Review
Oncology
Stefan Forster, Ramin Radpour
Summary: Multiple myeloma is a common malignant disease of plasma cells, and current treatments include chemotherapy, immunomodulatory agents, and monoclonal antibodies. The tumor microenvironment plays a crucial role in the development and progression of multiple myeloma, and understanding how different components of the bone marrow promote plasma cell dissemination is important for preventing the spread of the disease to other sites.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, Research & Experimental
M. Hope Robinson, Nancy Y. Villa, David L. Jaye, Ajay K. Nooka, Alyssa Duffy, Samuel S. McCachren, Julia Manalo, Jeffrey M. Switchenko, Sierra Barnes, Sayalee Potdar, Maryam I. Azeem, Ava A. Horvat, Vaunita C. Parihar, Jingjing Gong, Yan Liang, Geoffrey H. Smith, Vikas A. Gupta, Lawrence H. Boise, Jonathan L. Kaufman, Craig C. Hofmeister, Nisha S. Joseph, Sagar Lonial, Kavita M. Dhodapkar, Madhav V. Dhodapkar
Summary: This study investigates the mechanisms underlying immune infiltration in human multiple myeloma (MM) and its precursor monoclonal gammopathy of undetermined significance (MGUS) using high-dimensional spatial analyses and in vitro and in vivo modeling. The results suggest that MM exhibits clustered tumor growth and spatial heterogeneity with the coexistence of T cell-rich and T cell-sparse regions, as well as areas of T cell exclusion. T cell entry into MM clusters is regulated by agonistic signals and CD2-CD58 interactions, and CLEC9A+ DCs play a role in marking the portals of entry for T cell infiltration.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Oncology
Jennifer Sun, Chaelee Park, Nicole Guenthner, Shannon Gurley, Luna Zhang, Berit Lubben, Ola Adebayo, Hannah Bash, Yixuan Chen, Mina Maksimos, Barbara Muz, Abdel Kareem Azab
Summary: MM is a cancer of plasma cells in the bone marrow, with the tumor microenvironment playing a critical role in disease progression. TAMs in the TME have been found to support tumor survival and chemoresistance, highlighting the importance of exploring macrophage-targeted immunotherapy in MM treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Review
Oncology
Raquel Lopes, Bruna Velosa Ferreira, Joana Caetano, Filipa Barahona, Emilie Arnault Carneiro, Cristina Joao
Summary: Multiple myeloma is a hematological malignancy arising from the proliferation of tumor antibody-producing cells in the bone marrow. Immunotherapy is a form of cancer treatment that aims to stimulate the immune system to fight back tumor cells, but has not yet been able to cure multiple myeloma completely.
Review
Endocrinology & Metabolism
Annette Gilchrist, Stephanie L. Echeverria
Summary: Multiple myeloma is a difficult-to-cure malignancy with a lower survival rate compared to other hematologic cancers. Treatment options are limited, and there is a need for new approaches. Antagonists targeting chemokine-receptor 1 (CCR1) may provide a new treatment option for multiple myeloma. Existing studies have shown the potential therapeutic effects of CCR1 antagonists, but clinical trials are yet to be conducted.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Oncology
Almudena Garcia-Ortiz, Yaiza Rodriguez-Garcia, Jessica Encinas, Elena Maroto-Martin, Eva Castellano, Joaquin Teixido, Joaquin Martinez-Lopez
Summary: Multiple myeloma is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow, with disease progression influenced by the tumor microenvironment created by various cells and soluble factors. Understanding the elements that control the microenvironment could lead to better-targeted therapies for this incurable disease.
Article
Biochemical Research Methods
Elias Vera-Siguenza, Cristina Escribano-Gonzalez, Irene Serrano-Gonzalo, Kattri-Liis Eskla, Fabian Spill, Daniel Tennant
Summary: It is increasingly recognized that cancer cells adapt and manipulate the metabolism of other cells, which has important implications for understanding tumor metabolism and finding therapeutic targets. However, we still have limited knowledge about how cancer cells manipulate non-cancerous cell metabolism and its impact on survival and proliferation. This study employs an interdisciplinary approach, combining mathematical modeling and in-vitro co-culture models, to develop a functional simulated model that successfully reproduces key metabolic behaviors of its in-vitro counterpart.
