Panella, Shizuka Uchida
Summary: Although rare, cardiac tumor formation shares similarities in terms of pathogenesis with cancers and cardiovascular diseases, including angiogenesis, immune responses, and fibrosis. This has led to the emergence of the field of cardio-oncology. This review explores the similarities between cancer and cardiovascular disease from the perspective of microRNAs (miRNAs). In particular, it examines a specific set of miRNAs that act as both oncomiRs (miRNAs in cancer) and myomiRs (muscle-related miRNAs), as well as different categories of miRNAs related to similar pathogenesis.
Article
Urology & Nephrology
Temitope Rude, Odinachi Moghalu, John Stoffel, Sara Lenherr, Jeremy B. Myers, Sean Elliott, Blayne Welk, Jennifer S. Herrick, Angela P. Presson, David A. Ginsberg
Summary: The study found an association between insurance coverage and the type of bladder management following spinal cord injury, with publicly insured patients more likely to use indwelling catheters. However, insurance status did not impact bladder symptoms or quality of life when controlling for bladder management.
JOURNAL OF UROLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jordan B. King, Ransmond O. Berchie, Jennifer S. Herrick, Dave L. Dixon, Jordana B. Cohen, Daichi Shimbo, Ian M. Kronish, Joseph J. Saseen, Paul Muntner, Andrew E. Moran, Adam P. Bress
Summary: Combination antihypertensive therapy is underused, especially in certain race/ethnic groups, in the treatment of hypertension in the United States. Factors associated with monotherapy use despite uncontrolled blood pressure include higher systolic blood pressure, younger age, recent healthcare visits, higher body mass index, and the presence of heart failure.
AMERICAN HEART JOURNAL
(2022)
Article
Medicine, General & Internal
Zachary A. Marcum, Jordana B. Cohen, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: The use of antihypertensive medications that stimulate type 2 and 4 angiotensin II receptors is associated with a lower risk of dementia. This study examines the impact of exclusively stimulating vs inhibiting antihypertensive medication regimens on mild cognitive impairment (MCI) or dementia. The findings suggest that prevalent users of stimulating medications had lower rates of cognitive impairment.
Article
Cardiac & Cardiovascular Systems
Aubrey E. Jones, Madeleine M. McCarty, Juan P. Brito, Peter A. Noseworthy, Kerri L. Cavanaugh, Kenzie A. Cameron, Geoffrey D. Barnes, Benjamin A. Steinberg, Daniel M. Witt, George H. Crossley, Rod Passman, Preeti Kansal, Ian Hargraves, Monika Schmidt, Elizabeth Jackson, Adriana Guzman, Anthony Ariotti, Mandy L. Pershing, Jennifer Herrick, Victor M. Montori, Angela Fagerlin, Elissa M. Ozanne
Summary: This study aims to compare the effectiveness of patient decision aid (PDA) and encounter decision aid (EDA) in shared decision making. The study will recruit atrial fibrillation (AF) patients and their managing clinicians for stroke prevention strategies in a randomized controlled trial. The results will contribute to improving AF outcomes and patient experiences with stroke prevention strategies.
AMERICAN HEART JOURNAL
(2022)
Article
Clinical Neurology
Sudipto Dolui, John A. Detre, Sarah A. Gaussoin, Jennifer S. Herrick, Danny J. J. Wang, Manjula Kurella Tamura, Monique E. Cho, William E. Haley, Lenore J. Launer, Henry A. Punzi, Anjay Rastogi, Carolyn H. Still, Daniel E. Weiner, Jackson T. Wright, Jeff D. Williamson, Clinton B. Wright, R. Nick Bryan, Adam P. Bress, Nicholas M. Pajewski, Ilya M. Nasrallah
Summary: Intensive antihypertensive treatment is associated with increased cerebral perfusion, particularly in patients with a history of cardiovascular disease.
Review
Medicine, General & Internal
Chase Paulson, Samuel C. Thomas, Orlando Gonzalez, Samuel Taylor, Cole Swiston, Jennifer S. Herrick, Lori McCoy, Karen Curtin, Craig J. Chaya, Brian C. Stagg, Barbara M. Wirostko
Summary: This study is the largest epidemiological study of exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in the Baja Verapaz region of Guatemala among individuals seeking eye exams and interventions. The study found a high prevalence of XFS/XFG, particularly among individuals in rural areas and those who speak the Mayan language.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Jordana B. Cohen, Zachary A. Marcum, Chong Zhang, Catherine G. Derington, Tom H. Greene, Lama Ghazi, Jennifer S. Herrick, Jordan B. King, Alfred K. Cheung, Nick Bryan, Mark A. Supiano, Joshua A. Sonnen, William S. Weintraub, Daniel Scharfstein, Jeff Williamson, Nicholas M. Pajewski, Adam P. Bress
Summary: This observational cohort study aimed to evaluate the cognitive outcomes of individuals at risk for mild cognitive impairment and probable dementia after initiating an ARB- vs ACEI-based antihypertensive regimen. The study found no significant difference in the rate of amnestic MCI or PD among new users of ARB compared with ACEI.
