Article
Biochemistry & Molecular Biology
Andrea Kelemen, Idan Carmi, Adam Oszvald, Peter Lorincz, Gabor Petovari, Tamas Tolgyes, Kristof Dede, Attila Bursics, Edit Buzas, Zoltan Wiener
Summary: The study identified functional differences in EV uptake ability among CRC cells, which must be considered when using EVs as therapeutic tools for targeting cancer cells.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Multidisciplinary Sciences
Qingyan Li, Huixia Zhao, Weiwei Dong, Na Guan, Yanyan Hu, Zhiyan Zeng, He Zhang, Fengyun Zhang, Qiuwen Li, Jingwen Yang, Wenhua Xiao
Summary: This study demonstrates the significant role of RAB27A in the development and progression of colorectal cancer, indicating its potential as a therapeutic target and prognostic indicator.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Jiayu Wang, Mengxin Zhu, Jinghan Zhu, Juntao Li, Xingchao Zhu, Kun Wang, Kanger Shen, Kexi Yang, Xiangyu Ni, Xin Liu, Guangbo Zhang, Qinhua Xi, Tongguo Shi, Weichang Chen
Summary: This study found that HES1 plays a significant promotion role in colorectal cancer (CRC), enhancing aerobic glycolysis and progression through increasing the stability of m6A-modified GLUT1 mRNA in an IGF2BP2-dependent manner. This discovery may provide a potential therapeutic target for CRC treatment.
CELL DEATH DISCOVERY
(2023)
Article
Oncology
Hong-Tao Liu, Si-Yuan Chen, Ling-Long Peng, Li Zhong, Li Zhou, Si-Qi Liao, Zhi-Ji Chen, Qing-Liang Wang, Song He, Zhi-Hang Zhou
Summary: By using spatial transcriptomic techniques, we identified 13 genes that were overexpressed in invasive clusters in colorectal cancer (CRC). Among these genes, CSTB and TM4SF1 were found to be associated with poor progression-free survival in CRC patients. The ribosome pathway was increased, while the antigen processing and presentation pathway was decreased in CRC progression. Knockdown of AKR1B1 inhibited CRC cell proliferation, migration, and invasion. The study revealed the spatial heterogeneity within CRC tissues and identified novel genes associated with CRC invasion.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Yun Wang, Lu-Yao Ma, Xiao-Ping Yin, Bu-Lang Gao
Summary: This paper reviews the application of radiomics and radiogenomics in the diagnosis, treatment, monitoring of disease progression, and prognosis of patients with colorectal cancer liver metastases.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
YuJian Xia, Jian Chen, Guangyao Liu, WeiBin Huang, XiaoJing Wei, ZheWei Wei, YuLong He
Summary: The study revealed that STIP1 is highly expressed in CRC tissues and is associated with poor overall survival. STIP1 promotes CRC cell proliferation and invasion through the STAT3 pathway, while its knockdown inhibits these functions. This suggests that STIP1 could be a potential target for CRC therapy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Medicine, General & Internal
Wenxia Li, Tongsheng Wang, Yubing Zhu, Haijiao Yu, Ling Ma, Yuhan Ding, Gao Hong, Ding Lei
Summary: This study investigated the clinical characteristics, survival, prognostic factors, and treatment of brain metastasis from colorectal cancer. The researchers found that Karnofsky performance status and treatment modalities were independent prognostic factors, and patients with high Karnofsky performance status and multimodal treatment had improved survival.
