Article
Infectious Diseases
Boris Revollo, Laura Vinuela, Lorena de la Mora, Federico Garcia, Marc Noguera-Julian, Mariona Parera, Roger Paredes, Josep M. Llibre
Summary: This article reports a case of integrase resistance in a patient treated with co-formulated dolutegravir/lamivudine. It highlights the importance of carefully considering and monitoring drug-drug interactions, even when they are regarded as having a low potential.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2022)
Article
Multidisciplinary Sciences
Rachel D. Stelmach, Miriam Rabkin, Kouame Abo, Irma Ahoba, Mahena Gildas Anago, Rodrigo Boccanera, Hermann Brou, Rebecca Flueckiger, Kieran Hartsough, Martin Msukwa, Jennifer Zech, Felicity Young, Rachel Nugent
Summary: Despite the availability of free ART in Cote d'Ivoire, most participants still reported out-of-pocket spending on health care, with those with co-morbid NCDs experiencing higher costs.
Article
Multidisciplinary Sciences
Mhairi Maskew, Kieran Sharpey-Schafer, Lucien De Voux, Thomas Crompton, Jacob Bor, Marcus Rennick, Admire Chirowodza, Jacqui Miot, Seithati Molefi, Chuka Onaga, Pappie Majuba, Ian Sanne, Pedro Pisa
Summary: This study applied predictive machine learning algorithms to HIV programmatic data from South Africa and developed models to predict patient attendance and viral load suppression. Important predictors included previous visit history, viral load testing frequency, visit time, age, and treatment duration. The results showed that machine learning can effectively identify HIV patients at risk of disengagement and unsuppressed viral load.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Wendy L. Wobeser, Joanne E. McBane, Louise Balfour, Brian Conway, M. John Gill, Harold Huff, Donald L. P. Kilby, Dean A. Fergusson, Ranjeeta Mallick, Edward J. Mills, Katherine A. Muldoon, Anita Rachlis, Edward D. Ralph, Ron Rosenes, Joel Singer, Neera Singhal, Darrell Tan, Nancy Tremblay, Dong Vo, Sharon L. Walmsley, D. William Cameron
Summary: High-dose antioxidant and micronutrient supplementation compared to recommended daily allowance supplementation had no significant effect on disease progression or initiation of ART in HIV-infected individuals who have not received previous treatment.
Article
Multidisciplinary Sciences
Emmanuel Sendaula, Michael Buwembo, Denis Opio
Summary: The holistic care model supports individuals living with HIV in various aspects of their lives, resulting in improved treatment outcomes. Age and adherence are significantly associated with viral load suppression in HIV-infected adults receiving a holistic approach of care.
Article
Infectious Diseases
Barbara Rossetti, Massimiliano Fabbiani, Domenico Di Carlo, Francesca Incardona, Ana Abecasis, Perpetua Gomes, Anna Maria Geretti, Carole Seguin-Devaux, Federico Garcia, Rolf Kaiser, Sara Modica, Adrian Shallvari, Anders Sonnerborg, Maurizio Zazzi
Summary: This large multi-cohort study indicates high effectiveness of elvitegravir- or dolutegravir-based first-line ART in routine practice across Europe. Factors such as baseline viral load and CD4 cell count can affect the treatment outcomes.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Youngji Jo, Lise Jamieson, Bevis Phiri, Anna Grimsrud, Muya Mwansa, Hilda Shakwelele, Prudence Haimbe, Mpande Mukumbwa-Mwenechanya, Priscilla Lumano Mulenga, Brooke E. Nichols, Sydney Rosen
Summary: To improve access and remove barriers to HIV treatment, many sub-Saharan Africa countries are implementing differentiated service delivery (DSD) models. This study assessed factors associated with attrition after enrollment in DSD models in Zambia, focusing on patient-level characteristics. The results showed that nearly all DSD models out-performed conventional care in terms of retention.
