Article
Cell Biology
Yuqiang Li, Mengxiang Tian, Wenxue Liu, Dan Wang, Zhongyi Zhou, Qian Pei, Yan Huang, Fengbo Tan, Cenap Guengoer
Summary: The expression of FSTL3 is significantly higher in colon cancer specimens, and its expression is associated with increased invasive and metastatic capacity of tumor cells. Transcriptional regulation of FSTL3 is dependent on YAP1 de-phosphorylation events, leading to activation of the beta-Catenin pathway and promotion of EMT processes. Pharmacological targeting of YAP1 may offer a promising therapeutic strategy for anti-metastasis in CRC patients.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ningning Zhao, Jiajie Zhang, Qian Zhao, Chao Chen, Huijuan Wang
Summary: Glioma is a common and aggressive brain tumor with poor prognosis due to uncontrolled proliferation and metabolic reprogramming. Long noncoding RNAs play diverse roles in shaping the biological features of glioma, but more research is needed to fully understand their mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Rui Wang, Jian Liu, Kai Li, Ganghua Yang, Sisi Chen, Jie Wu, Xinming Xie, Hong Ren, Yamei Pang
Summary: SETD1A is significantly upregulated in NSCLC, and its overexpression predicts a poor prognosis for patients. Functional experiments demonstrate that SETD1A positively regulates cancer stem cell properties and negatively regulates cisplatin sensitivity in NSCLC cells through the Wnt/beta-catenin pathway. Additionally, SETD1A interacts with and stabilizes beta-catenin to positively regulate the Wnt/beta-catenin pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Zhaoyuan Meng, Xueli Bian, Leina Ma, Gang Zhang, Qingxia Ma, Qianqian Xu, Juanjuan Liu, Runze Wang, Jie Lun, Qian Lin, Gaoxiang Zhao, Hongfei Jiang, Wensheng Qiu, Jing Fang, Zhimin Lu
Summary: In this study, it was found that key glycolytic enzyme phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) can interact with SUMO-conjugating enzyme UBC9 and be SUMOylated in glioblastoma cells. Activation of EGFR increases the interaction between UBC9 and PFKFB3, leading to increased SUMOylation and expression of PFKFB3. These findings reveal a previously unknown mechanism underlying the regulation of the Warburg effect through EGFR activation-induced and UBC9-mediated SUMOylation and stabilization of PFKFB3.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Mingjun Gao, Jin Yang, Hailong Gong, Yuancai Lin, Jing Liu
Summary: Trametinib has the potential to inhibit glioma cell proliferation, migration, and invasion, induce apoptosis, and target the PKM2/c-myc pathway. The inhibitory effects on glycolytic metabolism may hold promise for the treatment of gliomas.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Yizhi Liang, Zilan Rao, Dongwei Du, Yiwen Wang, Taiyong Fang
Summary: Butyrate can suppress the growth and aerobic glycolysis of gastric cancer cells by downregulating the wnt/β-catenin/c-Myc signaling pathway.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Oncology
Wenjin Chen, Weiqiang Jia, Cuiying Wu, Lihua Chen, Kai Sun, Ji Wang, Boyun Ding, Ning Liu, Ruxiang Xu
Summary: The study revealed that P7C3 suppresses glioma by directly targeting PGK1 and regulating aerobic glycolysis. It was found for the first time the target proteins of P7C3, providing scientific clues for future studies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yong-Qiang Hua, Ke Zhang, Jie Sheng, Zhou-Yu Ning, Ye Li, Wei-Dong Shi, Lu-Ming Liu
Summary: The study revealed that Fam83D is overexpressed in pancreatic adenocarcinoma and associated with clinical features and patient outcomes. Knockdown of Fam83D inhibited proliferation, suppressed metabolism, and increased sensitivity to gemcitabine in PDAC cells.
