Review
Endocrinology & Metabolism
Caroline S. S. Johnson, Paul E. Micevych, Paul G. G. Mermelstein
Summary: Recent studies have shown that traditional estrogen receptors, alpha and beta, can also act at the cell surface in addition to their nuclear functions. Signaling from these membrane-bound estrogen receptors can rapidly affect cellular excitability and ultimately impact gene expression. The interaction between these membrane receptors and metabotropic glutamate receptors (mGluRs) plays a key role in various female functions such as reproduction and motivation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Medicine, Research & Experimental
Caglar Berkel, Ercan Cacan
Summary: Estrogen, estrogen receptors, and estrogen-related receptors play a role in cisplatin resistance, associated with higher resistance in cancer cells, mainly due to decreased caspase activity.
Review
Medicine, Research & Experimental
Agnieszka Anna Rawluszko-Wieczorek, Kamila Romanowska, Michal Nowicki
Summary: Estrogens, a group of hormones, play pivotal roles in physiological processes and are implicated in pathophysiological changes such as cancer. The two isoforms of estrogen receptor (ER), ER alpha and ER beta, elicit different transcriptional and tissue-specific responses. The expression of ER subtypes and their correlation with clinical outcomes of cancer are influenced by co-regulators, which play a role in modulating transcriptional activity on target gene chromatin. This review provides an overview of ER-driven responses, focusing on the complex interaction between ERs and chromatin modifiers, and discusses how chromatin accessibility and epigenetic modifications contribute to ER recruitment and transactivation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Pharmacology & Pharmacy
Sen He, Xin Li, Jie-Zhi Ma, Yuan Yang, Shuang Luo, Xian-De Xie, Bing-Hua Yan, Jian Yang, Lin Luo, Lin-Ying Cao
Summary: This study revealed the potential endocrine disruption mechanism of Niclosamide by activating estrogen receptors (ERs) and estrogen-related receptors (ERRs) at environmentally-related nanomolar levels. By fluorescence competitive binding assays and luciferase reporter gene assays, it was found that NIC showed higher binding affinity with ERR gamma than other receptors. Additionally, molecular docking simulations indicated that NIC could bind to ERR gamma with the highest binding energy.
Article
Biochemistry & Molecular Biology
Rebecca K. Dirkes, Nathan C. Winn, Thomas J. Jurrissen, Dennis B. Lubahn, Victoria J. Vieira-Potter, Jaume Padilla, Pamela S. Hinton
Summary: The study found that in male mice, ERKO has a positive impact on bone density, with exercise having little effect. ERKO has a negative impact on cortical geometry, but exercise can partially reverse this effect. Neither ERKO nor exercise have an effect on sclerostin expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Jir-You Wang, Chao-Ming Chen, Cheng-Fong Chen, Po-Kuei Wu, Wei-Ming Chen
Summary: Osteosarcoma is a highly malignant musculoskeletal tumor commonly seen in various age groups, with a survival rate of 70-80%. ER alpha plays a significant role in osteosarcoma pathogenesis and chemosensitivity, with potential as a target for current treatments and a prognostic factor for chemotherapy response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Muhammad Zafar Irshad Khan, Muhammad Uzair, Adila Nazli, Jian-Zhong Chen
Summary: Estrogen plays a crucial role in regulating various physiological actions and is particularly involved in breast cancer development. This review provides a comprehensive study on estrogen receptors and their relationship with diseases, laying a foundation for understanding the actions of estrogen and developing relevant therapeutic strategies.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Ying Zhao, Xin Wang, Yi Liu, Hao-Yu Wang, Jin Xiang
Summary: This review summarizes the effects of estrogen on the targets, metabolism, and resistance of anticancer drugs and describes the related pathways and underlying mechanisms. Understanding the relationship between estrogen and cancer drug therapy is crucial for developing specific treatment strategies to achieve optimal outcomes.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Shokouh Arjmand, Dirk Bender, Steen Jakobsen, Gregers Wegener, Anne M. Landau
Summary: This article discusses the role of estrogen receptors in brain function and disorders, as well as the limitations of using PET tracers for imaging ERs in the brain. The authors propose avenues for developing efficient PET tracers to study the dynamics of ERs and neuropsychiatric diseases associated with their malfunction.
Review
Oncology
Plabon Kumar Das, Joti Saha, Suja Pillai, Alfred K-Y Lam, Vinod Gopalan, Farhadul Islam
Summary: This study highlights the significant role of estrogens and their receptors, particularly ERβ, in the pathogenesis of colorectal carcinoma (CRC). Understanding the underlying mechanisms of estrogen and its receptors in CRC pathogenesis could offer new insights for therapeutic development.
Review
Endocrinology & Metabolism
Angeles C. Tecalco-Cruz, Lilia Lopez-Canovas, Elisa Azuara-Liceaga
Summary: Estrogen receptor alpha (ER alpha) is a transcription factor activated by estrogenic hormones to regulate gene expression in certain organs, including the brain. Estrogen signaling pathways play a crucial role in maintaining cognitive functions in the brain. Reduction of estrogens in menopause may increase the risk of neurodegeneration associated with Alzheimer's disease in women. Therefore, understanding estrogen/ER alpha signaling is important for identifying new biomarkers and potential therapeutic targets for Alzheimer's disease in women.
METABOLIC BRAIN DISEASE
(2023)
Review
Cardiac & Cardiovascular Systems
Yanan Sun, Shreya Sangam, Qiang Guo, Jian Wang, Haiyang Tang, Stephen M. Black, Ankit A. Desai
Summary: Estrogen plays a complex role in pulmonary arterial hypertension (PAH), with studies showing contradictory effects in patients and animal models. While patients may be adversely affected, animal models demonstrate protective effects of estrogen. Ovariectomy in female rats has been shown to worsen the condition, highlighting the need for further research on the tissue-specific interactions of estrogen in PAH and right heart function.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Oncology
Giuseppe Carruba
Summary: This review explores the role of estrogen in the human liver and investigates the mechanisms behind its transition from protective to harmful. Estrogens play key roles in liver development, homeostasis, and function, but excess estrogen may lead to chronic diseases, and even cancer. Multiple pieces of experimental evidence suggest that estrogen is involved in the development and progression of hepatocellular carcinoma.
Article
Fisheries
Shiyan Liu, Haofeng Ouyang, Chong Han, Jingjun Huang, Qiaoying Zhu, Dingrui Liu, Linqiang Han, Shuisheng Li, Guifeng Li, Haoran Lin, Yong Zhang
Summary: The study cloned six estrogen-related receptors (errs) from the gonads of mandarin fish and analyzed their expression patterns and functions.
AQUACULTURE REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Alessio Cimmino, Giovanni Francesco Fasciglione, Magda Gioia, Stefano Marini, Chiara Ciaccio
Summary: Phytoestrogens are plant-derived compounds with estrogen-like properties. This review explores their potential benefits in cancer prevention and treatment, with a focus on osteosarcoma. It discusses their effects on cell cycle, apoptosis, and ER signaling in osteosarcoma models, as well as their interactions with conventional chemotherapy agents. Understanding the impact of phytoestrogens in osteosarcoma holds promise for developing novel therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)