Article
Immunology
Jane S. Chen, Mitch Matoga, Cecilia Massa, Gerald Tegha, Beatrice Ndalama, Naomi Bonongwe, Esther Mathiya, Edward Jere, Gabriel Banda, Amy J. Loftis, Kathryn E. Lancaster, William C. Miller, Irving F. Hoffman, Myron S. Cohen
Summary: This study conducted in Lilongwe aimed to evaluate HIV shedding in men with urethritis receiving ART. The research found that despite viral suppression in the blood, some episodes of urethritis still showed seminal viral shedding. During non-urethritis follow-up, a small percentage of men had viral shedding in the semen while maintaining viral suppression in the blood.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Mohsen Sheykhhasan, Aidin Foroutan, Hamed Manoochehri, Saeideh Gholamzadeh Khoei, Naresh Poondla, Massoud Saidijam
Summary: HIV/AIDS remains a major global public health issue, with gene therapy showing promising results in combating HIV infection. Traditional treatment methods have limitations and side effects, making gene therapy an effective alternative.
Article
Multidisciplinary Sciences
Mario Songane, Celia C. Magaia, Aleny Couto, Nataniel Dengo, Abdul R. Cassamo, Rene Nhantumbo, Carlos Mahumane, Atanasio Mabote, Silvia Mikusova, Amancio Nhangave, Nilesh Bhatt, Sushant S. Mukherjee
Summary: In Mozambique, a pilot home-based HIV counseling and testing program targeting sexual partners, children, and parents of people living with HIV was implemented to increase HIV testing. The community index testing approach not only proved to be cost-effective, but also identified a significant number of new HIV cases, particularly among males.
Review
Medicine, General & Internal
Laura N. Broyles, Robert Luo, Debi Boeras, Lara Vojnov
Summary: This article summarizes the risk of sexual transmission of HIV from individuals with low-level viral loads and emphasizes its importance in public health. The review of 8 studies shows that the risk of HIV transmission is almost zero when viral loads are below 1000 copies per mL. These findings can help destigmatize HIV and promote adherence to antiretroviral therapy.
Article
Multidisciplinary Sciences
Ines Mendoza, Alicia Lazaro, Alfredo Espinosa, Lorenzo Sanchez, Ana Maria Horta, Miguel Torralba
Summary: This study shows that dolutegravir plus lamivudine (2-DR) is not as effective as bictegravir/emtricitabine/tenofovir alafenamide (3-DR) in treating HIV-1. However, the durability and safety of 2-DR are similar to 3-DR.
Review
Medicine, General & Internal
Robert Luo, Youyi Fong, Debi Boeras, Ilesh Jani, Lara Vojnov
Summary: This study aimed to compare the clinical effect of point-of-care HIV testing versus laboratory-based testing in HIV-exposed infants. The results showed that point-of-care testing significantly shortened the time to result delivery, time to antiretroviral therapy initiation, and increased the proportion of HIV-positive infants starting antiretroviral therapy within 60 days compared with standard of care.
Article
Medicine, General & Internal
Hendrik Streeck, Alvino Maestri, Daniel Habermann, Trevor A. Crowell, Allahna L. Esber, Gowoon Son, Leigh Anne Eller, Michael A. Eller, Ajay P. Parikh, Peter A. Horn, Lucas Maganga, Emmanuel Bahemana, Yakubu Adamu, Francis Kiweewa, Jonah Maswai, John Owuoth, Merlin L. Robb, Nelson L. Michael, Christina S. Polyak, Daniel Hoffmann, Julie A. Ake
Summary: Chronic immune activation in HIV-1 infection is influenced by factors such as HIV viral load, sex, age, region, and ART use. Predictors and associations among biomarkers and co-infections affect biomarkers associated with noncommunicable diseases.
Article
Multidisciplinary Sciences
William Reidy, Herve Nzereka Kambale, Allison B. Hughey, Tengetile Tezzy Nhlengethwa, Janki Tailor, Nomthandazo Lukhele, Simangele Mthethwa, Anita Hettema, Peter Preko, Miriam Rabkin
Summary: Differentiated antiretroviral therapy (ART) models in Eswatini have been well received by both patients and healthcare workers, with patients reporting high satisfaction levels and improved medication adherence. These models have also been effective in reducing the workload of healthcare providers and wait times for patients. However, it is important to offer a diverse portfolio of ART models to cater to the heterogeneous needs of people living with HIV.