Article
Chemistry, Medicinal
Yuehua Qi, Chunjing Zhang, Di Wu, Yue Zhang, Yunfeng Zhao, Wenjuan Li
Summary: I3C inhibits LDHA expression and glycolysis-related gene expression in liver cancer cells, stabilizes p53 expression through a pathway involving miR-34a, and inhibits MDM2-mediated degradation of p53.
Article
Biotechnology & Applied Microbiology
Yi Liu, Jun Ma, Jiu-Shan Song, Hai-Ying Zhou, Jing-Hui Li, Cheng Luo, Xin Geng, He-Xiang Zhao
Summary: TOP2A plays a critical role in the metastatic characteristics of glioma. High expression of TOP2A is associated with poor survival in glioma patients, while silencing TOP2A impairs glioma cell proliferation and aggressiveness. Mechanistically, TOP2A interacts with beta-catenin and promotes its translocation into the nucleus, affecting glioma cell growth and invasion through the Wnt/beta-catenin pathway.
Article
Medicine, Research & Experimental
Qingqu Guo, Yiming Chu, Hongbo Li, Dike Shi, Lele Lin, Weifeng Lan, Dan Wu
Summary: The overexpression of DKK3 enhances glucose uptake and proliferation, while inhibiting apoptosis in CD4(+) T cells. Experimental findings suggest that DKK3 overexpression may regulate the metabolism and function of CD4(+) T cells.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Immunology
Yuewen Tang, Feng Wan, Xuanli Tang, Yi Lin, Huaqin Zhang, Jiawei Cao, Ruchun Yang
Summary: Proteinuria is a risk factor for the progression of diabetic nephropathy and an imbalance in podocyte function exacerbates proteinuria. Celastrol, the active ingredient of T. wilfordii, has been effective in treating renal injury in diabetic nephropathy, but its mechanisms are unclear. This study investigated how celastrol prevents podocyte damage in diabetic nephropathy using in vivo and in vitro experiments. Celastrol reduced blood glucose levels, attenuated renal histomorphological injury, and induced anti-inflammatory effects. It upregulated SIRT1 expression and downregulated EZH2, inhibiting the wnt/beta-catenin pathway. SIRT1 repression aggravated podocyte injury, while celastrol protected podocyte injury via SIRT1/EZH2 in the wnt/beta-catenin pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yawei He, Wanjing Chen, Liang Yu, Yanwei Liu, Yunsheng Cheng, Xianghua Li, Gang Yu
Summary: Aerobic glycolysis is critical for cancer cell metabolism. This study found that the transcription factor FOXA2 is poorly expressed in thyroid carcinoma (THCA) cells. Upregulation of FOXA2 suppressed glucose uptake, lactate production, and acidification rate, while increasing oxygen consumption rate in THCA cells. FOXA2 overexpression also blocked proliferation, mobility, and tumorigenic activity of cancer cells. Furthermore, FOXA2 was found to bind to the PKM2 promoter and suppress its transcription, which was highly expressed in THCA cells. Upregulation of PKM2 restored glycolytic activity and malignant properties of cancer cells by activating the Wnt/beta-catenin pathway.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hongzao Ni, Daofei Ji, Jing Li, Zongren Zhao, Jiandong Zuo
Summary: The study revealed that IPO11 knockdown suppressed the malignant phenotypes of glioma cells by inactivating the Wnt/beta-catenin pathway, leading to inhibition of cell proliferation, promotion of apoptosis, and suppression of invasion.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Weicheng Liang, Chuanjian Shi, Weilong Hong, Panlong Li, Xue Zhou, Weiming Fu, Lizhu Lin, Jinfang Zhang
Summary: The study uncovered the role of lncRNA-DAW in hepatocellular carcinoma, showing its regulation by a liver-specific super-enhancer and the transcription factor HNF4G. It was found to promote tumor growth and activate the Wnt/β-catenin pathway by interacting with EZH2. This study suggests lncRNA-DAW as a potential oncogene and diagnostic biomarker in liver cancer.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