Article
Oncology
Zifeng Yang, Yong Li, Xiusen Qin, Zejian Lv, Huaiming Wang, Deqing Wu, Zixu Yuan, Hui Wang
Summary: A predictive nomogram was developed using multicenter data to predict the overall survival in CRC patients with S-PM, showing good discriminative ability and high accuracy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, Research & Experimental
Yang Yang, Mingyang Feng, LiangLiang Bai, Weiting Liao, Kexun Zhou, Mengxi Zhang, Qiuji Wu, Feng Wen, Wanting Lei, Pengfei Zhang, Nan Zhang, Jiaxing Huang, Qiu Li
Summary: This study analyzed EMT-related genes in CRC using bioinformatics methods, identified nine EMT-related genes that impact CRC prognosis, metastasis, drug efficacy, and immunity, and constructed a risk prognosis model.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Oncology
Furong Liu, Xiaoli Wei, Zhanhong Chen, Yanxing Chen, Peishan Hu, Ying Jin
Summary: The purpose of this study was to investigate the biological effect of PFKFB2 in CRC. PFKFB2 expression was downregulated in acidic culture medium and human CRC tissues compared to normal tissues. Low PFKFB2 expression was associated with shorter overall survival and disease-free survival in CRC patients. PFKFB2 could inhibit the metastasis and malignant progression of CRC cells through suppressing EMT and glycolysis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Chunrong Wu, Guiyin Sun, Fan Wang, Jiangyan Chen, Fangbiao Zhan, Xiaojuan Lian, Jie Wang, Fanbin Weng, Bo Li, Weijun Tang, Jin Quan, Debing Xiang
Summary: DYRK2 downregulation is correlated with poor prognosis in colorectal cancer (CRC). Overexpression of DYRK2 can reduce proliferative, migratory, and invasive activities of CRC cells, increase chemosensitivity, and inhibit epithelial-mesenchymal transition induction.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Honghua Peng, Guifeng Liu, Ying Bao, Xi Zhang, Lehong Zhou, Chenghui Huang, Zewen Song, Sudan Cao, Shiying Dang, Jing Zhang, Tanxiao Huang, Yuling Wu, Mingyan Xu, Lele Song, Peiguo Cao
Summary: The mutational landscape of CRC tissue was largely similar between patients with or without liver metastasis, with higher frequencies of TRIM77 and TCF7L2 mutations in patients with liver metastasis. TRIM77 mutations were identified as the independent risk factor for CRC patients with liver metastasis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jiamin Zhou, Longhai Feng, Xinxiang Li, Miao Wang, Yiming Zhao, Ning Zhang, Longrong Wang, Ti Zhang, Anrong Mao, Ye Xu, Lu Wang
Summary: The study aimed to investigate the value of total laparoscopic simultaneous colorectal and hepatic resection in patients with synchronous colorectal cancer liver metastases. The results showed that laparoscopic surgery had longer operation time and less intraoperative blood loss compared to open surgery. There were no significant differences in postoperative morbidity and long-term survival among the different surgery groups.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zongxia Wang, Lizhou Jia, Yushu Sun, Chunli Li, Lingli Zhang, Xiangcheng Wang, Hao Chen
Summary: The study revealed that CORO1C interacts with Trop2, and its high expression in CRC tissues is associated with tumor invasion, with CORO1C regulating tumor growth and invasion through the PI3K/AKT pathway. Therefore, CORO1C may serve as a valuable prognostic biomarker and drug target in CRC patients.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Gastroenterology & Hepatology
Niccolo Allievi, Paolo Goffredo, Kyle W. Freischlag, Alan F. Utria, John W. Cromwell, Michele Pisano, Elia Poiasina, Imran Hassan
Summary: This study compared the survival rates of nonmetastatic, node-negative colorectal cancers invading the submucosa and muscularis propria, and investigated factors associated with decreased survival. The results showed that T2 tumors had lower overall survival and disease-specific survival compared to T1 tumors, suggesting a need to revise the American Joint Committee on Cancer staging system.