Article
Nutrition & Dietetics
Fernanda Lambert de Andrade Freire, Raquel Costa Silva Dantas-Komatsu, Niethia Regina Dantas de Lira, Rosiane Viana Zuza Diniz, Severina Carla Vieira Cunha Lima, Fernando Barbosa Jr, Lucia Fatima Campos Pedrosa, Karine Cavalcanti Mauricio Sena-Evangelista
Summary: This study found that biomarkers of zinc and copper in patients with heart failure did not seem to be affected by differences in intake, but factors related to oxidative stress and inflammation should be monitored in clinical practice.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Article
Nutrition & Dietetics
Ligia Moriguchi Watanabe, Ana C. Bueno, Livia F. de Lima, Rafael Ferraz-Bannitz, Renata Dessordi, Mariana P. Guimaraes, Maria C. Foss-Freitas, Fernando Barbosa, Anderson M. Navarro
Summary: The study found that SNPs in selenoproteins were associated with individual responses to Brazil nut consumption, indicating that variations in Se homeostasis may impact health outcomes.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Food Science & Technology
Marilia Cristina Oliveira Souza, Bruno Alves Rocha, Juliana Maria Oliveira Souza, Joao Carlos Jacinto Souza, Fernando Barbosa
Summary: The study determined the levels of seven PBDE congeners in Brazilian food of animal origin, finding that the levels of PBDEs in milk samples were higher than those in studies from other countries, with milk products contributing more to PBDE exposure. The hazard index was found to be less than 1, indicating a relatively low risk of exposure to PBDEs.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Fabiana M. de O. Hernandez, Marilene O. Santos, Gabriela L. Venturin, Jaqueline P. Bragato, Gabriela T. Rebech, Larissa M. Melo, Sidnei F. Costa, Jessica H. de Freitas, Carlos Eduardo Siqueira, Deborah A. Morais, Wellington T. de S. Junior, Fernando B. Junior, Flavia L. Lopes, Valeria M. F. de Lima
Summary: Canine leishmaniasis is a chronic disease caused by Leishmania infantum, and the limitations of current treatments have led to the exploration of new alternatives, such as the use of immunomodulatory nutrients. This study aimed to determine the levels of vitamin A, vitamin D, and zinc in dogs with CanL and the effects of supplementation with these nutrients on spleen leukocyte cultures. The results suggest that the tested nutrients may play a role in the leishmanicidal mechanism and warrant further investigation in future studies.
Article
Chemistry, Multidisciplinary
Bruno A. Rocha, Cibele A. Cesila, Airton C. Martins, Marilia C. O. Souza, Fernando Barbosa Jr
Summary: A study established a method for detecting five commonly used parabens in sports supplements, revealing that almost all samples contained at least one paraben, with ethylparaben and methylparaben being the most frequently detected. Propylparaben, butylparaben, and benzylparaben, which are forbidden in food samples, were also found in some samples.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2022)
Article
Biochemistry & Molecular Biology
Isabela M. Bensenor, Fernando Barbosa Junior, Carolina Castro Porto Silva Janovsky, Dirce Marchioni, Maria de Fatima Haueisen Sander Diniz, Itamar de Souza Santos, Bianca de Almeida-Pititto, Jose Augusto Sgarbi, Maria del Carmen B. Molina, Jose Geraldo Mill, Paulo A. Lotufo
Summary: The study found that the majority of the participants had more than adequate iodine intake, but nearly a quarter of women of childbearing age were iodine deficient. There was a strong correlation between urinary iodine concentration and urinary sodium concentration, indicating the important impact of individual iodized salt consumption on urinary iodine concentration.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Environmental Sciences
Ana Carolina Cavalheiro Paulelli, Cibele Aparecida Cesila, Paula Picoli Devoz, Silvana Ruella de Oliveira, Joao Paulo Bianchi Ximenez, Walter dos Reis Pedreira Filho, Fernando Barbosa Jr
Summary: The study conducted in communities directly affected by the disaster revealed high levels of exposure to toxic metals such as aluminum, arsenic, mercury, and nickel. Factors such as community, drinking water, fish and seafood consumption, and smoking habits were found to be associated with metal/metalloid levels in their body. Well and tap water intake were identified as important sources of exposure to aluminum and nickel. The findings represent health risks to the groups living in the areas affected by the tailings dam failure, calling for further studies to evaluate the potential health effects of high exposure to metals and remediation actions from public health Brazilian authorities.