PLOS COMPUTATIONAL BIOLOGY
(2023)
Review
Hematology
Eline Menu, Karin Vanderkerken
Summary: This review summarizes the role of exosomes in multiple myeloma (MM), including their involvement in osteolysis, angiogenesis, immune suppression, and drug resistance. Targeting exosome secretion could potentially block these processes. The review also discusses current treatment strategies to counter these processes and explores how exosomes can be harnessed to deliver toxic payloads. Additionally, the review provides an overview of clinical studies investigating exosome cargo as potential MM biomarkers in liquid biopsies.
Review
Oncology
Fatih M. Uckun
Summary: T-cell engaging bispecific antibodies (BsABs) have the potential to delay disease progression in multiple myeloma by redirecting host T-cell cytotoxicity towards malignant MM clones and immunosuppressive myeloid-derived suppressor cells in the bone marrow microenvironment.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Niklas Kehl, Michael Kilian, Julius Michel, Tim R. Wagner, Sebastian Uhrig, Alexander Brobeil, Lilli-Sophie Sester, Sven Blobner, Simon Steiger, Michael Hundemer, Niels Weinhold, Karsten Rippe, Stefan Froehling, Stefan B. Eichmueller, Lukas Bunse, Carsten Mueller-Tidow, Hartmut Goldschmidt, Michael Platten, Marc-Steffen Raab, Mirco J. Friedrich
Summary: Multiple myeloma (MM) is a rare and aggressive hematological malignancy, and its classification and evolution can be deciphered by molecular features. IgE type MM is a subtype with a small percentage but poor prognosis, and currently there is limited genetic and immunological data available. In this study, comprehensive analysis at the genomic and immune repertoire level revealed the pathophysiological mechanisms and potential targeted therapy opportunities for IgE type MM.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Rodrigo Carlini Fernando, Fabricio de Carvalho, Adriana Franco Paes Leme, Gisele Wally Braga Colleoni
Summary: The tumor microenvironment plays a central role in promoting the proliferation, survival, migration, and drug resistance of tumor cells in cancers like multiple myeloma. Understanding and targeting the dysregulated biological pathways in the microenvironment may lead to new therapeutic opportunities for these patients.
FRONTIERS IN ONCOLOGY
(2021)
Article
Hematology
Yu Jia Shen, Yuji Mishima, Jiantao Shi, Romanos Sklavenitis-Pistofidis, Robert A. Redd, Michele Moschetta, Salomon Manier, Aldo M. Roccaro, Antonio Sacco, Yu-Tzu Tai, Francois Mercier, Yawara Kawano, Nang Kham Su, Brianna Berrios, John G. Doench, David E. Root, Franziska Michor, David T. Scadden, Irene M. Ghobrial
Summary: Clonal evolution plays a key role in tumor progression, dissemination, and relapse in multiple myeloma (MM). By developing a clone-tracking system, researchers studied clonal behavior in the bone marrow microenvironment, identifying specific clones able to adapt and colonize distant sites. RNA sequencing revealed a progression signature in MM tumor cells, leading to the prediction of 28 master regulators, with HMGA1 and PA2G4 validated as key players in MM progression and dissemination, impacting cell functions like proliferation, migration, and adhesion. This study successfully replicates key characteristics of human MM disease progression and suggests potential therapeutic targets.
Review
Biochemistry & Molecular Biology
Nikolaos Giannakoulas, Ioannis Ntanasis-Stathopoulos, Evangelos Terpos
Summary: Significant progress has been made in developing therapies for multiple myeloma, but it remains incurable. Research has shed light on the genetic background of malignant plasma cells and the crucial role of the bone marrow microenvironment. The interaction between myeloma cells and components of the microenvironment is considered essential in the pathogenesis of multiple myeloma.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Jelena Bila, Eirini Katodritou, Margarita Guenova, Sandra Basic-Kinda, Daniel Coriu, Milena Dapcevic, Lejla Ibricevic-Balic, Arben Ivanaj, Oliver Karanfilski, Samo Zver, Meral Beksac, Evangelos Terpos, Meletios Athanassios Dimopoulos
Summary: The course of multiple myeloma is influenced by tumor microenvironment. Treatment modalities like bortezomib can impact TME and individual profiles of MM patients need to be considered for optimal treatment.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Raquel Lopes, Joana Caetano, Bruna Ferreira, Filipa Barahona, Emilie Arnault Carneiro, Cristina Joao
Summary: The interaction between multiple myeloma and immune cells in the bone marrow microenvironment is considered a key aspect of this hematological disease. Understanding how myeloma cells disrupt immune homeostasis is crucial in developing effective treatments, particularly through immunotherapy. Ongoing pre-clinical studies are focused on targeting immune populations within the bone marrow niche, aiming to improve outcomes for patients with multiple myeloma.