DISEASES OF THE COLON & RECTUM
(2022)
Article
Pathology
Hyeongjoo Kim, Taewan Kim, Gunn Jaygal, Jongsoo Woo, Chang-Jin Kim, Moo-Jun Baek, Dongjun Jeong
PATHOLOGY RESEARCH AND PRACTICE
(2020)
Article
Biochemistry & Molecular Biology
Ita Novita Sari, Ying-Gui Yang, Yoseph Toni Wijaya, Nayoung Jun, Sanghyun Lee, Kwang Seock Kim, Jeevisha Bajaj, Vivian G. Oehler, Soo-Hyun Kim, Soo-Young Choi, Sa-Hee Park, Dong-Wook Kim, Tannishtha Reya, Jaeseok Han, Hyog Young Kwon
Summary: AMD1 plays a crucial role in the progression of myeloid leukemia, and its depletion leads to differentiation of leukemic stem cells and impairs leukemia progression. Pharmacological inhibition of AMD1 can significantly reduce the progression of leukemia cells, offering a new therapeutic approach for the treatment of myeloid leukemia.
Article
Oncology
Dong Hyun Kang, Dong Jun Jeong, Tae Sung Ahn, Hyun Yong Lee, Han Jo Kim, Sang Byung Bae, Hyeong Joo Kim, Moon Soo Lee, Hyog Young Kwon, Moo-Jun Baek
Summary: High expression levels of TET2 in colorectal cancer are associated with favorable prognosis, while AMPK expression levels do not significantly impact patient survival. Further functional analysis of AMPK/TET2 expression in CRC is necessary to better understand its clinical significance.
Article
Pharmacology & Pharmacy
Tejinder Singh, Dong Hyun Kang, Tae Wan Kim, Hye Jeong Kong, Jae Sung Ryu, Seob Jeon, Tae Sung Ahn, Dongjun Jeong, Moo Jun Baek, Jungkyun Im
Summary: The octaarginine-oxaliplatin conjugate successfully delivered oxaliplatin into colon cancer cells at low concentrations, showing high antitumor activity in both in vitro and in vivo studies. This strategy may provide a new approach for designing oxaliplatin derivatives with improved therapeutic capabilities.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Oncology
Takashi Semba, Xiaoping Wang, Xuemei Xie, Evan N. Cohen, James M. Reuben, Kevin N. Dalby, James P. Long, Lan Thi Hanh Phi, Debu Tripathy, Naoto T. Ueno
Summary: The study identified that high phosphorylated JNK level in TNBC is associated with increased Treg infiltration. Inhibition of JNK signaling led to reduced tumor growth and Treg infiltration, and increased CD8(+) T cell infiltration, possibly through suppression of CCL2 secretion. This suggests that targeting the JNK/C-JUN/CCL2 axis may offer new therapeutic strategies for combating the aggressiveness of TNBC.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Oncology
Ita Novita Sari, Tania Setiawan, Kwang Seock Kim, Yoseph Toni Wijaya, Kae Won Cho, Hyog Young Kwon
Summary: Polyamines, essential for the proliferation and development of eukaryotes, are low-molecular-weight organic polycations with strict intracellular regulation. In cancer, dysregulation of polyamine metabolism leads to elevated levels and interactions with oncogenic pathways like mTOR and RAS, making them potential therapeutic targets. Unraveling the molecular mechanisms linking polyamine metabolism to carcinogenesis is crucial for developing novel inhibitors and understanding the findings of clinical trials.
Article
Oncology
Yoseph Toni Wijaya, Tania Setiawan, Ita Novita Sari, Seung-Yeol Nah, Hyog Young Kwon
Summary: Gintonin (GT) protects against cancer cachexia by reducing oxidative stress and inhibiting inflammation-related genes, showing anti-atrophy effects in muscle cells and a mouse model.