Article
Cardiac & Cardiovascular Systems
Alexander R. Zheutlin, Catherine G. Derington, Jennifer S. Herrick, Robert S. Rosenson, Bharat Poudel, Monika M. Safford, Todd M. Brown, Elizabeth A. Jackson, Mark Woodward, Stephanie Reading, Kate Orroth, Jason Exter, Salim S. Virani, Paul Muntner, Adam P. Bress
Summary: This study investigated lipid-lowering therapy (LLT) among US veterans after myocardial infarction or elective coronary revascularization. The results showed that less than half of the patients received LLT intensification within one year, indicating a missed opportunity to reduce cardiovascular disease risk.
CIRCULATION-CARDIOVASCULAR QUALITY AND OUTCOMES
(2022)
Article
Peripheral Vascular Disease
Catherine G. Derington, Adam P. Bress, Andrew E. Moran, William S. Weintraub, Jennifer S. Herrick, William C. Cushman, Ian M. Kronish, Barry Stults, Daichi Shimbo, Paul Muntner, Tom Greene, Jeffrey T. Bates, Tara I. Chang, Lois Anne Katz, Shakaib U. Rehman, Christianne L. Roumie, Leonardo Tamariz, Jordan B. King
Summary: In the SPRINT study, the use of ACE inhibitors or ARBs, thiazide diuretics, and calcium channel blockers in combination is favored to target systolic blood pressure (SBP) < 120 mm Hg, instead of using ACE/ARB monotherapy to target SBP < 140 mm Hg.
Article
Peripheral Vascular Disease
Jordan B. King, Catherine G. Derington, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Molly B. Conroy, William C. Cushman, Adam P. Bress
Summary: This study aimed to assess the availability of commercially available single-pill combination (SPC) antihypertensive products for achieving an intensive systolic blood pressure goal of <120 mm Hg. The results showed that most participants in the intensive treatment arm were using antihypertensive regimens that are not available as class-equivalent SPC products. Therefore, improvements in the product landscape are needed to achieve the desired results in real-world settings and reduce medication burden.
Article
Peripheral Vascular Disease
Byron C. Jaeger, Ligong Chen, Kathryn Foti, Shakia T. Hardy, Adam P. Bress, Sean P. Kane, Lei Huang, Jennifer S. Herrick, Catherine G. Derington, Bharat Poudel, Ashley Christenson, Lisandro D. Colantonio, Paul Muntner
Summary: A web-based application was developed to provide hypertension statistics for US adults using data from the US National Health and Nutrition Examination Survey. The study found that the mean systolic blood pressure decreased from 123 mm Hg in 1999-2000 to 120 mm Hg in 2009-2010 and then increased to 123 mm Hg in 2017-2020. The age-adjusted prevalence of hypertension was 47.9% in 1999-2000, 43.0% in 2009-2010, and 44.7% in 2017-2020. The study also estimated that 115.3 million US adults had hypertension in 2017-2020.
Article
Cardiac & Cardiovascular Systems
Catherine G. G. Derington, Adam P. P. Bress, Jennifer S. S. Herrick, Joshua A. A. Jacobs, Alexander R. R. Zheutlin, Ransmond O. O. Berchie, Molly B. B. Conroy, William C. C. Cushman, Jordan B. B. King
Summary: It is found that only one-third of hypertensive patients in the US market can be satisfied with the currently available fixed-dose combination antihypertensive products, indicating the need for further improvement in the pharmaceutical product landscape.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Peripheral Vascular Disease
Alexander R. Zheutlin, Daniel K. Addo, Joshua A. Jacobs, Catherine G. Derington, Jennifer S. Herrick, Tom Greene, Eric L. Stulberg, Dan R. Berlowitz, Jeff D. Williamson, Nicholas M. Pajewski, Mark A. Supiano, Adam P. Bress
Summary: Despite evidence supporting the benefits of intensive blood pressure management, older adults have the lowest rates of blood pressure control. The association between age and therapeutic inertia was determined in the SPRINT study, with older age found to be associated with greater therapeutic inertia independent of physical or cognitive function. This suggests age bias in hypertension management.
Article
Cardiac & Cardiovascular Systems
Jordan B. King, Ransmond O. Berchie, Catherine G. Derington, Zachary A. Marcum, Daniel O. Scharfstein, Tom H. Greene, Jennifer S. Herrick, Joshua A. Jacobs, Alexander R. Zheutlin, Adam P. Bress, Jordana B. Cohen
Summary: This study compared the effects of new users of ARBs versus ACEIs on cardiovascular disease events and death. The results showed similar rates of cardiovascular disease events between the two groups, with lower death rates associated with ARBs. There were subgroup differences in the effects of ARBs versus ACEIs.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Catherine G. Derington, Adam P. Bress, Jennifer S. Herrick, Wenjun Fan, Nathan D. Wong, Katherine E. Andrade, Jonathan Johnson, Sephy Philip, David Abrahamson, Lixia Jiao, Deepak L. Bhatt, William S. Weintraub
Summary: Treating all eligible adults with icosapent ethyl as part of the REDUCE-IT trial can prevent a substantial number of ASCVD events, although there are significant medication costs involved. The indirect cost savings from event prevention may outweigh the incurred direct costs.
AMERICAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)