ENVIRONMENTAL RESEARCH
(2022)
Article
Microbiology
Erika G. Marques de Menezes, Xutao Deng, Jocelyn Liu, Scott A. Bowler, Cecilia M. Shikuma, Mars Stone, Peter W. Hunt, Lishomwa C. Ndhlovu, Philip J. Norris
Summary: HIV-infected individuals have an increased risk of cardiovascular disease, potentially due to persistent immune activation and systemic inflammation. Extracellular vesicles have been found to be associated with CVD, suggesting their potential importance in prevention and treatment.
Article
Immunology
Hector Bonilla, Dylan Hampton, Erika G. Marques de Menezes, Xutao Deng, Jose G. Montoya, Jill Anderson, Philip J. Norris
Summary: Myalgic encephalomyelitis, or chronic fatigue syndrome (ME/CFS), is a serious disease with an unknown cause and objective markers. This study found potential dysregulation of B cell and platelet activation or homeostasis in ME/CFS patients, which could be important for diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Igor Massari Correia, Anderson Marliere Navarro, Jessica Fernanda Correa Cordeiro, Euripedes Barsanulfo Goncalves Gomide, Lisa Fernanda Mazzonetto, Alcivandro de Sousa Oliveira, Emerson Sebastiao, Bruno Augusto Aguilar, Denise de Andrade, Dalmo Roberto Lopes Machado, Andre Pereira dos Santos
Summary: This study developed sex-specific anthropometric models to predict bone mineral content (BMC) in people living with HIV (PWH). The models showed high coefficients of determination and reduced estimation errors, providing a valid and low-cost alternative for monitoring bone health in PWH.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Immunology
Erika G. Marques de Menezes, Jocelyn S. Liu, Scott A. Bowler, Leila B. Giron, Michelle L. D'Antoni, Cecilia M. Shikuma, Mohamed Abdel-Mohsen, Lishomwa C. Ndhlovu, Philip J. Norris
Summary: The study found that EVs expressing markers of monocyte activation and neuronal injury were elevated in HIV-infected individuals with cognitive impairment, suggesting that specific EV subsets may serve as novel biomarkers of neuronal injury in HIV infection. Additionally, levels of circulating platelet EVs were linked to monocyte activation, indicating a potential novel interaction in the pathogenesis of HIV-related cognitive impairment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Carolina Momentti, Mariana de Souza Macedo, Ana Flavia de Sousa Silva, Vanessa Cristina de Oliveira Souza, Fernando Barbosa Junior, Sylvia do Carmo Castro Franceschini, Anderson Marliere Navarro
Summary: Pregnant women in a city of Southeastern Brazil have adequate iodine nutrition. Household salt storage and seasoning consumption are risk factors for insufficient iodine status.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Correction
Biochemistry & Molecular Biology
Ana Carolina Momentti, Mariana de Souza Macedo, Ana Flavia de Sousa Silva, Vanessa Cristina de Oliveira Souza, Fernando Barbosa Jr, Sylvia do Carmo Castro Franceschini, Anderson Marliere Navarro
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Neurosciences
Carrie D. D. Johnston, Erika G. Marques de Menezes, Scott Bowler, Eugenia L. L. Siegler, Courtney Friday, Philip J. J. Norris, Michelle C. C. Rice, Mary E. E. Choi, Marshall J. J. Glesby, Lishomwa C. C. Ndhlovu
Summary: This study explored the association between extracellular vesicles, cell-free mitochondrial DNA, and cognitive dysfunction in older people with HIV. The findings suggest that plasma EVs, urine cf-mtDNA, and 4-meter walk time can predict neurocognitive impairment.
JOURNAL OF NEUROVIROLOGY
(2023)
Article
Nutrition & Dietetics
Soraya Regina Abu Jamra, Camila Gomes Komatsu, Fernando Barbosa Jr, Persio Roxo-Junior, Anderson Marliere Navarro
Summary: The increase in life expectancy can be attributed to the world's socioeconomic, sanitary, and nutritional conditions. A higher diversity score in diet has been shown to reduce the risk of malnutrition and improve health status. Zinc and selenium deficiencies can lead to immune system abnormalities and increased susceptibility to infections.