Meeting Abstract
Oncology
Lan Phi, Takashi Semba, Jason Foulks, Steven Warner, David Bearss, Savitri Krishnamurthy, James Long, James Reuben, Debu Tripathy, Naoto Ueno, Xiaoping Wang
Meeting Abstract
Oncology
Xiaoping Wang, Takashi Semba, Ganiraju C. Manyam, Jing Wang, Shan Shao, Francois Bertucci, Pascal Finetti, Savitri Krishnamurthy, Lan ThiHanh Phi, Troy Pearson, Jared K. Burks, Evan N. Cohen, James M. Reuben, Fei Yang, Hu Min, Nicholas Navin, Toshiaki Iwase, Yichao Shen, Xiang Zhang, Debu Tripathy, Naoto T. Ueno
Article
Biochemistry & Molecular Biology
Sooyoun Kim, Doyeon Kim, Sanghyun Roh, Inpyo Hong, Hyeongjoo Kim, Tae Sung Ahn, Dong Hyun Kang, Moon Soo Lee, Moo-Jun Baek, Hyoung Jong Kwak, Chang-Jin Kim, Dongjun Jeong
Summary: This study revealed that SMOX is overexpressed in colorectal cancer and may serve as an important oncogene in CRC. Moreover, SMOX overexpression could be a valuable prognostic marker and potential therapeutic target for CRC.
Article
Geriatrics & Gerontology
Yoseph Toni Wijaya, Tania Setiawan, Ita Novita Sari, Keunwan Park, Chan Hee Lee, Kae Won Cho, Yun Kyung Lee, Jae-Young Lim, Jeong Kyo Yoon, Sae Hwan Lee, Hyog Young Kwon
Summary: Ginsenoside Rd (GRd) significantly ameliorates muscle wasting induced by aging and cancer through various mechanisms, demonstrating a potential therapeutic role in reversing muscle wasting in mice.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Oncology
Han Jo Kim, Inpyo Hong, Sanghyun Roh, Sooyoun Kim, Hyeongjoo Kim, Seunghyun Oh, Tae Sung Ahn, Dong Hyun Kang, Moo-Jun Baek, Dongjun Jeong
Summary: Colorectal cancer (CRC) is a common and deadly cancer. LY6E, a member of the LY6 family, is highly expressed in CRC and plays a role in CRC recurrence and metastasis. High expression of LY6E is associated with worse overall survival in CRC patients. Knockdown of LY6E inhibits CRC cell proliferation, migration, invasion, and colony formation, suggesting its oncogenic functions and potential as a therapeutic target in CRC.
Article
Medicine, General & Internal
Soohyeon Lee, Dong Hyun Kang, Tae Sung Ahn, Seung Soo Kim, Jong Hyuk Yun, Hyun Jung Kim, Seoung Hee Seo, Tae Wan Kim, Hye Jeong Kong, Moo Jun Baek
Summary: This study analyzed the medical records of 107 patients with stage III colorectal cancer who received adjuvant chemotherapy. Body composition and selected immunonutritional markers were analyzed to determine their impact on chemotherapy adherence. The results showed that skeletal muscle index was positively correlated with chemotherapy adherence, and there were differences in psoas muscle index between high and low adherence groups. Age, white blood cell count, and skeletal muscle index were identified as factors affecting chemotherapy adherence. Adjusting drug dosage based on these factors can improve treatment efficiency.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeong Won Lee, Hyein Ahn, Su Jin Jang, Moo-Jun Baek, Nam Hun Heo, Sang Mi Lee
Summary: This study found that computed tomography-attenuation and maximum F-18-FDG uptake in the liver on F-18-FDG PET/CT were significant predictive factors for hepatic RFS in patients with colorectal cancer after curative resection. However, these liver parameters were not significantly associated with extrahepatic RFS.
HELLENIC JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Oncology
Dae-Ro Lim, Dong-Hyun Kang, Jung-Chul Kuk, Tae-Hyung Kim, Eung-Jin Shin, Tae-Sung Ahn, Hyeong-Joo Kim, Dong-Jun Jeong, Moo-Jun Baek, Nam-Kyu Kim
Summary: The study investigated the role of GPR56 in CRC and found that its downregulation affected cell proliferation, invasion, and migration abilities, as well as inhibited colony-forming. High expression of GPR56 was negatively correlated with the overall survival rate of CRC patients, suggesting its potential as a prognostic indicator.