Article
Substance Abuse
Alexander W. Alund, Kelly E. Mercer, Casey F. Pulliam, Larry J. Suva, Jin-Ran Chen, Thomas M. Badger, Martin J. J. Ronis
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2017)
Review
Endocrinology & Metabolism
Maurizio Zangari, Larry J. Suva
Editorial Material
Endocrinology & Metabolism
Larry J. Suva, Dana Gaddy
CALCIFIED TISSUE INTERNATIONAL
(2016)
Article
Orthopedics
Dong Sun, Michael McCarthy, Adam C. Dooley, Raghu H. Ramakrishnaiah, R. Shane Shelton, Sandra G. McLaren, Robert A. Skinner, Larry J. Suva, Richard E. McCarthy
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Editorial Material
Endocrinology & Metabolism
Larry J. Suva, Peter A. Friedman
Article
Developmental Biology
Harunur Rashid, Haiyan Chen, Quamarul Hassan, Amjad Javed
Article
Endocrinology & Metabolism
Meera Mohan, Rohan S. Samant, Donghoon Yoon, Amy F. Buros, Antonio Branca, Corey O. Montgomery, Richard Nicholas, Larry J. Suva, Roy Morello, Sharmilan Thanendrarajan, Carolina Schinke, Shmuel Yaccoby, Frits van Rhee, Faith E. Davies, Gareth J. Morgan, Maurizio Zangari
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Endocrinology & Metabolism
Archana Kamalakar, Charity L. Washam, Nisreen S. Akel, Bethany J. Allen, Diarra K. Williams, Frances L. Swain, Kim Leitzel, Allan Lipton, Dana Gaddy, Larry J. Suva
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Orthopedics
Corey O. Montgomery, Austin Porter, Brant Sachleben, Larry J. Suva, Brian Rabenhorst
JOURNAL OF PEDIATRIC ORTHOPAEDICS-PART B
(2017)
Article
Otorhinolaryngology
Matthew Tamplen, Tristan Fowler, Jeffery Markey, P. Daniel Knott, Larry J. Suva, Tamara Alliston
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
(2018)
Article
Endocrinology & Metabolism
K. L. Seldeen, P. G. Halley, C. H. Volmar, M. A. Rodriguez, M. Hernandez, M. Pang, S. K. Carlsson, L. J. Suva, C. Wahlestedt, B. R. Troen, S. P. Brothers
Article
Biochemistry & Molecular Biology
Claire Stenhouse, Katherine M. Halloran, Amelia R. Tanner, Larry J. Suva, Paul J. Rozance, Russell Anthony, Fuller W. Bazer
Summary: This study used lentiviral-mediated RNA interference to investigate the regulatory role of chorionic somatomammotropin hormone (CSH) in the utilization of calcium, phosphate, and vitamin D in late gestation in sheep. The study found that CSH RNAi significantly affected the uptake and concentration of calcium, phosphate, and vitamin D, as well as the expression levels of several candidate mRNAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Maurizio Zangari, Hanna Yoo, Ik Jae Shin, Donghoon Yoon, Larry J. Suva
JOURNAL OF BONE ONCOLOGY
(2018)
Article
Endocrinology & Metabolism
Maurizio Zangari, Hanna Yoo, Ikjae Shin, Bumjun Kim, Ricky Edmondson, Gareth J. Morgan, Larry J. Suva, Donghoon Yoon
Review
Endocrinology & Metabolism
Rachelle W. Johnson, Larry J. Suva
CALCIFIED TISSUE INTERNATIONAL
(2018)