Journal
ONCOTARGET
Volume 8, Issue 22, Pages 35669-35680Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/oncotarget.10572
Keywords
IncRNA; T-UCRs; breast cancer; apoptosis; prognosis
Categories
Funding
- Associazione Habana per la Ricerca contro il Cancro (AIRC) [IG13387]
- Medical Research Council, UK
- Istituto Dermopatico dell'linmacolata/Istintto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS)
- MRC [MC_U132670600] Funding Source: UKRI
- Medical Research Council [MC_U132670600] Funding Source: researchfish
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Transcribed-ultraconserved regions (T-UCRs) are long non-coding RNAs (IncRNA) encoded by a subset of long ultraconserved stretches in the human genome. Recent studies revealed that the expression of several T-UCRs is altered in cancer and growing evidences underline the importance of T-UCRs in oncogenesis, offering also potential new strategies for diagnosis and prognosis. We found that overexpression of one specific T-UCRs named uc.63 is associated with bad outcome in luminal A subtype of breast cancer patients. uc.63 is localized in the third intron of exportin-1 gene (XPO1) and is transcribed in the same orientation of its host gene. Interestingly, silencing of uc.63 induces apoptosis in vitro. However, silencing of host gene XPO1 does not cause the same effect suggesting that the transcription of uc.63 is independent of XPO1. Our results reveal an important role of uc.63 in promoting breast cancer cells survival and offer the prospect to identify a signature associated with poor prognosis.
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